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115 relations: Active ingredient, Adenylyl cyclase, Adipose tissue, Adverse event, Agonist, Alcohol, Allosteric modulator, American Academy of Neurology, Analgesic, Anandamide, Anti-inflammatory, Anticonvulsant, Antiemetic, Antioxidant, Aromaticity, Biosynthesis, Botanical drug, Brain, Cannabichromene, Cannabidiol, Cannabigerol, Cannabinoid, Cannabinoid hyperemesis syndrome, Cannabinoid receptor, Cannabinoid receptor type 1, Cannabinoid receptor type 2, Cannabinol, Cannabis, Cannabis (drug), Capsule (pharmacy), Carbonyl group, Central nervous system, Chemotherapy, Chromatography, Controlled Substances Act, Convention on Psychotropic Substances, Cyclic adenosine monophosphate, CYP2C19, CYP2C9, CYP3A4, Cytochrome P450, Decarboxylation, Dimethylheptylpyran, Downregulation and upregulation, Dronabinol, Drug Enforcement Agency, Drugs controlled by the German Betäubungsmittelgesetz, Effects of cannabis, Endocannabinoid system, Enzyme, ..., Euphoria, Excitotoxicity, Feces, Food and Drug Administration, Geranyl pyrophosphate, Glucuronic acid, Glutamic acid, HIV/AIDS, Hops, HU-210, Humulone, Immune system, Immunoassay, Isomer, Israel, JWH-133, Lipid, Lipophilicity, List of investigational analgesics, Medical cannabis, Medicine, Metabolite, Multiple sclerosis, Nabilone, Nabiximols, National Association of Drug Court Professionals, National Institute on Drug Abuse, Neuropathic pain, Olivetol, Overactive bladder, Oxidative stress, Parahexyl, Pharmaceutical formulation, Pharmacodynamics, Predation, Prescription drug, Psychoactive drug, Raphael Mechoulam, Recreational drug use, Resin, Retrograde signaling, Secondary metabolite, Self-defense, Single Convention on Narcotic Drugs, Solubility, Solvent, Spasticity, Stereoisomerism, Stress (biology), Terpenoid, Tetrahydrocannabinolic acid, Tetrahydrocannabinolic acid synthase, Total synthesis, Ultraviolet, United Kingdom, United States Congress, Urine, War on drugs, Weizmann Institute of Science, WIN 55,212-2, World Health Organization, 11-Hydroxy-THC, 11-Nor-9-carboxy-THC, 2-Arachidonoylglycerol, 4-Toluenesulfonyl chloride. Expand index (65 more) »
Active ingredient
An active ingredient (AI) is the ingredient in a pharmaceutical drug that is biologically active.
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Adenylyl cyclase
Adenylyl cyclase (also commonly known as adenyl cyclase and adenylate cyclase, abbreviated AC) is an enzyme with key regulatory roles in essentially all cells.
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Adipose tissue
In biology, adipose tissue, body fat, or simply fat is a loose connective tissue composed mostly of adipocytes.
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Adverse event
An adverse event (AE) is any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment.
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Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Alcohol
In chemistry, an alcohol is any organic compound in which the hydroxyl functional group (–OH) is bound to a carbon.
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Allosteric modulator
In biochemistry and pharmacology, an allosteric modulator (allo- from the Greek meaning "other") is a substance which indirectly influences (modulates) the effects of a primary ligand that directly activates or deactivates the function of a target protein.
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American Academy of Neurology
The American Academy of Neurology (AAN) is a professional society representing over 34,000 neurologists and neuroscientists.
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Analgesic
An analgesic or painkiller is any member of the group of drugs used to achieve analgesia, relief from pain.
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Anandamide
Anandamide, also known as N-arachidonoylethanolamine or AEA, is a fatty acid neurotransmitter derived from the non-oxidative metabolism of eicosatetraenoic acid (arachidonic acid) an essential ω-6 polyunsaturated fatty acid.
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Anti-inflammatory
Anti-inflammatory, or antiinflammatory, refers to the property of a substance or treatment that reduces inflammation or swelling.
