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Mesenchymal stem cell

Index Mesenchymal stem cell

Mesenchymal stem cells are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue). [1]

81 relations: Adipocyte, Adipose tissue, Agranulocyte, Alexander A. Maximow, Amniocentesis, Amniotic fluid, Autoimmune disease, Bone marrow, CD14, CD19, CD34, CD79A, CD90, Cell culture, Cell growth, Cell nucleus, Cell potency, Cellular differentiation, Chondrocyte, Chromatin, Collagen, Connective tissue, Cord blood, Cord lining, Crohn's disease, Cytokine, Deciduous teeth, Dendritic cell, Dexamethasone, Embryo, Endoglin, Endoplasmic reticulum, Ernest McCulloch, Ex vivo, Experimental & Molecular Medicine, Extracellular matrix, Fetal bovine serum, Flow cytometry, Golgi apparatus, Graft-versus-host disease, Haematopoiesis, Hematopoietic stem cell, HLA-DR, Integrin alpha M, Intramembranous ossification, James Till, List of human cell types derived from the germ layers, Magnetic-activated cell sorting, Marrow adipose tissue, Mesenchyme, ..., Mesoderm, Micrograph, Mitochondrion, Motility, Multiple sclerosis, Muscle, Myocyte, NT5E, Nucleolus, Osteoblast, Phosphate, Placenta, Platelet lysate, Polysome, PTPRC, Reticular fiber, Sepsis, Soma (biology), STRO-1, Stroma of cornea, Stromal cell, Systemic lupus erythematosus, Systemic scleroderma, T cell, Transforming growth factor, Transmission electron microscopy, Transplant rejection, Ultrastructure, Umbilical cord, Vitamin C, Wharton's jelly. Expand index (31 more) »

Adipocyte

Adipocytes, also known as lipocytes and fat cells, are the cells that primarily compose adipose tissue, specialized in storing energy as fat.

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Adipose tissue

In biology, adipose tissue, body fat, or simply fat is a loose connective tissue composed mostly of adipocytes.

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Agranulocyte

Agranulocytes, also known as mononuclear leukocytes, are white blood cells with a one-lobed nucleus.

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Alexander A. Maximow

Alexander Alexandrowitsch Maximow (Александр Александрович Максимов; - December 4, 1928), was a Russian-American scientist in the fields of Histology and Embryology whose team developed the hypothesis about the existence of "polyblasts".

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Amniocentesis

Amniocentesis (also referred to as amniotic fluid test or AFT) is a medical procedure used in prenatal diagnosis of chromosomal abnormalities and fetal infections, and also for sex determination, in which a small amount of amniotic fluid, which contains fetal tissues, is sampled from the amniotic sac surrounding a developing fetus, and then the fetal DNA is examined for genetic abnormalities.

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Amniotic fluid

The amniotic fluid is the protective liquid contained by the amniotic sac of a gravid Amniote.

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Autoimmune disease

An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.

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Bone marrow

Bone marrow is a semi-solid tissue which may be found within the spongy or cancellous portions of bones.

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CD14

CD14 (cluster of differentiation 14) is a human gene.

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CD19

B-lymphocyte antigen CD19, also known as CD19 molecule ('''C'''luster of '''D'''ifferentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12 and CVID3 is a transmembrane protein that in humans is encoded by the gene CD19.

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CD34

CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 gene in humans, mice, rats and other species.

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CD79A

Cluster of differentiation CD79A also known as B-cell antigen receptor complex-associated protein alpha chain and MB-1 membrane glycoprotein, is a protein that in humans is encoded by the CD79A gene.

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CD90

Thy-1 or CD90 (Cluster of Differentiation 90) is a 25–37 kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen.

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Cell culture

Cell culture is the process by which cells are grown under controlled conditions, generally outside their natural environment.

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Cell growth

The term cell growth is used in the contexts of biological cell development and cell division (reproduction).

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Cell nucleus

In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.

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Cell potency

Cell potency is a cell's ability to differentiate into other cell types The more cell types a cell can differentiate into, the greater its potency.

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Cellular differentiation

In developmental biology, cellular differentiation is the process where a cell changes from one cell type to another.

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Chondrocyte

Chondrocytes (from Greek χόνδρος, chondros.

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Chromatin

Chromatin is a complex of macromolecules found in cells, consisting of DNA, protein, and RNA.

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Collagen

Collagen is the main structural protein in the extracellular space in the various connective tissues in animal bodies.

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Connective tissue

Connective tissue (CT) is one of the four basic types of animal tissue, along with epithelial tissue, muscle tissue, and nervous tissue.

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Cord blood

Umbilical cord blood is blood that remains in the placenta and in the attached umbilical cord after childbirth.

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Cord lining

Cord lining, cord tissue, or umbilical cord lining membrane, is the outermost layer of the umbilical cord.

