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88 relations: ABCA1, Antigen, Apoptosis, Aspartic acid, ATG12, ATG5, Autophagy, B cell, B-cell receptor, C-Jun N-terminal kinases, Casein kinase 1, alpha 1, Caspase, Caspase 10, Caspase 8, CD120, Cell cycle, Cell membrane, Cell migration, Cell nucleus, CFLAR, CFLR-FM, Cytoplasm, Death domain, Death effector domain, Death receptor 4, Death receptor 5, Death-inducing signaling complex, DEDD, DFFA, Drug resistance, Electrostatics, Embryogenesis, Eye, Fas ligand, Fas receptor, G1 phase, G2 phase, Glucose, Head and neck cancer, Heart, Hydrophobic effect, Inflammation, Interferon gamma, Interferon type I, Interleukin 1 receptor, type I, Intrinsic apoptosis, IRAK1, IRF7, Kinase, Lung cancer, ..., Macrophage, MBD4, Microtubule, Multiple sclerosis, MYD88, NACA (gene), Necroptosis, NF-κB, Nuclear export signal, Nuclear localization sequence, Ovarian cancer, Paclitaxel, PEA15, Phosphatase, Prognosis, Proinflammatory cytokine, Protein kinase C, Rheumatoid arthritis, RIPK1, RIPK3, Serine/threonine-specific protein kinase, Signal transducing adaptor protein, Spindle apparatus, Squamous cell carcinoma, Subcellular localization, T cell, T-cell receptor, Targeted therapy, TLR3, TLR4, TNF receptor superfamily, TRADD, TRAIL, Transcription (biology), Ubiquitin ligase, Virus, White blood cell, Zebrafish. Expand index (38 more) »
ABCA1
ATP-binding cassette transporter ABCA1 (member 1 of human transporter sub-family ABCA), also known as the cholesterol efflux regulatory protein (CERP) is a protein which in humans is encoded by the ABCA1 gene.
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Antigen
In immunology, an antigen is a molecule capable of inducing an immune response (to produce an antibody) in the host organism.
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Apoptosis
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
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Aspartic acid
Aspartic acid (symbol Asp or D; salts known as aspartates), is an α-amino acid that is used in the biosynthesis of proteins.
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ATG12
Autophagy-related protein 12 is a protein that in humans is encoded by the ATG12 gene.
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ATG5
Autophagy related 5 (ATG5) is a protein that, in humans, is encoded by the ATG5 gene located on Chromosome 6.
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Autophagy
Autophagy (or autophagocytosis) (from the Ancient Greek αὐτόφαγος autóphagos, meaning "self-devouring" and κύτος kýtos, meaning "hollow") is the natural, regulated, destructive mechanism of the cell that disassembles unnecessary or dysfunctional components.
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B cell
B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype.
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B-cell receptor
The B-cell receptor or BCR is composed of immunoglobulin molecules that form a type 1 transmembrane receptor protein usually located on the outer surface of a lymphocyte type known as B cells.
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C-Jun N-terminal kinases
c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser-63 and Ser-73 within its transcriptional activation domain.
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Casein kinase 1, alpha 1
Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene.
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Caspase
Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation.
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Caspase 10
Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene.
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Caspase 8
Caspase-8 is a caspase protein, encoded by the CASP8 gene.
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CD120
CD120 (Cluster of Differentiation 120) can refer to two members of the tumor necrosis factor receptor superfamily: tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2).
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Cell cycle
The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication of its DNA (DNA replication) to produce two daughter cells.
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Cell membrane
The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates the interior of all cells from the outside environment (the extracellular space).
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Cell migration
Cell migration is a central process in the development and maintenance of multicellular organisms.
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Cell nucleus
In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.
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CFLAR
CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.
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CFLR-FM
CFLR-FM is a Canadian radio station, broadcasting at 90.1 MHz (FM) in La Romaine, Quebec.
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Cytoplasm
In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus.
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Death domain
The death domain (DD) is a protein interaction module composed of a bundle of six alpha-helices.
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Death effector domain
The death-effector domain (DED) is a protein interaction domain found only in eukaryotes that regulates a variety of cellular signalling pathways.
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Death receptor 4
Death receptor 4 (DR4), also known as TRAIL receptor 1 (TRAILR1) and tumor necrosis factor receptor superfamily member 10A (TNFRSF10A), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.
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Death receptor 5
Death receptor 5 (DR5), also known as TRAIL receptor 2 (TRAILR2) and tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.
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Death-inducing signaling complex
The death-inducing signaling complex or DISC is a multi-protein complex formed by members of the "death receptor" family of apoptosis-inducing cellular receptors.
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DEDD
Death effector domain containing protein is a protein that in humans is encoded by the DEDD gene.
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DFFA
DNA fragmentation factor subunit alpha (DFFA), also known as Inhibitor of caspase-activated DNase (ICAD), is a protein that in humans is encoded by the DFFA gene.
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Drug resistance
Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in curing a disease or condition.
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Electrostatics
Electrostatics is a branch of physics that studies electric charges at rest.
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Embryogenesis
Embryogenesis is the process by which the embryo forms and develops.
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Eye
Eyes are organs of the visual system.
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Fas ligand
Fas ligand (FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family.
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Fas receptor
The first apoptosis signal receptor (Fas or FasR), also known as apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6) is a protein that in humans is encoded by the FAS gene.
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G1 phase
The g1 phase, or Gap 1 phase, is the first of four phases of the cell cycle that takes place in eukaryotic cell division.
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G2 phase
G2 phase, or Gap 2 phase, is the second subphase of Interphase in the cell cycle directly preceding mitosis.
