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Sepsis

Index Sepsis

Sepsis is a potentially life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. [1]

Table of Contents

  1. 371 relations: Abdomen, Abscess, Acetylcysteine, Acinetobacter baumannii, ACTH stimulation test, Acute kidney injury, Acute pancreatitis, Acute respiratory distress syndrome, Adaptive behavior, Adenosine triphosphate, Adrenal insufficiency, Aerobic organism, Agency for Healthcare Research and Quality, Alanine transaminase, Albumin, Alcohol withdrawal syndrome, All Things Considered, Altered level of consciousness, American College of Chest Physicians, American College of Emergency Physicians, Aminoglycoside, Anaerobic organism, Anaphylaxis, Antibiotic, Antifibrinolytic, Antigen, Antigen presentation, Antihypotensive agent, Antimicrobial, Anuria, AP-1 transcription factor, APACHE II, Apoptosis, Arrhythmia, Arterial line, Ascending cholangitis, Asplenia, Asthma, ATP-sensitive potassium channel, Avicenna, B cell, Bacteria, Bacterial adhesin, Bacteroides, Base excess, Beta2-adrenergic agonist, Bile acid, Bilirubin, Biological target, Biomarker, ... Expand index (321 more) »

  2. Causes of amputation

Abdomen

The abdomen (colloquially called the belly, tummy, midriff, tucky or stomach) is the part of the body between the thorax (chest) and pelvis, in humans and in other vertebrates.

See Sepsis and Abdomen

Abscess

An abscess is a collection of pus that has built up within the tissue of the body.

See Sepsis and Abscess

Acetylcysteine

Acetylcysteine, also known as N-acetylcysteine (NAC), not to be confused with N-Acetylcarnosine, which is also abbreviated "NAC," is a medication that is used to treat paracetamol overdose and to loosen thick mucus in individuals with chronic bronchopulmonary disorders like pneumonia and bronchitis.

See Sepsis and Acetylcysteine

Acinetobacter baumannii

Acinetobacter baumannii is a typically short, almost round, rod-shaped (coccobacillus) Gram-negative bacterium.

See Sepsis and Acinetobacter baumannii

ACTH stimulation test

The ACTH test (also called the cosyntropin, tetracosactide, or Synacthen test) is a medical test usually requested and interpreted by endocrinologists to assess the functioning of the adrenal glands' stress response by measuring the adrenal response to adrenocorticotropic hormone (ACTH; corticotropin) or another corticotropic agent such as tetracosactide (cosyntropin, tetracosactrin; Synacthen) or alsactide (Synchrodyn).

See Sepsis and ACTH stimulation test

Acute kidney injury

Acute kidney injury (AKI), previously called acute renal failure (ARF), is a sudden decrease in kidney function that develops within 7 days, as shown by an increase in serum creatinine or a decrease in urine output, or both. Sepsis and acute kidney injury are medical emergencies.

See Sepsis and Acute kidney injury

Acute pancreatitis

Acute pancreatitis (AP) is a sudden inflammation of the pancreas. Sepsis and Acute pancreatitis are medical emergencies.

See Sepsis and Acute pancreatitis

Acute respiratory distress syndrome

Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by rapid onset of widespread inflammation in the lungs. Sepsis and Acute respiratory distress syndrome are intensive care medicine.

See Sepsis and Acute respiratory distress syndrome

Adaptive behavior

Adaptive behavior is behavior that enables a person (usually used in the context of children) to cope in their environment with greatest success and least conflict with others.

See Sepsis and Adaptive behavior

Adenosine triphosphate

Adenosine triphosphate (ATP) is a nucleotide that provides energy to drive and support many processes in living cells, such as muscle contraction, nerve impulse propagation, and chemical synthesis.

See Sepsis and Adenosine triphosphate

Adrenal insufficiency

Adrenal insufficiency is a condition in which the adrenal glands do not produce adequate amounts of steroid hormones.

See Sepsis and Adrenal insufficiency

Aerobic organism

An aerobic organism or aerobe is an organism that can survive and grow in an oxygenated environment.

See Sepsis and Aerobic organism

Agency for Healthcare Research and Quality

The Agency for Healthcare Research and Quality (AHRQ; pronounced "ark" by initiates and often "A-H-R-Q" by the public) is one of twelve agencies within the United States Department of Health and Human Services (HHS).

See Sepsis and Agency for Healthcare Research and Quality

Alanine transaminase

Alanine transaminase (ALT) is a transaminase enzyme.

See Sepsis and Alanine transaminase

Albumin

Albumin is a family of globular proteins, the most common of which are the serum albumins.

See Sepsis and Albumin

Alcohol withdrawal syndrome

Alcohol withdrawal syndrome (AWS) is a set of symptoms that can occur following a reduction in alcohol use after a period of excessive use.

See Sepsis and Alcohol withdrawal syndrome

All Things Considered

All Things Considered (ATC) is the flagship news program on the American network National Public Radio (NPR).

See Sepsis and All Things Considered

Altered level of consciousness

An altered level of consciousness is any measure of arousal other than normal. Sepsis and altered level of consciousness are intensive care medicine.

See Sepsis and Altered level of consciousness

American College of Chest Physicians

The American College of Chest Physicians (CHEST) is a medical association in the United States consisting of physicians and non-physician specialists in the field of chest medicine, which includes pulmonology, critical care medicine, and sleep medicine.

See Sepsis and American College of Chest Physicians

American College of Emergency Physicians

The American College of Emergency Physicians (ACEP) is a professional organization of emergency medicine physicians in the United States.

See Sepsis and American College of Emergency Physicians

Aminoglycoside

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside (sugar).

See Sepsis and Aminoglycoside

Anaerobic organism

An anaerobic organism or anaerobe is any organism that does not require molecular oxygen for growth.

See Sepsis and Anaerobic organism

Anaphylaxis

Anaphylaxis (Greek: ana- ‘against’ + phylaxis ‘guarding’) is a serious, potentially fatal allergic reaction and medical emergency that is rapid in onset and requires immediate medical attention regardless of the use of emergency medication on site. Sepsis and Anaphylaxis are medical emergencies.

See Sepsis and Anaphylaxis

Antibiotic

An antibiotic is a type of antimicrobial substance active against bacteria.

See Sepsis and Antibiotic

Antifibrinolytic

Antifibrinolytics are a class of medication that are inhibitors of fibrinolysis.

See Sepsis and Antifibrinolytic

Antigen

In immunology, an antigen (Ag) is a molecule, moiety, foreign particulate matter, or an allergen, such as pollen, that can bind to a specific antibody or T-cell receptor.

See Sepsis and Antigen

Antigen presentation

Antigen presentation is a vital immune process that is essential for T cell immune response triggering.

See Sepsis and Antigen presentation

Antihypotensive agent

An antihypotensive agent, also known as a vasopressor agent or simply vasopressor, or pressor, is any substance, whether endogenous or a medication, that tends to raise low blood pressure. Sepsis and antihypotensive agent are intensive care medicine.

See Sepsis and Antihypotensive agent

Antimicrobial

An antimicrobial is an agent that kills microorganisms (microbicide) or stops their growth (bacteriostatic agent).

See Sepsis and Antimicrobial

Anuria

Anuria is nonpassage of urine, in practice is defined as passage of less than 100 milliliters of urine in a day.

See Sepsis and Anuria

AP-1 transcription factor

Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections.

See Sepsis and AP-1 transcription factor

APACHE II

APACHE II ("Acute Physiology and Chronic Health Evaluation II") is a severity-of-disease classification system, one of several ICU scoring systems.

See Sepsis and APACHE II

Apoptosis

Apoptosis (from falling off) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast.

See Sepsis and Apoptosis

Arrhythmia

Arrhythmias, also known as cardiac arrhythmias, are irregularities in the heartbeat, including when it is too fast or too slow. Sepsis and arrhythmia are medical emergencies.

See Sepsis and Arrhythmia

Arterial line

An arterial line (also art-line or a-line) is a thin catheter inserted into an artery.

See Sepsis and Arterial line

Ascending cholangitis

Ascending cholangitis, also known as acute cholangitis or simply cholangitis, is inflammation of the bile duct, usually caused by bacteria ascending from its junction with the duodenum (first part of the small intestine). Sepsis and ascending cholangitis are medical emergencies.

See Sepsis and Ascending cholangitis

Asplenia

Asplenia refers to the absence of normal spleen function and is associated with some serious infection risks.

See Sepsis and Asplenia

Asthma

Asthma is a long-term inflammatory disease of the airways of the lungs.

See Sepsis and Asthma

ATP-sensitive potassium channel

An ATP-sensitive potassium channel (or KATP channel) is a type of potassium channel that is gated by intracellular nucleotides, ATP and ADP.

