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162 relations: Acid sphingomyelinase, Active metabolite, Agonist, Agoraphobia, Alcohol dependence, Allopregnanolone, Alpha-1 adrenergic receptor, American Academy of Child and Adolescent Psychiatry, American Psychiatric Association, ANO1, Anorexia nervosa, Anticoagulant, Antidepressant, Antidepressant discontinuation syndrome, Antihistamine, Anxiety, Atomoxetine, Autism, Aviation medical examiner, Barr Pharmaceuticals, Binge eating disorder, Bioavailability, Biological half-life, Boxed warning, Breastfeeding, Bryan Molloy, Bulimia nervosa, Buspirone, Calcium-dependent chloride channel, Cataplexy, Ceramide, Citalopram, Cognitive behavioral therapy, Committee on Safety of Medicines, CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, Cytochrome P450, David Healy (psychiatrist), David T. Wong, Developing country, Dextromethorphan, Diagnostic and Statistical Manual of Mental Disorders, Diarrhea, Diphenhydramine, Dizziness, Donald Klein, ..., Dopamine, Dopamine transporter, Drug interaction, Drug metabolism, Dysthymia, Efficacy, Eli Lilly and Company, Enzyme inhibitor, Epileptic seizure, Escitalopram, Federal Aviation Administration, Florida, Fluvoxamine, Food and Drug Administration, GABAA receptor positive allosteric modulator, Generic drug, Genetic variability, Health system, Histamine H1 receptor, Human serum albumin, Imipramine, In vitro, In vivo, Insomnia, Ion channel, Isozyme, Lawton Chiles, Libido, Ligand (biochemistry), Liver, Loperamide, Macmillan Publishers, Major depressive disorder, Mania, MDMA, Medicines and Healthcare products Regulatory Agency, Membrane transport protein, Merck Manual of Diagnosis and Therapy, Meta-analysis, Metabolism, Methamphetamine, Mole (unit), Monoamine oxidase inhibitor, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M5, National Institute for Health and Care Excellence, Nausea, Newcastle University, Nicotinic acetylcholine receptor, Nonsteroidal anti-inflammatory drug, Norepinephrine, Norepinephrine transporter, Obesity, Obsessive–compulsive disorder, Oral administration, Oxford University Press, P-glycoprotein, Panic disorder, Paresthesia, Paroxetine, Persistent fetal circulation, Phenelzine, Physical dependence, Pilot in command, Pimozide, Placebo, Plasma protein binding, Posttraumatic stress disorder, Potency (pharmacology), Pregnancy, Premature ejaculation, Premenstrual dysphoric disorder, Product line extension, Prozac (disambiguation), Psychological dependence, Psychotherapy, Racemic mixture, Rash, Richard Wurtman, Selective serotonin reuptake inhibitor, Self-harm, Seproxetine, Serotonin, Serotonin syndrome, Serotonin transporter, Serotonin–norepinephrine reuptake inhibitor, Sertraline, Sigma-1 receptor, Somnolence, Sphingomyelin, Statistical significance, Suicide, Systematic review, The New York Times, The Village Voice, The Wall Street Journal, The Washington Post, Thioridazine, Tranylcypromine, Trichotillomania, Tricyclic antidepressant, Triptan, United States Department of Transportation, United States National Library of Medicine, WHO Model List of Essential Medicines, 5-HT2A receptor, 5-HT2B receptor, 5-HT2C receptor, 5-HT3 receptor. Expand index (112 more) »
Acid sphingomyelinase
Acid sphingomyelinase is one of the enzymes that make up the sphingomyelinase (SMase) family, responsible for catalyzing the breakdown of sphingomyelin to ceramide and phosphorylcholine.
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Active metabolite
An active metabolite is an active form of a drug after it has been processed by the body.
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Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Agoraphobia
Agoraphobia is an anxiety disorder characterized by symptoms of anxiety in situations where the person perceives the environment to be unsafe with no easy way to get away.
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Alcohol dependence
Alcohol dependence is a previous psychiatric diagnosis in which an individual is physically or psychologically dependent upon alcohol (also known formally as ethanol).
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Allopregnanolone
Allopregnanolone, also known as 5α-pregnan-3α-ol-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP), as well as brexanolone, is an endogenous inhibitory pregnane neurosteroid.
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Alpha-1 adrenergic receptor
The alpha-1 (α1) adrenergic receptor is a G protein-coupled receptor (GPCR) associated with the Gq heterotrimeric G-protein.
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American Academy of Child and Adolescent Psychiatry
The American Academy of Child and Adolescent Psychiatry (AACAP) is a 501(c)(3) non-profit professional association in the United States dedicated to facilitating psychiatric care for children and adolescents.
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American Psychiatric Association
The American Psychiatric Association (APA) is the main professional organization of psychiatrists and trainee psychiatrists in the United States, and the largest psychiatric organization in the world.
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ANO1
Anoctamin-1 (ANO1) also known as Transmembrane member 16A (TMEM16A) is a protein that, in humans, is encoded by the ANO1 gene.
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Anorexia nervosa
Anorexia nervosa, often referred to simply as anorexia, is an eating disorder characterized by low weight, fear of gaining weight, and a strong desire to be thin, resulting in food restriction.
