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146 relations: Adverse event, Akathisia, Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptor, Alpha-2A adrenergic receptor, Alpha-2B adrenergic receptor, Alpha-2C adrenergic receptor, American Psychiatric Association, Amphetamine, Aripiprazole lauroxil, Asenapine, Attention deficit hyperactivity disorder, Atypical antipsychotic, Australia, Autism, Barr Pharmaceuticals, Beta-1 adrenergic receptor, Beta-2 adrenergic receptor, Bioavailability, Bipolar disorder, Bloomberg L.P., Boxed warning, Brief Psychiatric Rating Scale, Bristol-Myers Squibb, British National Formulary, Carbamazepine, Caudate nucleus, Chemical synapse, Chlorpromazine, Citalopram, Clozapine, Cochrane (organisation), CYP2D6, CYP3A4, Dementia, Diabetes mellitus, Digital pill, Dopamine agonist, Dopamine receptor, Dopamine receptor D1, Dopamine receptor D2, Dopamine receptor D3, Dopamine receptor D4, Dopamine receptor D5, Dopaminergic, Drug development, Drug discovery, Drug Price Competition and Patent Term Restoration Act, Escitalopram, Etoperidone, ..., European Medicines Agency, Extrapyramidal symptoms, Feces, Fluoxetine, Fluvoxamine, Functional selectivity, Haloperidol, Histamine H1 receptor, Histamine H2 receptor, Histamine H3 receptor, Histamine H4 receptor, Histamine receptor, Hyperglycemia, Intramuscular injection, Intrinsic activity, Inverse agonist, Japan, Kidney, Ligand (biochemistry), Liver, Lundbeck, Lurasidone, Major depressive disorder, Mania, Mean absolute difference, Mechanism of action, Medscape, Mental disorder, Mental health, Mesocortical pathway, Mesolimbic pathway, Mixed affective state, Mood stabilizer, Muscarinic acetylcholine receptor, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M5, National Institute for Health and Care Excellence, Nefazodone, Neuroleptic malignant syndrome, NMDA receptor, Obsessive–compulsive disorder, Off-label use, Olanzapine, Oral administration, Orally disintegrating tablet, Otsuka Pharmaceutical, Paroxetine, Partial agonist, Pharmacodynamics, Phenylpiperazine, Positron emission tomography, Pregnancy category, Problem gambling, Prodrug, Putamen, QT interval, Quality of life, Quetiapine, Receptor antagonist, Relative risk, Risperidone, Schizophrenia, Selective serotonin reuptake inhibitor, Serotonin transporter, Sertraline, Solution, Stereotypy, Striatum, Supplementary protection certificate, Tablet (pharmacy), Tardive dyskinesia, Teva Pharmaceutical Industries, The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, Therapeutic Goods Administration, Tic disorder, Trazodone, U.S. state, United Kingdom, United States, United States District Court for the District of New Jersey, Ziprasidone, 5-HT receptor, 5-HT1A receptor, 5-HT1B receptor, 5-HT1D receptor, 5-HT1E receptor, 5-HT2A receptor, 5-HT2B receptor, 5-HT2C receptor, 5-HT3 receptor, 5-HT5A receptor, 5-HT6 receptor, 5-HT7 receptor. Expand index (96 more) »
Adverse event
An adverse event (AE) is any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment.
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Akathisia
Akathisia is a movement disorder characterized by a feeling of inner restlessness and inability to stay still.
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Alpha-1A adrenergic receptor
The alpha-1A adrenergic receptor (α1A adrenoreceptor), also known as ADRA1A, formerly known also as the alpha-1C adrenergic receptor, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.
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Alpha-1B adrenergic receptor
The alpha-1B adrenergic receptor (α1B adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.
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Alpha-2A adrenergic receptor
The alpha-2A adrenergic receptor (α2A adrenoceptor), also known as ADRA2A, is an α2 adrenergic receptor, and also denotes the human gene encoding it.
