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76 relations: Alexander Schmidt (physiologist), Antibody, Anticoagulant, Antiphospholipid syndrome, Antithrombin, Aqueous solution, Artery, Autoimmune disease, Beta barrel, Bovinae, Brain ischemia, Carboxyglutamic acid, Cerastocytin, Ceruloplasmin, Chromosome, Crohn's disease, Direct thrombin inhibitor, Endothelium, Enzyme, Factor V, Factor VIII, Factor X, Factor XI, Factor XIII, Fibrin, Fibrin glue, Fibrinogen, Fresh frozen plasma, Fusion protein, Gene, Gla domain, Hemostasis, Heparin, Hyperprothrombinemia, Hypoprothrombinemia, Infarction, Inflammatory bowel disease, Intracranial aneurysm, Iron oxide, Kringle domain, Lupus anticoagulant, MEROPS, Mitogen, PA clan, Platelet, Protease-activated receptor, Protein, Protein C, Protein S, Protein tag, ..., Protein–protein interaction, Proteolysis, Prothrombin complex concentrate, Prothrombin G20210A, Serine protease, Serpin, Stroke, Subarachnoid hemorrhage, Suidae, Swedish Consumers' Association, The Proteolysis Map, Thrombin, Thrombomodulin, Thrombosis, Thrombus, Topical medication, Transglutaminase, Trypsin, Ulcerative colitis, Unified atomic mass unit, Urine, Vasoconstriction, Vasospasm, Vitamin K, Warfarin, Zygosity. Expand index (26 more) »
Alexander Schmidt (physiologist)
Hermann Adolf Alexander Schmidt (1831 – 22 April 1894) was a Baltic German physiologist from what was then the Governorate of Livonia in the Russian Empire.
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Antibody
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.
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Anticoagulant
Anticoagulants, commonly referred to as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time.
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Antiphospholipid syndrome
Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by antiphospholipid antibodies.
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Antithrombin
Antithrombin (AT) is a small protein molecule that inactivates several enzymes of the coagulation system.
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Aqueous solution
An aqueous solution is a solution in which the solvent is water.
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Artery
An artery (plural arteries) is a blood vessel that takes blood away from the heart to all parts of the body (tissues, lungs, etc).
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Autoimmune disease
An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.
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Beta barrel
A beta barrel is a beta-sheet that twists and coils to form a closed structure in which the first strand is hydrogen bonded to the last.
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Bovinae
The biological subfamily Bovinae includes a diverse group of 10 genera of medium to large-sized ungulates, including domestic cattle, bison, African buffalo, the water buffalo, the yak, and the four-horned and spiral-horned antelopes.
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Brain ischemia
Brain ischemia (a.k.a. cerebral ischemia, cerebrovascular ischemia) is a condition in which there is insufficient blood flow to the brain to meet metabolic demand.
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Carboxyglutamic acid
Carboxyglutamic acid (or the conjugate base, carboxyglutamate), is an uncommon amino acid introduced into proteins by a post-translational carboxylation of glutamic acid residues.
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Cerastocytin
Cerastocytin is a thrombin-like serine protease in snake venom.
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Ceruloplasmin
Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene.
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Chromosome
A chromosome (from Ancient Greek: χρωμόσωμα, chromosoma, chroma means colour, soma means body) is a DNA molecule with part or all of the genetic material (genome) of an organism.
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Crohn's disease
Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any part of the gastrointestinal tract from mouth to anus.
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Direct thrombin inhibitor
Direct thrombin inhibitors (DTIs) are a class of medication that act as anticoagulants (delaying blood clotting) by directly inhibiting the enzyme thrombin (factor IIa).
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Endothelium
Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Factor V
Factor V (pronounced factor five) is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor.
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Factor VIII
Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF).
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Factor X
Factor X, also known by the eponym Stuart–Prower factor, is an enzyme of the coagulation cascade.
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Factor XI
Factor XI or plasma thromboplastin antecedent is the zymogen form of factor XIa, one of the enzymes of the coagulation cascade.
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Factor XIII
Factor XIII or fibrin stabilizing factor is an enzyme of the blood coagulation system that crosslinks fibrin.
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Fibrin
Fibrin (also called Factor Ia) is a fibrous, non-globular protein involved in the clotting of blood.
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Fibrin glue
Fibrin glue (also called fibrin sealant) is a surgical formulation used to create a fibrin clot for hemostasis or wound healing.
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Fibrinogen
Fibrinogen (factor I) is a glycoprotein that in vertebrates circulates in the blood.
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Fresh frozen plasma
Fresh frozen plasma (FFP) is a blood product made from the liquid portion of whole blood.
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Fusion protein
Fusion proteins or chimeric (\kī-ˈmir-ik) proteins (literally, made of parts from different sources) are proteins created through the joining of two or more genes that originally coded for separate proteins.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Gla domain
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain is a protein domain that contains post-translational modifications of many glutamate residues by vitamin K-dependent carboxylation to form γ-carboxyglutamate (Gla).
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Hemostasis
Hemostasis or haemostasis is a process which causes bleeding to stop, meaning to keep blood within a damaged blood vessel (the opposite of hemostasis is hemorrhage).
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Heparin
Heparin, also known as unfractionated heparin (UFH), is medication which is used as an anticoagulant (blood thinner).
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Hyperprothrombinemia
Hyperprothrombinemia is a state of high of prothrombin levels in the blood which leads to hypercoagulability.
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Hypoprothrombinemia
Hypoprothrombinemia is a rare blood disorder in which a deficiency in immunoreactive prothrombin (Factor II), produced in the liver, results in an impaired blood clotting reaction, leading to an increased physiological risk for spontaneous bleeding.