See Sepsis and ATP-sensitive potassium channel

Avicenna

Ibn Sina (translit; – 22 June 1037 CE), commonly known in the West as Avicenna, was a preeminent philosopher and physician of the Muslim world, flourishing during the Islamic Golden Age, serving in the courts of various Iranian rulers.

See Sepsis and Avicenna

B cell

B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype.

See Sepsis and B cell

Bacteria

Bacteria (bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell.

See Sepsis and Bacteria

Bacterial adhesin

Adhesins are cell-surface components or appendages of bacteria that facilitate adhesion or adherence to other cells or to surfaces, usually in the host they are infecting or living in.

See Sepsis and Bacterial adhesin

Bacteroides

Bacteroides is a genus of Gram-negative, obligate anaerobic bacteria.

See Sepsis and Bacteroides

Base excess

In physiology, base excess and base deficit refer to an excess or deficit, respectively, in the amount of base present in the blood.

See Sepsis and Base excess

Beta2-adrenergic agonist

Beta2-adrenergic agonists, also known as adrenergic β2 receptor agonists, are a class of drugs that act on the β2 adrenergic receptor.

See Sepsis and Beta2-adrenergic agonist

Bile acid

Bile acids are steroid acids found predominantly in the bile of mammals and other vertebrates.

See Sepsis and Bile acid

Bilirubin

Bilirubin (BR) (from the Latin for "red bile") is a red-orange compound that occurs in the normal catabolic pathway that breaks down heme in vertebrates.

See Sepsis and Bilirubin

Biological target

A biological target is anything within a living organism to which some other entity (like an endogenous ligand or a drug) is directed and/or binds, resulting in a change in its behavior or function.

See Sepsis and Biological target

Biomarker

In biomedical contexts, a biomarker, or biological marker, is a measurable indicator of some biological state or condition.

See Sepsis and Biomarker

Blood culture

A blood culture is a medical laboratory test used to detect bacteria or fungi in a person's blood.

See Sepsis and Blood culture

Blood gas test

A blood gas test or blood gas analysis tests blood to measure blood gas tension values, it also measures blood pH, and the level and base excess of bicarbonate.

See Sepsis and Blood gas test

Blood plasma

Blood plasma is a light amber-colored liquid component of blood in which blood cells are absent, but which contains proteins and other constituents of whole blood in suspension.

See Sepsis and Blood plasma

Blood pressure

Blood pressure (BP) is the pressure of circulating blood against the walls of blood vessels.

See Sepsis and Blood pressure

Blood sugar level

The blood sugar level, blood sugar concentration, blood glucose level, or glycemia is the measure of glucose concentrated in the blood.

See Sepsis and Blood sugar level

Bloodstream infection

Bloodstream infections (BSIs) are infections of blood caused by blood-borne pathogens.

See Sepsis and Bloodstream infection

Broad-spectrum antibiotic

A broad-spectrum antibiotic is an antibiotic that acts on the two major bacterial groups, Gram-positive and Gram-negative, or any antibiotic that acts against a wide range of disease-causing bacteria.

See Sepsis and Broad-spectrum antibiotic

Burn

A burn is an injury to skin, or other tissues, caused by heat, cold, electricity, chemicals, friction, or ultraviolet radiation (such as sunburn). Sepsis and burn are medical emergencies.

See Sepsis and Burn

C-type lectin

A C-type lectin (CLEC) is a type of carbohydrate-binding protein known as a lectin.

See Sepsis and C-type lectin

Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Sepsis and Cancer are causes of amputation.

See Sepsis and Cancer

Candida (fungus)

Candida is a genus of yeasts.

See Sepsis and Candida (fungus)

Capillary refill

Capillary refill time (CRT) is defined as the time taken for color to return to an external capillary bed after pressure is applied to cause blanching.

See Sepsis and Capillary refill

Carbapenem

Carbapenems are a class of very effective antibiotic agents most commonly used for treatment of severe bacterial infections.

See Sepsis and Carbapenem

Cardiac output

In cardiac physiology, cardiac output (CO), also known as heart output and often denoted by the symbols Q, \dot Q, or \dot Q_, edited by Catherine E. Williamson, Phillip Bennett is the volumetric flow rate of the heart's pumping output: that is, the volume of blood being pumped by a single ventricle of the heart, per unit time (usually measured per minute).

See Sepsis and Cardiac output

Caspofungin

Caspofungin (INN; brand name Cancidas) is a lipopeptide antifungal drug from Merck & Co., Inc..

See Sepsis and Caspofungin

CD4

In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR).

See Sepsis and CD4

Centers for Disease Control and Prevention

The Centers for Disease Control and Prevention (CDC) is the national public health agency of the United States.

See Sepsis and Centers for Disease Control and Prevention

Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord.

See Sepsis and Central nervous system

Central venous catheter

A central venous catheter (CVC), also known as a central line (c-line), central venous line, or central venous access catheter, is a catheter placed into a large vein.

See Sepsis and Central venous catheter

Central venous pressure

Central venous pressure (CVP) is the blood pressure in the venae cavae, near the right atrium of the heart.

See Sepsis and Central venous pressure

Chemical pneumonitis

Chemical pneumonitis is inflammation of the lung caused by aspirating or inhaling irritants.

See Sepsis and Chemical pneumonitis

Chest radiograph

A chest radiograph, chest X-ray (CXR), or chest film is a projection radiograph of the chest used to diagnose conditions affecting the chest, its contents, and nearby structures.

See Sepsis and Chest radiograph

Chronic kidney disease

Chronic kidney disease (CKD) is a type of long-term kidney disease, in which either there is a gradual loss of kidney function occurs over a period of months to years, or abnormal kidney structure (with normal function).

See Sepsis and Chronic kidney disease

Chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a type of progressive lung disease characterized by long-term respiratory symptoms and airflow limitation.

See Sepsis and Chronic obstructive pulmonary disease

Clostridium

Clostridium is a genus of anaerobic, Gram-positive bacteria.

See Sepsis and Clostridium

Coagulation

Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot.

See Sepsis and Coagulation

Coagulopathy

Coagulopathy (also called a bleeding disorder) is a condition in which the blood's ability to coagulate (form clots) is impaired.

See Sepsis and Coagulopathy

Cochrane Library

The Cochrane Library (named after Archie Cochrane) is a collection of databases in medicine and other healthcare specialties provided by Cochrane and other organizations.

See Sepsis and Cochrane Library

Complete blood count

A complete blood count (CBC), also known as a full blood count (FBC), is a set of medical laboratory tests that provide information about the cells in a person's blood.

See Sepsis and Complete blood count

Confusion

In medicine, confusion is the quality or state of being bewildered or unclear.

See Sepsis and Confusion

Continuous positive airway pressure

Continuous positive airway pressure (CPAP) is a form of positive airway pressure (PAP) ventilation in which a constant level of pressure greater than atmospheric pressure is continuously applied to the upper respiratory tract of a person.

See Sepsis and Continuous positive airway pressure

Coronary artery disease

Coronary artery disease (CAD), also called coronary heart disease (CHD), ischemic heart disease (IHD), myocardial ischemia, or simply heart disease, involves the reduction of blood flow to the cardiac muscle due to build-up of atherosclerotic plaque in the arteries of the heart.

See Sepsis and Coronary artery disease

Corticosteroid

Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones.

See Sepsis and Corticosteroid

Cortisol

Cortisol is a steroid hormone in the glucocorticoid class of hormones and a stress hormone.

See Sepsis and Cortisol

CpG site

The CpG sites or CG sites are regions of DNA where a cytosine nucleotide is followed by a guanine nucleotide in the linear sequence of bases along its 5' → 3' direction.

See Sepsis and CpG site

Creatinine

Creatinine (from Ancient Greek: κρέας (kréas) 'flesh') is a breakdown product of creatine phosphate from muscle and protein metabolism.

See Sepsis and Creatinine

Critical illness–related corticosteroid insufficiency

Critical illness–related corticosteroid insufficiency is a form of adrenal insufficiency in critically ill patients who have blood corticosteroid levels which are inadequate for the severe stress response they experience. Sepsis and critical illness–related corticosteroid insufficiency are intensive care medicine.

See Sepsis and Critical illness–related corticosteroid insufficiency

Cyanotic heart defect

A cyanotic heart defect is any congenital heart defect (CHD) that occurs due to deoxygenated blood bypassing the lungs and entering the systemic circulation, or a mixture of oxygenated and unoxygenated blood entering the systemic circulation.

See Sepsis and Cyanotic heart defect

Cytochrome c oxidase

The enzyme cytochrome c oxidase or Complex IV (was, now reclassified as a translocase) is a large transmembrane protein complex found in bacteria, archaea, and the mitochondria of eukaryotes.

See Sepsis and Cytochrome c oxidase

Cytokine

Cytokines are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling.