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Alpha-2B adrenergic receptor
The alpha-2B adrenergic receptor (α2B adrenoceptor), is a G-protein coupled receptor.
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Alpha-2C adrenergic receptor
The alpha-2C adrenergic receptor (α2C adrenoceptor), also known as ADRA2C, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.
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American Psychiatric Association
The American Psychiatric Association (APA) is the main professional organization of psychiatrists and trainee psychiatrists in the United States, and the largest psychiatric organization in the world.
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Amphetamine
Amphetamine (contracted from) is a potent central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity.
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Aripiprazole lauroxil
Aripiprazole lauroxil (USAN) (brand name Aristada) is a long-acting injectable atypical antipsychotic that was developed by Alkermes.
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Asenapine
Asenapine, sold under the trade names Saphris and Sycrest among others, is an atypical antipsychotic medication used to treat schizophrenia and acute mania associated with bipolar disorder.
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Attention deficit hyperactivity disorder
Attention-deficit hyperactivity disorder (ADHD) is a mental disorder of the neurodevelopmental type.
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Atypical antipsychotic
The atypical antipsychotics (AAP; also known as second generation antipsychotics (SGAs)) are a group of antipsychotic drugs (antipsychotic drugs in general are also known as major tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) used to treat psychiatric conditions.
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Australia
Australia, officially the Commonwealth of Australia, is a sovereign country comprising the mainland of the Australian continent, the island of Tasmania and numerous smaller islands.
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Autism
Autism is a developmental disorder characterized by troubles with social interaction and communication and by restricted and repetitive behavior.
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Barr Pharmaceuticals
Barr Pharmaceuticals was a global specialty and generic drug manufacturer with operations in 30 countries.
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Beta-1 adrenergic receptor
The beta-1 adrenergic receptor (β1 adrenoceptor), also known as ADRB1, is a beta-adrenergic receptor, and also denotes the human gene encoding it.
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Beta-2 adrenergic receptor
The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that interacts with (binds) epinephrine, a hormone and neurotransmitter (ligand synonym, adrenaline) whose signaling, via a downstream L-type calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation.
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Bioavailability
In pharmacology, bioavailability (BA or F) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.
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Bipolar disorder
Bipolar disorder, previously known as manic depression, is a mental disorder that causes periods of depression and periods of abnormally elevated mood.
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Bloomberg L.P.
Bloomberg L.P. is a privately held financial, software, data, and media company headquartered in Midtown Manhattan, New York City.
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Boxed warning
In the United States, a boxed warning (sometimes "black box warning", colloquially) is a type of warning that appears on the package insert for certain prescription drugs, so called because the U.S. Food and Drug Administration specifies that it is formatted with a 'box' or border around the text.
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Brief Psychiatric Rating Scale
The Brief Psychiatric Rating Scale (BPRS) is a rating scale which a clinician or researcher may use to measure psychiatric symptoms such as depression, anxiety, hallucinations and unusual behaviour.
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Bristol-Myers Squibb
Bristol-Myers Squibb (BMS) is an American pharmaceutical company, headquartered in New York City.
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British National Formulary
The British National Formulary (BNF) is a United Kingdom (UK) pharmaceutical reference book that contains a wide spectrum of information and advice on prescribing and pharmacology, along with specific facts and details about many medicines available on the UK National Health Service (NHS).
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Carbamazepine
Carbamazepine (CBZ), sold under the tradename Tegretol, among others, is a medication used primarily in the treatment of epilepsy and neuropathic pain.
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Caudate nucleus
The caudate nucleus is one of the structures that make up the dorsal striatum, which is a component of the basal ganglia.
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Chemical synapse
Chemical synapses are biological junctions through which neurons' signals can be exchanged to each other and to non-neuronal cells such as those in muscles or glands.
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Chlorpromazine
Chlorpromazine (CPZ), marketed under the trade names Thorazine and Largactil among others, is an antipsychotic medication.
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Citalopram
Citalopram (brand names: Celexa, Cipramil and others) is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class.