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Crohn's disease

Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any part of the gastrointestinal tract from mouth to anus.

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Cytokine

Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.

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Deciduous teeth

Deciduous teeth, commonly known as baby teeth and temporary teeth,Illustrated Dental Embryology, Histology, and Anatomy, Bath-Balogh and Fehrenbach, Elsevier, 2011, page 255 are the first set of teeth in the growth development of humans and other diphyodont mammals.

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Dendritic cell

Dendritic cells (DCs) are antigen-presenting cells (also known as accessory cells) of the mammalian immune system.

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Dexamethasone

Dexamethasone is a type of corticosteroid medication.

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Embryo

An embryo is an early stage of development of a multicellular diploid eukaryotic organism.

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Endoglin

Endoglin (ENG) is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex.

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Endoplasmic reticulum

The endoplasmic reticulum (ER) is a type of organelle found in eukaryotic cells that forms an interconnected network of flattened, membrane-enclosed sacs or tube-like structures known as cisternae.

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Ernest McCulloch

Ernest Armstrong McCulloch, (27 April 1926 – 20 January 2011) was a University of Toronto cellular biologist, best known for demonstrating – with James Till – the existence of stem cells.

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Ex vivo

Ex vivo (Latin: "out of the living") means that which takes place outside an organism.

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Experimental & Molecular Medicine

Experimental & Molecular Medicine is a monthly peer-reviewed open access medical journal covering biochemistry and molecular biology.

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Extracellular matrix

In biology, the extracellular matrix (ECM) is a collection of extracellular molecules secreted by support cells that provides structural and biochemical support to the surrounding cells.

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Fetal bovine serum

Fetal bovine serum (FBS) comes from the blood drawn from a bovine fetus via a closed system of collection at the slaughterhouse.

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Flow cytometry

In biotechnology, flow cytometry is a laser- or impedance-based, biophysical technology employed in cell counting, cell sorting, biomarker detection and protein engineering, by suspending cells in a stream of fluid and passing them through an electronic detection apparatus.

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Golgi apparatus

The Golgi apparatus, also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells.

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Graft-versus-host disease

Graft-versus-host disease (GvHD) is a medical complication following the receipt of transplanted tissue from a genetically different person.

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Haematopoiesis

Haematopoiesis (from Greek αἷμα, "blood" and ποιεῖν "to make"; also hematopoiesis in American English; sometimes also haemopoiesis or hemopoiesis) is the formation of blood cellular components.

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Hematopoietic stem cell

Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells.

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HLA-DR

HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31.

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Integrin alpha M

Integrin alpha M (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3).

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Intramembranous ossification

Intramembranous ossification is one of the two essential processes during fetal development of the gnathostome (excluding chondrichthyans such as sharks) skeletal system by which rudimentary bone tissue is created.

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James Till

James Edgar Till, (born August 25, 1931) is a University of Toronto biophysicist, best known for demonstrating – with Ernest McCulloch – the existence of stem cells.

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List of human cell types derived from the germ layers

This is a list of cells in humans derived from the germ layers, which includes the ectoderm, mesoderm, and endoderm.

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Magnetic-activated cell sorting

Magnetic-activated cell sorting (MACS) is a method for separation of various cell populations depending on their surface antigens (CD molecules) invented by Miltenyi Biotec.

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Marrow adipose tissue

Marrow adipose tissue (MAT), also known as bone marrow adipose tissue (BMAT), increases in states of low bone density -osteoporosis, anorexia nervosa/ caloric restriction, skeletal unweighting, anti-diabetes therapies). The marrow adipocytes originate from mesenchymal stem cell (MSC) progenitors that also give rise to osteoblasts, among other cell types. Thus, it is thought that MAT results from preferential MSC differentiation into the adipocyte, rather than osteoblast, lineage in the setting of osteoporosis. Since MAT is increased in the setting of obesity and is suppressed by endurance exercise, or vibration, it is likely that MAT physiology- in the setting of mechanical input/exercise- approximates that of white adipose tissue (WAT). MAT has qualities of both white and brown fat. Subcutaneous white fat contain excess energy, indicating a clear evolutionary advantage during times of scarcity. WAT is also the source of adipokines and inflammatory markers which have both positive (e.g., adiponectin) and negative effects on metabolic and cardiovascular endpoints. Visceral abdominal fat (VAT) is a distinct type of WAT that is "proportionally associated with negative metabolic and cardiovascular morbidity", regenerates cortisol, and recently has been tied to decreased bone formation Both types of WAT substantially differ from brown adipose tissue (BAT) as by a group of proteins that help BAT’s thermogenic role. MAT, by its "specific marrow location, and its adipocyte origin from at least LepR+ marrow MSC is separated from non-bone fat storage by larger expression of bone transcription factors", and likely indicates a different fat phenotype. Recently, MAT was noted to "produce a greater proportion of adiponectin - an adipokine associated with improved metabolism - than WAT", suggesting an endocrine function for this depot, akin, but different, from that of WAT.