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Anticonvulsant
Anticonvulsants (also commonly known as antiepileptic drugs or as antiseizure drugs) are a diverse group of pharmacological agents used in the treatment of epileptic seizures.
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Antiemetic
An antiemetic is a drug that is effective against vomiting and nausea.
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Antioxidant
Antioxidants are molecules that inhibit the oxidation of other molecules.
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Aromaticity
In organic chemistry, the term aromaticity is used to describe a cyclic (ring-shaped), planar (flat) molecule with a ring of resonance bonds that exhibits more stability than other geometric or connective arrangements with the same set of atoms.
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Biosynthesis
Biosynthesis (also called anabolism) is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms.
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Botanical drug
A botanical drug is defined in the United States Federal Food, Drug, and Cosmetic Act as a botanical product that is marketed as diagnosing, mitigating, treating, or curing a disease; a botanical product in turn, is a finished, labeled product that contains ingredients from plants.
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Brain
The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.
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Cannabichromene
Cannabichromene (CBC) is one of the 113 cannabinoids found in the Cannabis plant and therefore can be also described as a phytocannabinoid – from ancient Greek phyton.
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Cannabidiol
Cannabidiol (CBD) is a naturally occurring cannabinoid constituent of cannabis.
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Cannabigerol
Cannabigerol is one of some 560 cannabinoid compounds found in the plant genus Cannabis.
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Cannabinoid
A cannabinoid is one of a class of diverse chemical compounds that acts on cannabinoid receptors in cells that alter neurotransmitter release in the brain.
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Cannabinoid hyperemesis syndrome
Cannabinoid hyperemesis syndrome can occur with cannabis use and is characterized by recurrent nausea, vomiting, and crampy abdominal pain.
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Cannabinoid receptor
Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system, which is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory.
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Cannabinoid receptor type 1
The cannabinoid type 1 receptor, often abbreviated as CB1, is a G protein-coupled cannabinoid receptor located in the central and peripheral nervous system.
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Cannabinoid receptor type 2
The cannabinoid receptor type 2, abbreviated as CB2, is a G protein-coupled receptor from the cannabinoid receptor family that in humans is encoded by the CNR2 gene.
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Cannabinol
Cannabinol (CBN) is a non-psychoactive cannabinoid found only in trace amounts in Cannabis, and is mostly found in aged Cannabis. Pharmacologically relevant quantities are formed as a metabolite of tetrahydrocannabinol (THC).
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Cannabis
Cannabis is a genus of flowering plants in the family Cannabaceae.
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Cannabis (drug)
Cannabis, also known as marijuana among other names, is a psychoactive drug from the ''Cannabis'' plant intended for medical or recreational use.
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Capsule (pharmacy)
In the manufacture of pharmaceuticals, encapsulation refers to a range of dosage forms—techniques used to enclose medicines—in a relatively stable shell known as a capsule, allowing them to, for example, be taken orally or be used as suppositories.
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Carbonyl group
In organic chemistry, a carbonyl group is a functional group composed of a carbon atom double-bonded to an oxygen atom: C.
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Central nervous system
The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.
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Chemotherapy
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen.
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Chromatography
Chromatography is a laboratory technique for the separation of a mixture.
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Controlled Substances Act
The Controlled Substances Act (CSA) is the statute establishing federal U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated.
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Convention on Psychotropic Substances
The Convention on Psychotropic Substances of 1971 is a United Nations treaty designed to control psychoactive drugs such as amphetamine-type stimulants, barbiturates, benzodiazepines, and psychedelics signed in Vienna, Austria on 21 February 1971.
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Cyclic adenosine monophosphate
Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in many biological processes.
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CYP2C19
Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme.
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CYP2C9
Cytochrome P450 2C9 (abbreviated CYP2C9) is an enzyme that in humans is encoded by the CYP2C9 gene.
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CYP3A4
Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.
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Cytochrome P450
Cytochromes P450 (CYPs) are proteins of the superfamily containing heme as a cofactor and, therefore, are hemoproteins.
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Decarboxylation
Decarboxylation is a chemical reaction that removes a carboxyl group and releases carbon dioxide (CO2).
