Table of Contents
67 relations: Abortifacient, Acute lymphoblastic leukemia, Acute promyelocytic leukemia, Adenosine monophosphate, Adverse drug reaction, Allopurinol, Amidophosphoribosyltransferase, Antimetabolite, Autoimmune disease, Azathioprine, Bone marrow, Bone marrow suppression, Breathing, Cancer, Chemical weapon, Chromosome, Cornelius P. Rhoads, Crohn's disease, Cytotoxicity, Dizziness, DNA, Edema, Fever, Genetic testing, Genetic variation, George H. Hitchings, Gertrude B. Elion, GSK plc, Guanine, Hepatotoxicity, Human feces, Hypoxanthine, Hypoxanthine-guanine phosphoribosyltransferase, Immunization, Inosinic acid, Itch, Kidney, Melena, Memorial Sloan Kettering Cancer Center, Methotrexate, Methylation, National Center for Biotechnology Information, Nitrogen mustard, Nucleotide, NUDT15, Oral administration, Pancreatitis, Pharmacogenomics, Polio, Pregnancy, ... Expand index (17 more) »
- Purine antagonists
- Thiocarbonyl compounds
Abortifacient
An abortifacient ("that which will cause a miscarriage" from Latin: abortus "miscarriage" and faciens "making") is a substance that induces abortion.
See Mercaptopurine and Abortifacient
Acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes.
See Mercaptopurine and Acute lymphoblastic leukemia
Acute promyelocytic leukemia
Acute promyelocytic leukemia (APML, APL) is a subtype of acute myeloid leukemia (AML), a cancer of the white blood cells.
See Mercaptopurine and Acute promyelocytic leukemia
Adenosine monophosphate
Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide. Mercaptopurine and Adenosine monophosphate are purines.
See Mercaptopurine and Adenosine monophosphate
Adverse drug reaction
An adverse drug reaction (ADR) is a harmful, unintended result caused by taking medication.
See Mercaptopurine and Adverse drug reaction
Allopurinol
Allopurinol is a medication used to decrease high blood uric acid levels. Mercaptopurine and Allopurinol are World Health Organization essential medicines.
See Mercaptopurine and Allopurinol
Amidophosphoribosyltransferase
Amidophosphoribosyltransferase (ATase), also known as glutamine phosphoribosylpyrophosphate amidotransferase (GPAT), is an enzyme responsible for catalyzing the conversion of 5-phosphoribosyl-1-pyrophosphate (PRPP) into 5-phosphoribosyl-1-amine (PRA), using the amine group from a glutamine side-chain.
See Mercaptopurine and Amidophosphoribosyltransferase
Antimetabolite
An antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism.
See Mercaptopurine and Antimetabolite
Autoimmune disease
An autoimmune disease is a condition that results from an anomalous response of the adaptive immune system, wherein it mistakenly targets and attacks healthy, functioning parts of the body as if they were foreign organisms.
See Mercaptopurine and Autoimmune disease
Azathioprine
Azathioprine, sold under the brand name Imuran, among others, is an immunosuppressive medication. Mercaptopurine and Azathioprine are purine antagonists, purines and World Health Organization essential medicines.
See Mercaptopurine and Azathioprine
Bone marrow
Bone marrow is a semi-solid tissue found within the spongy (also known as cancellous) portions of bones.
See Mercaptopurine and Bone marrow
Bone marrow suppression
Bone marrow suppression also known as myelotoxicity or myelosuppression, is the decrease in production of cells responsible for providing immunity (leukocytes), carrying oxygen (erythrocytes), and/or those responsible for normal blood clotting (thrombocytes).
See Mercaptopurine and Bone marrow suppression
Breathing
Breathing (spiration or ventilation) is the rhythmical process of moving air into (inhalation) and out of (exhalation) the lungs to facilitate gas exchange with the internal environment, mostly to flush out carbon dioxide and bring in oxygen.
See Mercaptopurine and Breathing
Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
Chemical weapon
A chemical weapon (CW) is a specialized munition that uses chemicals formulated to inflict death or harm on humans.
See Mercaptopurine and Chemical weapon
Chromosome
A chromosome is a package of DNA with part or all of the genetic material of an organism.
See Mercaptopurine and Chromosome
Cornelius P. Rhoads
Cornelius Packard "Dusty" Rhoads (June 9, 1898 – August 13, 1959) was an American pathologist, oncologist, and hospital administrator who was involved in a racist scandal and subsequent whitewashing in the 1930s.
See Mercaptopurine and Cornelius P. Rhoads
Crohn's disease
Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any segment of the gastrointestinal tract.
See Mercaptopurine and Crohn's disease
Cytotoxicity
Cytotoxicity is the quality of being toxic to cells.
