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Biological plausibility

Index Biological plausibility

In epidemiology and biomedicine, the term biological plausibility refers to the proposal of a causal association — a relationship between a putative cause and an outcome — that is consistent with existing biological and medical knowledge. [1]

24 relations: Alternative medicine, Austin Bradford Hill, Biomedicine, Biopharmaceutical, Bradford Hill criteria, Canadian Medical Association Journal, Case report, Case series, Chimney sweep, Clinical trial, Dr. Watson, Drug, English people, Epidemiology, Journal of the Royal Society of Medicine, Op. cit., Percivall Pott, Randomized controlled trial, Rubella, Sherlock Holmes, Smoking and Health: Report of the Advisory Committee to the Surgeon General of the United States, Typhus, Vaccine controversies, Vermin.

Alternative medicine

Alternative medicine, fringe medicine, pseudomedicine or simply questionable medicine is the use and promotion of practices which are unproven, disproven, impossible to prove, or excessively harmful in relation to their effect — in the attempt to achieve the healing effects of medicine.--> --> --> They differ from experimental medicine in that the latter employs responsible investigation, and accepts results that show it to be ineffective. The scientific consensus is that alternative therapies either do not, or cannot, work. In some cases laws of nature are violated by their basic claims; in some the treatment is so much worse that its use is unethical. Alternative practices, products, and therapies range from only ineffective to having known harmful and toxic effects.--> Alternative therapies may be credited for perceived improvement through placebo effects, decreased use or effect of medical treatment (and therefore either decreased side effects; or nocebo effects towards standard treatment),--> or the natural course of the condition or disease. Alternative treatment is not the same as experimental treatment or traditional medicine, although both can be misused in ways that are alternative. Alternative or complementary medicine is dangerous because it may discourage people from getting the best possible treatment, and may lead to a false understanding of the body and of science.-->---> Alternative medicine is used by a significant number of people, though its popularity is often overstated.--> Large amounts of funding go to testing alternative medicine, with more than US$2.5 billion spent by the United States government alone.--> Almost none show any effect beyond that of false treatment,--> and most studies showing any effect have been statistical flukes. Alternative medicine is a highly profitable industry, with a strong lobby. This fact is often overlooked by media or intentionally kept hidden, with alternative practice being portrayed positively when compared to "big pharma". --> The lobby has successfully pushed for alternative therapies to be subject to far less regulation than conventional medicine.--> Alternative therapies may even be allowed to promote use when there is demonstrably no effect, only a tradition of use. Regulation and licensing of alternative medicine and health care providers varies between and within countries. Despite laws making it illegal to market or promote alternative therapies for use in cancer treatment, many practitioners promote them.--> Alternative medicine is criticized for taking advantage of the weakest members of society.--! Terminology has shifted over time, reflecting the preferred branding of practitioners.. Science Based Medicine--> For example, the United States National Institutes of Health department studying alternative medicine, currently named National Center for Complementary and Integrative Health, was established as the Office of Alternative Medicine and was renamed the National Center for Complementary and Alternative Medicine before obtaining its current name. Therapies are often framed as "natural" or "holistic", in apparent opposition to conventional medicine which is "artificial" and "narrow in scope", statements which are intentionally misleading. --> When used together with functional medical treatment, alternative therapies do not "complement" (improve the effect of, or mitigate the side effects of) treatment.--> Significant drug interactions caused by alternative therapies may instead negatively impact functional treatment, making it less effective, notably in cancer.--> Alternative diagnoses and treatments are not part of medicine, or of science-based curricula in medical schools, nor are they used in any practice based on scientific knowledge or experience.--> Alternative therapies are often based on religious belief, tradition, superstition, belief in supernatural energies, pseudoscience, errors in reasoning, propaganda, fraud, or lies.--> Alternative medicine is based on misleading statements, quackery, pseudoscience, antiscience, fraud, and poor scientific methodology. Promoting alternative medicine has been called dangerous and unethical.--> Testing alternative medicine that has no scientific basis has been called a waste of scarce research resources.--> Critics state that "there is really no such thing as alternative medicine, just medicine that works and medicine that doesn't",--> that the very idea of "alternative" treatments is paradoxical, as any treatment proven to work is by definition "medicine".-->.

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Austin Bradford Hill

Sir Austin Bradford Hill FRS (8 July 1897 – 18 April 1991), English epidemiologist and statistician, pioneered the randomized clinical trial and, together with Richard Doll, demonstrated the connection between cigarette smoking and lung cancer.