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Clozapine
Clozapine, sold under the brand name Clozaril among others, is an atypical antipsychotic medication.
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Cochrane (organisation)
Cochrane is a non-profit, non-governmental organization formed to organize medical research findings so as to facilitate evidence-based choices about health interventions faced by health professionals, patients, and policy makers.
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CYP2D6
Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene.
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CYP3A4
Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.
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Dementia
Dementia is a broad category of brain diseases that cause a long-term and often gradual decrease in the ability to think and remember that is great enough to affect a person's daily functioning.
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Diabetes mellitus
Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period.
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Digital pill
A digital pill is a pharmaceutical dosage form that contains an ingestible sensor inside of a pill.
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Dopamine agonist
A dopamine receptor agonist is a compound that activates dopamine receptors.
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Dopamine receptor
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS).
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Dopamine receptor D1
Dopamine receptor D1, also known as DRD1, is a protein that in humans is encoded by the DRD1 gene.
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Dopamine receptor D2
Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.
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Dopamine receptor D3
Dopamine receptor D3 is a protein that in humans is encoded by the DRD3 gene.
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Dopamine receptor D4
The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the gene on chromosome 11 at 11p15.5.
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Dopamine receptor D5
Dopamine receptor D5, also known as D1BR, is a protein that in humans is encoded by the DRD5 gene.
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Dopaminergic
Dopaminergic means "related to dopamine" (literally, "working on dopamine"), dopamine being a common neurotransmitter.
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Drug development
Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery.
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Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.
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Drug Price Competition and Patent Term Restoration Act
The Drug Price Competition and Patent Term Restoration Act (Public Law 98-417), informally known as the Hatch-Waxman Act, is a 1984 United States federal law which encourages the manufacture of generic drugs by the pharmaceutical industry and established the modern system of government generic drug regulation in the United States.
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Escitalopram
Escitalopram, sold under the brand names Cipralex and Lexapro among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
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Etoperidone
Etoperidone, associated with several brand names, is an atypical antidepressant which was developed in the 1970s and either is no longer marketed or was never marketed.
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European Medicines Agency
The European Medicines Agency (EMA) is a European Union agency for the evaluation of medicinal products.
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Extrapyramidal symptoms
Extrapyramidal symptoms (EPS), also known as extrapyramidal side effects (EPSE), are drug-induced movement disorders that include acute and tardive symptoms.
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Feces
Feces (or faeces) are the solid or semisolid remains of the food that could not be digested in the small intestine.
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Fluoxetine
Fluoxetine, also known by trade names Prozac and Sarafem, among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
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Fluvoxamine
Fluvoxamine, sold under the brand name Luvox among others, is a medication which is used primarily for the treatment of obsessive–compulsive disorder (OCD), and is also used to treat major depressive disorder and anxiety disorders such as panic disorder and post-traumatic stress disorder.
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Functional selectivity
Functional selectivity (or “agonist trafficking”, “biased agonism”, “biased signalling”, "ligand bias" and “differential engagement”) is the ligand-dependent selectivity for certain signal transduction pathways relative to a reference ligand (often the endogenous hormone or peptide) at the same receptor.
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Haloperidol
Haloperidol, marketed under the trade name Haldol among others, is a typical antipsychotic medication.
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Histamine H1 receptor
The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors.
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Histamine H2 receptor
H2 receptors are positively coupled to adenylate cyclase via Gs.
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Histamine H3 receptor
Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act as autoreceptors in presynaptic histaminergic neurons, and also control histamine turnover by feedback inhibition of histamine synthesis and release.
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Histamine H4 receptor
The histamine H4 receptor is, like the other three histamine receptors, a member of the G protein-coupled receptor superfamily.
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Histamine receptor
The histamine receptors are a class of G protein–coupled receptors which bind histamine as their primary endogenous ligand.
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Hyperglycemia
Hyperglycemia, or high blood sugar (also spelled hyperglycaemia or hyperglycæmia) is a condition in which an excessive amount of glucose circulates in the blood plasma.
