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Granulomatosis with polyangiitis

Index Granulomatosis with polyangiitis

Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis (WG), is a long-term systemic disorder that involves both granulomatosis and polyangiitis. [1]

115 relations: Acute kidney injury, African Americans, American College of Rheumatology, American Society of Nephrology, Anatomical pathology, Anti-neutrophil cytoplasmic antibody, Antibody, Arteriole, Arthritis, Azathioprine, Łódź, Biopsy, Bladder cancer, Blood vessel, Chapel Hill Consensus Conference, Chronic kidney disease, Cochrane (organisation), Conjunctivitis, Corticosteroid, CTLA-4, Cutaneous small-vessel vasculitis, Cyclophosphamide, Ear, Endothelium, Eosinophilic granulomatosis with polyangiitis, Etanercept, European League Against Rheumatism, Eustachian tube, Friedrich Wegener, Gastrointestinal tract, Genetics, Germany, Giant cell, Glomerulonephritis, Granuloma, H&E stain, Hearing loss, Heart, Hemoptysis, Hemorrhagic cystitis, Histopathology, Human brain, Human eye, Human leukocyte antigen, Human skin, Immune system, Immunosuppression, Incidence (epidemiology), Infertility, Inflammation, ..., Japan, Jews, Kidney, Lancashire Teaching Hospitals NHS Foundation Trust, Leflunomide, Lethal midline granuloma, Leukopenia, List of medical eponyms with Nazi associations, Lung, Lymphoma, Lymphomatoid granulomatosis, Mayo Clinic, Mesenteric ischemia, Methotrexate, Micrograph, Microhematuria, Microscopic polyangiitis, Microscopy, Mycophenolic acid, Nasal septum perforation, Nazism, Necrosis, Necrotizing vasculitis, Nervous system, Neutrophil, Nosebleed, Otorhinolaryngology, Pathogenesis, Pathology, Peripheral neuropathy, Plasmapheresis, Pneumocystis pneumonia, Pneumonia, Proteinase 3, PTPN22, Pulmonary hemorrhage, Pulmonary-renal syndrome, Purpura, Pus, Randomized controlled trial, Rapidly progressive glomerulonephritis, Respiratory failure, Respiratory tract, Rheumatoid arthritis, Rhinitis, Rhinorrhea, Rituximab, Saddle nose, Scleritis, Scottish people, Sensitivity and specificity, Staphylococcus aureus, Stenosis, Sturmabteilung, Symptom, The BMJ, Thoracoscopy, TNF inhibitor, Trachea, Trimethoprim/sulfamethoxazole, Uremia, Urinary cast, Uveitis, Vasculitis, White blood cell. Expand index (65 more) »

Acute kidney injury

Acute kidney injury (AKI), previously called acute renal failure (ARF), is an abrupt loss of kidney function that develops within 7 days.

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African Americans

African Americans (also referred to as Black Americans or Afro-Americans) are an ethnic group of Americans with total or partial ancestry from any of the black racial groups of Africa.

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American College of Rheumatology

The American College of Rheumatology is an organization of and for physicians, health professionals, and scientists that advances rheumatology through programs of education, research, advocacy and practice support that foster excellence in the care of people with arthritis and rheumatic and musculoskeletal diseases.

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American Society of Nephrology

Founded in 1966, the American Society of Nephrology (ASN) is the world’s largest professional society devoted to the study of kidney disease.

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Anatomical pathology

Anatomical pathology (Commonwealth) or Anatomic pathology (U.S.) is a medical specialty that is concerned with the diagnosis of disease based on the macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.

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Anti-neutrophil cytoplasmic antibody

Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies, mainly of the IgG type, against antigens in the cytoplasm of neutrophil granulocytes (the most common type of white blood cell) and monocytes.

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Antibody

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.

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Arteriole

An arteriole is a small-diameter blood vessel in the microcirculation that extends and branches out from an artery and leads to capillaries.

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Arthritis

Arthritis is a term often used to mean any disorder that affects joints.

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Azathioprine

Azathioprine (AZA), sold under the brand name Imuran among others, is an immunosuppressive medication.

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Łódź

Łódź (לאדזש, Lodzh; also written as Lodz) is the third-largest city in Poland and an industrial hub.

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Biopsy

A biopsy is a medical test commonly performed by a surgeon, interventional radiologist, or an interventional cardiologist involving extraction of sample cells or tissues for examination to determine the presence or extent of a disease.

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Bladder cancer

Bladder cancer is any of several types of cancer arising from the tissues of the urinary bladder.

