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99 relations: Acute myeloid leukemia, Alanine aminopeptidase, Anemia, Ascites, ASXL1, Autoantibody, Azacitidine, Barbara J. Bain, Bleeding, Blood film, Blood transfusion, Bone marrow, Bone marrow examination, Cancer, CBL (gene), CD117, CD14, CD16, CD2, CD23, CD33, CD4, CD64 (biology), CD7, CDKN2B, CEBPA, Cold agglutinin disease, Coombs test, Cytopenia, Decitabine, Dominance (genetics), Dysplasia, Epidemiology, Erythropoietin, European Medicines Agency, EZH2, Fever, Fibroblast growth factor receptor 1, Food and Drug Administration, French–American–British classification, GATA2, GATA2 deficiency, Gene, Genetic disorder, Granulocyte-macrophage colony-stimulating factor, Haematopoiesis, Haploinsufficiency, Hematology, Hematopoietic stem cell, Hematopoietic stem cell transplantation, ..., HLA-DR, Infection, Integrin alpha M, Integrin alpha X, Interleukin 10, Interleukin 3, Interleukin 4, Interleukin 6, International Prognostic Scoring System, Janus kinase 2, Juvenile myelomonocytic leukemia, KRAS, Leukemia, Leukostasis, Lymphadenopathy, Lymphatic system, Megakaryocyte, Monoblast, Monocyte, Monocytosis, Myeloblast, Myelocyte, Myelodysplastic syndrome, Myeloid tissue, Myeloproliferative neoplasm, Neprilysin, Neural cell adhesion molecule, Neuroblastoma RAS viral oncogene homolog, Night sweats, NPM1, Oncology, PDGFRA, PDGFRB, Pericardial effusion, Philadelphia chromosome, Pleural effusion, Precursor cell, Promonocyte, PTPRC, RUNX1, Splenomegaly, Synovitis, Tet methylcytosine dioxygenase 2, Transcription factor, Tumor necrosis factor superfamily, University of Texas MD Anderson Cancer Center, Weight loss, World Health Organization, WT1. Expand index (49 more) »
Acute myeloid leukemia
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells.
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Alanine aminopeptidase
Membrane alanyl aminopeptidase also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N) is an enzyme that in humans is encoded by the ANPEP gene.
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Anemia
Anemia is a decrease in the total amount of red blood cells (RBCs) or hemoglobin in the blood, or a lowered ability of the blood to carry oxygen.
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Ascites
Ascites is the abnormal buildup of fluid in the abdomen.
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ASXL1
Putative Polycomb group protein ASXL1 is a protein that in humans is encoded by the ASXL1 gene.
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Autoantibody
An autoantibody is an antibody (a type of protein) produced by the immune system that is directed against one or more of the individual's own proteins.
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Azacitidine
Azacitidine (INN; trade name Vidaza) is a chemical analog of cytidine, a nucleoside in DNA and RNA.
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Barbara J. Bain
Barbara Jane Bain is an haematologist and professor at the Imperial College Faculty of Medicine, and consultant at St Mary's Hospital, London.
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Bleeding
Bleeding, also known as hemorrhaging or haemorrhaging, is blood escaping from the circulatory system.
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Blood film
A blood film—or peripheral blood smear—is a thin layer of blood smeared on a glass microscope slide and then stained in such a way as to allow the various blood cells to be examined microscopically.
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Blood transfusion
Blood transfusion is generally the process of receiving blood or blood products into one's circulation intravenously.
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Bone marrow
Bone marrow is a semi-solid tissue which may be found within the spongy or cancellous portions of bones.
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Bone marrow examination
Bone marrow examination refers to the pathologic analysis of samples of bone marrow obtained by bone marrow biopsy (often called a trephine biopsy) and bone marrow aspiration.
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
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CBL (gene)
Cbl (named after Casitas B-lineage Lymphoma) is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination.
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CD117
Mast/stem cell growth factor receptor (SCFR), also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a receptor tyrosine kinase protein that in humans is encoded by the KIT gene.
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CD14
CD14 (cluster of differentiation 14) is a human gene.
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CD16
CD16, also known as FcγRIII, is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages.
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CD2
CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells.
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CD23
CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels.
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CD33
CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage.
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CD4
In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells.
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CD64 (biology)
CD64 (Cluster of Differentiation 64) is a type of integral membrane glycoprotein known as an Fc receptor that binds monomeric IgG-type antibodies with high affinity.
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CD7
CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.
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CDKN2B
Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15INK4b is a protein that is encoded by the CDKN2B gene in humans.
