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Carcinogenesis

Index Carcinogenesis

Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. [1]

181 relations: ABL (gene), Adult stem cell, Alcohol, Alfred G. Knudson, Allele, Aneuploidy, Angiogenesis, Animal, Antimicrobial resistance, Apoptosis, Astrobiology, Atavism, Backup, BCR (gene), Biochemistry, Bird, Bladder cancer, BRCA1, BRCA2, Breast cancer, Cancer, Cancer research, Cancer stem cell, Carcinogen, Carcinoma, Carcinoma in situ, Cell (biology), Cell cycle, Cell division, Cell nucleus, Cellular differentiation, Cervical cancer, Cholangiocarcinoma, Chromosomal translocation, Chromosome, Chronic myelogenous leukemia, Clonorchiasis, Clonorchis sinensis, Coding region, Colorectal cancer, CpG site, Deletion (genetics), Developmental biology, DNA, DNA damage (naturally occurring), DNA methylation, DNA methylation in cancer, DNA methyltransferase, DNA mismatch repair, DNA repair, ..., DNA repair-deficiency disorder, DNA replication, DNA virus, Dominance (genetics), Drug resistance, Dysplasia, Enzyme, Epidemiology of cancer, Epigenetics, Epstein–Barr virus, ERCC1, Estrogen, Evolution, Exogeny, Exome, Familial adenomatous polyposis, Feedback, Fusion protein, Gene, Gene duplication, Gene expression, Genetics, Genome, Genome instability, Genotoxicity, Germline, Growth factor, Haploinsufficiency, Helicobacter pylori, Hepatitis B, Histone, Histone code, Histone deacetylase inhibitor, HIV, HMGA2, Homeostasis, Homogeneity and heterogeneity, Homologous recombination, Hormone, Host (biology), Human, Human papillomavirus infection, Hyperplasia, Hypothesis, Hypoxia (medical), Infection, Insertion (genetics), Intestinal gland, Kaposi's sarcoma, Kaposi's sarcoma-associated herpesvirus, Knudson hypothesis, Leukemia, Li–Fraumeni syndrome, Liver cancer, Lung cancer, Lymphoma, Malignant transformation, MALT lymphoma, Melanoma, Metastasis, Methicillin-resistant Staphylococcus aureus, MicroRNA, Microscope, Missense mutation, Mitogen, Mitosis, Molecular biology, Multicellular organism, Mutagen, Mutation, Natural selection, Neoplasm, Non-coding DNA, Nucleotide, O-6-methylguanine-DNA methyltransferase, Offspring, Oncogene, Oncology, Oncovirus, Opisthorchiasis, Opisthorchis viverrini, Organ (anatomy), Oxidative phosphorylation, Oxidative stress, P53, Pancreatic cancer, Pesticide resistance, Phenotype, Philadelphia chromosome, PMS2, Point mutation, Prognosis, Programmed cell death, Promoter (genetics), Protein, Protein biosynthesis, Provirus, Radiation therapy, Radon, Ras subfamily, Reactive oxygen species, Receptor (biochemistry), Relapse, Retinoblastoma, Retinoblastoma protein, Retrovirus, Robert Weinberg, Schistosoma, Schistosomiasis, Senescence, Signal transduction, Single-nucleotide polymorphism, Somatic evolution in cancer, Stem cell, Stress (biology), Telomerase, Tissue (biology), Transcription (biology), Transcription factor, Tumor suppressor, Tumour heterogeneity, Tyrosine kinase, Ultraviolet, Viral transformation, Virtuous circle and vicious circle, Virus, Warburg effect, Warburg hypothesis, White blood cell, Wild type, Zygosity. Expand index (131 more) »

ABL (gene)

Abelson murine leukemia viral oncogene homolog 1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL) located on chromosome 9.

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Adult stem cell

Adult stem cells are undifferentiated cells, found throughout the body after development, that multiply by cell division to replenish dying cells and regenerate damaged tissues.

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Alcohol

In chemistry, an alcohol is any organic compound in which the hydroxyl functional group (–OH) is bound to a carbon.

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Alfred G. Knudson

Alfred George Knudson, Jr. (August 9, 1922 – July 10, 2016) was an American physician and geneticist specializing in cancer genetics.

