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69 relations: AIM2, Anthrax toxin, Apoptosis, Apoptosome, Asbestos, Atherosclerosis, Autoimmunity, Bacteria, Bcl-2, C-terminus, C-type lectin, CARD domain, Caspase 1, Caspase 5, Cholesterol, Cyclic adenosine monophosphate, Cytokine, Dendritic cell, DNA, Enzyme, Flagellin, Glycolysis, Gout, IFI16, IL1A, Immunosuppression, Infection, Influenza A virus, Innate immune system, Interferon gamma, Interferon type I, Interleukin 18, Interleukin 33, Interleukin-1 family, Legionella pneumophila, Leucine-rich repeat, Maitotoxin, MHC class II, Muramyl dipeptide, Myeloid tissue, NALP, NALP3, Natural killer cell, Neisseria gonorrhoeae, NF-κB, Nigericin, NLRC4, NLRP1, NOD-like receptor, Oligomer, ..., Palmitic acid, Pattern recognition receptor, Proinflammatory cytokine, Protein complex, Pseudomonas aeruginosa, PYCARD, Pyrin domain, Pyroptosis, RIG-I-like receptor, RNA, RNTP, Salmonella enterica subsp. enterica, Systemic lupus erythematosus, The FEBS Journal, Toll-like receptor, Type three secretion system, University of Lausanne, Uric acid, Virus. Expand index (19 more) »
AIM2
Interferon-inducible protein AIM2 also known as absent in melanoma 2 or simply AIM2 is a protein that in humans is encoded by the AIM2 gene.
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Anthrax toxin
Anthrax toxin is a three-protein exotoxin secreted by virulent strains of the bacterium, Bacillus anthracis—the causative agent of anthrax.
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Apoptosis
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
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Apoptosome
The apoptosome is a large quaternary protein structure formed in the process of apoptosis.
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Asbestos
Asbestos is a set of six naturally occurring silicate minerals, which all have in common their eponymous asbestiform habit: i.e. long (roughly 1:20 aspect ratio), thin fibrous crystals, with each visible fiber composed of millions of microscopic "fibrils" that can be released by abrasion and other processes.
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Atherosclerosis
Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque.
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Autoimmunity
Autoimmunity is the system of immune responses of an organism against its own healthy cells and tissues.
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Bacteria
Bacteria (common noun bacteria, singular bacterium) is a type of biological cell.
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Bcl-2
Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inducing (pro-apoptotic) or inhibiting (anti-apoptotic) apoptosis.
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C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
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C-type lectin
A C-type lectin (CLEC) is a type of carbohydrate-binding protein domain known as a lectin.
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CARD domain
Caspase recruitment domains, or Caspase activation and recruitment domains (CARDs), are interaction motifs found in a wide array of proteins, typically those involved in processes relating to inflammation and apoptosis.
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Caspase 1
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides.
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Caspase 5
Caspase 5 is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue, and belongs to a family of cysteine proteases called caspases.
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Cholesterol
Cholesterol (from the Ancient Greek chole- (bile) and stereos (solid), followed by the chemical suffix -ol for an alcohol) is an organic molecule.
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Cyclic adenosine monophosphate
Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in many biological processes.
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Cytokine
Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.
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Dendritic cell
Dendritic cells (DCs) are antigen-presenting cells (also known as accessory cells) of the mammalian immune system.
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DNA
Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Flagellin
Flagellin is a globular protein that arranges itself in a hollow cylinder to form the filament in a bacterial flagellum.
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Glycolysis
Glycolysis (from glycose, an older term for glucose + -lysis degradation) is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+.
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Gout
Gout is a form of inflammatory arthritis characterized by recurrent attacks of a red, tender, hot, and swollen joint.
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IFI16
Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.
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IL1A
Interleukin 1 alpha (IL-1α) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is encoded by the IL1A gene.
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Immunosuppression
Immunosuppression is a reduction of the activation or efficacy of the immune system.
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Infection
Infection is the invasion of an organism's body tissues by disease-causing agents, their multiplication, and the reaction of host tissues to the infectious agents and the toxins they produce.
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Influenza A virus
Influenza A virus causes influenza in birds and some mammals, and is the only species of influenza virus A genus of the Orthomyxoviridae family of viruses.
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Innate immune system
The innate immune system, also known as the non-specific immune system or in-born immunity system, is an important subsystem of the overall immune system that comprises the cells and mechanisms involved in the defense of the host from infection by other organisms.
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Interferon gamma
Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class of interferons.
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Interferon type I
Human type I interferons (IFNs) are a large subgroup of interferon proteins that help regulate the activity of the immune system.
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Interleukin 18
Interleukin-18 (IL18, also known as interferon-gamma inducing factor) is a protein which in humans is encoded by the IL18 gene.
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Interleukin 33
Interleukin 33 (IL-33) is a protein that in humans is encoded by the IL33 gene.
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Interleukin-1 family
The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults.
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Legionella pneumophila
Legionella pneumophila is a thin, aerobic, pleomorphic, flagellated, nonspore-forming, Gram-negative bacterium of the genus Legionella.