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Dimethylheptylpyran
Dimethylheptylpyran (DMHP, 3-(1,2-dimethylheptyl)-Δ6a,10a-THC, 1,2-dimethylheptyl-Δ3THC, A-40824, EA-2233) is a synthetic analogue of THC, which was invented in 1949 during attempts to elucidate the structure of Δ9-THC, one of the active components of cannabis.
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Downregulation and upregulation
In the biological context of organisms' production of gene products, downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external stimulus.
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Dronabinol
Dronabinol – trade names Marinol and Syndros – is a synthetic form of tetrahydrocannabinol (THC) approved by the FDA as an appetite stimulant for people with AIDS and antiemetic for people receiving chemotherapy.
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Drug Enforcement Agency
The Drug Enforcement Agency (DEA) is an agency within the Liberian government charged with fighting drug-related crimes.
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Drugs controlled by the German Betäubungsmittelgesetz
Drugs controlled by the German Betäubungsmittelgesetz (BtMG).
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Effects of cannabis
The effects of cannabis are caused by the chemical compounds in the plant, including cannabinoids, such as tetrahydrocannabinol (THC), which is only one of more than 100 different cannabinoids present in the plant.
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Endocannabinoid system
The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, which are endogenous lipid-based retrograde neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout the mammalian central nervous system (including the brain) and peripheral nervous system.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Euphoria
Euphoria is an affective state in which a person experiences pleasure or excitement and intense feelings of well-being and happiness.
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Excitotoxicity
Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate and similar substances.
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Feces
Feces (or faeces) are the solid or semisolid remains of the food that could not be digested in the small intestine.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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Geranyl pyrophosphate
Geranyl pyrophosphate (GPP), also known as geranyl diphosphate (GDP), is an intermediate in the HMG-CoA reductase pathway used by organisms in the biosynthesis of farnesyl pyrophosphate, geranylgeranyl pyrophosphate.
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Glucuronic acid
Glucuronic acid (from Greek γλυκύς "sweet" and οὖρον "urine") is a uronic acid that was first isolated from urine (hence the name).
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Glutamic acid
Glutamic acid (symbol Glu or E) is an α-amino acid with formula.
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HIV/AIDS
Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV).
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Hops
Hops are the flowers (also called seed cones or strobiles) of the hop plant Humulus lupulus. They are used primarily as a flavouring and stability agent in beer, to which they impart bitter, zesty, or citric flavours; though they are also used for various purposes in other beverages and herbal medicine.
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HU-210
HU-210 is a synthetic cannabinoid that was first synthesized in 1988 from (1R,5S)-myrtenol by a group led by Professor Raphael Mechoulam at the Hebrew University.
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Humulone
Humulone (α-lupulic acid), a vinylogous type of organic acid, is a bitter-tasting chemical compound found in the resin of mature hops (Humulus lupulus).
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Immune system
The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease.
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Immunoassay
An immunoassay is a biochemical test that measures the presence or concentration of a macromolecule or a small molecule in a solution through the use of an antibody (usually) or an antigen (sometimes).
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Isomer
An isomer (from Greek ἰσομερής, isomerès; isos.
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Israel
Israel, officially the State of Israel, is a country in the Middle East, on the southeastern shore of the Mediterranean Sea and the northern shore of the Red Sea.
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JWH-133
JWH-133 is a potent selective CB2 receptor agonist with a Ki of 3.4nM and selectivity of around 200x for CB2 over CB1 receptors.
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Lipid
In biology and biochemistry, a lipid is a biomolecule that is soluble in nonpolar solvents.
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Lipophilicity
Lipophilicity (from Greek λίπος "fat" and φίλος "friendly"), refers to the ability of a chemical compound to dissolve in fats, oils, lipids, and non-polar solvents such as hexane or toluene.
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List of investigational analgesics
This is a list of investigational analgesics, or analgesics that are currently under development for clinical use but are not yet approved.
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Medical cannabis
Medical cannabis, or medical marijuana, is cannabis and cannabinoids that are recommended by doctors for their patients.