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Allele

An allele is a variant form of a given gene.

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Aneuploidy

Aneuploidy is the presence of an abnormal number of chromosomes in a cell, for example a human cell having 45 or 47 chromosomes instead of the usual 46.

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Angiogenesis

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels.

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Animal

Animals are multicellular eukaryotic organisms that form the biological kingdom Animalia.

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Antimicrobial resistance

Antimicrobial resistance (AMR or AR) is the ability of a microbe to resist the effects of medication that once could successfully treat the microbe.

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Apoptosis

Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.

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Astrobiology

Astrobiology is a branch of biology concerned with the origins, early evolution, distribution, and future of life in the universe.

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Atavism

In biology, an atavism is a modification of a biological structure whereby an ancestral trait reappears after having been lost through evolutionary change in previous generations.

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Backup

In information technology, a backup, or the process of backing up, refers to the copying into an archive file of computer data so it may be used to restore the original after a data loss event.

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BCR (gene)

The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is encoded by the BCR gene.

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Biochemistry

Biochemistry, sometimes called biological chemistry, is the study of chemical processes within and relating to living organisms.

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Bird

Birds, also known as Aves, are a group of endothermic vertebrates, characterised by feathers, toothless beaked jaws, the laying of hard-shelled eggs, a high metabolic rate, a four-chambered heart, and a strong yet lightweight skeleton.

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Bladder cancer

Bladder cancer is any of several types of cancer arising from the tissues of the urinary bladder.

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BRCA1

BRCA1 and BRCA1 are a human gene and its protein product, respectively.

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BRCA2

BRCA2 and BRCA2 are a human gene and its protein product, respectively.

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Breast cancer

Breast cancer is cancer that develops from breast tissue.

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Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Cancer research

Cancer research is research into cancer to identify causes and develop strategies for prevention, diagnosis, treatment, and cure.

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Cancer stem cell

Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample.

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Carcinogen

A carcinogen is any substance, radionuclide, or radiation that promotes carcinogenesis, the formation of cancer.

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Carcinoma

Carcinoma is a type of cancer that develops from epithelial cells.

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Carcinoma in situ

Carcinoma in situ (CIS), also known as in situ neoplasm, is a group of abnormal cells.

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Cell (biology)

The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.

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Cell cycle

The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication of its DNA (DNA replication) to produce two daughter cells.

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Cell division

Cell division is the process by which a parent cell divides into two or more daughter cells.

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Cell nucleus

In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.

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Cellular differentiation

In developmental biology, cellular differentiation is the process where a cell changes from one cell type to another.

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Cervical cancer

Cervical cancer is a cancer arising from the cervix.

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Cholangiocarcinoma

Cholangiocarcinoma, also known as bile duct cancer or "sneaky Pete", is a form of cancer that is composed of mutated epithelial cells (or cells showing characteristics of epithelial differentiation) that originate in the bile ducts which drain bile from the liver into the small intestine.

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Chromosomal translocation

In genetics, a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes.

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Chromosome

A chromosome (from Ancient Greek: χρωμόσωμα, chromosoma, chroma means colour, soma means body) is a DNA molecule with part or all of the genetic material (genome) of an organism.

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Chronic myelogenous leukemia

Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells.

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Clonorchiasis

Clonorchiasis is an infectious disease caused by the Chinese liver fluke, Clonorchis sinensis, and two related species.

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Clonorchis sinensis

Clonorchis sinensis, the Chinese liver fluke, is a human liver fluke belonging to the class Trematoda, phylum Platyhelminthes.

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Coding region

The coding region of a gene, also known as the CDS (from CoDing Sequence), is that portion of a gene's DNA or RNA that codes for protein.

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Colorectal cancer

Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum (parts of the large intestine).

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CpG site

The CpG sites or CG sites are regions of DNA where a cytosine nucleotide is followed by a guanine nucleotide in the linear sequence of bases along its 5' → 3' direction.

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Deletion (genetics)

In genetics, a deletion (also called gene deletion, deficiency, or deletion mutation) (sign: Δ) is a mutation (a genetic aberration) in which a part of a chromosome or a sequence of DNA is lost during DNA replication.

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Developmental biology

Developmental biology is the study of the process by which animals and plants grow and develop.

