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48 relations: Ambrisentan, Amino acid, Atherosclerosis, Basic research, Blood pressure, Bosentan, BQ-123, BQ-788, Cancer, Cardiovascular disease, Cerebrum, Circulatory system, Clinical research, Convulsion, Dengue fever, Diabetes mellitus type 2, Electrolyte, Endothelial dysfunction, Endothelin 1, Endothelin 2, Endothelin 3, Endothelin receptor, Endothelium, Epilepsy, Gene expression, Hirschsprung's disease, Homeostasis, Hypertension, Insulin resistance, Lateral ventricles, Macitentan, Metabolism, Nitric oxide, OLR1, Pain, Peptide, Pituitary gland, Platelet, Proceedings of the National Academy of Sciences of the United States of America, Protein isoform, Pulmonary hypertension, Receptor (biochemistry), Sitaxentan, Smooth muscle tissue, Subarachnoid hemorrhage, Vasoconstriction, Vasospasm, Ventricular hypertrophy.
Ambrisentan
Ambrisentan (U.S. trade name Letairis; E.U. trade name Volibris; India trade name Pulmonext by MSN labs) is a drug indicated for use in the treatment of pulmonary hypertension.
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Amino acid
Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.
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Atherosclerosis
Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque.
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Basic research
Basic research, also called pure research or fundamental research, has the scientific research aim to improve scientific theories for improved understanding or prediction of natural or other phenomena.
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Blood pressure
Blood pressure (BP) is the pressure of circulating blood on the walls of blood vessels.
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Bosentan
Bosentan is a dual endothelin receptor antagonist used in the treatment of pulmonary artery hypertension (PAH).
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BQ-123
BQ-123 is a cyclic peptide consisting of five amino acids.
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BQ-788
BQ-788 is a selective ETB antagonist.
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
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Cardiovascular disease
Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels.
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Cerebrum
The cerebrum is a large part of the brain containing the cerebral cortex (of the two cerebral hemispheres), as well as several subcortical structures, including the hippocampus, basal ganglia, and olfactory bulb.
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Circulatory system
The circulatory system, also called the cardiovascular system or the vascular system, is an organ system that permits blood to circulate and transport nutrients (such as amino acids and electrolytes), oxygen, carbon dioxide, hormones, and blood cells to and from the cells in the body to provide nourishment and help in fighting diseases, stabilize temperature and pH, and maintain homeostasis.
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Clinical research
Clinical research is a branch of healthcare science that determines the safety and effectiveness (efficacy) of medications, devices, diagnostic products and treatment regimens intended for human use.
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Convulsion
A convulsion is a medical condition where body muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body.
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Dengue fever
Dengue fever is a mosquito-borne tropical disease caused by the dengue virus.
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Diabetes mellitus type 2
Diabetes mellitus type 2 (also known as type 2 diabetes) is a long-term metabolic disorder that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
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Electrolyte
An electrolyte is a substance that produces an electrically conducting solution when dissolved in a polar solvent, such as water.
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Endothelial dysfunction
In vascular diseases, endothelial dysfunction is a systemic pathological state of the endothelium.
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Endothelin 1
Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a potent vasoconstrictor that in humans is encoded by the EDN1 gene and produced by vascular endothelial cells.
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Endothelin 2
Endothelin 2, also known as ET-2, is a protein that in humans is encoded by the EDN2 gene.
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Endothelin 3
Endothelin-3 is a protein that in humans is encoded by the EDN3 gene.
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Endothelin receptor
There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose activation result in elevation of intracellular-free calcium, which constricts the smooth muscles of the blood vessels, raising blood pressure, or relaxes the smooth muscles of the blood vessels, lowering blood pressure, among other functions.
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Endothelium
Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.
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Epilepsy
Epilepsy is a group of neurological disorders characterized by epileptic seizures.
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Gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product.
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Hirschsprung's disease
Hirschsprung's disease (HD or HSCR) is a birth defect in which nerves are missing from parts of the intestine.
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Homeostasis
Homeostasis is the tendency of organisms to auto-regulate and maintain their internal environment in a stable state.
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Hypertension
Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.
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Insulin resistance
Insulin resistance (IR) is a pathological condition in which cells fail to respond normally to the hormone insulin.
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Lateral ventricles
The lateral ventricles are the two largest cavities of the ventricular system of the human brain and contain cerebrospinal fluid (CSF).
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Macitentan
Macitentan (trade name Opsumit) is an endothelin receptor antagonist (ERA) approved for the treatment of pulmonary arterial hypertension (PAH).
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Metabolism
Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.
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Nitric oxide
Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula NO.
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OLR1
Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded by the OLR1 gene.
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Pain
Pain is a distressing feeling often caused by intense or damaging stimuli.
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Peptide
Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.
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Pituitary gland
An explanation of the development of the pituitary gland (Hypophysis cerebri) & the congenital anomalies. In vertebrate anatomy, the pituitary gland, or hypophysis, is an endocrine gland about the size of a pea and weighing in humans.
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Platelet
Platelets, also called thrombocytes (from Greek θρόμβος, "clot" and κύτος, "cell"), are a component of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot.
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Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America (PNAS) is the official scientific journal of the National Academy of Sciences, published since 1915.
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Protein isoform
A protein isoform, or "protein variant" is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.
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Pulmonary hypertension
Pulmonary hypertension (PH or PHTN) is a condition of increased blood pressure within the arteries of the lungs.
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Receptor (biochemistry)
In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.
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Sitaxentan
Sitaxentan sodium (TBC-11251) is a medication for the treatment of pulmonary arterial hypertension (PAH).
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Smooth muscle tissue
Smooth muscle is an involuntary non-striated muscle.
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Subarachnoid hemorrhage
Subarachnoid hemorrhage (SAH) is bleeding into the subarachnoid space—the area between the arachnoid membrane and the pia mater surrounding the brain.
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Vasoconstriction
Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, in particular the large arteries and small arterioles.
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Vasospasm
Vasospasm refers to a condition in which an arterial spasm leads to vasoconstriction.
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Ventricular hypertrophy
Ventricular hypertrophy (VH) is thickening of the walls of a ventricle (lower chamber) of the heart.
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Endothelin-1, Endothelin-2, Endothelin-3, Endothelins.
References
[1] https://en.wikipedia.org/wiki/Endothelin