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Biomedicine

Biomedicine (i.e. medical biology) is a branch of medical science that applies biological and physiological principles to clinical practice.

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Biopharmaceutical

A biopharmaceutical, also known as a biologic(al) medical product, biological, or biologic, is any pharmaceutical drug product manufactured in, extracted from, or semisynthesized from biological sources.

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Bradford Hill criteria

The Bradford Hill criteria, otherwise known as Hill's criteria for causation, are a group of 9 principles, established in 1965 by the English epidemiologist Sir Austin Bradford Hill.

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Canadian Medical Association Journal

The Canadian Medical Association Journal (French Journal de l'Association Médicale Canadienne) is a peer-reviewed general medical journal published by the Canadian Medical Association (CMA).

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Case report

In medicine, a case report is a detailed report of the symptoms, signs, diagnosis, treatment, and follow-up of an individual patient.

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Case series

A case series (also known as a clinical series) is a type of medical research study that tracks subjects with a known exposure, such as patients who have received a similar treatment, or examines their medical records for exposure and outcome.

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Chimney sweep

A chimney sweep is a person who clears ash and soot from chimneys.

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Clinical trial

Clinical trials are experiments or observations done in clinical research.

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Dr. Watson

John H. Watson, known as Dr.

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Drug

A drug is any substance (other than food that provides nutritional support) that, when inhaled, injected, smoked, consumed, absorbed via a patch on the skin, or dissolved under the tongue causes a temporary physiological (and often psychological) change in the body.

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English people

The English are a nation and an ethnic group native to England who speak the English language. The English identity is of early medieval origin, when they were known in Old English as the Angelcynn ("family of the Angles"). Their ethnonym is derived from the Angles, one of the Germanic peoples who migrated to Great Britain around the 5th century AD. England is one of the countries of the United Kingdom, and the majority of people living there are British citizens. Historically, the English population is descended from several peoples the earlier Celtic Britons (or Brythons) and the Germanic tribes that settled in Britain following the withdrawal of the Romans, including Angles, Saxons, Jutes and Frisians. Collectively known as the Anglo-Saxons, they founded what was to become England (from the Old English Englaland) along with the later Danes, Anglo-Normans and other groups. In the Acts of Union 1707, the Kingdom of England was succeeded by the Kingdom of Great Britain. Over the years, English customs and identity have become fairly closely aligned with British customs and identity in general. Today many English people have recent forebears from other parts of the United Kingdom, while some are also descended from more recent immigrants from other European countries and from the Commonwealth. The English people are the source of the English language, the Westminster system, the common law system and numerous major sports such as cricket, football, rugby union, rugby league and tennis. These and other English cultural characteristics have spread worldwide, in part as a result of the former British Empire.

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Epidemiology

Epidemiology is the study and analysis of the distribution (who, when, and where) and determinants of health and disease conditions in defined populations.

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Journal of the Royal Society of Medicine

The Journal of the Royal Society of Medicine is an open peer-reviewed medical journal.

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Op. cit.

Op.

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Percivall Pott

Percivall Pott (6 January 1714 in London – 22 December 1788) was an English surgeon, one of the founders of orthopedics, and the first scientist to demonstrate that a cancer may be caused by an environmental carcinogen.

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Randomized controlled trial

A randomized controlled trial (or randomized control trial; RCT) is a type of scientific (often medical) experiment which aims to reduce bias when testing a new treatment.

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Rubella

Rubella, also known as German measles or three-day measles, is an infection caused by the rubella virus.

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Sherlock Holmes

Sherlock Holmes is a fictional private detective created by British author Sir Arthur Conan Doyle.

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Smoking and Health: Report of the Advisory Committee to the Surgeon General of the United States

Smoking and Health: Report of the Advisory Committee to the Surgeon General of the United States was a landmark report published on January 11, 1964 by the Surgeon General's Advisory Committee on Smoking and Health, chaired by then-Surgeon General of the United States Luther Terry regarding the negative health effects of tobacco smoking.

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Typhus

Typhus, also known as typhus fever, is a group of infectious diseases that include epidemic typhus, scrub typhus and murine typhus.

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Vaccine controversies

Vaccine controversies have occurred since almost 80 years before the terms vaccine and vaccination were introduced, and continue to this day.

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Vermin

Vermin (colloquially varmint or varmit) are pests or nuisance animals, that spread diseases or destroy crops or livestock.

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Biologically plausible.

References

[1] https://en.wikipedia.org/wiki/Biological_plausibility

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