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DNA

Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.

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DNA damage (naturally occurring)

DNA damage is distinctly different from mutation, although both are types of error in DNA.

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DNA methylation

DNA methylation is a process by which methyl groups are added to the DNA molecule.

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DNA methylation in cancer

DNA methylation in cancer plays a variety of roles, helping to change the healthy regulation of gene expression to a disease pattern.

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DNA methyltransferase

In biochemistry, the DNA methyltransferase (DNA MTase) family of enzymes catalyze the transfer of a methyl group to DNA.

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DNA mismatch repair

DNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage.

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DNA repair

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.

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DNA repair-deficiency disorder

A DNA repair-deficiency disorder is a medical condition due to reduced functionality of DNA repair.

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DNA replication

In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule.

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DNA virus

A DNA virus is a virus that has DNA as its genetic material and replicates using a DNA-dependent DNA polymerase.

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Dominance (genetics)

Dominance in genetics is a relationship between alleles of one gene, in which the effect on phenotype of one allele masks the contribution of a second allele at the same locus.

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Drug resistance

Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in curing a disease or condition.

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Dysplasia

Dysplasia (from Ancient Greek δυσ- dys-, "bad" or "difficult" and πλάσις plasis, "formation") is a term used in pathology to refer to an abnormality of development or an epithelial anomaly of growth and differentiation (epithelial dysplasia).

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Enzyme

Enzymes are macromolecular biological catalysts.

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Epidemiology of cancer

The epidemiology of cancer is the study of the factors affecting cancer, as a way to infer possible trends and causes.

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Epigenetics

Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence.

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Epstein–Barr virus

The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is one of eight known human herpesvirus types in the herpes family, and is one of the most common viruses in humans.

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ERCC1

DNA excision repair protein ERCC-1 is a protein that in humans is encoded by the ERCC1 gene.

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Estrogen

Estrogen, or oestrogen, is the primary female sex hormone.

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Evolution

Evolution is change in the heritable characteristics of biological populations over successive generations.

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Exogeny

In a variety of contexts, exogeny or exogeneity is the fact of an action or object originating externally.

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Exome

The exome is the part of the genome composed of exons, the sequences which, when transcribed, remain within the mature RNA after introns are removed by RNA splicing and contribute to the final protein product encoded by that gene.

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Familial adenomatous polyposis

Familial adenomatous polyposis (FAP) is an autosomal dominant inherited condition in which numerous adenomatous polyps form mainly in the epithelium of the large intestine.

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Feedback

Feedback occurs when outputs of a system are routed back as inputs as part of a chain of cause-and-effect that forms a circuit or loop.

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Fusion protein

Fusion proteins or chimeric (\kī-ˈmir-ik) proteins (literally, made of parts from different sources) are proteins created through the joining of two or more genes that originally coded for separate proteins.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Gene duplication

Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is generated during molecular evolution.

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Gene expression

Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product.

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Genetics

Genetics is the study of genes, genetic variation, and heredity in living organisms.

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Genome

In the fields of molecular biology and genetics, a genome is the genetic material of an organism.

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Genome instability

Genome instability (also genetic instability or genomic instability) refers to a high frequency of mutations within the genome of a cellular lineage.

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Genotoxicity

In genetics, genotoxicity describes the property of chemical agents that damages the genetic information within a cell causing mutations, which may lead to cancer.

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Germline

In biology and genetics, the germline in a multicellular organism is the population of its bodily cells that are so differentiated or segregated that in the usual processes of reproduction they may pass on their genetic material to the progeny.

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Growth factor

A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation.

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Haploinsufficiency

Haploinsufficiency is a mechanism of action to explain a phenotype when a diploid organism has lost one copy of a gene and is left with a single functional copy of that gene.

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Helicobacter pylori

Helicobacter pylori, previously known as Campylobacter pylori, is a gram-negative, microaerophilic bacterium usually found in the stomach.

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Hepatitis B

Hepatitis B is an infectious disease caused by the hepatitis B virus (HBV) that affects the liver.

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Histone

In biology, histones are highly alkaline proteins found in eukaryotic cell nuclei that package and order the DNA into structural units called nucleosomes.