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Intramuscular injection
Intramuscular (also IM or im) injection is the injection of a substance directly into muscle.
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Intrinsic activity
Intrinsic activity (IA) or efficacy refers to the relative ability of a drug-receptor complex to produce a maximum functional response.
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Inverse agonist
In the field of pharmacology, an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist.
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Japan
Japan (日本; Nippon or Nihon; formally 日本国 or Nihon-koku, lit. "State of Japan") is a sovereign island country in East Asia.
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Kidney
The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.
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Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
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Liver
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
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Lundbeck
H.
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Lurasidone
Lurasidone (trade name Latuda) is an atypical antipsychotic developed by Dainippon Sumitomo Pharma and marketed by Sunovion in the U.S. It has been an FDA approved treatment for schizophrenia since 2010 and for treating depressive episodes in adults with bipolar I disorder since 2013.
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Major depressive disorder
Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.
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Mania
Mania, also known as manic syndrome, is a state of abnormally elevated arousal, affect, and energy level, or "a state of heightened overall activation with enhanced affective expression together with lability of affect." Although mania is often conceived as a "mirror image" to depression, the heightened mood can be either euphoric or irritable; indeed, as the mania intensifies, irritability can be more pronounced and result in violence, or anxiety.
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Mean absolute difference
The mean absolute difference (univariate) is a measure of statistical dispersion equal to the average absolute difference of two independent values drawn from a probability distribution.
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Mechanism of action
In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect.
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Medscape
Medscape is a website providing access to medical information for clinicians; the organization also provides continuing education for physicians and health professionals.
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Mental disorder
A mental disorder, also called a mental illness or psychiatric disorder, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning.
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Mental health
Mental health is a level of psychological well-being or an absence of mental illness.
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Mesocortical pathway
The mesocortical pathway is a dopaminergic pathway that connects the ventral tegmentum to the prefrontal cortex.
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Mesolimbic pathway
The mesolimbic pathway, sometimes referred to as the reward pathway, is a dopaminergic pathway in the brain.
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Mixed affective state
Traditionally, a mixed affective state, formerly known as a mixed-manic or mixed episode, has been defined as a state wherein features unique to both depression and mania—such as despair, fatigue, morbid or suicidal ideation, racing thoughts, pressure of activity, and heightened irritability—occur either simultaneously or in very short succession.
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Mood stabilizer
A mood stabilizer is a psychiatric pharmaceutical drug used to treat mood disorders characterized by intense and sustained mood shifts, typically bipolar disorder type I or type II, borderline personality disorder (BPD) and schizophrenia.
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Muscarinic acetylcholine receptor
Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons and other cells.
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Muscarinic acetylcholine receptor M1
The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the CHRM1 gene.
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Muscarinic acetylcholine receptor M2
The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor that in humans is encoded by the CHRM2 gene.
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Muscarinic acetylcholine receptor M3
The muscarinic acetylcholine receptor, also known as cholinergic/acetylcholine receptor M3, or the muscarinic 3, is a muscarinic acetylcholine receptor encoded by the human gene CHRM3.
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Muscarinic acetylcholine receptor M4
The muscarinic acetylcholine receptor M4, also known as the cholinergic receptor, muscarinic 4 (CHRM4), is a protein that, in humans, is encoded by the CHRM4 gene.
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Muscarinic acetylcholine receptor M5
The human muscarinic acetylcholine receptor M5, encoded by the gene, is a member of the G protein-coupled receptor superfamily of integral membrane proteins.
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National Institute for Health and Care Excellence
The National Institute for Health and Care Excellence (NICE) is an executive non-departmental public body of the Department of Health in the United Kingdom, which publishes guidelines in four areas.
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Nefazodone
Nefazodone, sold formerly under the brand names Serzone, Dutonin, and Nefadar among others, is an atypical antidepressant which was first marketed by Bristol-Myers Squibb in 1994 but has since largely been discontinued.
