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34 relations: AA amyloidosis, Anakinra, Arthralgia, Arthritis, Canakinumab, Caspase 1, Cataract, Cold urticaria, Conjunctivitis, Corneal endothelium, Epileptic seizure, Glaucoma, Headache, Hearing loss, Hives, Hydrocephalus, Inflammasome, Interleukin 1 beta, Interleukin 18, Interleukin-1 family, Keratoendotheliitis fugax hereditaria, Maculopapular rash, Meningitis, Muckle–Wells syndrome, Myalgia, NALP3, Neonatal-onset multisystem inflammatory disease, Osteolysis, Papilledema, Periodic fever syndrome, Rilonacept, Thalidomide, Tocilizumab, Uveitis.
AA amyloidosis
AA amyloidosis is a form of amyloidosis, a disease characterized by the abnormal deposition of fibers of insoluble protein in the extracellular space of various tissues and organs.
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Anakinra
Anakinra (brand name Kineret) is a biopharmaceutical drug used to treat rheumatoid arthritis.
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Arthralgia
Arthralgia (from Greek arthro-, joint + -algos, pain) literally means joint pain; it is a symptom of injury, infection, illnesses (in particular arthritis) or an allergic reaction to medication.
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Arthritis
Arthritis is a term often used to mean any disorder that affects joints.
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Canakinumab
Canakinumab (INN, trade name Ilaris, previously ACZ885) is a human monoclonal antibody targeted at interleukin-1 beta.
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Caspase 1
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides.
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Cataract
A cataract is a clouding of the lens in the eye which leads to a decrease in vision.
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Cold urticaria
Cold urticaria (essentially meaning "cold hives") is a disorder where hives (urticaria) or large red welts form on the skin after exposure to a cold stimulus.
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Conjunctivitis
Conjunctivitis, also known as pink eye, is inflammation of the outermost layer of the white part of the eye and the inner surface of the eyelid.
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Corneal endothelium
The corneal endothelium is a single layer of cells on the inner surface of the cornea.
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Epileptic seizure
An epileptic seizure is a brief episode of signs or symptoms due to abnormally excessive or synchronous neuronal activity in the brain.
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Glaucoma
Glaucoma is a group of eye diseases which result in damage to the optic nerve and vision loss.
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Headache
Headache is the symptom of pain anywhere in the region of the head or neck.
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Hearing loss
Hearing loss, also known as hearing impairment, is a partial or total inability to hear.
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Hives
Hives, also known as urticaria, is a kind of skin rash with red, raised, itchy bumps.
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Hydrocephalus
Hydrocephalus is a condition in which there is an accumulation of cerebrospinal fluid (CSF) within the brain.
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Inflammasome
The inflammasome is a multiprotein oligomer responsible for the activation of inflammatory responses.
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Interleukin 1 beta
Interleukin 1 beta (IL1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the IL1B gene.
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Interleukin 18
Interleukin-18 (IL18, also known as interferon-gamma inducing factor) is a protein which in humans is encoded by the IL18 gene.
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Interleukin-1 family
The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults.
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Keratoendotheliitis fugax hereditaria
Keratoendotheliitis fugax hereditaria is an autosomal dominantly inherited disease of the cornea, caused by a point mutation in cryopyrin (also known as NALP3) that in humans is encoded by the NLRP3 gene located on the long arm of chromosome 1.
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Maculopapular rash
A maculopapular rash is a type of rash characterized by a flat, red area on the skin that is covered with small confluent bumps.
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Meningitis
Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges.
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Muckle–Wells syndrome
Muckle–Wells syndrome (MWS), also known as urticaria-deafness-amyloidosis syndrome (UDA), is a rare autosomal dominant disease which causes sensorineural deafness and recurrent hives, and can lead to amyloidosis.
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Myalgia
Myalgia, or muscle pain, is a symptom of many diseases and disorders.
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NALP3
NACHT, LRR and PYD domains-containing protein 3 (NALP3), also known as cryopyrin, is a protein that in humans is encoded by the NLRP3 gene located on the long arm of chromosome 1.
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Neonatal-onset multisystem inflammatory disease
Neonatal-onset multisystem inflammatory disease (abbreviated NOMID, also known as chronic infantile neurologic cutaneous and articular syndrome,James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders.. or CINCA) is a rare genetic periodic fever syndrome which causes uncontrolled inflammation in multiple parts of the body starting in the newborn period.
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Osteolysis
Osteolysis is an active resorption of bone matrix by osteoclasts and can be interpreted as the reverse of ossification.
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Papilledema
Papilledema (or papilloedema) is optic disc swelling that is caused by increased intracranial pressure due to any cause.
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Periodic fever syndrome
Periodic fever syndromes (also known as autoinflammatory diseases or autoinflammatory syndromes) are a set of disorders characterized by recurrent episodes of systemic and organ-specific inflammation.
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Rilonacept
Rilonacept, also known as IL-1 Trap (marketed by Regeneron Pharmaceuticals under the trade name Arcalyst), is an interleukin 1 inhibitor.
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Thalidomide
Thalidomide, sold under the brand name Immunoprin, among others, is an immunomodulatory drug and the prototype of the thalidomide class of drugs.
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Tocilizumab
Tocilizumab, also known as atlizumab, is an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis, a severe form of arthritis in children.
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Uveitis
Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the outer fibrous layer composed of the sclera and cornea.
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References
[1] https://en.wikipedia.org/wiki/Cryopyrin-associated_periodic_syndrome
