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36 relations: Adipose tissue, Annonaceae, Atherosclerosis, Basal lamina, Bleeding diathesis, Blood vessel, Cancer, Chromosome 7, Connective tissue, Endothelium, Fibrin, Fibrinolysis, Fibrosis, Gene, Hypertension, MEROPS, Metabolic syndrome, Nexin, Obesity, ORM1, Placenta, Plasmin, Plasminogen activator inhibitor-2, Polymorphism (biology), Pregnancy, Protease, Protein, Protein–protein interaction, Renin–angiotensin system, Serine protease, Serpin, Thrombosis, Thrombus, Tiplasinin, Tissue plasminogen activator, Urokinase.
Adipose tissue
In biology, adipose tissue, body fat, or simply fat is a loose connective tissue composed mostly of adipocytes.
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Annonaceae
The Annonaceae are a family, the custard apple family, of flowering plants consisting of trees, shrubs, or rarely lianas.
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Atherosclerosis
Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque.
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Basal lamina
The basal lamina is a layer of extracellular matrix secreted by the epithelial cells, on which the epithelium sits.
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Bleeding diathesis
In medicine (hematology), bleeding diathesis (h(a)emorrhagic diathesis) is an unusual susceptibility to bleed (hemorrhage) mostly due to hypocoagulability, in turn caused by a coagulopathy (a defect in the system of coagulation).
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Blood vessel
The blood vessels are the part of the circulatory system, and microcirculation, that transports blood throughout the human body.
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
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Chromosome 7
Chromosome 7 is one of the 23 pairs of chromosomes in humans.
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Connective tissue
Connective tissue (CT) is one of the four basic types of animal tissue, along with epithelial tissue, muscle tissue, and nervous tissue.
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Endothelium
Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.
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Fibrin
Fibrin (also called Factor Ia) is a fibrous, non-globular protein involved in the clotting of blood.
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Fibrinolysis
Fibrinolysis is a process that prevents blood clots from growing and becoming problematic.
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Fibrosis
Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Hypertension
Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.
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MEROPS
MEROPS is an on-line database for peptidases (also known as proteases, proteinases and proteolytic enzymes) and their inhibitors.
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Metabolic syndrome
Metabolic syndrome, sometimes known by other names, is a clustering of at least three of the five following medical conditions: abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides and low high-density lipoprotein (HDL) levels.
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Nexin
Nexin is a proteinous inter-doublet linkage that prevents microtubules in the outer layer of axonemes from movement with respect to each other.
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Obesity
Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health.
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ORM1
Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene.
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Placenta
The placenta is an organ that connects the developing fetus to the uterine wall to allow nutrient uptake, thermo-regulation, waste elimination, and gas exchange via the mother's blood supply; to fight against internal infection; and to produce hormones which support pregnancy.
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Plasmin
Plasmin is an important enzyme present in blood that degrades many blood plasma proteins, including fibrin clots.
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Plasminogen activator inhibitor-2
Plasminogen activator inhibitor-2 (placental PAI, SerpinB2, PAI-2), a serine protease inhibitor of the serpin superfamily, is a coagulation factor that inactivates tPA and urokinase.
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Polymorphism (biology)
Polymorphism in biology and zoology is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species.
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Pregnancy
Pregnancy, also known as gestation, is the time during which one or more offspring develops inside a woman.
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Protease
A protease (also called a peptidase or proteinase) is an enzyme that performs proteolysis: protein catabolism by hydrolysis of peptide bonds.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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Renin–angiotensin system
The renin–angiotensin system (RAS) or the renin–angiotensin–aldosterone system (RAAS) is a hormone system that regulates blood pressure and fluid balance.
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Serine protease
Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the (enzyme's) active site.
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Serpin
Serpins are a superfamily of proteins with similar structures that were first identified for their protease inhibition activity and are found in all kingdoms of life.
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Thrombosis
Thrombosis (from Ancient Greek θρόμβωσις thrómbōsis "clotting”) is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.
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Thrombus
A thrombus, colloquially called a blood clot, is the final product of the blood coagulation step in hemostasis.
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Tiplasinin
Tiplasinin or tiplaxtinin (PAI-039) is a drug which acts as an inhibitor of the serpin protein plasminogen activator inhibitor-1 (PAI-1), thereby increasing activity of the enzymes tissue plasminogen activator and urokinase, which are involved in the blood clotting cascade.
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Tissue plasminogen activator
Tissue plasminogen activator (abbreviated tPA or PLAT) is a protein involved in the breakdown of blood clots.
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Urokinase
Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals.
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Redirects here:
PAI-1, PAI-I, PAI1, Plasminogen activator inhibitor, Plasminogen activator inhibitor 1, SERPINE1, SERPINE1 (gene), Serpine 1.
References
[1] https://en.wikipedia.org/wiki/Plasminogen_activator_inhibitor-1