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Medicine
Medicine is the science and practice of the diagnosis, treatment, and prevention of disease.
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Metabolite
A metabolite is the intermediate end product of metabolism.
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Multiple sclerosis
Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged.
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Nabilone
Nabilone is a synthetic cannabinoid with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain.
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Nabiximols
Nabiximols (USAN, trade name Sativex) is a specific extract of Cannabis that was approved as a botanical drug in the United Kingdom in 2010 as a mouth spray to alleviate neuropathic pain, spasticity, overactive bladder, and other symptoms of multiple sclerosis; it was developed by the UK company GW Pharmaceuticals.
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National Association of Drug Court Professionals
The National Association of Drug Court Professionals (NADCP) is an American 501(c)(3) non-profit drug court organization.
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National Institute on Drug Abuse
The National Institute on Drug Abuse (NIDA) is a United States federal-government research institute whose mission is to "lead the Nation in bringing the power of science to bear on drug abuse and addiction." The institute has conducted an in-depth study of addiction according to its biological, behavioral and social components.
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Neuropathic pain
Neuropathic pain is pain caused by damage or disease affecting the somatosensory nervous system.
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Olivetol
Olivetol, also known as 5-pentylresorcinol or 5-pentyl-1,3-benzenediol, is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of tetrahydrocannabinol.
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Overactive bladder
Overactive bladder (OAB) is a condition where there is a frequent feeling of needing to urinate to a degree that it negatively affects a person's life.
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Oxidative stress
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.
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Parahexyl
Parahexyl (Synhexyl, n-hexyl-Δ3THC) is a synthetic homologue of THC, which was invented in 1949 during attempts to elucidate the structure of Δ9-THC, one of the active components of cannabis.
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Pharmaceutical formulation
Pharmaceutical formulation, in pharmaceutics, is the process in which different chemical substances, including the active drug, are combined to produce a final medicinal product.
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Pharmacodynamics
Pharmacodynamics is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).
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Predation
Predation is a biological interaction where a predator (a hunting animal) kills and eats its prey (the organism that is attacked).
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Prescription drug
A prescription drug (also prescription medication or prescription medicine) is a pharmaceutical drug that legally requires a medical prescription to be dispensed.
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Psychoactive drug
A psychoactive drug, psychopharmaceutical, or psychotropic is a chemical substance that changes brain function and results in alterations in perception, mood, consciousness, cognition, or behavior.
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Raphael Mechoulam
Raphael Mechoulam (רפאל משולם) (born 1930) is an Israeli organic chemist and professor of Medicinal Chemistry at the Hebrew University of Jerusalem in Israel.
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Recreational drug use
Recreational drug use is the use of a psychoactive drug to induce an altered state of consciousness for pleasure, by modifying the perceptions, feelings, and emotions of the user.
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Resin
In polymer chemistry and materials science, resin is a "solid or highly viscous substance" of plant or synthetic origin that is typically convertible into polymers.
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Retrograde signaling
Retrograde signaling in biology is a process whereby function of one part of a cell is controlled by feedback from another part of the cell, or where one cell sends reciprocal messages back to another cell that regulates it.
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Secondary metabolite
Secondary metabolites are organic compounds that are not directly involved in the normal growth, development, or reproduction of an organism.
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Self-defense
Self-defence (self-defense in some varieties of English) is a countermeasure that involves defending the health and well-being of oneself from harm.
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Single Convention on Narcotic Drugs
The Single Convention on Narcotic Drugs of 1961 is an international treaty to prohibit production and supply of specific (nominally narcotic) drugs and of drugs with similar effects except under licence for specific purposes, such as medical treatment and research.
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Solubility
Solubility is the property of a solid, liquid or gaseous chemical substance called solute to dissolve in a solid, liquid or gaseous solvent.
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Solvent
A solvent (from the Latin solvō, "loosen, untie, solve") is a substance that dissolves a solute (a chemically distinct liquid, solid or gas), resulting in a solution.
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Spasticity
Spasticity is a feature of altered skeletal muscle performance with a combination of paralysis, increased tendon reflex activity, and hypertonia.