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Histone code

The histone code is a hypothesis that the transcription of genetic information encoded in DNA is in part regulated by chemical modifications to histone proteins, primarily on their unstructured ends.

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Histone deacetylase inhibitor

Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are chemical compounds that inhibit histone deacetylases.

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HIV

The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).

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HMGA2

High-mobility group AT-hook 2, also known as HMGA2, is a protein that, in humans, is encoded by the HMGA2 gene.

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Homeostasis

Homeostasis is the tendency of organisms to auto-regulate and maintain their internal environment in a stable state.

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Homogeneity and heterogeneity

Homogeneity and heterogeneity are concepts often used in the sciences and statistics relating to the uniformity in a substance or organism.

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Homologous recombination

Homologous recombination is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical molecules of DNA.

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Hormone

A hormone (from the Greek participle “ὁρμῶ”, "to set in motion, urge on") is any member of a class of signaling molecules produced by glands in multicellular organisms that are transported by the circulatory system to target distant organs to regulate physiology and behaviour.

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Host (biology)

In biology and medicine, a host is an organism that harbours a parasitic, a mutualistic, or a commensalist guest (symbiont), the guest typically being provided with nourishment and shelter.

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Human

Humans (taxonomically Homo sapiens) are the only extant members of the subtribe Hominina.

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Human papillomavirus infection

Human papillomavirus infection is an infection by human papillomavirus (HPV).

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Hyperplasia

Hyperplasia (from ancient Greek ὑπέρ huper, "over" + πλάσις plasis, "formation"), or hypergenesis, is an increase in the amount of organic tissue that results from cell proliferation.

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Hypothesis

A hypothesis (plural hypotheses) is a proposed explanation for a phenomenon.

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Hypoxia (medical)

Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level.

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Infection

Infection is the invasion of an organism's body tissues by disease-causing agents, their multiplication, and the reaction of host tissues to the infectious agents and the toxins they produce.

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Insertion (genetics)

In genetics, an insertion (also called an insertion mutation) is the addition of one or more nucleotide base pairs into a DNA sequence.

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Intestinal gland

In histology, an intestinal gland (also crypt of Lieberkühn and intestinal crypt) is a gland found in the intestinal epithelium lining of the small intestine and large intestine (colon).

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Kaposi's sarcoma

Kaposi's sarcoma (KS) is a type of cancer that can form masses in the skin, lymph nodes, or other organs.

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Kaposi's sarcoma-associated herpesvirus

Kaposi's sarcoma-associated herpesvirus (KSHV) is the ninth known human herpesvirus; its formal name according to the International Committee on Taxonomy of Viruses (ICTV) is HHV-8.

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Knudson hypothesis

The Knudson hypothesis, also known as the two-hit hypothesis or multiple-hit hypothesis, is the hypothesis that cancer is the result of accumulated mutations to a cell's DNA.

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Leukemia

Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells.

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Li–Fraumeni syndrome

Li–Fraumeni syndrome is a rare, autosomal dominant, hereditary disorder that pre-disposes carriers to cancer development.

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Liver cancer

Liver cancer, also known as hepatic cancer and primary hepatic cancer, is cancer that starts in the liver.

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Lung cancer

Lung cancer, also known as lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung.

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Lymphoma

Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell).

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Malignant transformation

Malignant transformation is the process by which cells acquire the properties of cancer.

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MALT lymphoma

MALT lymphoma (MALToma) is a form of lymphoma involving the mucosa-associated lymphoid tissue (MALT), frequently of the stomach, but virtually any mucosal site can be afflicted.

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Melanoma

Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes.

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Metastasis

Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; it is typically spoken of as such spread by a cancerous tumor.

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Methicillin-resistant Staphylococcus aureus

Methicillin-resistant Staphylococcus aureus (MRSA) refers to a group of gram-positive bacteria that are genetically distinct from other strains of Staphylococcus aureus.

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MicroRNA

A microRNA (abbreviated miRNA) is a small non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression.

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Microscope

A microscope (from the μικρός, mikrós, "small" and σκοπεῖν, skopeîn, "to look" or "see") is an instrument used to see objects that are too small to be seen by the naked eye.

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Missense mutation

In genetics, a missense mutation is a point mutation in which a single nucleotide change results in a codon that codes for a different amino acid.

