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Coalescent theory

Index Coalescent theory

Coalescent theory is a model of how gene variants sampled from a population may have originated from a common ancestor. [1]

53 relations: Allele, Applied Probability Trust, Approximate Bayesian computation, Bayesian inference, Cambridge University Press, Chromosome, Claudia Neuhauser, Cystic fibrosis, Dendrogram, DNA, Effective population size, Epistasis, Evolution (journal), Expected value, Exponential distribution, Exponential growth, Gamma distribution, Gene flow, Genetic linkage, Genetic recombination, Geometric distribution, Homologous recombination, Importance sampling, John Kingman, Jonathan K. Pritchard, JSTOR, Lineage (evolution), Linkage disequilibrium, Markov chain Monte Carlo, Maximum likelihood estimation, Mendelian inheritance, Mitochondrial DNA, Most recent common ancestor, Mutation, Natural selection, Neutral theory of molecular evolution, Nucleotide, Oxford University Press, Panmixia, Penetrance, Ploidy, Poisson distribution, Polygene, Population genetics, R (programming language), Recombination hotspot, Sickle cell disease, Single-nucleotide polymorphism, Standard deviation, Taylor's law, ..., Tweedie distribution, Variance, Zygosity. Expand index (3 more) »

Allele

An allele is a variant form of a given gene.

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Applied Probability Trust

The Applied Probability Trust is a UK-based non-profit foundation for study and research in the mathematical sciences, founded in 1964 and based at the University of Sheffield.

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Approximate Bayesian computation

Approximate Bayesian computation (ABC) constitutes a class of computational methods rooted in Bayesian statistics.

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Bayesian inference

Bayesian inference is a method of statistical inference in which Bayes' theorem is used to update the probability for a hypothesis as more evidence or information becomes available.

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Cambridge University Press

Cambridge University Press (CUP) is the publishing business of the University of Cambridge.

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Chromosome

A chromosome (from Ancient Greek: χρωμόσωμα, chromosoma, chroma means colour, soma means body) is a DNA molecule with part or all of the genetic material (genome) of an organism.

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Claudia Neuhauser

Claudia Maria Neuhauser is a mathematical biologist.

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Cystic fibrosis

Cystic fibrosis (CF) is a genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine.

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Dendrogram

A dendrogram (from Greek dendro "tree" and gramma "drawing") is a tree diagram frequently used to illustrate the arrangement of the clusters produced by hierarchical clustering.

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DNA

Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.

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Effective population size

The effective population size is "the number of individuals in a population who contribute offspring to the next generation," or all the breeding adults in that population.

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Epistasis

Epistasis is the phenomenon where the effect of one gene (locus) is dependent on the presence of one or more 'modifier genes', i.e. the genetic background.

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Evolution (journal)

Evolution, the International Journal of Organic Evolution, is a monthly scientific journal that publishes significant new results of empirical or theoretical investigations concerning facts, processes, mechanics, or concepts of evolutionary phenomena and events.

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Expected value

In probability theory, the expected value of a random variable, intuitively, is the long-run average value of repetitions of the experiment it represents.

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Exponential distribution

No description.

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Exponential growth

Exponential growth is exhibited when the rate of change—the change per instant or unit of time—of the value of a mathematical function is proportional to the function's current value, resulting in its value at any time being an exponential function of time, i.e., a function in which the time value is the exponent.

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Gamma distribution

In probability theory and statistics, the gamma distribution is a two-parameter family of continuous probability distributions.

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Gene flow

In population genetics, gene flow (also known as gene migration or allele flow) is the transfer of genetic variation from one population to another.

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Genetic linkage

Genetic linkage is the tendency of DNA sequences that are close together on a chromosome to be inherited together during the meiosis phase of sexual reproduction.

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Genetic recombination

Genetic recombination (aka genetic reshuffling) is the production of offspring with combinations of traits that differ from those found in either parent.

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Geometric distribution

In probability theory and statistics, the geometric distribution is either of two discrete probability distributions.

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Homologous recombination

Homologous recombination is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical molecules of DNA.

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Importance sampling

In statistics, importance sampling is a general technique for estimating properties of a particular distribution, while only having samples generated from a different distribution than the distribution of interest.

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John Kingman

Sir John Frank Charles Kingman (born 28 August 1939) is a British mathematician.

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Jonathan K. Pritchard

Jonathan Karl Pritchard is an English-born professor of genetics at Stanford University, best known for his development of the STRUCTURE algorithm for studying population structure and his work on human genetic variation and evolution.

