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70 relations: Active metabolite, Adrenergic receptor, Aggression, Alpha-1 adrenergic receptor, Alpha-1A adrenergic receptor, Alpha-2 adrenergic receptor, Anticholinergic, Antihistamine, Atypical antidepressant, Bioavailability, Biological half-life, Brain, Bristol-Myers Squibb, Chemical compound, Clinical trial, CYP2D6, CYP3A4, Dopamine, Dopamine receptor D2, Dopamine transporter, Enzyme, Enzyme inhibitor, Etoperidone, FDA citizen petition, Feces, Generic drug, Hepatotoxicity, Histamine, Histamine H1 receptor, Hydrochloride, Hydroxynefazodone, Incidence (epidemiology), Jaundice, Liver, Major depressive disorder, Membrane transport protein, Merck Manual of Diagnosis and Therapy, Meta-Chlorophenylpiperazine, Metabolism, Migraine, Muscarinic acetylcholine receptor, Norepinephrine transporter, Oral administration, Orthostatic hypotension, Panic disorder, Pharmacodynamics, Pharmacokinetics, Phenylpiperazine, Placebo, Plasma protein binding, ..., Potency (pharmacology), Priapism, Public Citizen, Receptor antagonist, Serotonin, Serotonin antagonist and reuptake inhibitor, Serotonin transporter, Serotonin–norepinephrine–dopamine reuptake inhibitor, Side effect, Tablet (pharmacy), Trademark distinctiveness, Trazodone, Triazoledione, United States, Urine, Weakness, Xerostomia, 5-HT1A receptor, 5-HT2A receptor, 5-HT2C receptor. Expand index (20 more) »
Active metabolite
An active metabolite is an active form of a drug after it has been processed by the body.
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Adrenergic receptor
The adrenergic receptors (or adrenoceptors) are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine (noradrenaline) and epinephrine (adrenaline).
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Aggression
Aggression is overt, often harmful, social interaction with the intention of inflicting damage or other unpleasantness upon another individual.
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Alpha-1 adrenergic receptor
The alpha-1 (α1) adrenergic receptor is a G protein-coupled receptor (GPCR) associated with the Gq heterotrimeric G-protein.
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Alpha-1A adrenergic receptor
The alpha-1A adrenergic receptor (α1A adrenoreceptor), also known as ADRA1A, formerly known also as the alpha-1C adrenergic receptor, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.
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Alpha-2 adrenergic receptor
The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein.
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Anticholinergic
An anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system.
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Antihistamine
Antihistamines are drugs which treat allergic rhinitis and other allergies.
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Atypical antidepressant
An atypical antidepressant is a type of antidepressant medication which acts in an atypical manner relative to most other antidepressants.
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Bioavailability
In pharmacology, bioavailability (BA or F) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.
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Biological half-life
The biological half-life of a biological substance is the time it takes for half to be removed by biological processes when the rate of removal is roughly exponential.
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Brain
The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.
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Bristol-Myers Squibb
Bristol-Myers Squibb (BMS) is an American pharmaceutical company, headquartered in New York City.
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Chemical compound
A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) composed of atoms from more than one element held together by chemical bonds.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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CYP2D6
Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene.
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CYP3A4
Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.
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Dopamine
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.
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Dopamine receptor D2
Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.
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Dopamine transporter
The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Enzyme inhibitor
4QI9) An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.
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Etoperidone
Etoperidone, associated with several brand names, is an atypical antidepressant which was developed in the 1970s and either is no longer marketed or was never marketed.
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FDA citizen petition
An FDA citizen petition is a process provided by the United States Food and Drug Administration for individuals and community organizations to make requests to the FDA for changes to health policy.
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Feces
Feces (or faeces) are the solid or semisolid remains of the food that could not be digested in the small intestine.
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Generic drug
A generic drug is a pharmaceutical drug that is equivalent to a brand-name product in dosage, strength, route of administration, quality, performance, and intended use, but does not carry the brand name.
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Hepatotoxicity
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.
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Histamine
Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus.
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Histamine H1 receptor
The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors.
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Hydrochloride
In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (e.g. an amine).
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Hydroxynefazodone
Hydroxynefazodone is a phenylpiperazine compound and a major metabolite of the antidepressant nefazodone.