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Blood vessel

The blood vessels are the part of the circulatory system, and microcirculation, that transports blood throughout the human body.

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Chapel Hill Consensus Conference

The Chapel Hill Consensus Conferences (CHCC) (1994 and 2012) are a pair of international conferences which addressed the need of standardized classification system for systemic vasculitides.

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Chronic kidney disease

Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney function over a period of months or years.

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Cochrane (organisation)

Cochrane is a non-profit, non-governmental organization formed to organize medical research findings so as to facilitate evidence-based choices about health interventions faced by health professionals, patients, and policy makers.

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Conjunctivitis

Conjunctivitis, also known as pink eye, is inflammation of the outermost layer of the white part of the eye and the inner surface of the eyelid.

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Corticosteroid

Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones.

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CTLA-4

CTLA4 or CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.

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Cutaneous small-vessel vasculitis

Cutaneous small-vessel vasculitis, also known as hypersensitivity vasculitis, cutaneous leukocytoclastic vasculitis, hypersensitivity angiitis, cutaneous leukocytoclastic angiitis, cutaneous necrotizing vasculitis and cutaneous necrotizing venulitis, is inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura.

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Cyclophosphamide

Cyclophosphamide (CP), also known as cytophosphane among other, is a medication used as chemotherapy and to suppress the immune system.

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Ear

The ear is the organ of hearing and, in mammals, balance.

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Endothelium

Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.

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Eosinophilic granulomatosis with polyangiitis

Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg–Strauss syndrome (CSS) or allergic granulomatosis, is an extremely rare autoimmune condition that causes inflammation of small and medium-sized blood vessels (vasculitis) in persons with a history of airway allergic hypersensitivity (atopy).

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Etanercept

Etanercept (trade name Enbrel) is a biopharmaceutical that treats autoimmune diseases by interfering with tumor necrosis factor (TNF, a soluble inflammatory cytokine) by acting as a TNF inhibitor.

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European League Against Rheumatism

The European League Against Rheumatism (abbr. EULAR) is a European non-governmental organization which represents the people with arthritis/rheumatism, health professional and scientific societies of rheumatology of all the European nations.

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Eustachian tube

The Eustachian tube, also known as the auditory tube or pharyngotympanic tube, is a tube that links the nasopharynx to the middle ear.

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Friedrich Wegener

Friedrich Wegener (April 7, 1907, Varel – July 9, 1990, Lübeck) was a German pathologist who is notable for his description of a rare disease now referred to as granulomatosis with polyangiitis.

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Gastrointestinal tract

The gastrointestinal tract (digestive tract, digestional tract, GI tract, GIT, gut, or alimentary canal) is an organ system within humans and other animals which takes in food, digests it to extract and absorb energy and nutrients, and expels the remaining waste as feces.

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Genetics

Genetics is the study of genes, genetic variation, and heredity in living organisms.

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Germany

Germany (Deutschland), officially the Federal Republic of Germany (Bundesrepublik Deutschland), is a sovereign state in central-western Europe.

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Giant cell

A giant cell (multinucleated giant cell, multinucleate giant cell) is a mass formed by the union of several distinct cells (usually macrophages), often forming a granuloma.

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Glomerulonephritis

Glomerulonephritis (GN), also known as glomerular nephritis, is a term used to refer to several kidney diseases (usually affecting both kidneys).

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Granuloma

Granuloma is an inflammation found in many diseases.

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H&E stain

Hematoxylin and eosin stain or haematoxylin and eosin stain (H&E stain or HE stain) is one of the principal stains in histology.

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Hearing loss

Hearing loss, also known as hearing impairment, is a partial or total inability to hear.

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Heart

The heart is a muscular organ in most animals, which pumps blood through the blood vessels of the circulatory system.

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Hemoptysis

Hemoptysis is the coughing up of blood or blood-stained mucus from the bronchi, larynx, trachea, or lungs.

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Hemorrhagic cystitis

Hemorrhagic cystitis or Haemorrhagic cystitis is defined by lower urinary tract symptoms that include dysuria, hematuria, and hemorrhage.

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Histopathology

Histopathology (compound of three Greek words: ἱστός histos "tissue", πάθος pathos "suffering", and -λογία -logia "study of") refers to the microscopic examination of tissue in order to study the manifestations of disease.

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Human brain

The human brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system.

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Human eye

The human eye is an organ which reacts to light and pressure.

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Human leukocyte antigen

The human leukocyte antigen (HLA) system or complex is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans.

