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RNA-induced silencing complex

Index RNA-induced silencing complex

The RNA-induced silencing complex, or RISC, is a multiprotein complex, specifically a ribonucleoprotein, which incorporates one strand of a single-stranded RNA (ssRNA) fragment, such as microRNA (miRNA), or double-stranded small interfering RNA (siRNA). [1]

66 relations: Antagomir, Argonaute, Complementarity (molecular biology), Danesh Moazed, Dicer, Drosha, Elisa Izaurralde, Endoribonuclease, Epigenetic regulation of transposable elements in the plant kingdom, Exosome (vesicle), Gene expression, Gene knockdown, Gene product, Gene silencing, Hsa-piR-1082, List of MeSH codes (D08), List of MeSH codes (D12.776), List of MeSH codes (D12.776.157), Malignant transformation, Messenger RNA, MicroRNA, Microrna 210, MicroRNA 5680, MiR-146, MiR-150, MiR-191, MiR-203, MiR-208, MiR-214, Mir-29 microRNA precursor, MiR-296, MiR-338, MIR1269A, MIR133A1, MIR187, MIR194-1, MIR361, MIR3648, MIR494, MIR561, MIR7-1, MIR941-1, MIR95, MIR96 (gene), MIRN21, Molecular and epigenetic mechanisms of alcoholism, MTDH, P-bodies, Piwi, Piwi-interacting RNA, ..., Post-transcriptional regulation, RDE-1, RISC (disambiguation), RNA interference, RNA silencing, RNA silencing suppressor p19, Sense (molecular biology), Short hairpin RNA, Small interfering RNA, SND1, Stable nucleic acid lipid particle, Tomato bushy stunt virus, Trans-acting siRNA, Viroid, Virus, ZGRF1. Expand index (16 more) »

Antagomir

Antagomirs also known as anti-miRs or blockmirs are a class of chemically engineered oligonucleotides that prevent other molecules from binding to a desired site on an mRNA molecule.

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Argonaute

The Argonaute protein family plays a central role in RNA silencing processes, as essential components of the RNA-induced silencing complex (RISC).

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Complementarity (molecular biology)

In molecular biology, complementarity describes a relationship between two structures each following the lock-and-key principle.

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Danesh Moazed

Danesh Moazed is a Professor of the Department of Cell Biology at Harvard Medical School and an investigator at Howard Hughes Medical Institute.

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Dicer

Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene.

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Drosha

Drosha is a Class 2 ribonuclease III enzyme that in humans is encoded by the DROSHA (formerly RNASEN) gene.

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Elisa Izaurralde

Elisa Izaurralde (20 September 1959 in Montevideo, Uruguay – 30 April 2018 in Tübingen, Germany) was an Uruguayan biochemist and molecular biologist.

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Endoribonuclease

An Endoribonuclease is a ribonuclease endonuclease.

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Epigenetic regulation of transposable elements in the plant kingdom

Transposable elements (transposons, TEs, 'jumping genes') are short strands of repetitive DNA that can self-replicate and translocate within the eukaryotic genome, and are generally perceived as parasitic in nature.

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Exosome (vesicle)

Exosomes are cell-derived vesicles that are present in many and perhaps all eukaryotic fluids, including blood, urine, and cultured medium of cell cultures.

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Gene expression

Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product.

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Gene knockdown

Gene knockdown is an experimental technique by which the expression of one or more of an organism's genes are reduced.

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Gene product

A gene product is the biochemical material, either RNA or protein, resulting from expression of a gene.

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Gene silencing

Gene silencing is the regulation of gene expression in a cell to prevent the expression of a certain gene.

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Hsa-piR-1082

piwi-interacting RNA (piRNA) belongs to the small RNA class found in eukaryotic organisms, their major role is to regulate the expression of genes by the mRNA degradation or silencing.

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List of MeSH codes (D08)

This is the fourth part of the list of the "D" codes for MeSH.

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List of MeSH codes (D12.776)

This is part of the list of the "D" codes for MeSH.

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List of MeSH codes (D12.776.157)

This is a sub-part (carrier proteins only) of List of MeSH codes (D12.776), itself a part of the list of the "D" codes for MeSH.

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Malignant transformation

Malignant transformation is the process by which cells acquire the properties of cancer.

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Messenger RNA

Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.

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MicroRNA

A microRNA (abbreviated miRNA) is a small non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression.

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Microrna 210

MicroRNA 210 is a protein that in humans is encoded by the MIR210 gene.

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MicroRNA 5680

MicroRNA 5680 is a protein that in humans is encoded by the MIR5680 gene.

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MiR-146

miR-146 is a family of microRNA precursors found in mammals, including humans.

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MiR-150

miR-150 is a family of microRNA precursors found in mammals, including humans.

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MiR-191

miR-191 is a family of microRNA precursors found in mammals, including humans.

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MiR-203

In molecular biology miR-203 is a short non-coding RNA molecule.

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MiR-208

miR-208 is a family of microRNA precursors found in animals, including humans.

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MiR-214

miR-214 is a vertebrate-specific family of microRNA precursors.

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Mir-29 microRNA precursor

The miR-29 microRNA precursor, or pre-miRNA, is a small RNA molecule in the shape of a stem-loop or hairpin.