See Sepsis and Cytokine

Cytokine storm

A cytokine storm, also called hypercytokinemia, is a pathological reaction in humans and other animals in which the innate immune system causes an uncontrolled and excessive release of pro-inflammatory signaling molecules called cytokines.

See Sepsis and Cytokine storm

Cytoplasm

In cell biology, the cytoplasm describes all material within a eukaryotic cell, enclosed by the cell membrane, except for the cell nucleus.

See Sepsis and Cytoplasm

Damage-associated molecular pattern

Damage-associated molecular patterns (DAMPs) are molecules within cells that are a component of the innate immune response released from damaged or dying cells due to trauma or an infection by a pathogen.

See Sepsis and Damage-associated molecular pattern

Decomposer

Decomposers are organisms that break down dead or decaying organisms; they carry out decomposition, a process possible by only certain kingdoms, such as fungi.

See Sepsis and Decomposer

Decomposition

Decomposition or rot is the process by which dead organic substances are broken down into simpler organic or inorganic matter such as carbon dioxide, water, simple sugars and mineral salts.

See Sepsis and Decomposition

Deep vein thrombosis

Deep vein thrombosis (DVT) is a type of venous thrombosis involving the formation of a blood clot in a deep vein, most commonly in the legs or pelvis.

See Sepsis and Deep vein thrombosis

Dendritic cell

A dendritic cell (DC) is an antigen-presenting cell (also known as an accessory cell) of the mammalian immune system.

See Sepsis and Dendritic cell

Developed country

A developed country, or advanced country, is a sovereign state that has a high quality of life, developed economy, and advanced technological infrastructure relative to other less industrialized nations.

See Sepsis and Developed country

Developmental disability

Developmental disability is a diverse group of chronic conditions, comprising mental or physical impairments that arise before adulthood.

See Sepsis and Developmental disability

Diabetes

Diabetes mellitus, often known simply as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. Sepsis and diabetes are causes of amputation.

See Sepsis and Diabetes

Differential diagnosis

In healthcare, a differential diagnosis (DDx) is a method of analysis that distinguishes a particular disease or condition from others that present with similar clinical features.

See Sepsis and Differential diagnosis

Disseminated intravascular coagulation

Disseminated intravascular coagulation (DIC) is a condition in which blood clots form throughout the body, blocking small blood vessels. Sepsis and Disseminated intravascular coagulation are intensive care medicine and medical emergencies.

See Sepsis and Disseminated intravascular coagulation

Distributive shock

Distributive shock is a medical condition in which abnormal distribution of blood flow in the smallest blood vessels results in inadequate supply of blood to the body's tissues and organs. Sepsis and Distributive shock are medical emergencies.

See Sepsis and Distributive shock

Dobutamine

Dobutamine is a medication used in the treatment of cardiogenic shock (as a result of inadequate tissue perfusion) and severe heart failure.

See Sepsis and Dobutamine

Domperidone

Domperidone, sold under the brand name Motilium among others, is a dopamine antagonist medication which is used to treat nausea and vomiting and certain gastrointestinal problems like gastroparesis (delayed gastric emptying).

See Sepsis and Domperidone

Dopamine

Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells.

See Sepsis and Dopamine

Drotrecogin alfa

Drotrecogin alfa (activated) (Xigris, marketed by Eli Lilly and Company) is a recombinant form of human activated protein C that has anti-thrombotic, anti-inflammatory, and profibrinolytic properties. Sepsis and Drotrecogin alfa are intensive care medicine.

See Sepsis and Drotrecogin alfa

Dysuria

Dysuria refers to painful or uncomfortable urination.

See Sepsis and Dysuria

Early goal-directed therapy

Early goal-directed therapy (EGDT or EGDT) was introduced by Emanuel P. Rivers in The New England Journal of Medicine in 2001 and is a technique used in critical care medicine involving intensive monitoring and aggressive management of perioperative hemodynamics in patients with a high risk of morbidity and mortality. Sepsis and Early goal-directed therapy are intensive care medicine.

See Sepsis and Early goal-directed therapy

Echinocandin

Echinocandins are a class of antifungal drugs that inhibit the synthesis of β-glucan in the fungal cell wall via noncompetitive inhibition of the enzyme 1,3-β glucan synthase.

See Sepsis and Echinocandin

Echinococcus

Echinococcus is a genus within Cestoda, a parasitic class of the platyhelminthes phylum (colloquially known as flatworms).

See Sepsis and Echinococcus

Edema

Edema (AmE), also spelled oedema (BrE), and also known as fluid retention, dropsy, hydropsy and swelling, is the build-up of fluid in the body's tissue.

See Sepsis and Edema

Electrolyte imbalance

Electrolyte imbalance, or water-electrolyte imbalance, is an abnormality in the concentration of electrolytes in the body.

See Sepsis and Electrolyte imbalance

Electronic health record

An electronic health record (EHR) is the systematized collection of patient and population electronically stored health information in a digital format.

See Sepsis and Electronic health record

Elsevier

Elsevier is a Dutch academic publishing company specializing in scientific, technical, and medical content.

See Sepsis and Elsevier

Encephalopathy

Encephalopathy (from ἐνκέφαλος "brain" + πάθος "suffering") means any disorder or disease of the brain, especially chronic degenerative conditions.

See Sepsis and Encephalopathy

End organ damage

End organ damage is severe impairment of major body organs due to systemic disease.

See Sepsis and End organ damage

Endothelium

The endothelium (endothelia) is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels.

See Sepsis and Endothelium

Eritoran

Eritoran is a synthetic lipid that inhibits the receptor TLR4.

See Sepsis and Eritoran

Erythromycin

Erythromycin is an antibiotic used for the treatment of a number of bacterial infections.

See Sepsis and Erythromycin

Erythropoietin

Erythropoietin (EPO), also known as erythropoetin, haematopoietin, or haemopoietin, is a glycoprotein cytokine secreted mainly by the kidneys in response to cellular hypoxia; it stimulates red blood cell production (erythropoiesis) in the bone marrow.

See Sepsis and Erythropoietin

Escherichia coli

Escherichia coliWells, J. C. (2000) Longman Pronunciation Dictionary.

See Sepsis and Escherichia coli

Etomidate

Etomidate (USAN, INN, BAN; marketed as Amidate) is a short-acting intravenous anaesthetic agent used for the induction of general anaesthesia and sedation for short procedures such as reduction of dislocated joints, tracheal intubation, cardioversion and electroconvulsive therapy.

See Sepsis and Etomidate

Exotoxin

An exotoxin is a toxin secreted by bacteria.

See Sepsis and Exotoxin

Extracorporeal membrane oxygenation

Extracorporeal membrane oxygenation (ECMO), is a form of extracorporeal life support, providing prolonged cardiac and respiratory support to persons whose heart and lungs are unable to provide an adequate amount of oxygen, gas exchange or blood supply (perfusion) to sustain life. Sepsis and extracorporeal membrane oxygenation are intensive care medicine.

See Sepsis and Extracorporeal membrane oxygenation

Feeding tube

A feeding tube is a medical device used to provide nutrition to people who cannot obtain nutrition by mouth, are unable to swallow safely, or need nutritional supplementation.

See Sepsis and Feeding tube

Fever

Fever or pyrexia in humans is a body temperature above the normal range due to an increase in the body's temperature set point in the hypothalamus.

See Sepsis and Fever

Flagellin

Flagellins are a family of proteins present in flagellated bacteria which arrange themselves in a hollow cylinder to form the filament in a bacterial flagellum.

See Sepsis and Flagellin

Fluconazole

Fluconazole is an antifungal medication used for a number of fungal infections.

See Sepsis and Fluconazole

Fluid replacement

Fluid replacement or fluid resuscitation is the medical practice of replenishing bodily fluid lost through sweating, bleeding, fluid shifts or other pathologic processes. Sepsis and fluid replacement are medical emergencies.

See Sepsis and Fluid replacement

Focus of infection

A focus of infection is a place containing whatever epidemiological factors are needed for transmission of an infection.

See Sepsis and Focus of infection

Fresh frozen plasma

Fresh frozen plasma (FFP) is a blood product made from the liquid portion of whole blood.

See Sepsis and Fresh frozen plasma

Fungal infection

Fungal infection, also known as mycosis, is a disease caused by fungi.

See Sepsis and Fungal infection

Fungemia

Fungemia is the presence of fungi or yeast in the blood.

See Sepsis and Fungemia

Fungus

A fungus (fungi or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms.

See Sepsis and Fungus

Gastroenteritis

Gastroenteritis, also known as infectious diarrhea, is an inflammation of the gastrointestinal tract including the stomach and intestine.

See Sepsis and Gastroenteritis

Gastrointestinal tract

The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and other animals, including the esophagus, stomach, and intestines.

