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44 relations: ABCC3, Aldehyde oxidase, Androgen receptor, Arsenic biochemistry, Bardoxolone methyl, Biochemical cascade, BZIP domain, C-jun, Caspase 3, CREB-binding protein, Cyclopentenone prostaglandins, Dimethyl fumarate, EIF2AK3, Epidermal differentiation complex, Fumaric acid, Genistein, Glutamate–cysteine ligase, Hereditary leiomyomatosis and renal cell cancer syndrome, Isothiocyanate, Jun dimerization protein, KEAP1, KLF9, Lipoxin, MAFF (gene), MAFG, MAFK, MTORC1, NAD(P)H dehydrogenase (quinone 1), Neuronal lineage marker, NFE2L3, NRF1, Nrf2 internal ribosome entry site (IRES), Nutrigenomics, Omaveloxolone, P21, Reata Pharmaceuticals, Response element, SLC7A11, Small Maf, SOD2, Specialized pro-resolving mediators, Thioredoxin, Ubiquitin C, 15-Hydroxyeicosatetraenoic acid.
ABCC3
Canalicular multispecific organic anion transporter 2 is a protein that in humans is encoded by the ABCC3 gene.
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Aldehyde oxidase
Aldehyde oxidase (AO) is a metabolizing enzyme, located in the cytosolic compartment of tissues in many organisms.
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Androgen receptor
The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus.
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Arsenic biochemistry
Arsenic biochemistry refers to biochemical processes that can use arsenic or its compounds, such as arsenate.
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Bardoxolone methyl
Bardoxolone methyl (also known as “RTA 402”, “CDDO-methyl ester”, and CDDO-Me) is an experimental and orally-bioavailable semi-synthetic triterpenoid, based on the scaffold of the natural product oleanolic acid.
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Biochemical cascade
A biochemical cascade, also known as a signaling cascade or signaling pathway, is a series of chemical reactions which are initiated by a stimulus (first messenger) acting on a receptor that is transduced to the cell interior through second messengers (which amplify the initial signal) and ultimately to effector molecules, resulting in a cell response to the initial stimulus.
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BZIP domain
The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins.
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C-jun
c-Jun is a protein that in humans is encoded by the JUN gene.
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Caspase 3
Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9.
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CREB-binding protein
CREB-binding protein, also known as CREBBP or CBP, is a protein that in humans is encoded by the CREBBP gene.
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Cyclopentenone prostaglandins
Cyclopentenone prostaglandins are a subset of prostaglandins (PGs) or prostenoids (see eicosanoid#classic eicosanoids and eicosanoid#nonclassic eicosanoids) that has 15-deoxy-Δ12,14-prostaglandin J2 (15-d-Δ12,14-PGJ2), Δ12-PGJ2, and PGJ2 as its most prominent members but also including PGA2, PGA1, and, while not classified as such, other PGs.
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Dimethyl fumarate
Dimethyl fumarate (DMF) is the methyl ester of fumaric acid.
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EIF2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene.
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Epidermal differentiation complex
The epidermal differentiation complex (EDC) is a gene complex comprising over fifty genes encoding proteins involved in the terminal differentiation and cornification of keratinocytes, the primary cell type of the epidermis.
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Fumaric acid
Fumaric acid or trans-butenedioic acid is the chemical compound with the formula HO2CCH.
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Genistein
Genistein is an isoflavone that is described as an angiogenesis inhibitor and a phytoestrogen.
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Glutamate–cysteine ligase
Glutamate Cysteine Ligase (GCL), previously known as gamma-glutamylcysteine synthetase (GCS), is the first enzyme of the cellular glutathione (GSH) biosynthetic pathway that catalyzes the chemical reaction: L-glutamate + L-cysteine + ATP \rightleftharpoons gamma-glutamyl cysteine + ADP + Pi GSH, and by extension GCL, is critical to cell survival.
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Hereditary leiomyomatosis and renal cell cancer syndrome
Reed’s syndrome (or familial leiomyomatosis cutis et uteri) is a rare inherited condition characterised by multiple cutaneous leiomyomas and, in women, uterine leiomyomas.