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Leucine-rich repeat
A leucine-rich repeat (LRR) is a protein structural motif that forms an α/β horseshoe fold.
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Maitotoxin
Maitotoxin (or MTX) is an extremely potent toxin produced by Gambierdiscus toxicus, a dinoflagellate species.
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MHC class II
MHC class II molecules are a class of major histocompatibility complex (MHC) molecules normally found only on antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells.
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Muramyl dipeptide
Muramyl dipeptide is constituent of both Gram-positive and Gram-negative bacteria composed of N-acetylmuramic acid linked by its lactic acid moiety to the N-terminus of an L-alanine D-isoglutamine dipeptide.
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Myeloid tissue
Myeloid tissue, in the bone marrow sense of the word myeloid (myelo- + -oid), is tissue of bone marrow, of bone marrow cell lineage, or resembling bone marrow, and myelogenous tissue (myelo- + -genous) is any tissue of, or arising from, bone marrow; in these senses the terms are usually used synonymously, as for example with chronic myeloid/myelogenous leukemia.
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NALP
NALP is a type of NOD-like receptor.
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NALP3
NACHT, LRR and PYD domains-containing protein 3 (NALP3), also known as cryopyrin, is a protein that in humans is encoded by the NLRP3 gene located on the long arm of chromosome 1.
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Natural killer cell
Natural killer cells or NK cells are a type of cytotoxic lymphocyte critical to the innate immune system.
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Neisseria gonorrhoeae
Neisseria gonorrhoeae, also known as gonococcus (singular), or gonococci (plural) is a species of gram-negative diplococci bacteria isolated by Albert Neisser in 1879.
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NF-κB
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival.
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Nigericin
Nigericin is an antibiotic derived from Streptomyces hygroscopicus.
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NLRC4
NLR family CARD domain-containing protein 4 is a protein that in humans is encoded by the NLRC4 gene.
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NLRP1
NACHT, LRR and PYD domains-containing protein 1 is a protein that in humans is encoded by the NLRP1 gene.
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NOD-like receptor
The nucleotide-binding oligomerization domain-like receptors, in short NOD-like receptors (NLRs), are intracellular sensors of PAMPs that enter the cell via phagocytosis or pores and DAMPs that are associated with cell stress.
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Oligomer
An oligomer (oligo-, "a few" + -mer, "parts") is a molecular complex of chemicals that consists of a few monomer units, in contrast to a polymer, where the number of monomers is, in principle, infinite.
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Palmitic acid
Palmitic acid, or hexadecanoic acid in IUPAC nomenclature, is the most common saturated fatty acid found in animals, plants and microorganisms.
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Pattern recognition receptor
Pattern recognition receptors (PRRs) play a crucial role in the proper function of the innate immune system.
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Proinflammatory cytokine
A proinflammatory cytokine or more simply an inflammatory cytokine is a type of signaling molecule (a cytokine) that is excreted from immune cells like helper T cells (Th) and macrophages, and certain other cell types that promote inflammation.
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Protein complex
A protein complex or multiprotein complex is a group of two or more associated polypeptide chains.
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Pseudomonas aeruginosa
Pseudomonas aeruginosa is a common Gram-negative, rod-shaped bacterium that can cause disease in plants and animals, including humans.
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PYCARD
PYCARD, often referred to as ASC (Apoptosis-associated speck-like protein containing a CARD), is a protein that in humans is encoded by the PYCARD gene.
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Pyrin domain
A pyrin domain is a protein domain and a subclass of protein motif known as the death fold; it allows a pyrin domain containing protein to interact with other proteins that contain a pyrin domain.
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Pyroptosis
Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response.
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RIG-I-like receptor
RIG-I-like receptors (retinoic acid-inducible gene-I-like receptors, or RLRs) are a type of intracellular pattern recognition receptor involved in the recognition of viruses by the innate immune system.
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RNA
Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation, and expression of genes.
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RNTP
A ribonucleoside tri-phosphate (rNTP) is a ribonucleoside with 3 phosphate groups.
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Salmonella enterica subsp. enterica
Salmonella enterica subsp.
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Systemic lupus erythematosus
Systemic lupus erythematosus (SLE), also known simply as lupus, is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body.
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The FEBS Journal
The FEBS Journal is a biweekly peer-reviewed scientific journal published by John Wiley & Sons on behalf of the Federation of European Biochemical Societies.
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Toll-like receptor
Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system.
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Type three secretion system
Type three secretion system (often written Type III secretion system and abbreviated TTSS or T3SS, also called Injectisome) is a protein appendage found in several Gram-negative bacteria.
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University of Lausanne
The University of Lausanne (UNIL, French: Université de Lausanne) in Lausanne, Switzerland was founded in 1537 as a school of theology, before being made a university in 1890.
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Uric acid
Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C5H4N4O3.
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Virus
A virus is a small infectious agent that replicates only inside the living cells of other organisms.
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References
[1] https://en.wikipedia.org/wiki/Inflammasome
