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Tolvaptan

Index Tolvaptan

Tolvaptan (INN, trade names Samsca and Jinarc) is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). [1]

13 relations: Aquaretic, ATC code C03, Autosomal dominant polycystic kidney disease, Cardiorenal syndrome, Demeclocycline, Diuretic, Hypotonic hyponatremia, Management of heart failure, Syndrome of inappropriate antidiuretic hormone secretion, Vasopressin, Vasopressin receptor, Vasopressin receptor 2, Vasopressin receptor antagonist.

Aquaretic

An aquaretic is a class of drug that is used to promote aquaresis, the excretion of water without electrolyte loss.

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ATC code C03

C03.

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Autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent, potentially lethal, monogenic human disorder.

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Cardiorenal syndrome

Cardiorenal syndrome (CRS) is an umbrella term used in the medical field that defines disorders of the heart and kidneys whereby “acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other”.

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Demeclocycline

Demeclocycline (INN, BAN, USAN) (brand names Declomycin, Declostatin, Ledermycin, Bioterciclin, Deganol, Deteclo), also known under the brand names Detravis, Meciclin, Mexocine, Clortetrin, is a semisynthetic tetracycline antibiotic which was derived from a strain of Streptomyces aureofaciens.

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Diuretic

A diuretic is any substance that promotes diuresis, the increased production of urine.

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Hypotonic hyponatremia

Hypoosmolar hyponatremia is a condition where hyponatremia associated with a low plasma osmolality.

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Management of heart failure

Management of heart failure requires a multimodal approach.

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Syndrome of inappropriate antidiuretic hormone secretion

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is characterized by excessive unsuppressible release of antidiuretic hormone (ADH) either from the posterior pituitary gland, or an abnormal non-pituitary source.

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Vasopressin

Vasopressin, also named antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP.

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Vasopressin receptor

The actions of vasopressin are mediated by stimulation of tissue-specific G protein-coupled receptors (GPCRs) called vasopressin receptors that are classified into the V1 (V1A), V2, and V3 (V1B) receptor subtypes.

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Vasopressin receptor 2

Vasopressin receptor 2 (V2R), or arginine vasopressin receptor 2 (officially called AVPR2), is a protein that acts as receptor for vasopressin.

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Vasopressin receptor antagonist

A vasopressin receptor antagonist (VRA) is an agent that interferes with action at the vasopressin receptors.

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Redirects here:

ATC code C03XA01, ATCvet code QC03XA01, C26H25ClN2O3, Jinarc, Samsca.

References

[1] https://en.wikipedia.org/wiki/Tolvaptan

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