See Mercaptopurine and Cytotoxicity
Dizziness
Dizziness is an imprecise term that can refer to a sense of disorientation in space, vertigo, or lightheadedness.
See Mercaptopurine and Dizziness
DNA
Deoxyribonucleic acid (DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix.
Edema
Edema (AmE), also spelled oedema (BrE), and also known as fluid retention, dropsy, hydropsy and swelling, is the build-up of fluid in the body's tissue.
Fever
Fever or pyrexia in humans is a body temperature above the normal range due to an increase in the body's temperature set point in the hypothalamus.
Genetic testing
Genetic testing, also known as DNA testing, is used to identify changes in DNA sequence or chromosome structure.
See Mercaptopurine and Genetic testing
Genetic variation
Genetic variation is the difference in DNA among individuals or the differences between populations among the same species.
See Mercaptopurine and Genetic variation
George H. Hitchings
George Herbert Hitchings (April 18, 1905 – February 27, 1998) was an American medical doctor who shared the 1988 Nobel Prize in Physiology or Medicine with Sir James Black and Gertrude Elion "for their discoveries of important principles for drug treatment", Hitchings specifically for his work on chemotherapy.
See Mercaptopurine and George H. Hitchings
Gertrude B. Elion
Gertrude "Trudy" Belle Elion (January 23, 1918 – February 21, 1999) was an American biochemist and pharmacologist, who shared the 1988 Nobel Prize in Physiology or Medicine with George H. Hitchings and Sir James Black for their use of innovative methods of rational drug design for the development of new drugs.
See Mercaptopurine and Gertrude B. Elion
GSK plc
GSK plc (an acronym from its former name GlaxoSmithKline plc) is a British multinational pharmaceutical and biotechnology company with global headquarters in London.
See Mercaptopurine and GSK plc
Guanine
Guanine (symbol G or Gua) is one of the four main nucleobases found in the nucleic acids DNA and RNA, the others being adenine, cytosine, and thymine (uracil in RNA). Mercaptopurine and Guanine are purines.
See Mercaptopurine and Guanine
Hepatotoxicity
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.
See Mercaptopurine and Hepatotoxicity
Human feces
Human feces (or faeces in British English) are the solid or semisolid remains of food that could not be digested or absorbed in the small intestine of humans, but has been further broken down by bacteria in the large intestine.
See Mercaptopurine and Human feces
Hypoxanthine
Hypoxanthine is a naturally occurring purine derivative. Mercaptopurine and Hypoxanthine are purines.
See Mercaptopurine and Hypoxanthine
Hypoxanthine-guanine phosphoribosyltransferase
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is an enzyme encoded in humans by the HPRT1 gene.
See Mercaptopurine and Hypoxanthine-guanine phosphoribosyltransferase
Immunization
Immunization, or immunisation, is the process by which an individual's immune system becomes fortified against an infectious agent (known as the immunogen).
See Mercaptopurine and Immunization
Inosinic acid
Inosinic acid or inosine monophosphate (IMP) is a nucleotide (that is, a nucleoside monophosphate). Mercaptopurine and Inosinic acid are purines.
See Mercaptopurine and Inosinic acid
Itch
An itch (also known as pruritus) is a sensation that causes a strong desire or reflex to scratch.
Kidney
In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation.
Melena
Melena is a form of blood in stool which refers to the dark black, tarry feces that are commonly associated with upper gastrointestinal bleeding.
Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Cancer Center (MSK or MSKCC) is a cancer treatment and research institution in Manhattan in New York City.
See Mercaptopurine and Memorial Sloan Kettering Cancer Center
Methotrexate
Methotrexate, formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. Mercaptopurine and Methotrexate are World Health Organization essential medicines.
See Mercaptopurine and Methotrexate
Methylation
Methylation, in the chemical sciences, is the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group.
See Mercaptopurine and Methylation
National Center for Biotechnology Information
The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health (NIH).
See Mercaptopurine and National Center for Biotechnology Information
Nitrogen mustard
Nitrogen mustards (NMs) are cytotoxic organic compounds with the bis(2-chloroethyl)amino ((ClC2H4)2NR) functional group.
See Mercaptopurine and Nitrogen mustard
Nucleotide
Nucleotides are organic molecules composed of a nitrogenous base, a pentose sugar and a phosphate.
See Mercaptopurine and Nucleotide
NUDT15
Nudix hydrolase 15 is a protein that in humans is encoded by the NUDT15 gene.
Oral administration
| name.
See Mercaptopurine and Oral administration
Pancreatitis
Pancreatitis is a condition characterized by inflammation of the pancreas.