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Stereoisomerism
In stereochemistry, stereoisomers are isomeric molecules that have the same molecular formula and sequence of bonded atoms (constitution), but differ in the three-dimensional orientations of their atoms in space.
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Stress (biology)
Physiological or biological stress is an organism's response to a stressor such as an environmental condition.
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Terpenoid
The terpenoids, sometimes called isoprenoids, are a large and diverse class of naturally occurring organic chemicals derived from terpenes.
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Tetrahydrocannabinolic acid
Tetrahydrocannabinolic acid (THCA, 2-COOH-THC; conjugate base tetrahydrocannabinolate) is a precursor of tetrahydrocannabinol (THC), the active component of cannabis.
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Tetrahydrocannabinolic acid synthase
Tetrahydrocannabinolic acid (THCA) synthase (full name Δ1-tetrahydrocannabinolic acid synthase) is an enzyme responsible for catalyzing the formation of THCA from cannabigerolic acid (CBGA).
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Total synthesis
Total synthesis is the complete chemical synthesis of a complex molecule, often a natural product, from simple, commercially available precursors.
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Ultraviolet
Ultraviolet (UV) is electromagnetic radiation with a wavelength from 10 nm to 400 nm, shorter than that of visible light but longer than X-rays.
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United Kingdom
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain,Usage is mixed with some organisations, including the and preferring to use Britain as shorthand for Great Britain is a sovereign country in western Europe.
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United States Congress
The United States Congress is the bicameral legislature of the Federal government of the United States.
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Urine
Urine is a liquid by-product of metabolism in humans and in many animals.
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War on drugs
War on Drugs is an American term usually applied to the U.S. federal government's campaign of prohibition of drugs, military aid, and military intervention, with the stated aim being to reduce the illegal drug trade.
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Weizmann Institute of Science
The Weizmann Institute of Science (מכון ויצמן למדע Machon Weizmann LeMada) is a public research university in Rehovot, Israel, established in 1934, 14 years before the State of Israel.
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WIN 55,212-2
WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure.
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World Health Organization
The World Health Organization (WHO; French: Organisation mondiale de la santé) is a specialized agency of the United Nations that is concerned with international public health.
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11-Hydroxy-THC
11-Hydroxy-Δ9-tetrahydrocannabinol (11-OH-THC), usually referred to as 11-hydroxy-THC, is the main active metabolite of tetrahydrocannabinol (THC), which is formed in the body after cannabis is consumed.
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11-Nor-9-carboxy-THC
11-Nor-9-carboxy-Δ9-tetrahydrocannabinol (11-COOH-THC or THC-COOH), often referred to as 11-nor-9-carboxy-THC or THC-11-oic acid, is the main secondary metabolite of tetrahydrocannabinol (THC), which is formed in the body after cannabis is consumed.
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2-Arachidonoylglycerol
2-Arachidonoylglycerol (2-AG) is an endocannabinoid, an endogenous agonist of the CB1 receptor and the primary endogenous ligand for the CB2 receptor.
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4-Toluenesulfonyl chloride
4-Toluenesulfonyl chloride (p-toluenesulfonyl chloride, toluene-p-sulfonyl chloride) is an organic compound with the formula CH3C6H4SO2Cl.
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ATC code A04AD10, ATCvet code QA04AD10, Abbott 40566, D9-tetrahydrocannabinol, Dea No. 7369, Dea No. 7370, Delta 9-tetrahydrocannabinol, Delta-9-THC, Delta-9-tetrahydrocannabinol, Delta-9-tetrahydrocannibinol, Delta9-tetrahydrocannabinol, Deltanyne, Dronabinolum, LD50 of THC, THC, THC-A oil, Tetrahydrocanabinol, Tetrahydrocannabinal, Tetrahydrocannibinol, Thc, Trans-tetrahydrocannabinol, Δ-9-Tetrahydrocannabinol, Δ9-THC, Δ9-tetrahydrocannabinol.
References
[1] https://en.wikipedia.org/wiki/Tetrahydrocannabinol
