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Mechanotransduction

Index Mechanotransduction

Mechanotransduction (mechano + transduction) is any of various mechanisms by which cells convert mechanical stimulus into electrochemical activity. [1]

67 relations: Allosteric regulation, Anabolism, Annexin A5, Apoptosis, Auditory system, Autocrine signalling, Balance (ability), Basilar membrane, Biological engineering, Biomechanics, Cartilage, Catabolism, CD44, Cell (biology), Chondrocyte, Cilium, Cochlea, Cytokine, Database of Molecular Motions, Eardrum, Electrochemistry, Extracellular matrix, Fibronectin, Focal adhesion, Fourier transform, Growth factor, Hair cell, Hearing, Integrin, Intrinsically disordered proteins, Ion channel, Kinase, Laminin, Mechanism (biology), Mechanoreceptor, Mechanosensitive channels, Molecular machine, Molecular motor, Neutron spin echo, Organ of Corti, Osteopontin, Oval window, Paracrine signalling, Paxillin, Physiology, Proprioception, Protease, Proteoglycan, PTK2, Receptor potential, ..., Reticular connective tissue, Sense, Sensory neuron, SH2 domain, Signal transducing adaptor protein, Signal transduction, Somatosensory system, Talin protein, Tectorial membrane, Transcription factor, Transduction (physiology), Transforming growth factor beta, Tympanic duct, Type II collagen, Vestibular duct, Vitronectin, Wolff's law. Expand index (17 more) »

Allosteric regulation

In biochemistry, allosteric regulation (or allosteric control) is the regulation of an enzyme by binding an effector molecule at a site other than the enzyme's active site.

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Anabolism

Anabolism (from ἁνά, "upward" and βάλλειν, "to throw") is the set of metabolic pathways that construct molecules from smaller units.

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Annexin A5

Annexin A5 (or annexin V) is a cellular protein in the annexin group.

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Apoptosis

Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.

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Auditory system

The auditory system is the sensory system for the sense of hearing.

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Autocrine signalling

Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine agent) that binds to autocrine receptors on that same cell, leading to changes in the cell.

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Balance (ability)

In biomechanics, balance is an ability to maintain the line of gravity (vertical line from centre of mass) of a body within the base of support with minimal postural sway.

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Basilar membrane

The basilar membrane within the cochlea of the inner ear is a stiff structural element that separates two liquid-filled tubes that run along the coil of the cochlea, the scala media and the scala tympani (see figure).

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Biological engineering

Biological engineering or bio-engineering is the application of principles of biology and the tools of engineering to create usable, tangible, economically viable products.

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Biomechanics

Biomechanics is the study of the structure and function of the mechanical aspects of biological systems, at any level from whole organisms to organs, cells and cell organelles, using the methods of mechanics.

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Cartilage

Cartilage is a resilient and smooth elastic tissue, a rubber-like padding that covers and protects the ends of long bones at the joints, and is a structural component of the rib cage, the ear, the nose, the bronchial tubes, the intervertebral discs, and many other body components.

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Catabolism

Catabolism (from Greek κάτω kato, "downward" and βάλλειν ballein, "to throw") is the set of metabolic pathways that breaks down molecules into smaller units that are either oxidized to release energy or used in other anabolic reactions.

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CD44

The CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration.

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Cell (biology)

The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.

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Chondrocyte

Chondrocytes (from Greek χόνδρος, chondros.

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Cilium

A cilium (the plural is cilia) is an organelle found in eukaryotic cells.

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Cochlea

The cochlea is the part of the inner ear involved in hearing.

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Cytokine

Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.

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Database of Molecular Motions

The Database of Macromolecular Motions is a bioinformatics database and software-as-a-service tool that attempts to categorize macromolecular motions, sometimes also known as conformational change.

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Eardrum

In the anatomy of humans and various other tetrapods, the eardrum, also called the tympanic membrane or myringa, is a thin, cone-shaped membrane that separates the external ear from the middle ear.

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Electrochemistry

Electrochemistry is the branch of physical chemistry that studies the relationship between electricity, as a measurable and quantitative phenomenon, and identifiable chemical change, with either electricity considered an outcome of a particular chemical change or vice versa.

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Extracellular matrix

In biology, the extracellular matrix (ECM) is a collection of extracellular molecules secreted by support cells that provides structural and biochemical support to the surrounding cells.

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Fibronectin

Fibronectin is a high-molecular weight (~440kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins.

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Focal adhesion

In cell biology, focal adhesions (also cell–matrix adhesions or FAs) are large macromolecular assemblies through which mechanical force and regulatory signals are transmitted between the extracellular matrix (ECM) and an interacting cell.

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Fourier transform

The Fourier transform (FT) decomposes a function of time (a signal) into the frequencies that make it up, in a way similar to how a musical chord can be expressed as the frequencies (or pitches) of its constituent notes.

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Growth factor

A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation.