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Neuroleptic malignant syndrome
Neuroleptic malignant syndrome (NMS) is a life-threatening reaction that occasionally occurs in response to neuroleptic or antipsychotic medication.
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NMDA receptor
The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells.
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Obsessive–compulsive disorder
Obsessive–compulsive disorder (OCD) is a mental disorder where people feel the need to check things repeatedly, perform certain routines repeatedly (called "rituals"), or have certain thoughts repeatedly (called "obsessions").
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Off-label use
Off-label use is the use of pharmaceutical drugs for an unapproved indication or in an unapproved age group, dosage, or route of administration.
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Olanzapine
Olanzapine (originally branded Zyprexa) is an antipsychotic medication used to treat schizophrenia and bipolar disorder.
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Oral administration
| name.
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Orally disintegrating tablet
An orally disintegrating tablet or orally dissolving tablet (ODT) is a drug dosage form available for a limited range of over-the-counter (OTC) and prescription medications.
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Otsuka Pharmaceutical
(), abbreviated OPC, is a pharmaceutical company headquartered in Tokyo, Osaka and Naruto, Japan.
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Paroxetine
Paroxetine, also known by trade names including Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive-compulsive disorder, social anxiety disorder, panic disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder. It has also been used in the treatment of hot flashes and night sweats associated with menopause. It has a similar tolerability profile to other SSRIs. The common side effects include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping and delayed ejaculation. It may also be associated with a slightly increased risk of birth defects. The rate of withdrawal symptoms in young people may be higher with paroxetine and venlafaxine than other SSRIs and SNRIs. Several studies have associated paroxetine with suicidal thinking and behavior in children and adolescents. Marketing of the drug began in 1992 by the pharmaceutical company SmithKline Beecham, known since 2000 as GlaxoSmithKline. Generic formulations have been available since 2003 when the patent expired. The United States Department of Justice fined GlaxoSmithKline $3 billion in 2012, including a sum for withholding data on paroxetine, unlawfully promoting it for under-18s and preparing an article, following one of its clinical trials, study 329, that misleadingly reported the drug was effective in treating adolescent depression.
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Partial agonist
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.
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Pharmacodynamics
Pharmacodynamics is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).
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Phenylpiperazine
1-Phenylpiperazine is a simple chemical compound featuring a phenyl group bound to a piperazine ring.
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Positron emission tomography
Positron-emission tomography (PET) is a nuclear medicine functional imaging technique that is used to observe metabolic processes in the body as an aid to the diagnosis of disease.
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Pregnancy category
The pregnancy category of a medication is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy.
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Problem gambling
Problem gambling (or ludomania, but usually referred to as "gambling addiction" or "compulsive gambling") is an urge to gamble continuously despite harmful negative consequences or a desire to stop.
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Prodrug
A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug.
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Putamen
The putamen is a round structure located at the base of the forebrain (telencephalon).
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QT interval
In cardiology, the QT interval is a measure of the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle.
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Quality of life
Quality of life (QOL) is the general well-being of individuals and societies, outlining negative and positive features of life.
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Quetiapine
Quetiapine, marketed as Seroquel among other names, is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.
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Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
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Relative risk
In statistics and epidemiology, relative risk or risk ratio (RR) is the ratio of the probability of an event occurring (for example, developing a disease, being injured) in an exposed group to the probability of the event occurring in a comparison, non-exposed group.
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Risperidone
Risperidone, sold under the trade name Risperdal among others, is an antipsychotic medication.
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Schizophrenia
Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand reality.
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Selective serotonin reuptake inhibitor
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders.
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Serotonin transporter
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.
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Sertraline
Sertraline, sold under the trade names Zoloft among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
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Solution
In chemistry, a solution is a special type of homogeneous mixture composed of two or more substances.
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Stereotypy
A stereotypy is a repetitive or ritualistic movement, posture, or utterance.