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MiR-296

miR-296 is a family of microRNA precursors found in mammals, including humans.

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MiR-338

miR-338 is a family of brain-specific microRNA precursors found in mammals, including humans.

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MIR1269A

MicroRNA 1269a is a protein that in humans is encoded by the MIR1269A gene.

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MIR133A1

MicroRNA 133a-1 is a MicroRNA that in humans is encoded by the MIR133A1 gene, and is a known extracellular RNA (exRNA).

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MIR187

MicroRNA 187 is a protein that in humans is encoded by the MIR187 gene.

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MIR194-1

MicroRNA 194-1 is a non-coding RNA that in humans is encoded by the MIR194-1 gene.

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MIR361

MicroRNA 361 is a micro RNA that in humans is encoded by the MIR361 gene.

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MIR3648

MicroRNA 3648 is a protein that in humans is encoded by the MIR3648 gene.

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MIR494

MicroRNA 494 is a microRNA that in humans is encoded by the MIR494 gene.

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MIR561

MicroRNA 561 is a protein that in humans is encoded by the MIR561 gene.

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MIR7-1

MicroRNA 7-1 is a protein that in humans is encoded by the MIR7-1 gene.

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MIR941-1

MicroRNA 941-1 is a human specific microRNA that is encoded by the MIR941-1 gene.

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MIR95

MicroRNA 95 is a small non-coding RNA that in humans is encoded by the MIR95 gene.

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MIR96 (gene)

MicroRNA 96 is a protein that in humans is encoded by the MIR96 gene.

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MIRN21

microRNA 21 also known as hsa-mir-21 or miRNA21 is a mammalian microRNA that is encoded by the MIR21 gene.

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Molecular and epigenetic mechanisms of alcoholism

Alcoholism is a chronic disease characterized by trouble controlling the consumption of alcohol, dependence (needing to consume more to achieve the same effects), and withdrawal upon rapid cessation of drinking.

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MTDH

Metadherin, also known as protein LYRIC or astrocyte elevated gene-1 protein (AEG-1) is a protein that in humans is encoded by the MTDH gene.

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P-bodies

Processing bodies (P-bodies) are distinct foci within the cytoplasm of the eukaryotic cell consisting of many enzymes involved in mRNA turnover.

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Piwi

Piwi (or PIWI) genes were identified as regulatory proteins responsible for stem cell and germ cell differentiation.

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Piwi-interacting RNA

Piwi-interacting RNA (piRNA) is the largest class of small non-coding RNA molecules expressed in animal cells.

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Post-transcriptional regulation

Italic textÀ Post-transcriptional regulation is the control of gene expression at the RNA level, therefore between the transcription and the translation of the gene.

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RDE-1

RDE-1 (RNAi-DEfective 1) is a primary Argonaute protein required for RNA-mediated interference (RNAi) in Caenorhabditis elegans.

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RISC (disambiguation)

RISC is an abbreviation for reduced instruction set computer.

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RNA interference

RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression or translation, by neutralizing targeted mRNA molecules.

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RNA silencing

RNA silencing or RNA interference refers to a family of gene silencing effects by which gene expression is negatively regulated by non-coding RNAs such as microRNAs.

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RNA silencing suppressor p19

RNA silencing suppressor p19 (also known as Tombusvirus P19 core protein and 19 kDa symptom severity modulator) is a protein expressed from the ORF4 gene in the genome of tombusviruses.

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Sense (molecular biology)

In molecular biology and genetics, the sense of nucleic acid molecules (often DNA or RNA) is the nature of their roles and their complementary molecules' nucleic acid units' roles in specifying amino acids.

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Short hairpin RNA

A short hairpin RNA or small hairpin RNA (shRNA/Hairpin Vector) is an artificial RNA molecule with a tight hairpin turn that can be used to silence target gene expression via RNA interference (RNAi).

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Small interfering RNA

Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA molecules, 20-25 base pairs in length, similar to miRNA, and operating within the RNA interference (RNAi) pathway.

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SND1

Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a protein that in humans is encoded by the SND1 gene.

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Stable nucleic acid lipid particle

Stable nucleic acid lipid particles (SNALPs) are microscopic particles approximately 120 nanometers in diameter, smaller than the wavelengths of visible light.

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Tomato bushy stunt virus

Tomato bushy stunt virus (TBSV) is a virus that is the type species of the tombusvirus family.

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Trans-acting siRNA

Trans-acting siRNA (abbreviated "ta-siRNA" or "tasiRNA") are a class of small interfering RNA (siRNA) that repress gene expression through post-transcriptional gene silencing in land plants.

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Viroid

Viroids are the smallest infectious pathogens known.

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Virus

A virus is a small infectious agent that replicates only inside the living cells of other organisms.

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ZGRF1

ZGRF1 is a protein in humans that is encoded by the ZGRF1 gene that has uncharacterised function and a weight of 236.6 kDa.

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Redirects here:

Guide strand, MiRISC, RNA induced silencing complex, Rna-induced silencing complex.

References

[1] https://en.wikipedia.org/wiki/RNA-induced_silencing_complex

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