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Mitogen

A mitogen is a chemical substance that encourages a cell to commence cell division, triggering mitosis.

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Mitosis

In cell biology, mitosis is a part of the cell cycle when replicated chromosomes are separated into two new nuclei.

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Molecular biology

Molecular biology is a branch of biology which concerns the molecular basis of biological activity between biomolecules in the various systems of a cell, including the interactions between DNA, RNA, proteins and their biosynthesis, as well as the regulation of these interactions.

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Multicellular organism

Multicellular organisms are organisms that consist of more than one cell, in contrast to unicellular organisms.

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Mutagen

In genetics, a mutagen is a physical or chemical agent that changes the genetic material, usually DNA, of an organism and thus increases the frequency of mutations above the natural background level.

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Mutation

In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.

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Natural selection

Natural selection is the differential survival and reproduction of individuals due to differences in phenotype.

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Neoplasm

Neoplasia is a type of abnormal and excessive growth of tissue.

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Non-coding DNA

In genomics and related disciplines, noncoding DNA sequences are components of an organism's DNA that do not encode protein sequences.

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Nucleotide

Nucleotides are organic molecules that serve as the monomer units for forming the nucleic acid polymers deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules within all life-forms on Earth.

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O-6-methylguanine-DNA methyltransferase

O6-alkylguanine DNA alkyltransferase (also known as AGT, MGMT or AGAT) is a protein that in humans is encoded by the O6-methylguanine DNA methyltransferase (MGMT) gene.

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Offspring

In biology, offspring are the young born of living organisms, produced either by a single organism or, in the case of sexual reproduction, two organisms.

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Oncogene

An oncogene is a gene that has the potential to cause cancer.

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Oncology

Oncology is a branch of medicine that deals with the prevention, diagnosis, and treatment of cancer.

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Oncovirus

An oncovirus is a virus that can cause cancer.

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Opisthorchiasis

Opisthorchiasis is a parasitic disease caused by species in the genus Opisthorchis (specifically, Opisthorchis viverrini and Opisthorchis felineus).

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Opisthorchis viverrini

Opisthorchis viverrini, common name Southeast Asian liver fluke, is a food-borne trematode parasite from the family Opisthorchiidae that infects the bile duct.

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Organ (anatomy)

Organs are collections of tissues with similar functions.

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Oxidative phosphorylation

Oxidative phosphorylation (or OXPHOS in short) (UK, US) is the metabolic pathway in which cells use enzymes to oxidize nutrients, thereby releasing energy which is used to produce adenosine triphosphate (ATP).

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Oxidative stress

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.

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P53

Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).

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Pancreatic cancer

Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass.

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Pesticide resistance

Pesticide resistance describes the decreased susceptibility of a pest population to a pesticide that was previously effective at controlling the pest.

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Phenotype

A phenotype is the composite of an organism's observable characteristics or traits, such as its morphology, development, biochemical or physiological properties, behavior, and products of behavior (such as a bird's nest).

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Philadelphia chromosome

The Philadelphia chromosome or Philadelphia translocation (Ph) is a specific genetic abnormality in chromosome 22 of leukemia cancer cells (particularly chronic myeloid leukemia (CML) cells).

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PMS2

Mismatch repair endonuclease PMS2 is an enzyme that in humans is encoded by the PMS2 gene.

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Point mutation

A point mutation is a genetic mutation where a single nucleotide base is changed, inserted or deleted from a sequence of DNA or RNA.

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Prognosis

Prognosis (Greek: πρόγνωσις "fore-knowing, foreseeing") is a medical term for predicting the likely or expected development of a disease, including whether the signs and symptoms will improve or worsen (and how quickly) or remain stable over time; expectations of quality of life, such as the ability to carry out daily activities; the potential for complications and associated health issues; and the likelihood of survival (including life expectancy).

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Programmed cell death

Programmed cell death (or PCD) is the death of a cell in any form, mediated by an intracellular program.

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Promoter (genetics)

In genetics, a promoter is a region of DNA that initiates transcription of a particular gene.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein biosynthesis

Protein synthesis is the process whereby biological cells generate new proteins; it is balanced by the loss of cellular proteins via degradation or export.

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Provirus

A provirus is a virus genome that is integrated into the DNA of a host cell.