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Human skin

The human skin is the outer covering of the body.

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Immune system

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease.

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Immunosuppression

Immunosuppression is a reduction of the activation or efficacy of the immune system.

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Incidence (epidemiology)

Incidence in epidemiology is a measure of the probability of occurrence of a given medical condition in a population within a specified period of time.

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Infertility

Infertility is the inability of a person, animal or plant to reproduce by natural means.

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Inflammation

Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.

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Japan

Japan (日本; Nippon or Nihon; formally 日本国 or Nihon-koku, lit. "State of Japan") is a sovereign island country in East Asia.

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Jews

Jews (יְהוּדִים ISO 259-3, Israeli pronunciation) or Jewish people are an ethnoreligious group and a nation, originating from the Israelites Israelite origins and kingdom: "The first act in the long drama of Jewish history is the age of the Israelites""The people of the Kingdom of Israel and the ethnic and religious group known as the Jewish people that descended from them have been subjected to a number of forced migrations in their history" and Hebrews of the Ancient Near East.

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Kidney

The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.

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Lancashire Teaching Hospitals NHS Foundation Trust

Lancashire Teaching Hospitals NHS Foundation Trust is one of the United Kingdom's NHS Foundation Trusts.

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Leflunomide

Leflunomide (original brand name Arava) is an immunosuppressive disease-modifying antirheumatic drug (DMARD), used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis.

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Lethal midline granuloma

Lethal midline granuloma is a condition affecting the nose and palate.

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Leukopenia

Leukopenia is a decrease in the number of white blood cells (leukocytes) found in the blood, which places individuals at increased risk of infection.

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List of medical eponyms with Nazi associations

This article lists medical eponyms which have been associated with Nazi human experimentation or Nazi politics.

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Lung

The lungs are the primary organs of the respiratory system in humans and many other animals including a few fish and some snails.

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Lymphoma

Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell).

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Lymphomatoid granulomatosis

Lymphomatoid granulomatosis (LYG or LG) is a very rare lymphoproliferative disorder first characterized in 1972 with lymphomatoid meaning lymphoma-like and granulomatosis denoting one of its microscopic characteristics, polymorphic lymphoid infiltrates and focal necrosis within it.

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Mayo Clinic

The Mayo Clinic is a nonprofit academic medical center based in Rochester, Minnesota focused on integrated clinical practice, education, and research.

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Mesenteric ischemia

Mesenteric ischemia is a medical condition in which injury of the small intestine occurs due to not enough blood supply.

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Methotrexate

Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune system suppressant.

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Micrograph

A micrograph or photomicrograph is a photograph or digital image taken through a microscope or similar device to show a magnified image of an item.

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Microhematuria

Microscopic hematuria is a medical condition in which urine contains small amounts of blood; the blood quantity is too low to change the color of the urine (otherwise, it is known as gross hematuria).

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Microscopic polyangiitis

Microscopic polyangiitis is an ill-defined autoimmune disease characterized by a systemic, pauci-immune, necrotizing, small-vessel vasculitis without clinical or pathological evidence of necrotizing granulomatous inflammation.

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Microscopy

Microscopy is the technical field of using microscopes to view objects and areas of objects that cannot be seen with the naked eye (objects that are not within the resolution range of the normal eye).

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Mycophenolic acid

Mycophenolic acid, less accurately called mycophenolate, is an immunosuppressant drug used to prevent rejection in organ transplantation.

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Nasal septum perforation

A nasal septum perforation is a medical condition in which the nasal septum, the cartilaginous membrane dividing the nostrils, develops a hole or fissure.

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Nazism

National Socialism (Nationalsozialismus), more commonly known as Nazism, is the ideology and practices associated with the Nazi Party – officially the National Socialist German Workers' Party (Nationalsozialistische Deutsche Arbeiterpartei or NSDAP) – in Nazi Germany, and of other far-right groups with similar aims.

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Necrosis

Necrosis (from the Greek νέκρωσις "death, the stage of dying, the act of killing" from νεκρός "dead") is a form of cell injury which results in the premature death of cells in living tissue by autolysis.

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Necrotizing vasculitis

Necrotizing vasculitis also called Systemic necrotizing vasculitus (SNV) is a category of vasculitis, comprising vasculitides that present with necrosis.

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Nervous system

The nervous system is the part of an animal that coordinates its actions by transmitting signals to and from different parts of its body.

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Neutrophil

Neutrophils (also known as neutrocytes) are the most abundant type of granulocytes and the most abundant (40% to 70%) type of white blood cells in most mammals.

