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17 relations: Bile acid, Biochemical cascade, CYP7B1, Cytochrome P450, Farnesoid X receptor, FGF19, Fibroblast growth factor, Hydroxylation, Levoketoconazole, List of cytochrome P450 modulators, List of MeSH codes (D08), List of MeSH codes (D12.776), Liver X receptor, PGRMC1, Steroidogenesis inhibitor, 7α-Hydroxy-4-cholesten-3-one, 7α-Hydroxycholesterol.
Bile acid
Bile acids are steroid acids found predominantly in the bile of mammals and other vertebrates.
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Biochemical cascade
A biochemical cascade, also known as a signaling cascade or signaling pathway, is a series of chemical reactions which are initiated by a stimulus (first messenger) acting on a receptor that is transduced to the cell interior through second messengers (which amplify the initial signal) and ultimately to effector molecules, resulting in a cell response to the initial stimulus.
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CYP7B1
25-hydroxycholesterol 7-alpha-hydroxylase also known as oxysterol and steroid 7-alpha-hydroxylase is an enzyme that in humans is encoded by the CYP7B1 gene.
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Cytochrome P450
Cytochromes P450 (CYPs) are proteins of the superfamily containing heme as a cofactor and, therefore, are hemoproteins.
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Farnesoid X receptor
The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that is encoded by the NR1H4 gene in humans.
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FGF19
Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene.
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Fibroblast growth factor
The fibroblast growth factors are a family of cell signalling proteins that are involved in a wide variety of processes, most notably as crucial elements for normal development.
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Hydroxylation
Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound.
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Levoketoconazole
Levoketoconazole (INN, USAN) (developmental code name COR-003; tentative brand name Recorlev, previously NormoCort), also known as (2S,4R)-ketoconazole, is a steroidogenesis inhibitor that is under development by Strongbridge Biopharma (formerly Cortendo AB) for the treatment of Cushing's syndrome.
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List of cytochrome P450 modulators
This is a list of cytochrome P450 modulators, or inhibitors and inducers of cytochrome P450 enzymes.
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List of MeSH codes (D08)
This is the fourth part of the list of the "D" codes for MeSH.
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List of MeSH codes (D12.776)
This is part of the list of the "D" codes for MeSH.
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Liver X receptor
The liver X receptor (LXR) is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the PPARs, FXR and RXR.
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PGRMC1
Progesterone receptor membrane component 1 (abbreviated PGRMC1) is a protein which co-purifies with progesterone binding proteins in the liver and ovary.
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Steroidogenesis inhibitor
A steroidogenesis inhibitor, also known as a steroid biosynthesis inhibitor, is a type of drug which inhibits one or more of the enzymes that are involved in the process of steroidogenesis, the biosynthesis of endogenous steroids and steroid hormones.
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7α-Hydroxy-4-cholesten-3-one
7α-Hydroxy-4-cholesten-3-one is an intermediate in the biochemical synthesis of bile acids from cholesterol.
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7α-Hydroxycholesterol
7α-Hydroxycholesterol is a precursor of bile acids, created by cholesterol 7α-hydroxylase.
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Redirects here:
7 alpha-hydroxylase, 7α-Hydroxylase, CYP7A1, CYP7A1 (gene), Cholesterol 7α-hydroxylase.
References
[1] https://en.wikipedia.org/wiki/Cholesterol_7_alpha-hydroxylase
