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41 relations: Acute lymphoblastic leukemia, Acute myeloid leukemia, ASH2L, Atlas of Genetics and Cytogenetics in Oncology and Haematology, C-terminus, Chromatin, Chromosome 11, CREB-binding protein, CTBP1, Embryonic stem cell, Enzyme, Epiblast-derived stem cell, Epigenetics, Exon, Gene, Glutamate decarboxylase, Haematopoiesis, HDAC1, Histone H3, Histone-modifying enzymes, Host cell factor C1, Hox gene, Leukemia, Lysine, MEIS2, MEN1, Methylation, Methyltransferase, N-terminus, PPIE (gene), PPP1R15A, Prefrontal cortex, Protein, Protein–protein interaction, RBBP5, SATB2, Schizophrenia, SET domain, TASP1, Transcription (biology), WDR5.
Acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes.
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Acute myeloid leukemia
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells.
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ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2 is an enzyme that in humans is encoded by the ASH2L gene.
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Atlas of Genetics and Cytogenetics in Oncology and Haematology
The Atlas of Genetics and Cytogenetics in Oncology and Haematology, created in 1997 by Jean-Loup Huret (with bioinformatics by Philippe Dessen) is a collection of resources on genes, chromosomes anomalies, leukemias, solid tumours, and cancer-prone diseases.
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C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
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Chromatin
Chromatin is a complex of macromolecules found in cells, consisting of DNA, protein, and RNA.
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Chromosome 11
Chromosome 11 is one of the 23 pairs of chromosomes in humans.
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CREB-binding protein
CREB-binding protein, also known as CREBBP or CBP, is a protein that in humans is encoded by the CREBBP gene.
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CTBP1
C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene.
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Embryonic stem cell
Embryonic stem cells (ES cells or ESCs) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Epiblast-derived stem cell
After the blastocyst stage, once an embryo implanted in endometrium (in case of rodent), the inner cell mass (ICM) of a fertilized embryo segregates into two layers: hypoblast and epiblast.
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Epigenetics
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence.
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Exon
An exon is any part of a gene that will encode a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Glutamate decarboxylase
Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to GABA and CO2.
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Haematopoiesis
Haematopoiesis (from Greek αἷμα, "blood" and ποιεῖν "to make"; also hematopoiesis in American English; sometimes also haemopoiesis or hemopoiesis) is the formation of blood cellular components.
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HDAC1
Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.
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Histone H3
Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells.
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Histone-modifying enzymes
The packaging of the eukaryotic genome into highly condensed chromatin makes it inaccessible to the factors required for gene transcription, DNA replication, recombination and repair.
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Host cell factor C1
Host cell factor 1 (HCFC1, HCF1, or HCF-1), also known as VP16-accessory protein, is a protein that in humans is encoded by the HCFC1 gene.
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Hox gene
Hox genes, a subset of homeotic genes, are a group of related genes that control the body plan of an embryo along the head-tail axis.
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Leukemia
Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells.
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Lysine
Lysine (symbol Lys or K) is an α-amino acid that is used in the biosynthesis of proteins.
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MEIS2
Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.
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MEN1
Menin is a protein that in humans is encoded by the MEN1 gene.
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Methylation
In the chemical sciences, methylation denotes the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group.
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Methyltransferase
Methyltransferases are a large group of enzymes that all methylate their substrates but can be split into several subclasses based on their structural features.
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N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.
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PPIE (gene)
Peptidylprolyl isomerase E (cyclophilin E), also known as PPIE, is an enzyme which in humans is encoded by the PPIE gene on chromosome 1.
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PPP1R15A
Protein phosphatase 1 regulatory subunit 15A also known as growth arrest and DNA damage-inducible protein GADD34 is a protein that in humans is encoded by the PPP1R15A gene.
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Prefrontal cortex
In mammalian brain anatomy, the prefrontal cortex (PFC) is the cerebral cortex which covers the front part of the frontal lobe.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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RBBP5
Retinoblastoma-binding protein 5 is a protein that in humans is encoded by the RBBP5 gene.
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SATB2
Special AT-rich sequence-binding protein 2 (SATB2) also known as DNA-binding protein SATB2 is a protein that in humans is encoded by the SATB2 gene.
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Schizophrenia
Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand reality.
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SET domain
The SET domain is a protein domain.
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TASP1
Threonine aspartase 1 is an enzyme that in humans is encoded by the TASP1 gene.
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Transcription (biology)
Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.
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WDR5
WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene.
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Redirects here:
ALL-1, HRX, MLL (gene), MLL1, Mixed Lineage Leukemia 1, Mixed-lineage leukemia 1, Mll1, Myeloid/lymphoid or mixed-lineage leukemia, Myeloid/lymphoid or mixed-lineage leukemia 1.
References
[1] https://en.wikipedia.org/wiki/KMT2A