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Mesenchyme

Mesenchyme, in vertebrate embryology, is a type of connective tissue found mostly during the development of the embryo.

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Mesoderm

In all bilaterian animals, the mesoderm is one of the three primary germ layers in the very early embryo.

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Micrograph

A micrograph or photomicrograph is a photograph or digital image taken through a microscope or similar device to show a magnified image of an item.

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Mitochondrion

The mitochondrion (plural mitochondria) is a double-membrane-bound organelle found in most eukaryotic organisms.

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Motility

Motility is the ability of an organism to move independently, using metabolic energy.

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Multiple sclerosis

Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged.

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Muscle

Muscle is a soft tissue found in most animals.

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Myocyte

A myocyte (also known as a muscle cell) is the type of cell found in muscle tissue.

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NT5E

5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that in humans is encoded by the NT5E gene.

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Nucleolus

The nucleolus (plural nucleoli) is the largest structure in the nucleus of eukaryotic cells.

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Osteoblast

Osteoblasts (from the Greek combining forms for "bone", ὀστέο-, osteo- and βλαστάνω, blastanō "germinate") are cells with a single nucleus that synthesize bone.

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Phosphate

A phosphate is chemical derivative of phosphoric acid.

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Placenta

The placenta is an organ that connects the developing fetus to the uterine wall to allow nutrient uptake, thermo-regulation, waste elimination, and gas exchange via the mother's blood supply; to fight against internal infection; and to produce hormones which support pregnancy.

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Platelet lysate

Human platelet lysate (or hPL) is a substitute supplement for fetal bovine serum (FBS) in experimental and clinical cell culture.

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Polysome

A polyribosome (or polysome) is a complex of an mRNA molecule and two or more ribosomes that act to translate mRNA instructions into polypeptides.

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PTPRC

Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene.

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Reticular fiber

Reticular fibers, reticular fibres or reticulin is a type of fiber in connective tissue composed of type III collagen secreted by reticular cells.

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Sepsis

Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs.

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Soma (biology)

The soma (pl. somata or somas), perikaryon (pl. perikarya), neurocyton, or cell body is the bulbous, non-process portion of a neuron or other brain cell type, containing the cell nucleus.

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STRO-1

STRO-1 (Stro-1 in mouse, rat, etc.) is a gene for a protein marker of mesenchymal stem cells (MSC).

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Stroma of cornea

The substantia propria (or stroma of cornea) is fibrous, tough, unyielding, and perfectly transparent.

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Stromal cell

Stromal cells are connective tissue cells of any organ, for example in the uterine mucosa (endometrium), prostate, bone marrow, lymph node and the ovary.

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Systemic lupus erythematosus

Systemic lupus erythematosus (SLE), also known simply as lupus, is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body.

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Systemic scleroderma

Systemic scleroderma, also called diffuse scleroderma or systemic sclerosis, is an autoimmune disease of the connective tissue.

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T cell

A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.

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Transforming growth factor

Transforming growth factor (sometimes referred to as Tumor growth factor, or TGF) is used to describe two classes of polypeptide growth factors, TGFα and TGFβ.

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Transmission electron microscopy

Transmission electron microscopy (TEM, also sometimes conventional transmission electron microscopy or CTEM) is a microscopy technique in which a beam of electrons is transmitted through a specimen to form an image.

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Transplant rejection

Transplant rejection occurs when transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue.

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Ultrastructure

Ultrastructure (or ultra-structure) is the architecture of cells that is visible at higher magnifications than found on a standard optical light microscope.

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Umbilical cord

In placental mammals, the umbilical cord (also called the navel string, birth cord or funiculus umbilicalis) is a conduit between the developing embryo or fetus and the placenta.

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Vitamin C

Vitamin C, also known as ascorbic acid and L-ascorbic acid, is a vitamin found in food and used as a dietary supplement.

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Wharton's jelly

Wharton's jelly (substantia gelatinea funiculi umbilicalis) is a gelatinous substance within the umbilical cord also present in vitreous humor of the eyeball, largely made up of mucopolysaccharides (hyaluronic acid and chondroitin sulfate).

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Redirects here:

Cellula mesenchymatica praecursoria, Cellula mesenchymatica precursoria, Cellulae mesenchymaticae praecursoriae, Cellulae mesenchymaticae precursoriae, Marrow Stromal Cell, Marrow stroma cell, Mesenchymal Stem Cell, Mesenchymal cell, Mesenchymal cells, Mesenchymal stem cells, Primary mesenchyme, Undifferentiated mesenchymal cell.

References

[1] https://en.wikipedia.org/wiki/Mesenchymal_stem_cell

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