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Nosebleed

A nosebleed, also known as epistaxis, is the common occurrence of bleeding from the nose.

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Otorhinolaryngology

Otorhinolaryngology (also called otolaryngology and otolaryngology–head and neck surgery) is a surgical subspecialty within medicine that deals with conditions of the ear, nose, and throat (ENT) and related structures of the head and neck.

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Pathogenesis

The pathogenesis of a disease is the biological mechanism (or mechanisms) that leads to the diseased state.

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Pathology

Pathology (from the Ancient Greek roots of pathos (πάθος), meaning "experience" or "suffering" and -logia (-λογία), "study of") is a significant field in modern medical diagnosis and medical research, concerned mainly with the causal study of disease, whether caused by pathogens or non-infectious physiological disorder.

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Peripheral neuropathy

Peripheral neuropathy (PN) is damage to or disease affecting nerves, which may impair sensation, movement, gland or organ function, or other aspects of health, depending on the type of nerve affected.

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Plasmapheresis

Plasmapheresis (from the Greek πλάσμα—plasma, something molded, and ἀφαίρεσις—aphairesis, taking away) is the removal, treatment, and return or exchange of blood plasma or components thereof from and to the blood circulation.

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Pneumocystis pneumonia

Pneumocystis pneumonia (PCP) is a form of pneumonia that is caused by the yeast-like fungus Pneumocystis jirovecii.

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Pneumonia

Pneumonia is an inflammatory condition of the lung affecting primarily the small air sacs known as alveoli.

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Proteinase 3

Proteinase 3 also known as PRTN3 is an enzyme that in humans is encoded by the PRTN3 gene.

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PTPN22

Protein tyrosine phosphatase, non-receptor type 22 (lymphoid), also known as PTPN22, is a protein that in humans is encoded by the PTPN22 gene.

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Pulmonary hemorrhage

Pulmonary hemorrhage (or pulmonary haemorrhage) is an acute bleeding from the lung, from the upper respiratory tract and the trachea, and the alveoli.

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Pulmonary-renal syndrome

Pulmonary-renal syndrome (PRS) is a rare medical syndrome in which respiratory failure involving bleeding in the lungs and kidney failure (glomerulonephritis) occur.

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Purpura

Purpura is a condition of red or purple discolored spots on the skin that do not blanch on applying pressure.

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Pus

Pus is an exudate, typically white-yellow, yellow, or yellow-brown, formed at the site of inflammation during bacterial or fungal infection.

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Randomized controlled trial

A randomized controlled trial (or randomized control trial; RCT) is a type of scientific (often medical) experiment which aims to reduce bias when testing a new treatment.

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Rapidly progressive glomerulonephritis

Rapidly progressive glomerulonephritis (RPGN) is a syndrome of the kidney that is characterized by a rapid loss of renal function, Citing: McGraw-Hill Concise Dictionary of Modern Medicine.

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Respiratory failure

Respiratory failure results from inadequate gas exchange by the respiratory system, meaning that the arterial oxygen, carbon dioxide or both cannot be kept at normal levels.

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Respiratory tract

In humans, the respiratory tract is the part of the anatomy of the respiratory system involved with the process of respiration.

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Rheumatoid arthritis

Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints.

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Rhinitis

Rhinitis, also known as coryza, is irritation and inflammation of the mucous membrane inside the nose.

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Rhinorrhea

Rhinorrhea or rhinorrhoea is a condition where the nasal cavity is filled with a significant amount of mucus fluid.

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Rituximab

Rituximab, sold under the brand name Rituxan among others, is a medication used to treat certain autoimmune diseases and types of cancer.

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Saddle nose

Saddle nose is a condition associated with nasal trauma, congenital syphilis, relapsing polychondritis, granulomatosis with polyangiitis, cocaine abuse, and leprosy, among other conditions.

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Scleritis

Scleritis is a serious inflammatory disease that affects the white outer coating of the eye, known as the sclera.

