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33 relations: Aromatase inhibitor, Atrophic vaginitis, Bioavailability, Breast cancer, Clinical trial, Dyspareunia, Estradiol, Estrogen receptor, Estrogen receptor alpha, Estrogen receptor beta, Europe, Food and Drug Administration, IC50, Ligand (biochemistry), Ligand Pharmaceuticals, List of investigational sexual dysfunction drugs, Lithuania, Meta-analysis, Metastatic breast cancer, Nafoxidine, Naphthalene, New Drug Application, Nonsteroidal, Oral administration, Osteoporosis, Ovarian cancer, Pfizer, Portugal, Raloxifene, Selective estrogen receptor modulator, Tamoxifen, Tartrate, United States.
Aromatase inhibitor
Aromatase inhibitors (AIs) are a class of drugs used in the treatment of breast cancer in postmenopausal women and gynecomastia in men.
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Atrophic vaginitis
Atrophic vaginitis is the chronic and progressive inflammation of the vagina (and the lower urinary tract) due to the thinning and shrinking of the vaginal tissues and is often accompanied by vulvar and urinary pathologies.
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Bioavailability
In pharmacology, bioavailability (BA or F) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.
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Breast cancer
Breast cancer is cancer that develops from breast tissue.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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Dyspareunia
Dyspareunia is painful sexual intercourse due to medical or psychological causes.
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Estradiol
Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone.
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Estrogen receptor
Estrogen receptors (ERs) are a group of proteins found inside cells.
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Estrogen receptor alpha
Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen.
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Estrogen receptor beta
Estrogen receptor beta (ER-β), also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2), is one of two main types of estrogen receptor, a nuclear receptor which is activated by the sex hormone estrogen.
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Europe
Europe is a continent located entirely in the Northern Hemisphere and mostly in the Eastern Hemisphere.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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IC50
The half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function.
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Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
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Ligand Pharmaceuticals
Ligand Pharmaceuticals is a biopharmaceutical company based out of San Diego, California that develops programs through a portfolio of assorted strategies and properties in the pharmaceutical industry.
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List of investigational sexual dysfunction drugs
This is a list of investigational sexual dysfunction drugs, or drugs that are currently under development for clinical treatment of sexual dysfunction but are not yet approved.
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Lithuania
Lithuania (Lietuva), officially the Republic of Lithuania (Lietuvos Respublika), is a country in the Baltic region of northern-eastern Europe.
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Meta-analysis
A meta-analysis is a statistical analysis that combines the results of multiple scientific studies.
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Metastatic breast cancer
Metastatic breast cancer, also referred to as metastases, advanced breast cancer, secondary tumours, secondaries or stage 4 breast cancer, is a stage of breast cancer where the disease has spread to distant sites beyond the axillary lymph nodes.
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Nafoxidine
Nafoxidine (INN) (developmental code names U-11,000A, NSC-70735), or nafoxidine hydrochloride (USAN), is a nonsteroidal selective estrogen receptor modulator (SERM) or partial antiestrogen of the triphenylethylene group that was developed for the treatment of advanced breast cancer by Upjohn in the 1970s but was never marketed.
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Naphthalene
Naphthalene is an organic compound with formula.
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New Drug Application
The Food and Drug Administration's New Drug Application (NDA) is the vehicle in the United States through which drug sponsors formally propose that the FDA approve a new pharmaceutical for sale and marketing.
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Nonsteroidal
Nonsteroidal is a term which is used to describe a compound that is not a steroid.
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Oral administration
| name.
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Osteoporosis
Osteoporosis is a disease where increased bone weakness increases the risk of a broken bone.
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Ovarian cancer
Ovarian cancer is a cancer that forms in or on an ovary.
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Pfizer
Pfizer Inc. is an American pharmaceutical conglomerate headquartered in New York City, with its research headquarters in Groton, Connecticut.
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Portugal
Portugal, officially the Portuguese Republic (República Portuguesa),In recognized minority languages of Portugal: Portugal is the oldest state in the Iberian Peninsula and one of the oldest in Europe, its territory having been continuously settled, invaded and fought over since prehistoric times.
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Raloxifene
Raloxifene, developed by Eli Lilly in 1997 and sold under the brand name Evista among others, is a medication which is used in the prevention and treatment of osteoporosis in postmenopausal women and to reduce the risk of breast cancer in postmenopausal women with osteoporosis or at high risk for breast cancer.
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Selective estrogen receptor modulator
Selective estrogen receptor modulators (SERMs) are a class of drugs that act on the estrogen receptor (ER).
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Tamoxifen
Tamoxifen (TMX), sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men.
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Tartrate
A tartrate is a salt or ester of the organic compound tartaric acid, a dicarboxylic acid.
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United States
The United States of America (USA), commonly known as the United States (U.S.) or America, is a federal republic composed of 50 states, a federal district, five major self-governing territories, and various possessions.
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ATC code G03XC03, ATCvet code QG03XC03.
References
[1] https://en.wikipedia.org/wiki/Lasofoxifene