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CEBPA
CCAAT/enhancer-binding protein alpha is a protein encoded by the CEBPA gene in humans.
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Cold agglutinin disease
Cold agglutinin disease is an autoimmune disease characterized by the presence of high concentrations of circulating antibodies, usually IgM, directed against red blood cells.
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Coombs test
A Coombs test (also known as antiglobulin test or AGT) is either of two clinical blood tests used in immunohematology and immunology.
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Cytopenia
Cytopenia is a reduction in the number of mature blood cells.
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Decitabine
Decitabine (trade name Dacogen), or 5-aza-2'-deoxycytidine, acts as an Nucleic Acid Synthesis Inhibitor.
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Dominance (genetics)
Dominance in genetics is a relationship between alleles of one gene, in which the effect on phenotype of one allele masks the contribution of a second allele at the same locus.
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Dysplasia
Dysplasia (from Ancient Greek δυσ- dys-, "bad" or "difficult" and πλάσις plasis, "formation") is a term used in pathology to refer to an abnormality of development or an epithelial anomaly of growth and differentiation (epithelial dysplasia).
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Epidemiology
Epidemiology is the study and analysis of the distribution (who, when, and where) and determinants of health and disease conditions in defined populations.
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Erythropoietin
Erythropoietin (EPO), also known as hematopoietin or hemopoietin, is a glycoprotein cytokine secreted by the kidney in response to cellular hypoxia; it stimulates red blood cell production (erythropoiesis) in the bone marrow.
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European Medicines Agency
The European Medicines Agency (EMA) is a European Union agency for the evaluation of medicinal products.
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EZH2
Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme (EC 2.1.1.43) encoded by EZH2 gene, that participates in histone methylation and, ultimately, transcriptional repression.
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Fever
Fever, also known as pyrexia and febrile response, is defined as having a temperature above the normal range due to an increase in the body's temperature set-point.
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Fibroblast growth factor receptor 1
Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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French–American–British classification
The French–American–British (FAB) classification systems refers to a series of classifications of hematologic diseases.
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GATA2
GATA2 or GATA-binding factor 2 is a transcription factor, i.e. a nuclear protein which regulates the expression of genes.
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GATA2 deficiency
GATA2 deficiency (also termed GATA2 haploinsufficiency or GATA2 deficiency syndrome) is a recently defined grouping of several disorders caused by common defect, viz., familial or sporadic inactivating mutations in one of the two parental GATA2 genes.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Genetic disorder
A genetic disorder is a genetic problem caused by one or more abnormalities in the genome.
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Granulocyte-macrophage colony-stimulating factor
Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine.
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Haematopoiesis
Haematopoiesis (from Greek αἷμα, "blood" and ποιεῖν "to make"; also hematopoiesis in American English; sometimes also haemopoiesis or hemopoiesis) is the formation of blood cellular components.
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Haploinsufficiency
Haploinsufficiency is a mechanism of action to explain a phenotype when a diploid organism has lost one copy of a gene and is left with a single functional copy of that gene.
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Hematology
Hematology, also spelled haematology, is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood.
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Hematopoietic stem cell
Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells.
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Hematopoietic stem cell transplantation
Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood.
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HLA-DR
HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31.
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Infection
Infection is the invasion of an organism's body tissues by disease-causing agents, their multiplication, and the reaction of host tissues to the infectious agents and the toxins they produce.
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Integrin alpha M
Integrin alpha M (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3).
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Integrin alpha X
CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c.
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Interleukin 10
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine.
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Interleukin 3
Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene.
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Interleukin 4
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells.
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Interleukin 6
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine.
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International Prognostic Scoring System
The International Prognostic Scoring System (IPSS), published in 1997, is used by many doctors to help assess the severity of a patient's myelodysplastic syndrome (MDS).
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Janus kinase 2
Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase.
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Juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is a serious chronic leukemia (cancer of the blood) that affects children mostly aged 4 and younger.
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KRAS
KRAS (K-ras or Ki-ras) is a gene that acts as an on/off switch in cell signalling.
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Leukemia
Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells.
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Leukostasis
Leukostasis (also called symptomatic hyperleukocytosis) is a medical emergency most commonly seen in patients with acute myeloid leukemia.
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Lymphadenopathy
Lymphadenopathy or adenopathy is disease of the lymph nodes, in which they are abnormal in size, number, or consistency.
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Lymphatic system
The lymphatic system is part of the vascular system and an important part of the immune system, comprising a network of lymphatic vessels that carry a clear fluid called lymph (from Latin, lympha meaning "water") directionally towards the heart.