See Mercaptopurine and Pancreatitis
Pharmacogenomics
Pharmacogenomics, often abbreviated "PGx," is the study of the role of the genome in drug response.
See Mercaptopurine and Pharmacogenomics
Polio
Poliomyelitis, commonly shortened to polio, is an infectious disease caused by the poliovirus.
Pregnancy
Pregnancy is the time during which one or more offspring develops (gestates) inside a woman's uterus (womb).
See Mercaptopurine and Pregnancy
Purine
Purine is a heterocyclic aromatic organic compound that consists of two rings (pyrimidine and imidazole) fused together. Mercaptopurine and Purine are purines.
Rash
A rash is a change of the skin that affects its color, appearance, or texture.
Red blood cell
Red blood cells (RBCs), referred to as erythrocytes (with -cyte translated as 'cell' in modern usage) in academia and medical publishing, also known as red cells, erythroid cells, and rarely haematids, are the most common type of blood cell and the vertebrate's principal means of delivering oxygen to the body tissues—via blood flow through the circulatory system.
See Mercaptopurine and Red blood cell
RNA
Ribonucleic acid (RNA) is a polymeric molecule that is essential for most biological functions, either by performing the function itself (non-coding RNA) or by forming a template for the production of proteins (messenger RNA).
Sore throat
Sore throat, also known as throat pain, is pain or irritation of the throat.
See Mercaptopurine and Sore throat
Thiopurine
The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis), and organ transplant recipients. Mercaptopurine and thiopurine are purines.
See Mercaptopurine and Thiopurine
Thiopurine methyltransferase
Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) is an enzyme that in humans is encoded by the TPMT gene.
See Mercaptopurine and Thiopurine methyltransferase
Tuckahoe (village), New York
Tuckahoe is a village in Westchester County, New York, United States.
See Mercaptopurine and Tuckahoe (village), New York
Ulcerative colitis
Ulcerative colitis (UC) is one of the two types of inflammatory bowel disease (IBD), with the other type being Crohn's disease.
See Mercaptopurine and Ulcerative colitis
Urine
Urine is a liquid by-product of metabolism in humans and in many other animals.
Vaccination
Vaccination is the administration of a vaccine to help the immune system develop immunity from a disease.
See Mercaptopurine and Vaccination
Vacuum aspiration
Vacuum or suction aspiration is a procedure that uses a vacuum source to remove an embryo or fetus through the cervix.
See Mercaptopurine and Vacuum aspiration
White blood cell
White blood cells (scientific name leukocytes), also called immune cells or immunocytes, are cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.
See Mercaptopurine and White blood cell
WHO Model List of Essential Medicines
The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system. Mercaptopurine and WHO Model List of Essential Medicines are World Health Organization essential medicines.
See Mercaptopurine and WHO Model List of Essential Medicines
Xanthine oxidase
Xanthine oxidase (XO, sometimes XAO) is a form of xanthine oxidoreductase, a type of enzyme that generates reactive oxygen species.
See Mercaptopurine and Xanthine oxidase
Xanthosine monophosphate
Xanthosine monophosphate (xanthylate) is an intermediate in purine metabolism.
See Mercaptopurine and Xanthosine monophosphate
Zygosity
Zygosity (the noun, zygote, is from the Greek "yoked," from "yoke") is the degree to which both copies of a chromosome or gene have the same genetic sequence.
See Mercaptopurine and Zygosity
See also
Purine antagonists
- Azathioprine
- Cladribine
- Clofarabine
- Fludarabine
- Mercaptopurine
- Nelarabine
- Pentostatin
- Tioguanine
Thiocarbonyl compounds
- Anethole trithione
- Bisthiosemicarbazone
- Diethyl dixanthogen disulfide
- Dithiocarbamates
- Dithizone
- Dixanthogen disulfide
- Ethylene trithiocarbonate
- Mercaptopurine
- Oltipraz
- Potassium ethyl xanthate
- Potassium trithiocarbonate
- S,S'-Dimethyl dithiocarbonate
- Sodium ethyl xanthate
- Sulfoaildenafil
- Suritozole
- Thioaldehydes
- Thiocarbamates
- Thioketones
- Thiophosgene
- Thiosemicarbazones
- Thioureas
- Thiouric acid
- Thioxanthate
- Tisopurine
- Xanthate
References
Also known as 6 MP, 6 mercaptopurine, 6-MP, 6-Mercaptopurine, 6-mercaptopurine monohydrate, 6MP, ATC code L01BB02, ATCvet code QL01BB02, Ismipur, Leukerin, Leupurin, Mercaleukim, Mercaleukin, Puri-Nethol, Purimethol, Purinethiol, Purinethol, Purinetol, Purixan, Xaluprine.