See Sepsis and Gastrointestinal tract

Glasgow Coma Scale

The Glasgow Coma Scale (GCS) is a clinical scale used to reliably measure a person's level of consciousness after a brain injury.

See Sepsis and Glasgow Coma Scale

Glucocorticoid

Glucocorticoids (or, less commonly, glucocorticosteroids) are a class of corticosteroids, which are a class of steroid hormones.

See Sepsis and Glucocorticoid

Glycocalyx

The glycocalyx (glycocalyces or glycocalyxes), also known as the pericellular matrix and sometime cell coat, is a glycoprotein and glycolipid covering which surrounds the cell membranes of bacteria, epithelial cells, and other cells.

See Sepsis and Glycocalyx

Gram-negative bacteria

Gram-negative bacteria are bacteria that unlike gram-positive bacteria do not retain the crystal violet stain used in the Gram staining method of bacterial differentiation.

See Sepsis and Gram-negative bacteria

Gram-positive bacteria

In bacteriology, gram-positive bacteria are bacteria that give a positive result in the Gram stain test, which is traditionally used to quickly classify bacteria into two broad categories according to their type of cell wall.

See Sepsis and Gram-positive bacteria

Growth medium

A growth medium or culture medium is a solid, liquid, or semi-solid designed to support the growth of a population of microorganisms or cells via the process of cell proliferation or small plants like the moss Physcomitrella patens.

See Sepsis and Growth medium

H2 receptor antagonist

H2 antagonists, sometimes referred to as H2RAs and also called H2 blockers, are a class of medications that block the action of histamine at the histamine H2 receptors of the parietal cells in the stomach.

See Sepsis and H2 receptor antagonist

Health insurance in the United States

In the United States, health insurance helps pay for medical expenses through privately purchased insurance, social insurance, or a social welfare program funded by the government.

See Sepsis and Health insurance in the United States

Heart failure

Heart failure (HF), also known as congestive heart failure (CHF), is a syndrome caused by an impairment in the heart's ability to fill with and pump blood.

See Sepsis and Heart failure

Heart rate

Heart rate is the frequency of the heartbeat measured by the number of contractions of the heart per minute (beats per minute, or bpm).

See Sepsis and Heart rate

Hemodialysis

Hemodialysis, also spelled haemodialysis, or simply dialysis, is a process of filtering the blood of a person whose kidneys are not working normally.

See Sepsis and Hemodialysis

Hemodynamics

Hemodynamics or haemodynamics are the dynamics of blood flow.

See Sepsis and Hemodynamics

Hemoglobin

Hemoglobin (haemoglobin, Hb or Hgb) is a protein containing iron that facilitates the transport of oxygen in red blood cells.

See Sepsis and Hemoglobin

Hemoperfusion

Hemoperfusion or hæmoperfusion (see spelling differences) is a method of filtering the blood extracorporeally (that is, outside the body) to remove a toxin.

See Sepsis and Hemoperfusion

Hemophagocytic lymphohistiocytosis

In hematology, hemophagocytic lymphohistiocytosis (HLH), also known as haemophagocytic lymphohistiocytosis (British spelling), and hemophagocytic or haemophagocytic syndrome, is an uncommon hematologic disorder seen more often in children than in adults.

See Sepsis and Hemophagocytic lymphohistiocytosis

Heparin

Heparin, also known as unfractionated heparin (UFH), is a medication and naturally occurring glycosaminoglycan.

See Sepsis and Heparin

Hippocrates

Hippocrates of Kos (Hippokrátēs ho Kôios), also known as Hippocrates II, was a Greek physician and philosopher of the classical period who is considered one of the most outstanding figures in the history of medicine.

See Sepsis and Hippocrates

Horowitz index

The Horowitz index or Horovitz index (also known as the Horowitz quotient or the P/F ratio) is a ratio used to assess lung function in patients, particularly those on ventilators.

See Sepsis and Horowitz index

Hospital-acquired infection

A hospital-acquired infection, also known as a nosocomial infection (from the Greek, meaning "hospital"), is an infection that is acquired in a hospital or other healthcare facility. Sepsis and hospital-acquired infection are intensive care medicine.

See Sepsis and Hospital-acquired infection

Hydrocortisone

Hydrocortisone is the name for the hormone cortisol when supplied as a medication.

See Sepsis and Hydrocortisone

Hydroxyethyl starch

Hydroxyethyl starch (HES/HAES), sold under the brand name Voluven among others, is a nonionic starch derivative, used as a volume expander in intravenous therapy.

See Sepsis and Hydroxyethyl starch

Hypercapnia

Hypercapnia (from the Greek hyper. Sepsis and Hypercapnia are medical emergencies.

See Sepsis and Hypercapnia

Hyperglycemia

Hyperglycemia or Hyperglycaemia is a condition in which an excessive amount of glucose circulates in the blood plasma.

See Sepsis and Hyperglycemia

Hyperthyroidism

Hyperthyroidism is the condition that occurs due to excessive production of thyroid hormones by the thyroid gland.

See Sepsis and Hyperthyroidism

Hyperventilation

Hyperventilation is irregular breathing that occurs when the rate or tidal volume of breathing eliminates more carbon dioxide than the body can produce.

See Sepsis and Hyperventilation

Hypotension

Hypotension, also known as low blood pressure, is a cardiovascular condition characterized by abnormally reduced blood pressure.

See Sepsis and Hypotension

Hypothermia

Hypothermia is defined as a body core temperature below in humans. Sepsis and Hypothermia are medical emergencies.

See Sepsis and Hypothermia

Hypovolemia

Hypovolemia, also known as volume depletion or volume contraction, is a state of abnormally low extracellular fluid in the body. Sepsis and Hypovolemia are medical emergencies.

See Sepsis and Hypovolemia

Hypoxemia

Hypoxemia is an abnormally low level of oxygen in the blood.

See Sepsis and Hypoxemia

ICD-10

ICD-10 is the 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD), a medical classification list by the World Health Organization (WHO).

See Sepsis and ICD-10

Ileus

Ileus is a disruption of the normal propulsive ability of the intestine.

See Sepsis and Ileus

Immune system

The immune system is a network of biological systems that protects an organism from diseases.

See Sepsis and Immune system

Immunodeficiency

Immunodeficiency, also known as immunocompromisation, is a state in which the immune system's ability to fight infectious diseases and cancer is compromised or entirely absent.

See Sepsis and Immunodeficiency

Immunoglobulin M

Immunoglobulin M (IgM) is the largest of several isotypes of antibodies (also known as immunoglobulin) that are produced by vertebrates.

See Sepsis and Immunoglobulin M

Immunoglobulin therapy

Immunoglobulin therapy is the use of a mixture of antibodies (normal human immunoglobulin) to treat several health conditions.

See Sepsis and Immunoglobulin therapy

Immunosuppression

Immunosuppression is a reduction of the activation or efficacy of the immune system.

See Sepsis and Immunosuppression

Immunosuppressive drug

Immunosuppressive drugs, also known as immunosuppressive agents, immunosuppressants and antirejection medications, are drugs that inhibit or prevent the activity of the immune system.

See Sepsis and Immunosuppressive drug

Incidence (epidemiology)

In epidemiology, incidence reflects the number of new cases of a given medical condition in a population within a specified period of time.

See Sepsis and Incidence (epidemiology)

Incision and drainage

Incision and drainage (I&D), also known as clinical lancing, are minor surgical procedures to release pus or pressure built up under the skin, such as from an abscess, boil, or infected paranasal sinus.

See Sepsis and Incision and drainage

Infection

An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce.

See Sepsis and Infection

Infectious diseases (medical specialty)

Infectious diseases (ID), also known as infectiology, is a medical specialty dealing with the diagnosis and treatment of infections.

See Sepsis and Infectious diseases (medical specialty)

Inflammation

Inflammation (from inflammatio) is part of the biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants.

See Sepsis and Inflammation

Influenza vaccine

Influenza vaccines, colloquially known as flu shots, are vaccines that protect against infection by influenza viruses.

See Sepsis and Influenza vaccine

Inhalational anesthetic

An inhalational anesthetic is a chemical compound possessing general anesthetic properties that is delivered via inhalation.

See Sepsis and Inhalational anesthetic

Inotrope

An inotrope or inotropic is a drug or any substance that alters the force or energy of muscular contractions. Negatively inotropic agents weaken the force of muscular contractions. Positively inotropic agents increase the strength of muscular contraction. The term inotropic state is most commonly used in reference to various drugs that affect the strength of contraction of heart muscle.

See Sepsis and Inotrope

Insulin

Insulin (from Latin insula, 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (INS) gene.

See Sepsis and Insulin

Intellectual disability

Intellectual disability (ID), also known as general learning disability (in the United Kingdom) and formerly mental retardation (in the United States),Rosa's Law, Pub.