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Megakaryocyte
A megakaryocyte (mega- + karyo- + -cyte, "large-nucleus cell") is a large bone marrow cell with a lobated nucleus responsible for the production of blood thrombocytes (platelets), which are necessary for normal blood clotting.
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Monoblast
Monoblasts are normally found in bone marrow and do not appear in the normal peripheral blood.
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Monocyte
Monocytes are a type of leukocyte, or white blood cell.
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Monocytosis
Monocytosis is an increase in the number of monocytes circulating in the blood.
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Myeloblast
The myeloblast is a unipotent stem cell, which will differentiate into one of the effectors of the granulocyte series.
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Myelocyte
A myelocyte is a young cell of the granulocytic series, occurring normally in bone marrow (can be found in circulating blood when caused by certain diseases).
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Myelodysplastic syndrome
Myelodysplastic syndromes (MDS) are a group of cancers in which immature blood cells in the bone marrow do not mature and therefore do not become healthy blood cells.
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Myeloid tissue
Myeloid tissue, in the bone marrow sense of the word myeloid (myelo- + -oid), is tissue of bone marrow, of bone marrow cell lineage, or resembling bone marrow, and myelogenous tissue (myelo- + -genous) is any tissue of, or arising from, bone marrow; in these senses the terms are usually used synonymously, as for example with chronic myeloid/myelogenous leukemia.
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Myeloproliferative neoplasm
The myeloproliferative neoplasms (MPNs), previously myeloproliferative diseases (MPDs), are a group of diseases of the bone marrow in which excess cells are produced.
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Neprilysin
Neprilysin, also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10), and common acute lymphoblastic leukemia antigen (CALLA) is an enzyme that in humans is encoded by the MME gene.
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Neural cell adhesion molecule
Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle.
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Neuroblastoma RAS viral oncogene homolog
NRAS is an enzyme that in humans is encoded by the NRAS gene.
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Night sweats
Night sweats, also known as nocturnal hyperhidrosis, is the occurrence of excessive sweating during sleep.
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NPM1
Nucleophosmin (NPM), also known as nucleolar phosphoprotein B23 or numatrin, is a protein that in humans is encoded by the NPM1 gene.
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Oncology
Oncology is a branch of medicine that deals with the prevention, diagnosis, and treatment of cancer.
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PDGFRA
PDGFRA, i.e. platelet-derived growth factor receptor A, also termed PDGFRα, i.e. platelet-derived growth factor receptor α, is a receptor located on the surface of a wide range of cell types.
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PDGFRB
Beta-type platelet-derived growth factor receptor is a protein that in humans is encoded by the PDGFRB gene.
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Pericardial effusion
Pericardial effusion ("fluid around the heart") is an abnormal accumulation of fluid in the pericardial cavity.
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Philadelphia chromosome
The Philadelphia chromosome or Philadelphia translocation (Ph) is a specific genetic abnormality in chromosome 22 of leukemia cancer cells (particularly chronic myeloid leukemia (CML) cells).
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Pleural effusion
A pleural effusion is excess fluid that accumulates in the pleural cavity, the fluid-filled space that surrounds the lungs.
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Precursor cell
In cell biology, a precursor cell, also called a blast cell or simply blast, is a partially differentiated cell, usually referred to as a unipotent cell that has lost most of its stem cell properties.
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Promonocyte
A promonocyte (or premonocyte) is a cell arising from a monoblast and developing into a monocyte.
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PTPRC
Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene.
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RUNX1
Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor subunit alpha-2 (CBFA2) is a protein that in humans is encoded by the RUNX1 gene.
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Splenomegaly
Splenomegaly is an enlargement of the spleen.
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Synovitis
Synovitis is the medical term for inflammation of the synovial membrane.
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Tet methylcytosine dioxygenase 2
Tet methylcytosine dioxygenase 2 (TET2) is a human gene.
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Transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.
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Tumor necrosis factor superfamily
The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers.
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University of Texas MD Anderson Cancer Center
The University of Texas MD Anderson Cancer Center (colloquially MD Anderson) is one of the original three comprehensive cancer centers in the United States.
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Weight loss
Weight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, due to a mean loss of fluid, body fat or adipose tissue or lean mass, namely bone mineral deposits, muscle, tendon, and other connective tissue.
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World Health Organization
The World Health Organization (WHO; French: Organisation mondiale de la santé) is a specialized agency of the United Nations that is concerned with international public health.
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WT1
Wilms tumor protein is a protein that in humans is encoded by the WT1 gene on chromosome 11p.
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References
[1] https://en.wikipedia.org/wiki/Chronic_myelomonocytic_leukemia