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Hair cell

Hair cells are the sensory receptors of both the auditory system and the vestibular system in the ears of all vertebrates.

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Hearing

Hearing, or auditory perception, is the ability to perceive sounds by detecting vibrations, changes in the pressure of the surrounding medium through time, through an organ such as the ear.

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Integrin

Integrins are transmembrane receptors that facilitate cell-extracellular matrix (ECM) adhesion.

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Intrinsically disordered proteins

An intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure.

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Ion channel

Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore.

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Kinase

In biochemistry, a kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.

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Laminin

Laminins are high-molecular weight (~400 to ~900 kDa) proteins of the extracellular matrix.

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Mechanism (biology)

In the science of biology, a mechanism is a system of causally interacting parts and processes that produce one or more effects.

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Mechanoreceptor

A mechanoreceptor is a sensory receptor that responds to mechanical pressure or distortion.

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Mechanosensitive channels

Mechanosensitive channels, mechanosensitive ion channels or stretch-gated ion channels.

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Molecular machine

A molecular machine, nanite, or nanomachine, refers to any discrete number of molecular components that produce quasi-mechanical movements (output) in response to specific stimuli (input).

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Molecular motor

Molecular motors are biological molecular machines that are the essential agents of movement in living organisms.

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Neutron spin echo

Neutron spin echo spectroscopy is an inelastic neutron scattering technique invented by Ferenc Mezei in the 1970s, and developed in collaboration with John Hayter.

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Organ of Corti

The organ of Corti, or spiral organ, is the receptor organ for hearing and is located in the mammalian cochlea.

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Osteopontin

Osteopontin (OPN), also known as bone sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1).

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Oval window

The oval window (or fenestra vestibuli) is a membrane-covered opening that leads from the middle ear to the vestibule of the inner ear.

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Paracrine signalling

Paracrine signaling is a form of cell-to-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior of those cells.

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Paxillin

Paxillin is a protein that in humans is encoded by the PXN gene.

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Physiology

Physiology is the scientific study of normal mechanisms, and their interactions, which work within a living system.

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Proprioception

Proprioception, from Latin proprius, meaning "one's own", "individual", and capio, capere, to take or grasp, is the sense of the relative position of one's own parts of the body and strength of effort being employed in movement.

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Protease

A protease (also called a peptidase or proteinase) is an enzyme that performs proteolysis: protein catabolism by hydrolysis of peptide bonds.

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Proteoglycan

Proteoglycans are proteins that are heavily glycosylated.

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PTK2

PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene.

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Receptor potential

A receptor potential, also known as a generator potential, a type of graded potential, is the transmembrane potential difference produced by activation of a sensory receptor.

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Reticular connective tissue

Reticular connective tissue is a type of connective tissue with a network of reticular fibers, made of type III collagen (reticulum.

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Sense

A sense is a physiological capacity of organisms that provides data for perception.

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Sensory neuron

Sensory neurons also known as afferent neurons are neurons that convert a specific type of stimulus, via their receptors, into action potentials or graded potentials.

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SH2 domain

The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins.

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Signal transducing adaptor protein

Signal transducing adaptor proteins are proteins that are accessory to main proteins in a signal transduction pathway.

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Signal transduction

Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.

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Somatosensory system

The somatosensory system is a part of the sensory nervous system.

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Talin protein

Talin is a high-molecular-weight cytoskeletal protein concentrated at regions of cell–substratum contact and, in lymphocytes, at cell–cell contacts.

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Tectorial membrane

The tectorial membrane (TM) is one of two acellular membranes in the cochlea of the inner ear, the other being the basilar membrane (BM).

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Transcription factor

In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.

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Transduction (physiology)

In physiology, sensory transduction is the conversion of a sensory stimulus from one form to another.

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Transforming growth factor beta

Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes four different isoforms (TGF-β 1 to 4, HGNC symbols TGFB1, TGFB2, TGFB3, TGFB4) and many other signaling proteins produced by all white blood cell lineages.

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Tympanic duct

The tympanic duct or scala tympani is one of the perilymph-filled cavities in the inner ear of the human.

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Type II collagen

Type II collagen is the basis for articular cartilage and hyaline cartilage, formed by homotrimers of collagen, type II, alpha 1 chains.

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Vestibular duct

The vestibular duct or scala vestibuli is a perilymph-filled cavity inside the cochlea of the inner ear that conducts sound vibrations to the cochlear duct.

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Vitronectin

Vitronectin (VTN or VN) is a glycoprotein of the hemopexin family which is abundantly found in serum, the extracellular matrix and bone.

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Wolff's law

Wolff's law, developed by the German anatomist and surgeon Julius Wolff (1836–1902) in the 19th century, states that bone in a healthy person or animal will adapt to the loads under which it is placed.

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Mechanotransduction, cellular.

References

[1] https://en.wikipedia.org/wiki/Mechanotransduction

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