See Sepsis and Intellectual disability

Intensive care medicine

Intensive care medicine, also called critical care medicine, is a medical specialty that deals with seriously or critically ill patients who have, are at risk of, or are recovering from conditions that may be life-threatening.

See Sepsis and Intensive care medicine

Intensive care unit

An intensive care unit (ICU), also known as an intensive therapy unit or intensive treatment unit (ITU) or critical care unit (CCU), is a special department of a hospital or health care facility that provides intensive care medicine. Sepsis and intensive care unit are intensive care medicine.

See Sepsis and Intensive care unit

Interleukin 10

Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine.

See Sepsis and Interleukin 10

Interleukin 6

Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine.

See Sepsis and Interleukin 6

Interleukin-1 family

The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults.

See Sepsis and Interleukin-1 family

Intermittent pneumatic compression

Intermittent pneumatic compression is a therapeutic technique used in medical devices that include an air pump and inflatable auxiliary sleeves, gloves or boots in a system designed to improve venous circulation in the limbs of patients who have edema or the risk of deep vein thrombosis (DVT), pulmonary embolism (PE), or the combination of DVT and PE which is (VTE).

See Sepsis and Intermittent pneumatic compression

International Classification of Diseases

The International Classification of Diseases (ICD) is a globally used medical classification used in epidemiology, health management and for clinical purposes.

See Sepsis and International Classification of Diseases

Intravenous therapy

Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein.

See Sepsis and Intravenous therapy

Intubation

Intubation (sometimes entubation) is a medical procedure involving the insertion of a tube into the body.

See Sepsis and Intubation

Itraconazole

Itraconazole, sometimes abbreviated ITZ, is an antifungal medication used to treat a number of fungal infections. This includes aspergillosis, blastomycosis, coccidioidomycosis, histoplasmosis, and paracoccidioidomycosis. It may be given by mouth or intravenously. Common side effects include nausea, diarrhea, abdominal pain, rash, and headache.

See Sepsis and Itraconazole

Jaundice

Jaundice, also known as icterus, is a yellowish or greenish pigmentation of the skin and sclera due to high bilirubin levels.

See Sepsis and Jaundice

Journal of the National Cancer Institute

The Journal of the National Cancer Institute (JNCI) is a peer-reviewed medical journal covering research in oncology that was established in August 1940.

See Sepsis and Journal of the National Cancer Institute

Kidney dialysis

Kidney dialysis (from Greek,, 'dissolution'; from,, 'through', and,, 'loosening or splitting') is the process of removing excess water, solutes, and toxins from the blood in people whose kidneys can no longer perform these functions naturally.

See Sepsis and Kidney dialysis

Kidney failure

Kidney failure, also known as end-stage renal disease (ESRD), is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. Kidney failure is classified as either acute kidney failure, which develops rapidly and may resolve; and chronic kidney failure, which develops slowly and can often be irreversible.

See Sepsis and Kidney failure

Klebsiella

Klebsiella is a genus of Gram-negative, oxidase-negative, rod-shaped bacteria with a prominent polysaccharide-based capsule.

See Sepsis and Klebsiella

Lactic acid

Lactic acid is an organic acid.

See Sepsis and Lactic acid

Lactic acidosis

Lactic acidosis is a medical condition characterized by a build-up of lactate (especially -lactate) in the body, with formation of an excessively low pH in the bloodstream.

See Sepsis and Lactic acidosis

Lactobacillus

Lactobacillus is a genus of gram-positive, aerotolerant anaerobes or microaerophilic, rod-shaped, non-spore-forming bacteria.

See Sepsis and Lactobacillus

Legionella

Legionella is a genus of pathogenic gram-negative bacteria that includes the species L. pneumophila, causing legionellosis (all illnesses caused by Legionella) including a pneumonia-type illness called Legionnaires' disease and a mild flu-like illness called Pontiac fever.

See Sepsis and Legionella

Lightheadedness

Lightheadedness is a common and typically unpleasant sensation of dizziness or a feeling that one may faint.

See Sepsis and Lightheadedness

Lipid A

Lipid A is a lipid component of an endotoxin held responsible for the toxicity of gram-negative bacteria.

See Sepsis and Lipid A

Lipopolysaccharide

Lipopolysaccharide, now more commonly known as Endotoxin, is a collective term for components of the outermost membrane of cell envelope of Gram-negative bacteria, such as E. coli and Salmonella.

See Sepsis and Lipopolysaccharide

Lipoteichoic acid

Lipoteichoic acid (LTA) is a major constituent of the cell wall of gram-positive bacteria.

See Sepsis and Lipoteichoic acid

Low-molecular-weight heparin

Low-molecular-weight heparin (LMWH) is a class of anticoagulant medications.

See Sepsis and Low-molecular-weight heparin

Lung

The lungs are the central organs of the respiratory system in humans and some other animals, including tetrapods, some snails and a small number of fish.

See Sepsis and Lung

Macrolide

Macrolides are a class of mostly natural products with a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached.

See Sepsis and Macrolide

Macrophage

Macrophages (abbreviated Mφ, MΦ or MP) are a type of white blood cell of the innate immune system that engulf and digest pathogens, such as cancer cells, microbes, cellular debris, and foreign substances, which do not have proteins that are specific to healthy body cells on their surface.

See Sepsis and Macrophage

Major histocompatibility complex

The major histocompatibility complex (MHC) is a large locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for cell surface proteins essential for the adaptive immune system.

See Sepsis and Major histocompatibility complex

Major trauma

Major trauma is any injury that has the potential to cause prolonged disability or death. Sepsis and Major trauma are medical emergencies.

See Sepsis and Major trauma

Malaria

Malaria is a mosquito-borne infectious disease that affects vertebrates.

See Sepsis and Malaria

Mammal

A mammal is a vertebrate animal of the class Mammalia.

See Sepsis and Mammal

McGraw Hill Education

McGraw Hill is an American publishing company for educational content, software, and services for pre-K through postgraduate education.

See Sepsis and McGraw Hill Education

Mean arterial pressure

In medicine, the mean arterial pressure (MAP) is an average calculated blood pressure in an individual during a single cardiac cycle.

See Sepsis and Mean arterial pressure

Mechanical ventilation

Mechanical ventilation or assisted ventilation is the medical term for using a machine called a ventilator to fully or partially provide artificial ventilation. Sepsis and Mechanical ventilation are intensive care medicine.

See Sepsis and Mechanical ventilation

Medicaid

In the United States, Medicaid is a government program that provides health insurance for adults and children with limited income and resources.

See Sepsis and Medicaid

Medical imaging

Medical imaging is the technique and process of imaging the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology).

See Sepsis and Medical imaging

Medicare (United States)

Medicare is a federal health insurance program in the United States for people age 65 or older and younger people with disabilities, including those with end stage renal disease and amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease).

See Sepsis and Medicare (United States)

Meningitis

Meningitis is acute or chronic inflammation of the protective membranes covering the brain and spinal cord, collectively called the meninges. Sepsis and Meningitis are medical emergencies.

See Sepsis and Meningitis

Merck & Co.

Merck & Co., Inc. is an American multinational pharmaceutical company headquartered in Rahway, New Jersey, and is named for Merck Group, founded in Germany in 1668, of which it was once the American arm.

See Sepsis and Merck & Co.

Metabolic acidosis

Metabolic acidosis is a serious electrolyte disorder characterized by an imbalance in the body's acid-base balance.

See Sepsis and Metabolic acidosis

Methicillin-resistant Staphylococcus aureus

Methicillin-resistant Staphylococcus aureus (MRSA) is a group of gram-positive bacteria that are genetically distinct from other strains of Staphylococcus aureus.

See Sepsis and Methicillin-resistant Staphylococcus aureus

Metoclopramide

Metoclopramide is a medication used for stomach and esophageal problems.

See Sepsis and Metoclopramide

Micafungin

Micafungin, sold under the brand name Mycamine, is an echinocandin antifungal medication used to treat and prevent invasive fungal infections including candidemia, abscesses, and esophageal candidiasis.

See Sepsis and Micafungin

Microbiome

A microbiome is the community of microorganisms that can usually be found living together in any given habitat.

See Sepsis and Microbiome

Microorganism

A microorganism, or microbe, is an organism of microscopic size, which may exist in its single-celled form or as a colony of cells. The possible existence of unseen microbial life was suspected from ancient times, such as in Jain scriptures from sixth century BC India. The scientific study of microorganisms began with their observation under the microscope in the 1670s by Anton van Leeuwenhoek.

See Sepsis and Microorganism

Millimetre of mercury

A millimetre of mercury is a manometric unit of pressure, formerly defined as the extra pressure generated by a column of mercury one millimetre high, and currently defined as exactly pascals or exactly pascals.