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Radiation therapy

Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is therapy using ionizing radiation, generally as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator.

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Radon

Radon is a chemical element with symbol Rn and atomic number 86.

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Ras subfamily

Ras is a family of related proteins which is expressed in all animal cell lineages and organs.

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Reactive oxygen species

Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen.

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Receptor (biochemistry)

In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.

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Relapse

In medicine, relapse or recidivism is a recurrence of a past (typically medical) condition.

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Retinoblastoma

Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, the light-detecting tissue of the eye.

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Retinoblastoma protein

The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers.

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Retrovirus

A retrovirus is a single-stranded positive-sense RNA virus with a DNA intermediate and, as an obligate parasite, targets a host cell.

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Robert Weinberg

Robert Allan Weinberg (born November 11, 1942) is a biologist, Daniel K. Ludwig Professor for Cancer Research at Massachusetts Institute of Technology (MIT), director of the Ludwig Center of the MIT, and American Cancer Society Research Professor.

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Schistosoma

Schistosoma is a genus of trematodes, commonly known as blood flukes.

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Schistosomiasis

Schistosomiasis, also known as snail fever and bilharzia, is a disease caused by parasitic flatworms called schistosomes.

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Senescence

Senescence or biological ageing is the gradual deterioration of function characteristic of most complex lifeforms, arguably found in all biological kingdoms, that on the level of the organism increases mortality after maturation.

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Signal transduction

Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.

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Single-nucleotide polymorphism

A single-nucleotide polymorphism, often abbreviated to SNP (plural), is a variation in a single nucleotide that occurs at a specific position in the genome, where each variation is present to some appreciable degree within a population (e.g. > 1%).

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Somatic evolution in cancer

Somatic evolution is the accumulation of mutations and epimutations in somatic cells (the cells of a body, as opposed to germplasm and stem cells) during a lifetime, and the effects of those mutations and epimutations on the fitness of those cells.

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Stem cell

Stem cells are biological cells that can differentiate into other types of cells and can divide to produce more of the same type of stem cells.

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Stress (biology)

Physiological or biological stress is an organism's response to a stressor such as an environmental condition.

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Telomerase

Telomerase, also called terminal transferase, is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres.

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Tissue (biology)

In biology, tissue is a cellular organizational level between cells and a complete organ.

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Transcription (biology)

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.

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Transcription factor

In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.

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Tumor suppressor

A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer.

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Tumour heterogeneity

Tumour heterogeneity describes the observation that different tumour cells can show distinct morphological and phenotypic profiles, including cellular morphology, gene expression, metabolism, motility, proliferation, and metastatic potential.

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Tyrosine kinase

A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell.

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Ultraviolet

Ultraviolet (UV) is electromagnetic radiation with a wavelength from 10 nm to 400 nm, shorter than that of visible light but longer than X-rays.

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Viral transformation

Viral transformation is the change in growth, phenotype, or indefinite reproduction of cells caused by the introduction of inheritable material.

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Virtuous circle and vicious circle

The terms virtuous circle and vicious circle (also referred to as virtuous cycle and vicious cycle) refer to complex chains of events that reinforce themselves through a feedback loop.

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Virus

A virus is a small infectious agent that replicates only inside the living cells of other organisms.

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Warburg effect

"Warburg effect" describes two unrelated observations in biochemistry, one in plant physiology and the other in oncology, both due to Nobel laureate Otto Heinrich Warburg.

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Warburg hypothesis

The Warburg hypothesis, sometimes known as the Warburg theory of cancer, postulates that the driver of tumorigenesis is an insufficient cellular respiration caused by insult to mitochondria.

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White blood cell

White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.

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Wild type

Wild type (WT) refers to the phenotype of the typical form of a species as it occurs in nature.

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Zygosity

Zygosity is the degree of similarity of the alleles for a trait in an organism.

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Cancer induction, Cancer initiation, Carciogenesis, Neoplastic transformation, Oncogenesis, Oncogenic, Photocarcinogenesis, Tumorigenesis, Tumorigeneticity, Tumorigenic, Tumorigenicity, Tumorogenesis, Tumourigenesis.

References

[1] https://en.wikipedia.org/wiki/Carcinogenesis

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