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Scottish people

The Scottish people (Scots: Scots Fowk, Scottish Gaelic: Albannaich), or Scots, are a nation and ethnic group native to Scotland. Historically, they emerged from an amalgamation of two Celtic-speaking peoples, the Picts and Gaels, who founded the Kingdom of Scotland (or Alba) in the 9th century. Later, the neighbouring Celtic-speaking Cumbrians, as well as Germanic-speaking Anglo-Saxons and Norse, were incorporated into the Scottish nation. In modern usage, "Scottish people" or "Scots" is used to refer to anyone whose linguistic, cultural, family ancestral or genetic origins are from Scotland. The Latin word Scoti originally referred to the Gaels, but came to describe all inhabitants of Scotland. Considered archaic or pejorative, the term Scotch has also been used for Scottish people, primarily outside Scotland. John Kenneth Galbraith in his book The Scotch (Toronto: MacMillan, 1964) documents the descendants of 19th-century Scottish pioneers who settled in Southwestern Ontario and affectionately referred to themselves as 'Scotch'. He states the book was meant to give a true picture of life in the community in the early decades of the 20th century. People of Scottish descent live in many countries other than Scotland. Emigration, influenced by factors such as the Highland and Lowland Clearances, Scottish participation in the British Empire, and latterly industrial decline and unemployment, have resulted in Scottish people being found throughout the world. Scottish emigrants took with them their Scottish languages and culture. Large populations of Scottish people settled the new-world lands of North and South America, Australia and New Zealand. Canada has the highest level of Scottish descendants per capita in the world and the second-largest population of Scottish descendants, after the United States. Scotland has seen migration and settlement of many peoples at different periods in its history. The Gaels, the Picts and the Britons have their respective origin myths, like most medieval European peoples. Germanic peoples, such as the Anglo-Saxons, arrived beginning in the 7th century, while the Norse settled parts of Scotland from the 8th century onwards. In the High Middle Ages, from the reign of David I of Scotland, there was some emigration from France, England and the Low Countries to Scotland. Some famous Scottish family names, including those bearing the names which became Bruce, Balliol, Murray and Stewart came to Scotland at this time. Today Scotland is one of the countries of the United Kingdom, and the majority of people living there are British citizens.

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Sensitivity and specificity

Sensitivity and specificity are statistical measures of the performance of a binary classification test, also known in statistics as a classification function.

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Staphylococcus aureus

Staphylococcus aureus is a Gram-positive, round-shaped bacterium that is a member of the Firmicutes, and it is a member of the normal flora of the body, frequently found in the nose, respiratory tract, and on the skin.

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Stenosis

A stenosis is an abnormal narrowing in a blood vessel or other tubular organ or structure.

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Sturmabteilung

The Sturmabteilung (SA), literally Storm Detachment, functioned as the original paramilitary wing of the Nazi Party (NSDAP).

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Symptom

A symptom (from Greek σύμπτωμα, "accident, misfortune, that which befalls", from συμπίπτω, "I befall", from συν- "together, with" and πίπτω, "I fall") is a departure from normal function or feeling which is noticed by a patient, reflecting the presence of an unusual state, or of a disease.

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The BMJ

The BMJ is a weekly peer-reviewed medical journal.

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Thoracoscopy

Thoracoscopy is a medical procedure involving internal examination, biopsy, and/or resection of disease or masses within the pleural cavity and thoracic cavity.

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TNF inhibitor

A TNF inhibitor is a pharmaceutical drug that suppresses the physiologic response to tumor necrosis factor (TNF), which is part of the inflammatory response.

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Trachea

The trachea, colloquially called the windpipe, is a cartilaginous tube that connects the pharynx and larynx to the lungs, allowing the passage of air, and so is present in almost all air-breathing animals with lungs.

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Trimethoprim/sulfamethoxazole

Trimethoprim/sulfamethoxazole (TMP/SMX), also known as co-trimoxazole among other names, is an antibiotic used to treat a variety of bacterial infections.

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Uremia

Uremia is the condition of having "urea in the blood".

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Urinary cast

Urinary casts are microscopic cylindrical structures produced by the kidney and present in the urine in certain disease states.

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Uveitis

Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the outer fibrous layer composed of the sclera and cornea.

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Vasculitis

Vasculitis is a group of disorders that destroy blood vessels by inflammation.

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White blood cell

White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.

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Redirects here:

Anti-neutrophil cytoplasmic antibody-associated vasculitis, C-ANCA positive (Wegener's) granulomatosis, Coin lesion, pulmonary, Granulomatosis with Polyangiitis (Wegener's), Granulomatosis with polyangiitis (Wegener's), Granulomatosis with polyangitis, Granulomatous vasculitis, Morbus Wegener, Wegener disease, Wegener granulomatosis, Wegener vasculitis, Wegener's, Wegener's Granulomatosis, Wegener's disease, Wegener's granulomatosis, Wegener's vasculitis, Wegeners, Wegeners granulomatosis, Wegner's Granulomatosis.

References

[1] https://en.wikipedia.org/wiki/Granulomatosis_with_polyangiitis

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