See Sepsis and Millimetre of mercury

Minimum inhibitory concentration

In microbiology, the minimum inhibitory concentration (MIC) is the lowest concentration of a chemical, usually a drug, which prevents visible in vitro growth of bacteria or fungi.

See Sepsis and Minimum inhibitory concentration

Mitochondrion

A mitochondrion is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi.

See Sepsis and Mitochondrion

Monocyte

Monocytes are a type of leukocyte or white blood cell.

See Sepsis and Monocyte

Mouse

A mouse (mice) is a small rodent.

See Sepsis and Mouse

Multiple drug resistance

Multiple drug resistance (MDR), multidrug resistance or multiresistance is antimicrobial resistance shown by a species of microorganism to at least one antimicrobial drug in three or more antimicrobial categories.

See Sepsis and Multiple drug resistance

Multiple myeloma

Multiple myeloma (MM), also known as plasma cell myeloma and simply myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibodies.

See Sepsis and Multiple myeloma

Multiple organ dysfunction syndrome

Multiple organ dysfunction syndrome (MODS) is altered organ function in an acutely ill patient requiring medical intervention to achieve homeostasis. Sepsis and Multiple organ dysfunction syndrome are intensive care medicine and medical emergencies.

See Sepsis and Multiple organ dysfunction syndrome

Muramyl dipeptide

Muramyl dipeptide is a component of bacterial peptidoglycan, a recognition structure or activator for nucleotide-binding oligomerization domain 2 (NOD2) protein.

See Sepsis and Muramyl dipeptide

Mutualism (biology)

Mutualism describes the ecological interaction between two or more species where each species has a net benefit.

See Sepsis and Mutualism (biology)

National Heart, Lung, and Blood Institute

The National Heart, Lung, and Blood Institute (NHLBI) is the third largest Institute of the National Institutes of Health, located in Bethesda, Maryland, United States.

See Sepsis and National Heart, Lung, and Blood Institute

National Institutes of Health

The National Institutes of Health, commonly referred to as NIH, is the primary agency of the United States government responsible for biomedical and public health research.

See Sepsis and National Institutes of Health

Neonatal sepsis

Neonatal sepsis is a type of neonatal infection and specifically refers to the presence in a newborn baby of a bacterial blood stream infection (BSI) (such as meningitis, pneumonia, pyelonephritis, or gastroenteritis) in the setting of fever. Sepsis and neonatal sepsis are Neonatology.

See Sepsis and Neonatal sepsis

Neurogenic shock

Neurogenic shock is a distributive type of shock resulting in hypotension (low blood pressure), often with bradycardia (slowed heart rate), caused by disruption of autonomic nervous system pathways.

See Sepsis and Neurogenic shock

Neuromuscular-blocking drug

Neuromuscular-blocking drugs, or Neuromuscular blocking agents (NMBAs), block transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles.

See Sepsis and Neuromuscular-blocking drug

Neutrophil

Neutrophils (also known as neutrocytes, heterophils or polymorphonuclear leukocytes) are a type of white blood cell.

See Sepsis and Neutrophil

NF-κB

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a family of transcription factor protein complexes that controls transcription of DNA, cytokine production and cell survival.

See Sepsis and NF-κB

Nitric oxide

Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula.

See Sepsis and Nitric oxide

NOD-like receptor

The nucleotide-binding oligomerization domain-like receptors, or NOD-like receptors (NLRs) (also known as nucleotide-binding leucine-rich repeat receptors), are intracellular sensors of pathogen-associated molecular patterns (PAMPs) that enter the cell via phagocytosis or pores, and damage-associated molecular patterns (DAMPs) that are associated with cell stress.

See Sepsis and NOD-like receptor

Norepinephrine (medication)

Norepinephrine, also known as noradrenaline, is a medication used to treat people with very low blood pressure. Sepsis and Norepinephrine (medication) are intensive care medicine.

See Sepsis and Norepinephrine (medication)

NPR

National Public Radio (NPR, stylized as npr) is an American public broadcasting organization headquartered in Washington, D.C., with its NPR West headquarters in Culver City, California.

See Sepsis and NPR

Omega-3 fatty acid

Omega−3 fatty acids, also called Omega−3 oils, ω−3 fatty acids, Ω-3 Fatty acids or n−3 fatty acids, are polyunsaturated fatty acids (PUFAs) characterized by the presence of a double bond three atoms away from the terminal methyl group in their chemical structure.

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Organ (biology)

In a multicellular organism, an organ is a collection of tissues joined in a structural unit to serve a common function.

See Sepsis and Organ (biology)

Organ dysfunction

Organ dysfunction is a condition where an organ does not perform its expected function.

See Sepsis and Organ dysfunction

Oxygen saturation

Oxygen saturation (symbol SO2) is a relative measure of the concentration of oxygen that is dissolved or carried in a given medium as a proportion of the maximal concentration that can be dissolved in that medium at the given temperature.

See Sepsis and Oxygen saturation

Oxygen saturation (medicine)

Oxygen saturation is the fraction of oxygen-saturated haemoglobin relative to total haemoglobin (unsaturated + saturated) in the blood.

See Sepsis and Oxygen saturation (medicine)

Packed red blood cells

Packed red blood cells, also known as packed cells, are red blood cells that have been separated for blood transfusion.

See Sepsis and Packed red blood cells

Pain

Pain is a distressing feeling often caused by intense or damaging stimuli.

See Sepsis and Pain

Pancreatitis

Pancreatitis is a condition characterized by inflammation of the pancreas.

See Sepsis and Pancreatitis

Parasitic disease

A parasitic disease, also known as parasitosis, is an infectious disease caused by parasites.

See Sepsis and Parasitic disease

Parenteral nutrition

Parenteral nutrition (PN) is the feeding of nutritional products to a person intravenously, bypassing the usual process of eating and digestion. Sepsis and Parenteral nutrition are intensive care medicine.

See Sepsis and Parenteral nutrition

Pathogen-associated molecular pattern

Pathogen-associated molecular patterns (PAMPs) are small molecular motifs conserved within a class of microbes, but not present in the host.

See Sepsis and Pathogen-associated molecular pattern

Pathogenic bacteria

Pathogenic bacteria are bacteria that can cause disease.

See Sepsis and Pathogenic bacteria

Pattern recognition receptor

Pattern recognition receptors (PRRs) play a crucial role in the proper function of the innate immune system.

See Sepsis and Pattern recognition receptor

Paul E. Marik

Paul Ellis Marik (born March 26, 1958) is an American physician and former professor of medicine who until his resignation in January 2022 served as chair of the Division of Pulmonary and Critical Care Medicine at Eastern Virginia Medical School in Norfolk, Virginia, and was also a critical care doctor at Sentara Norfolk General Hospital.

See Sepsis and Paul E. Marik

Peptic ulcer disease

Peptic ulcer disease is a break in the inner lining of the stomach, the first part of the small intestine, or sometimes the lower esophagus.

See Sepsis and Peptic ulcer disease

Peptidoglycan

Peptidoglycan or murein is a unique large macromolecule, a polysaccharide, consisting of sugars and amino acids that forms a mesh-like layer (sacculus) that surrounds the bacterial cytoplasmic membrane.

See Sepsis and Peptidoglycan

Percutaneous

In surgery, a percutaneous procedure is any medical procedure or method where access to inner organs or other tissue is done via needle-puncture of the skin, rather than by using an "open" approach where inner organs or tissue are exposed (typically with the use of a scalpel).

See Sepsis and Percutaneous

Petechia

A petechia (petechiae) is a small red or purple spot (≤4 mm in diameter) that can appear on the skin, conjunctiva, retina, and mucous membranes which is caused by haemorrhage of capillaries.

See Sepsis and Petechia

Phenotypic plasticity

Phenotypic plasticity refers to some of the changes in an organism's behavior, morphology and physiology in response to a unique environment.

See Sepsis and Phenotypic plasticity

Plasmodium

Plasmodium is a genus of unicellular eukaryotes that are obligate parasites of vertebrates and insects.

See Sepsis and Plasmodium

Plateau pressure

Plateau pressure (PPLAT) is the pressure applied to small airways and alveoli during positive-pressure mechanical ventilation.

See Sepsis and Plateau pressure

Platelet

Platelets or thrombocytes are a blood component whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot.

See Sepsis and Platelet

Pneumococcal vaccine

Pneumococcal vaccines are vaccines against the bacterium Streptococcus pneumoniae.

See Sepsis and Pneumococcal vaccine

Pneumonia

Pneumonia is an inflammatory condition of the lung primarily affecting the small air sacs known as alveoli.

See Sepsis and Pneumonia

Point of care

Clinical point of care (POC) is the point in time when clinicians deliver healthcare products and services to patients at the time of care.

