29 relations: Allosteric regulation, Bacteriophage, C-terminus, Cell (biology), Clinical trial, Covalent bond, DNA, Elvitegravir, Enzyme, HIV, Human foamy virus, Integrase inhibitor, Lambda phage, Morpheein, N-terminus, Pre-integration complex, Protein, PSIP1, Raltegravir, Retrovirus, Reverse transcriptase, Rous sarcoma virus, SH3 domain, Simian immunodeficiency virus, Site-specific recombinase technology, Site-specific recombination, Tetrameric protein, Transesterification, Unified atomic mass unit.
Allosteric regulation
In biochemistry, allosteric regulation (or allosteric control) is the regulation of an enzyme by binding an effector molecule at a site other than the enzyme's active site.
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Bacteriophage
A bacteriophage, also known informally as a phage, is a virus that infects and replicates within Bacteria and Archaea.
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C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
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Cell (biology)
The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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Covalent bond
A covalent bond, also called a molecular bond, is a chemical bond that involves the sharing of electron pairs between atoms.
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DNA
Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.
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Elvitegravir
Elvitegravir (EVG) is an integrase inhibitor used to treat HIV infection.
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Enzyme
Enzymes are macromolecular biological catalysts.
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HIV
The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).
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Human foamy virus
Human foamy virus (HFV) is a retrovirus and specifically belongs to the genus Spumavirus.
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Integrase inhibitor
Integrase inhibitors (INIs) are a class of antiretroviral drug designed to block the action of integrase, a viral enzyme that inserts the viral genome into the DNA of the host cell.
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Lambda phage
Enterobacteria phage λ (lambda phage, coliphage λ) is a bacterial virus, or bacteriophage, that infects the bacterial species Escherichia coli (E. coli).
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Morpheein
Morpheeins are proteins that can form two or more different homo-oligomers (morpheein forms), but must come apart and change shape to convert between forms.
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N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.
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Pre-integration complex
The pre-integration complex (PIC) is a nucleoprotein complex of viral genetic material and associated viral and host proteins which is capable of inserting a viral genome into a host genome.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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PSIP1
PC4 and SFRS1 interacting protein 1, also known as lens epithelium-derived growth factor (LEDGF/p75), dense fine speckles 70kD protein (DFS 70) or transcriptional coactivator p75/p52, is a protein that in humans is encoded by the PSIP1 gene.
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Raltegravir
Raltegravir (RAL), sold under the brand name Isentress, is an antiretroviral medication used, together with other medication, to treat HIV/AIDS.
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Retrovirus
A retrovirus is a single-stranded positive-sense RNA virus with a DNA intermediate and, as an obligate parasite, targets a host cell.
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Reverse transcriptase
A reverse transcriptase (RT) is an enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription.
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Rous sarcoma virus
Rous sarcoma virus (RSV) is a retrovirus and is the first oncovirus to have been described: it causes sarcoma in chickens.
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SH3 domain
The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues.
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Simian immunodeficiency virus
Simian immunodeficiency viruses (SIVs) are retroviruses that cause persistent infections in at least 45 species of African non-human primates.
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Site-specific recombinase technology
Site-specific recombinase technologies are genome engineering tools that depend on recombinase enzymes to replace targeted sections of DNA.
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Site-specific recombination
Site-specific recombination, also known as conservative site-specific recombination, is a type of genetic recombination in which DNA strand exchange takes place between segments possessing at least a certain degree of sequence homology.
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Tetrameric protein
A tetrameric protein is a protein with a quaternary structure of four subunits (tetrameric).
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Transesterification
In organic chemistry, transesterfication is the process of exchanging the organic group R″ of an ester with the organic group R′ of an alcohol.
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Unified atomic mass unit
The unified atomic mass unit or dalton (symbol: u, or Da) is a standard unit of mass that quantifies mass on an atomic or molecular scale (atomic mass).
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HIV Integrase, HIV integrase, HIV-Integrase, Hiv integrase, Integrases, Retroviral integrase.
References
[1] https://en.wikipedia.org/wiki/Integrase