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Infarction
Infarction is tissue death (necrosis) due to inadequate blood supply to the affected area.
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Inflammatory bowel disease
Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine.
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Intracranial aneurysm
Intracranial aneurysm, also known as brain aneurysm, is a cerebrovascular disorder in which weakness in the wall of a cerebral artery or vein causes a localized dilation or ballooning of the blood vessel.
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Iron oxide
Iron oxides are chemical compounds composed of iron and oxygen.
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Kringle domain
Kringle Domains are autonomous protein domains that fold into large loops stabilized by 3 disulfide linkages.
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Lupus anticoagulant
Lupus anticoagulant (also known as lupus antibody, LA, LAC, or lupus inhibitors) is an immunoglobulin that binds to phospholipids and proteins associated with the cell membrane.
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MEROPS
MEROPS is an on-line database for peptidases (also known as proteases, proteinases and proteolytic enzymes) and their inhibitors.
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Mitogen
A mitogen is a chemical substance that encourages a cell to commence cell division, triggering mitosis.
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PA clan
The PA clan ('''P'''roteases of mixed nucleophile, superfamily A) is the largest group of proteases with common ancestry as identified by structural homology.
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Platelet
Platelets, also called thrombocytes (from Greek θρόμβος, "clot" and κύτος, "cell"), are a component of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot.
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Protease-activated receptor
Protease-activated receptors are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular domain.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Protein C
Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, is a zymogen, the activated form of which plays an important role in regulating anticoagulation, inflammation, cell death, and maintaining the permeability of blood vessel walls in humans and other animals.
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Protein S
Protein S (also known as S-Protein) is a vitamin K-dependent plasma glycoprotein synthesized in the liver.
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Protein tag
Protein tags are peptide sequences genetically grafted onto a recombinant protein.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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Proteolysis
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids.
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Prothrombin complex concentrate
Prothrombin complex concentrate (PCC), also known as factor IX complex, is a medication made up of blood clotting factors II, IX, and X. Some versions also contain factor VII.
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Prothrombin G20210A
Prothrombin G20210A is a genetic condition that increases the risk of blood clots including deep vein thrombosis and pulmonary embolism.
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Serine protease
Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the (enzyme's) active site.
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Serpin
Serpins are a superfamily of proteins with similar structures that were first identified for their protease inhibition activity and are found in all kingdoms of life.
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Stroke
A stroke is a medical condition in which poor blood flow to the brain results in cell death.
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Subarachnoid hemorrhage
Subarachnoid hemorrhage (SAH) is bleeding into the subarachnoid space—the area between the arachnoid membrane and the pia mater surrounding the brain.
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Suidae
Suidae is a family of artiodactyl mammals which are commonly called pigs, hogs or boars.
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Swedish Consumers' Association
The Swedish Consumers' Association (Swedish: Sveriges Konsumenter) is a consumer organization based in Sweden.
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The Proteolysis Map
The Proteolysis MAP (PMAP) is an integrated web resource focused on proteases.
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Thrombin
Thrombin (fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene.
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Thrombomodulin
Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin.
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Thrombosis
Thrombosis (from Ancient Greek θρόμβωσις thrómbōsis "clotting”) is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.
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Thrombus
A thrombus, colloquially called a blood clot, is the final product of the blood coagulation step in hemostasis.
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Topical medication
A topical medication is a medication that is applied to a particular place on or in the body.
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Transglutaminase
A transglutaminase is an enzyme that catalyzes the formation of an isopeptide bond between a free amine group (e.g., protein- or peptide-bound lysine) and the acyl group at the end of the side chain of protein- or peptide-bound glutamine.
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Trypsin
Trypsin is a serine protease from the PA clan superfamily, found in the digestive system of many vertebrates, where it hydrolyzes proteins.
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Ulcerative colitis
Ulcerative colitis (UC) is a long-term condition that results in inflammation and ulcers of the colon and rectum.
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Unified atomic mass unit
The unified atomic mass unit or dalton (symbol: u, or Da) is a standard unit of mass that quantifies mass on an atomic or molecular scale (atomic mass).
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Urine
Urine is a liquid by-product of metabolism in humans and in many animals.
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Vasoconstriction
Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, in particular the large arteries and small arterioles.
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Vasospasm
Vasospasm refers to a condition in which an arterial spasm leads to vasoconstriction.
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Vitamin K
Vitamin K is a group of structurally similar, fat-soluble vitamins that the human body requires for complete synthesis of certain proteins that are prerequisites for blood coagulation (K from Koagulation, Danish for "coagulation") and which the body also needs for controlling binding of calcium in bones and other tissues.
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Warfarin
Warfarin, sold under the brand name Coumadin among others, is a medication that is used as an anticoagulant (blood thinner).
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Zygosity
Zygosity is the degree of similarity of the alleles for a trait in an organism.
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Redirects here:
ATC code B02BC06, ATC code B02BD30, ATCvet code QB02BC06, ATCvet code QB02BD30, Activated blood-coagulation factor II, Beta-thrombin, Blood-coagulation factor IIa, Coagulation factor 2, Coagulation factor II, Dysprothrombinemia, E thrombin, EC 3.4.21.5, F2 (gene), F2 gene, Factor 2, Factor II, Factor II deficiency, Factor IIa, Fibrimex, Fibrinogenase, Gamma-thrombin, Prothrombin, Prothrombin g20210a mutation, Receptors, thrombin, Thrombase, Thrombin-C, Thrombinogen, Thrombofort, Thrombogen, Tropostasin.
References
[1] https://en.wikipedia.org/wiki/Thrombin