See Sepsis and Point of care

Polymerase chain reaction

The polymerase chain reaction (PCR) is a method widely used to make millions to billions of copies of a specific DNA sample rapidly, allowing scientists to amplify a very small sample of DNA (or a part of it) sufficiently to enable detailed study.

See Sepsis and Polymerase chain reaction

Polytrauma

Polytrauma and multiple trauma are medical terms describing the condition of a person who has been subjected to multiple traumatic injuries, such as a serious head injury in addition to a serious burn. Sepsis and Polytrauma are medical emergencies.

See Sepsis and Polytrauma

Positive end-expiratory pressure

Positive end-expiratory pressure (PEEP) is the pressure in the lungs (alveolar pressure) above atmospheric pressure (the pressure outside of the body) that exists at the end of expiration. Sepsis and Positive end-expiratory pressure are intensive care medicine.

See Sepsis and Positive end-expiratory pressure

Pressure ulcer

Pressure ulcers, also known as pressure sores, bed sores or pressure injuries, are localised damage to the skin and/or underlying tissue that usually occur over a bony prominence as a result of usually long-term pressure, or pressure in combination with shear or friction.

See Sepsis and Pressure ulcer

Procalcitonin

Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin, the latter being involved with calcium homeostasis.

See Sepsis and Procalcitonin

Prokinetic agent

A prokinetic agent (also prokineticin, gastroprokinetic agent, gastrokinetic agent or propulsive) is a type of small peptide drug which enhances gastrointestinal motility by increasing the frequency or strength of contractions, but without disrupting their rhythm.

See Sepsis and Prokinetic agent

Protein C

Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, is a zymogen, that is, an inactive enzyme.

See Sepsis and Protein C

Proteus (bacterium)

Proteus is a genus of Gram-negative bacteria.

See Sepsis and Proteus (bacterium)

Prothrombin time

The prothrombin time (PT) – along with its derived measures of prothrombin ratio (PR) and international normalized ratio (INR) – is an assay for evaluating the extrinsic pathway and common pathway of coagulation.

See Sepsis and Prothrombin time

Proton-pump inhibitor

Proton-pump inhibitors (PPIs) are a class of medications that cause a profound and prolonged reduction of stomach acid production.

See Sepsis and Proton-pump inhibitor

Pseudomonas aeruginosa

Pseudomonas aeruginosa is a common encapsulated, Gram-negative, aerobic–facultatively anaerobic, rod-shaped bacterium that can cause disease in plants and animals, including humans.

See Sepsis and Pseudomonas aeruginosa

Pulmonary edema

Pulmonary edema (British English: oedema), also known as pulmonary congestion, is excessive fluid accumulation in the tissue or air spaces (usually alveoli) of the lungs. Sepsis and pulmonary edema are medical emergencies.

See Sepsis and Pulmonary edema

Pulmonary embolism

Pulmonary embolism (PE) is a blockage of an artery in the lungs by a substance that has moved from elsewhere in the body through the bloodstream (embolism). Sepsis and Pulmonary embolism are medical emergencies.

See Sepsis and Pulmonary embolism

Pulse pressure

Pulse pressure is the difference between systolic and diastolic blood pressure.

See Sepsis and Pulse pressure

Purpura

Purpura is a condition of red or purple discolored spots on the skin that do not blanch on applying pressure.

See Sepsis and Purpura

Purpura fulminans

Purpura fulminans is an acute, often fatal, thrombotic disorder which manifests as blood spots, bruising and discolouration of the skin resulting from coagulation in small blood vessels within the skin and rapidly leads to skin necrosis and disseminated intravascular coagulation.

See Sepsis and Purpura fulminans

Pus

Pus is an exudate, typically white-yellow, yellow, or yellow-brown, formed at the site of inflammation during infections, regardless of cause.

See Sepsis and Pus

Pyelonephritis

Pyelonephritis is inflammation of the kidney, typically due to a bacterial infection.

See Sepsis and Pyelonephritis

QT interval

The QT interval is a measurement made on an electrocardiogram used to assess some of the electrical properties of the heart.

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Quinolone antibiotic

Quinolone antibiotics constitute a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone.

See Sepsis and Quinolone antibiotic

Recombinant DNA

Recombinant DNA (rDNA) molecules are DNA molecules formed by laboratory methods of genetic recombination (such as molecular cloning) that bring together genetic material from multiple sources, creating sequences that would not otherwise be found in the genome.

See Sepsis and Recombinant DNA

Regulatory T cell

The regulatory T cells (Tregs or Treg cells), formerly known as suppressor T cells, are a subpopulation of T cells that modulate the immune system, maintain tolerance to self-antigens, and prevent autoimmune disease.

See Sepsis and Regulatory T cell

Renal replacement therapy

Renal replacement therapy (RRT) is therapy that replaces the normal blood-filtering function of the kidneys.

See Sepsis and Renal replacement therapy

Respiratory alkalosis

Respiratory alkalosis is a medical condition in which increased respiration elevates the blood pH beyond the normal range (7.35–7.45) with a concurrent reduction in arterial levels of carbon dioxide.

See Sepsis and Respiratory alkalosis

Respiratory disease

Respiratory diseases, or lung diseases, are pathological conditions affecting the organs and tissues that make gas exchange difficult in air-breathing animals.

See Sepsis and Respiratory disease

Respiratory failure

Respiratory failure results from inadequate gas exchange by the respiratory system, meaning that the arterial oxygen, carbon dioxide, or both cannot be kept at normal levels. Sepsis and respiratory failure are intensive care medicine and medical emergencies.

See Sepsis and Respiratory failure

Respiratory rate

The respiratory rate is the rate at which breathing occurs; it is set and controlled by the respiratory center of the brain.

See Sepsis and Respiratory rate

Review

A review is an evaluation of a publication, product, service, or company or a critical take on current affairs in literature, politics or culture.

See Sepsis and Review

Richard Friedrich Johannes Pfeiffer

Richard Friedrich Johannes Pfeiffer FRS (27 March 1858 – 15 September 1945) was a German physician and bacteriologist.

See Sepsis and Richard Friedrich Johannes Pfeiffer

RIG-I-like receptor

RIG-I-like receptors (retinoic acid-inducible gene-I-like receptors, RLRs) are a type of intracellular pattern recognition receptor involved in the recognition of viruses by the innate immune system.

See Sepsis and RIG-I-like receptor

Schistosoma

Schistosoma is a genus of trematodes, commonly known as blood flukes.

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Science by press conference

Science by press conference or science by press release is the practice by which scientists put an unusual focus on publicizing results of research in the news media via press conferences or press releases.

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Sensitivity and specificity

In medicine and statistics, sensitivity and specificity mathematically describe the accuracy of a test that reports the presence or absence of a medical condition.

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Sepsis Alliance

Sepsis Alliance is a non-profit organization dedicated to raising awareness of sepsis.

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Sepsis Six

The Sepsis Six is the name given to a bundle of medical therapies designed to reduce mortality in patients with sepsis.

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Septic shock

Septic shock is a potentially fatal medical condition that occurs when sepsis, which is organ injury or damage in response to infection, leads to dangerously low blood pressure and abnormalities in cellular metabolism. Sepsis and Septic shock are intensive care medicine and medical emergencies.

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Shock (circulatory)

Shock is the state of insufficient blood flow to the tissues of the body as a result of problems with the circulatory system. Sepsis and Shock (circulatory) are intensive care medicine and medical emergencies.

See Sepsis and Shock (circulatory)

Society of Critical Care Medicine

The Society of Critical Care Medicine (SCCM) is the largest non-profit medical organization in the practice of critical care.

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Sodium bicarbonate

Sodium bicarbonate (IUPAC name: sodium hydrogencarbonate), commonly known as baking soda or bicarbonate of soda, is a chemical compound with the formula NaHCO3.

See Sepsis and Sodium bicarbonate

SOFA score

The sequential organ failure assessment score (SOFA score), previously known as the sepsis-related organ failure assessment score, is used to track a person's status during the stay in an intensive care unit (ICU) to determine the extent of a person's organ function or rate of failure.

See Sepsis and SOFA score

Soluble urokinase plasminogen activator receptor

Soluble urokinase plasminogen activator receptor (suPAR) (NCBI Accession no. AAK31795) is a protein and the soluble form of uPAR.

See Sepsis and Soluble urokinase plasminogen activator receptor

Spontaneous breathing trial

A spontaneous breathing trial is a test for patients on mechanical ventilation, before they can be weaned from the ventilator, i.e. return to normal breathing.

See Sepsis and Spontaneous breathing trial

Staphylococcus

Staphylococcus is a genus of Gram-positive bacteria in the family Staphylococcaceae from the order Bacillales.