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Incidence (epidemiology)
Incidence in epidemiology is a measure of the probability of occurrence of a given medical condition in a population within a specified period of time.
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Jaundice
Jaundice, also known as icterus, is a yellowish or greenish pigmentation of the skin and whites of the eyes due to high bilirubin levels.
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Liver
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
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Major depressive disorder
Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.
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Membrane transport protein
A membrane transport protein (or simply transporter) is a membrane protein involved in the movement of ions, small molecules, or macromolecules, such as another protein, across a biological membrane.
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Merck Manual of Diagnosis and Therapy
The Merck Manual of Diagnosis and Therapy, referred to as The Merck Manual, is the world's best-selling medical textbook, and the oldest continuously published English language medical textbook.
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Meta-Chlorophenylpiperazine
meta-Chlorophenylpiperazine (mCPP) is a psychoactive drug of the phenylpiperazine class.
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Metabolism
Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.
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Migraine
A migraine is a primary headache disorder characterized by recurrent headaches that are moderate to severe.
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Muscarinic acetylcholine receptor
Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons and other cells.
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Norepinephrine transporter
The norepinephrine transporter (NET), also known as solute carrier family 6 member 2 (SLC6A2), is a protein that in humans is encoded by the SLC6A2 gene.
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Oral administration
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Orthostatic hypotension
Orthostatic hypotension, also known as postural hypotension, occurs when a person's blood pressure falls when suddenly standing up from a lying or sitting position.
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Panic disorder
Panic disorder is an anxiety disorder characterized by reoccurring unexpected panic attacks.
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Pharmacodynamics
Pharmacodynamics is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).
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Pharmacokinetics
Pharmacokinetics (from Ancient Greek pharmakon "drug" and kinetikos "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to determining the fate of substances administered to a living organism.
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Phenylpiperazine
1-Phenylpiperazine is a simple chemical compound featuring a phenyl group bound to a piperazine ring.
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Placebo
A placebo is a substance or treatment of no intended therapeutic value.
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Plasma protein binding
Plasma protein binding refers to the degree to which medications attach to proteins within the blood.
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Potency (pharmacology)
In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.
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Priapism
Priapism is a condition in which a penis remains erect for hours in the absence of stimulation or after stimulation has ended.
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Public Citizen
Public Citizen is a non-profit, liberal / progressive consumer rights advocacy group and think tank based in Washington, D.C., United States, with a branch in Austin, Texas.
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Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
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Serotonin
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
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Serotonin antagonist and reuptake inhibitor
Serotonin antagonist and reuptake inhibitors (SARIs) are a class of drugs used mainly as antidepressants, but also as anxiolytics and hypnotics.
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Serotonin transporter
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.
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Serotonin–norepinephrine–dopamine reuptake inhibitor
A serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI), is a type of drug that acts as a combined reuptake inhibitor of the monoamine neurotransmitters serotonin, norepinephrine, and dopamine.
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Side effect
In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.
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Tablet (pharmacy)
A tablet is a pharmaceutical dosage form.
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Trademark distinctiveness
Trademark distinctiveness is an important concept in the law governing trademarks and service marks.
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Trazodone
Trazodone, sold under many brand names worldwide, Page accessed Feb 10, 2016 is an antidepressant medication.
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Triazoledione
Triazoledione (developmental code name BMS-180492) is a phenylpiperazine compound and a major metabolite of the antidepressant nefazodone.
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United States
The United States of America (USA), commonly known as the United States (U.S.) or America, is a federal republic composed of 50 states, a federal district, five major self-governing territories, and various possessions.
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Urine
Urine is a liquid by-product of metabolism in humans and in many animals.
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Weakness
Weakness or asthenia is a symptom of a number of different conditions.
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Xerostomia
Xerostomia, also known as dry mouth and dry mouth syndrome, is dryness in the mouth, which may be associated with a change in the composition of saliva, or reduced salivary flow, or have no identifiable cause.
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5-HT1A receptor
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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5-HT2A receptor
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).
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5-HT2C receptor
The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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Redirects here:
ATC code N06AX06, ATCvet code QN06AX06, C25H32ClN5O2, Dutonin, Nefadozone, Nefazadone, Nefazodone hydrochloride, Serzone.
References
[1] https://en.wikipedia.org/wiki/Nefazodone