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Glucose
Glucose is a simple sugar with the molecular formula C6H12O6.
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Head and neck cancer
Head and neck cancer is a group of cancers that starts in the mouth, nose, throat, larynx, sinuses, or salivary glands.
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Heart
The heart is a muscular organ in most animals, which pumps blood through the blood vessels of the circulatory system.
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Hydrophobic effect
The hydrophobic effect is the observed tendency of nonpolar substances to aggregate in an aqueous solution and exclude water molecules.
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Inflammation
Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.
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Interferon gamma
Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class of interferons.
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Interferon type I
Human type I interferons (IFNs) are a large subgroup of interferon proteins that help regulate the activity of the immune system.
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Interleukin 1 receptor, type I
Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor.
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Intrinsic apoptosis
Apoptosis is a programmed form of cell death involving the degradation of cellular constituents by a group of cysteine proteases called caspases.
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IRAK1
Interleukin-1 receptor-associated kinase 1 is an enzyme that in humans is encoded by the IRAK1 gene.
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IRF7
Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors.
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Kinase
In biochemistry, a kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.
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Lung cancer
Lung cancer, also known as lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung.
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Macrophage
Macrophages (big eaters, from Greek μακρός (makrós).
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MBD4
Methyl-CpG-binding domain protein 4 is a protein that in humans is encoded by the MBD4 gene.
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Microtubule
Microtubules are tubular polymers of tubulin that form part of the cytoskeleton that provides the cytoplasm of eukaryotic cells and some bacteria with structure and shape.
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Multiple sclerosis
Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged.
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MYD88
Myeloid differentiation primary response 88 (MYD88) is a protein that, in humans, is encoded by the MYD88 gene.
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NACA (gene)
Nascent-polypeptide-associated complex alpha polypeptide, also known as NACA, is a protein which in humans is encoded by the NACA gene.
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Necroptosis
Necroptosis is a programmed form of necrosis, or inflammatory cell death.
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NF-κB
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival.
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Nuclear export signal
A nuclear export signal (NES) is a short amino acid sequence of 4 hydrophobic residues in a protein that targets it for export from the cell nucleus to the cytoplasm through the nuclear pore complex using nuclear transport.
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Nuclear localization sequence
A nuclear localization signal or sequence (NLS) is an amino acid sequence that 'tags' a protein for import into the cell nucleus by nuclear transport.
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Ovarian cancer
Ovarian cancer is a cancer that forms in or on an ovary.
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Paclitaxel
Paclitaxel (PTX), sold under the brand name Taxol among others, is a chemotherapy medication used to treat a number of types of cancer.
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PEA15
Astrocytic phosphoprotein PEA-15 is a protein that in humans is encoded by the PEA15 gene.
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Phosphatase
A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol.
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Prognosis
Prognosis (Greek: πρόγνωσις "fore-knowing, foreseeing") is a medical term for predicting the likely or expected development of a disease, including whether the signs and symptoms will improve or worsen (and how quickly) or remain stable over time; expectations of quality of life, such as the ability to carry out daily activities; the potential for complications and associated health issues; and the likelihood of survival (including life expectancy).
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Proinflammatory cytokine
A proinflammatory cytokine or more simply an inflammatory cytokine is a type of signaling molecule (a cytokine) that is excreted from immune cells like helper T cells (Th) and macrophages, and certain other cell types that promote inflammation.
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Protein kinase C
Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.
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Rheumatoid arthritis
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints.
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RIPK1
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is an enzyme that in humans is encoded by the RIPK1 gene, which is located on chromosome 6.
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RIPK3
Receptor-interacting serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the RIPK3 gene.
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Serine/threonine-specific protein kinase
A serine/threonine protein kinase is a kinase enzyme that phosphorylates the OH group of serine or threonine (which have similar sidechains).
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Signal transducing adaptor protein
Signal transducing adaptor proteins are proteins that are accessory to main proteins in a signal transduction pathway.
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Spindle apparatus
In cell biology, the spindle apparatus (or mitotic spindle) refers to the cytoskeletal structure of eukaryotic cells that forms during cell division to separate sister chromatids between daughter cells.
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Squamous cell carcinoma
Squamous cell carcinomas, also known as epidermoid carcinoma are a number of different types of cancer that result from squamous cells.
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Subcellular localization
The cells of eukaryotic organisms are elaborately subdivided into functionally-distinct membrane-bound compartments.
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T cell
A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.
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T-cell receptor
The T-cell receptor, or TCR, is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.
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Targeted therapy
Targeted therapy or molecularly targeted therapy is one of the major modalities of medical treatment (pharmacotherapy) for cancer, others being hormonal therapy and cytotoxic chemotherapy.
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TLR3
Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a protein that in humans is encoded by the TLR3 gene.
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TLR4
Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene.
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TNF receptor superfamily
The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine-rich domain.
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TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.
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TRAIL
In the field of cell biology, TNF-related apoptosis-inducing ligand (TRAIL), is a protein functioning as a ligand that induces the process of cell death called apoptosis.
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Transcription (biology)
Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.
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Ubiquitin ligase
A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin, recognizes a protein substrate, and assists or directly catalyzes the transfer of ubiquitin from the E2 to the protein substrate.
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Virus
A virus is a small infectious agent that replicates only inside the living cells of other organisms.
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White blood cell
White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.
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Zebrafish
The zebrafish (Danio rerio) is a freshwater fish belonging to the minnow family (Cyprinidae) of the order Cypriniformes.
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Redirects here:
FADD (gene), FAS-associating death domain-containing protein.
References
[1] https://en.wikipedia.org/wiki/FADD