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Isothiocyanate
Isothiocyanate is the chemical group –N.
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Jun dimerization protein
Jun dimerization protein 2 (JUNDM2) is a protein that in humans is encoded by the JDP2 gene.
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KEAP1
Kelch-like ECH-associated protein 1 is a protein that in humans is encoded by the Keap1 gene.
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KLF9
Krueppel-like factor 9 is a protein that in humans is encoded by the KLF9 gene.
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Lipoxin
Lipoxins (LXs or Lxs), an acronym for lipoxygenase interaction products, are bioactive autacoid metabolites of arachidonic acid made by various cell types.
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MAFF (gene)
Transcription factor MafF is a bZip Maf transcription factor protein that in humans is encoded by the MAFF gene.
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MAFG
Transcription factor MafG is a bZip Maf transcription factor protein that in humans is encoded by the MAFG gene.
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MAFK
Transcription factor MafK is a bZip Maf transcription factor protein that in humans is encoded by the MAFK gene.
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MTORC1
mTORC1, also known as mammalian target of rapamycin complex 1 or mechanistic target of rapamycin complex 1, is a protein complex that functions as a nutrient/energy/redox sensor and controls protein synthesis.
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NAD(P)H dehydrogenase (quinone 1)
NAD(P)H dehydrogenase 1 is an enzyme that in humans is encoded by the NQO1 gene.
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Neuronal lineage marker
A Neuronal lineage marker is an endogenous tag that is expressed in different cells along neurogenesis and differentiated cells such as neurons.
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NFE2L3
Nuclear Factor (Erythroid 2) - Like Factor 3, also known as NFE2L3 or 'NRF3', is a transcription factor that in humans is encoded by the Nfe2l3 gene.
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NRF1
Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
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Nrf2 internal ribosome entry site (IRES)
In molecular biology, the Ure2 internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA encoding the transcription factor Nrf2.
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Nutrigenomics
Nutrigenomics is a branch of nutritional genomics and is the study of the effects of foods and food constituents on gene expression.
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Omaveloxolone
Omaveloxolone (RTA 408) is a second generation member of the synthetic oleanane triterpenoid compounds and currently in clinical development by Reata Pharmaceuticals.
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P21
p21Cip1 (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, though is primarily associated with inhibition of CDK2.
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Reata Pharmaceuticals
Reata Pharmaceuticals, Inc. is a pharmaceutical company based in Irving, Texas.
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Response element
Response elements are short sequences of DNA within a gene promoter region that are able to bind specific transcription factors and regulate transcription of genes.
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SLC7A11
Cystine/glutamate transporter is an antiporter that in humans is encoded by the SLC7A11 gene.
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Small Maf
Small Maf (musculoaponeurotic fibrosarcoma) proteins are basic region leucine zipper-type transcription factors that can bind to DNA and regulate gene regulation.
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SOD2
Superoxide dismutase 2, mitochondrial (SOD2), also known as manganese-dependent superoxide dismutase (MnSOD), is an enzyme which in humans is encoded by the SOD2 gene on chromosome 6.
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Specialized pro-resolving mediators
Specialized pro-resolving mediators (SPM, also termed specialized proresolving mediators) are a large and growing class of cell signaling molecules formed in cells by the metabolism of polyunsaturated fatty acids (PUFA) by one or a combination of lipoxygenase, cyclooxygenase, and cytochrome P450 monooxygenase enzymes.
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Thioredoxin
Thioredoxin is a class of small redox proteins known to be present in all organisms.
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Ubiquitin C
Polyubiquitin-C is a protein encoded by the UBC gene in humans.
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15-Hydroxyeicosatetraenoic acid
15-Hydroxyeicosatetraenoic acid (also termed 15-HETE, 15(S)-HETE, and 15S-HETE) is an eicosanoid, i.e. a metabolite of arachidonic acid.
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Redirects here:
NFE2L2 (gene), NRF2, Nrf2, Nuclear factor (erythroid-derived 2)-like 2.
References
[1] https://en.wikipedia.org/wiki/NFE2L2