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JSTOR

JSTOR (short for Journal Storage) is a digital library founded in 1995.

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Lineage (evolution)

An evolutionary lineage is a temporal series of organisms, populations, cells, or genes connected by a continuous line of descent from ancestor to descendent.

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Linkage disequilibrium

In population genetics, linkage disequilibrium is the non-random association of alleles at different loci in a given population.

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Markov chain Monte Carlo

In statistics, Markov chain Monte Carlo (MCMC) methods comprise a class of algorithms for sampling from a probability distribution.

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Maximum likelihood estimation

In statistics, maximum likelihood estimation (MLE) is a method of estimating the parameters of a statistical model, given observations.

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Mendelian inheritance

Mendelian inheritance is a type of biological inheritance that follows the laws originally proposed by Gregor Mendel in 1865 and 1866 and re-discovered in 1900.

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Mitochondrial DNA

Mitochondrial DNA (mtDNA or mDNA) is the DNA located in mitochondria, cellular organelles within eukaryotic cells that convert chemical energy from food into a form that cells can use, adenosine triphosphate (ATP).

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Most recent common ancestor

In biology and genealogy, the most recent common ancestor (MRCA, also last common ancestor (LCA), or concestor) of any set of organisms is the most recent individual from which all the organisms are directly descended.

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Mutation

In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.

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Natural selection

Natural selection is the differential survival and reproduction of individuals due to differences in phenotype.

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Neutral theory of molecular evolution

The neutral theory of molecular evolution holds that at the molecular level most evolutionary changes and most of the variation within and between species is not caused by natural selection but by genetic drift of mutant alleles that are neutral.

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Nucleotide

Nucleotides are organic molecules that serve as the monomer units for forming the nucleic acid polymers deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules within all life-forms on Earth.

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Oxford University Press

Oxford University Press (OUP) is the largest university press in the world, and the second oldest after Cambridge University Press.

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Panmixia

Panmixia (or panmixis) means random mating.

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Penetrance

Penetrance in genetics is the proportion of individuals carrying a particular variant (or allele) of a gene (the genotype) that also express an associated trait (the phenotype).

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Ploidy

Ploidy is the number of complete sets of chromosomes in a cell, and hence the number of possible alleles for autosomal and pseudoautosomal genes.

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Poisson distribution

In probability theory and statistics, the Poisson distribution (in English often rendered), named after French mathematician Siméon Denis Poisson, is a discrete probability distribution that expresses the probability of a given number of events occurring in a fixed interval of time or space if these events occur with a known constant rate and independently of the time since the last event.

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Polygene

A "polygene” or "multiple gene inheritance" is a member of a group of non-epistatic genes that interact additively to influence a phenotypic trait.

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Population genetics

Population genetics is a subfield of genetics that deals with genetic differences within and between populations, and is a part of evolutionary biology.

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R (programming language)

R is a programming language and free software environment for statistical computing and graphics that is supported by the R Foundation for Statistical Computing.

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Recombination hotspot

Recombination hotspots are regions in a genome that exhibit elevated rates of recombination relative to a neutral expectation.

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Sickle cell disease

Sickle cell disease (SCD) is a group of blood disorders typically inherited from a person's parents.

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Single-nucleotide polymorphism

A single-nucleotide polymorphism, often abbreviated to SNP (plural), is a variation in a single nucleotide that occurs at a specific position in the genome, where each variation is present to some appreciable degree within a population (e.g. > 1%).

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Standard deviation

In statistics, the standard deviation (SD, also represented by the Greek letter sigma σ or the Latin letter s) is a measure that is used to quantify the amount of variation or dispersion of a set of data values.

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Taylor's law

Taylor's law (also known as Taylor's power law) is an empirical law in ecology that relates the variance of the number of individuals of a species per unit area of habitat to the corresponding mean by a power law relationship.

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Tweedie distribution

In probability and statistics, the Tweedie distributions are a family of probability distributions which include the purely continuous normal and gamma distributions, the purely discrete scaled Poisson distribution, and the class of mixed compound Poisson–gamma distributions which have positive mass at zero, but are otherwise continuous.

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Variance

In probability theory and statistics, variance is the expectation of the squared deviation of a random variable from its mean.

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Zygosity

Zygosity is the degree of similarity of the alleles for a trait in an organism.

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Redirects here:

Coalescence (genetics), Coalescence theory, Coalescent Theory, Coalescent tree, Lineage sorting.

References

[1] https://en.wikipedia.org/wiki/Coalescent_theory

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