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Striatum
The striatum, or corpus striatum (also called the neostriatum and the striate nucleus) is a nucleus (a cluster of neurons) in the subcortical basal ganglia of the forebrain.
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Supplementary protection certificate
In the European Economic Area (European Union member countries, Iceland, Liechtenstein and Norway), a supplementary protection certificate (SPC) is a sui generis intellectual property (IP) right that extends the duration of certain rights associated with a patent.
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Tablet (pharmacy)
A tablet is a pharmaceutical dosage form.
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Tardive dyskinesia
Tardive dyskinesia (TD) is a disorder that results in involuntary, repetitive body movements.
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Teva Pharmaceutical Industries
Teva Pharmaceutical Industries Ltd. (טבע תעשיות פרמצבטיות בע"מ) is an Israeli multinational pharmaceutical company headquartered in Petah Tikva, Israel.
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The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach
The GRADE approach (Grading of Recommendations Assessment, Development and Evaluation) is a method of assessing the certainty in evidence (also known as quality of evidence or confidence in effect estimates) and the strength of recommendations in health care.
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Therapeutic Goods Administration
The Therapeutic Goods Administration (TGA) is the regulatory body for therapeutic goods (including medicines, medical devices, gene technology, and blood products) in Australia.
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Tic disorder
Tic disorders is defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM) based on type (motor or phonic) and duration of tics (sudden, rapid, nonrhythmic movements).
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Trazodone
Trazodone, sold under many brand names worldwide, Page accessed Feb 10, 2016 is an antidepressant medication.
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U.S. state
A state is a constituent political entity of the United States.
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United Kingdom
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain,Usage is mixed with some organisations, including the and preferring to use Britain as shorthand for Great Britain is a sovereign country in western Europe.
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United States
The United States of America (USA), commonly known as the United States (U.S.) or America, is a federal republic composed of 50 states, a federal district, five major self-governing territories, and various possessions.
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United States District Court for the District of New Jersey
The United States District Court for the District of New Jersey (in case citations, D.N.J.) is a federal court in the Third Circuit (except for patent claims and claims against the U.S. government under the Tucker Act, which are appealed to the Federal Circuit).
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Ziprasidone
Ziprasidone, sold under the brand name Geodon among others, is an atypical antipsychotic which is used for the treatment of schizophrenia as well as acute mania and mixed states associated with bipolar disorder.
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5-HT receptor
5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.
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5-HT1A receptor
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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5-HT1B receptor
5-hydroxytryptamine receptor 1B also known as the 5-HT1B receptor is a protein that in humans is encoded by the HTR1B gene.
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5-HT1D receptor
5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it.
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5-HT1E receptor
5-hydroxytryptamine (serotonin) 1E receptor (5-HT1E) is a highly expressed human G-protein coupled receptor that belongs to the 5-HT1 receptor family (Gi-coupled serotonin receptor).
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5-HT2A receptor
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).
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5-HT2B receptor
5-Hydroxytryptamine receptor 2B (5-HT2B) also known as serotonin receptor 2B is a protein that in humans is encoded by the HTR2B gene.
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5-HT2C receptor
The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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5-HT3 receptor
The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin) receptors which are G protein-coupled receptors.
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5-HT5A receptor
5-Hydroxytryptamine (serotonin) receptor 5A, also known as HTR5A, is a protein that in humans is encoded by the HTR5A gene.
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5-HT6 receptor
The 5HT6 receptor is a subtype of 5HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5HT).
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5-HT7 receptor
The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) The 5-HT7 receptor is coupled to Gs (stimulates the production of the intracellular signaling molecule cAMP) and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in various blood vessels.
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Redirects here:
ATC code N05AX12, ATCvet code QN05AX12, Abilify, Abilitat, Aripiprazole cavoxil, Aripiprex, Aripiprozole, Ariprazole, Biopiprazole, C23H27Cl2N3O2, OPC-14597.
References
[1] https://en.wikipedia.org/wiki/Aripiprazole