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Staphylococcus aureus

Staphylococcus aureus is a gram-positive spherically shaped bacterium, a member of the Bacillota, and is a usual member of the microbiota of the body, frequently found in the upper respiratory tract and on the skin.

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Steroid

A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration.

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Streptococcus pneumoniae

Streptococcus pneumoniae, or pneumococcus, is a Gram-positive, spherical bacteria, alpha-hemolytic member of the genus Streptococcus.

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Streptococcus pyogenes

Streptococcus pyogenes is a species of Gram-positive, aerotolerant bacteria in the genus Streptococcus.

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Stress ulcer

A stress ulcer is a single or multiple mucosal defect usually caused by physiological (not psychological) stress which can become complicated by upper gastrointestinal bleeding. Sepsis and stress ulcer are intensive care medicine.

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Stroke volume

In cardiovascular physiology, stroke volume (SV) is the volume of blood pumped from the ventricle per beat.

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Superantigen

Superantigens (SAgs) are a class of antigens that result in excessive activation of the immune system.

See Sepsis and Superantigen

Superior vena cava

The superior vena cava (SVC) is the superior of the two venae cavae, the great venous trunks that return deoxygenated blood from the systemic circulation to the right atrium of the heart.

See Sepsis and Superior vena cava

Surviving Sepsis Campaign

The Surviving Sepsis Campaign (SSC) is a global initiative to bring together professional organizations in reducing mortality from sepsis. Sepsis and Surviving Sepsis Campaign are intensive care medicine.

See Sepsis and Surviving Sepsis Campaign

Systematic review

A systematic review is a scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic.

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Systemic inflammatory response syndrome

In immunology, systemic inflammatory response syndrome (SIRS) is an inflammatory state affecting the whole body. Sepsis and systemic inflammatory response syndrome are intensive care medicine.

See Sepsis and Systemic inflammatory response syndrome

T helper cell

The T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells, are a type of T cell that play an important role in the adaptive immune system.

See Sepsis and T helper cell

T-cell receptor

The T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.

See Sepsis and T-cell receptor

Tachycardia

Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate.

See Sepsis and Tachycardia

Tachypnea

Tachypnea, also spelt tachypnoea, is a respiratory rate greater than normal, resulting in abnormally rapid and shallow breathing.

See Sepsis and Tachypnea

Teicoplanin

Teicoplanin is an semisynthetic glycopeptide antibiotic with a spectrum of activity similar to vancomycin.

See Sepsis and Teicoplanin

The Merck Manuals

The Merck Manuals (outside the U.S. and Canada: The MSD Manuals) are medical references published by the American pharmaceutical company Merck & Co. (known as MSD outside the United States and Canada), that cover a wide range of medical topics, including disorders, tests, diagnoses, and drugs.

See Sepsis and The Merck Manuals

Therapeutic drug monitoring

Therapeutic drug monitoring (TDM) is a branch of clinical chemistry and clinical pharmacology that specializes in the measurement of medication levels in blood.

See Sepsis and Therapeutic drug monitoring

Thermoregulation

Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different.

See Sepsis and Thermoregulation

Thiamine

Thiamine, also known as thiamin and vitamin B1, is a vitamin, an essential micronutrient for humans and animals.

See Sepsis and Thiamine

Thrombosis

Thrombosis is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.

See Sepsis and Thrombosis

Tidal volume

Tidal volume (symbol VT or TV) is the volume of air inspired and expired with each passive breath.

See Sepsis and Tidal volume

Toll-like receptor

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system.

See Sepsis and Toll-like receptor

Torsades de pointes

Torsades de pointes, torsade de pointes or torsades des pointes (TdP; also called torsades) (translated as "twisting of peaks") is a specific type of abnormal heart rhythm that can lead to sudden cardiac death.

See Sepsis and Torsades de pointes

Toxin

A toxin is a naturally occurring poison produced by metabolic activities of living cells or organisms.

See Sepsis and Toxin

Triazole

A triazole is a heterocyclic compound featuring a five-membered ring of two carbon atoms and three nitrogen atoms with molecular formula C2H3N3.

See Sepsis and Triazole

Troponin

s2cid.

See Sepsis and Troponin

Tumor necrosis factor

Tumor necrosis factor (TNF, cachexin, or cachectin; formerly known as tumor necrosis factor alpha, TNFα or TNF-α) is a cytokine and member of the TNF superfamily, which consists of various transmembrane proteins with a homologous TNF domain.

See Sepsis and Tumor necrosis factor

U.S. state

In the United States, a state is a constituent political entity, of which there are 50.

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Ubi pus, ibi evacua

is a Latin aphorism or adage, often cited in medicine, meaning "where pus, there evacuate ". It refers to what clinicians should do when there is a collection of pus in the body; that is, to create an opening for it to evacuate.

See Sepsis and Ubi pus, ibi evacua

United Kingdom

The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Northwestern Europe, off the coast of the continental mainland.

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United States

The United States of America (USA or U.S.A.), commonly known as the United States (US or U.S.) or America, is a country primarily located in North America.

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United States National Library of Medicine

The United States National Library of Medicine (NLM), operated by the United States federal government, is the world's largest medical library.

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Upper gastrointestinal bleeding

Upper gastrointestinal bleeding (UGIB) is gastrointestinal bleeding in the upper gastrointestinal tract, commonly defined as bleeding arising from the esophagus, stomach, or duodenum. Sepsis and upper gastrointestinal bleeding are medical emergencies.

See Sepsis and Upper gastrointestinal bleeding

Urinary system

The human urinary system, also known as the urinary tract or renal system, consists of the kidneys, ureters, bladder, and the urethra.

See Sepsis and Urinary system

Vaccination

Vaccination is the administration of a vaccine to help the immune system develop immunity from a disease.

See Sepsis and Vaccination

Vancomycin

Vancomycin is a glycopeptide antibiotic medication used to treat a number of bacterial infections.

See Sepsis and Vancomycin

Vascular resistance

Vascular resistance is the resistance that must be overcome for blood to flow through the circulatory system.

See Sepsis and Vascular resistance

Vasoconstriction

Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, in particular the large arteries and small arterioles.

See Sepsis and Vasoconstriction

Vasodilation

Vasodilation, also known as vasorelaxation, is the widening of blood vessels.

See Sepsis and Vasodilation

Vasopressin

Human vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized from the AVP gene as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP.

See Sepsis and Vasopressin

Venous thrombosis

Venous thrombosis is the blockage of a vein caused by a thrombus (blood clot).

See Sepsis and Venous thrombosis

Vibrio cholerae

Vibrio cholerae is a species of Gram-negative, facultative anaerobe and comma-shaped bacteria.

See Sepsis and Vibrio cholerae

Viral disease

A viral disease (or viral infection) occurs when an organism's body is invaded by pathogenic viruses, and infectious virus particles (virions) attach to and enter susceptible cells.

See Sepsis and Viral disease

Viremia

Viremia is a medical condition where viruses enter the bloodstream and hence have access to the rest of the body.

See Sepsis and Viremia

Virulence factor

Virulence factors (preferably known as pathogenicity factors or effectors in botany) are cellular structures, molecules and regulatory systems that enable microbial pathogens (bacteria, viruses, fungi, and protozoa) to achieve the following.

See Sepsis and Virulence factor

Virus

A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism.

See Sepsis and Virus

Vitamin C

Vitamin C (also known as ascorbic acid and ascorbate) is a water-soluble vitamin found in citrus and other fruits, berries and vegetables.

See Sepsis and Vitamin C

Volume expander

A volume expander is a type of intravenous therapy that has the function of providing volume for the circulatory system.

See Sepsis and Volume expander

Volume overload

Volume overload refers to the state of one of the chambers of the heart in which too large a volume of blood exists within it for it to function efficiently.

See Sepsis and Volume overload

White blood cell

White blood cells (scientific name leukocytes), also called immune cells or immunocytes, are cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.

See Sepsis and White blood cell

Wiley (publisher)

John Wiley & Sons, Inc., commonly known as Wiley, is an American multinational publishing company that focuses on academic publishing and instructional materials.

See Sepsis and Wiley (publisher)

Yeast

Yeasts are eukaryotic, single-celled microorganisms classified as members of the fungus kingdom.

See Sepsis and Yeast

See also

Causes of amputation

References

[1] https://en.wikipedia.org/wiki/Sepsis

Also known as Bacterial sepsis, Blood poisoning, Blood-poisoning, Candida septicaemia, Epidemiology of sepsis, Gonococcal septicaemia affecting skin, Sepsis-induced hypotension, Septacemia, Septasemia, Septecemia, Septicaemia, Septicaemia affecting skin, Septicemia, Septicemias, Septicimia, Severe sepsis, Streptococcal septicaemia, Viral sepsis, Wound fever.

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