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Anticoagulant
Anticoagulants, commonly referred to as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time.
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Antidepressant
Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.
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Antidepressant discontinuation syndrome
Antidepressant discontinuation syndrome is a condition that can occur following the interruption, dose reduction, or discontinuation of antidepressant drugs, including selective serotonin re-uptake inhibitors (SSRIs) or serotonin–norepinephrine reuptake inhibitors (SNRIs).
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Antihistamine
Antihistamines are drugs which treat allergic rhinitis and other allergies.
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Anxiety
Anxiety is an emotion characterized by an unpleasant state of inner turmoil, often accompanied by nervous behaviour such as pacing back and forth, somatic complaints, and rumination.
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Atomoxetine
Atomoxetine, sold under the brand name Strattera among others, is a norepinephrine (noradrenaline) reuptake inhibitor which is approved for the treatment of attention deficit hyperactivity disorder (ADHD).
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Autism
Autism is a developmental disorder characterized by troubles with social interaction and communication and by restricted and repetitive behavior.
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Aviation medical examiner
In the United States and other countries, an aviation medical examiner (AME) is a physician designated by the local aviation authority and given the authority to perform flight physical examinations and issue aviation medical certificates.
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Barr Pharmaceuticals
Barr Pharmaceuticals was a global specialty and generic drug manufacturer with operations in 30 countries.
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Binge eating disorder
Binge eating disorder (BED) is an eating disorder characterized by frequent and recurrent binge eating episodes with associated negative psychological and social problems, but without subsequent purging episodes (e.g. vomiting).
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Bioavailability
In pharmacology, bioavailability (BA or F) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.
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Biological half-life
The biological half-life of a biological substance is the time it takes for half to be removed by biological processes when the rate of removal is roughly exponential.
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Boxed warning
In the United States, a boxed warning (sometimes "black box warning", colloquially) is a type of warning that appears on the package insert for certain prescription drugs, so called because the U.S. Food and Drug Administration specifies that it is formatted with a 'box' or border around the text.
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Breastfeeding
Breastfeeding, also known as nursing, is the feeding of babies and young children with milk from a woman's breast.
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Bryan Molloy
Dr Bryan Barnet Molloy (30 March 1939 – 20 May 2004) was a Scottish chemist, known notably for helping to invent the antidepressant Prozac, a name for fluoxetine.
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Bulimia nervosa
Bulimia nervosa, also known as simply bulimia, is an eating disorder characterized by binge eating followed by purging.
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Buspirone
Buspirone, sold under the brand name Buspar, is an anxiolytic drug that is primarily used to treat generalized anxiety disorder (GAD).
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Calcium-dependent chloride channel
The Calcium-Dependent Chloride Channel (Ca-ClC) proteins (or calcium-activated chloride channels (CaCCs), are heterogeneous groups of ligand-gated ion channels for chloride that have been identified in many epithelial and endothelial cell types as well as in smooth muscle cells. They include proteins from several structurally different families: chloride channel accessory (CLCA), bestrophin (BEST), and calcium-dependent chloride channel anoctamin (ANO or TMEM16) channels ANO1 is highly expressed in human gastrointestinal interstitial cells of Cajal, which are proteins which serve as intestinal pacemakers for peristalsis. In addition to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors. These eukaryotic proteins are "required for normal electrolyte and fluid secretion, olfactory perception, and neuronal and smooth muscle excitability" in animals. Members of the Ca-CIC family are generally 600 to 1000 amino acyl residues (aas) in length and exhibit 7 to 10 transmembrane segments (TMSs).
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Cataplexy
Cataplexy is a sudden and transient episode of muscle weakness accompanied by full conscious awareness, typically triggered by emotions such as laughing, crying, or terror.
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Ceramide
Ceramides are a family of waxy lipid molecules.
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Citalopram
Citalopram (brand names: Celexa, Cipramil and others) is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class.
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Cognitive behavioral therapy
Cognitive-behavioral therapy (CBT) is a psycho-social intervention that is the most widely used evidence-based practice aimed at improving mental health.
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Committee on Safety of Medicines
The Committee on Safety of Medicines (CSM) was an independent advisory committee that advised the UK Licensing Authority on the quality, efficacy and safety of medicines.
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CYP1A2
Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.
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CYP2B6
Cytochrome P450 2B6 is an enzyme that in humans is encoded by the CYP2B6 gene.
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CYP2C19
Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme.
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CYP2C9
Cytochrome P450 2C9 (abbreviated CYP2C9) is an enzyme that in humans is encoded by the CYP2C9 gene.
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CYP2D6
Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene.
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CYP3A4
Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.
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Cytochrome P450
Cytochromes P450 (CYPs) are proteins of the superfamily containing heme as a cofactor and, therefore, are hemoproteins.
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David Healy (psychiatrist)
David Healy, a professor of psychiatry at Bangor University in the United Kingdom, is a psychiatrist, psychopharmacologist, scientist and author.
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David T. Wong
David T. Wong (born circa 1936 in Hong Kong) is a Hong Kong-born American neuroscientist.
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Developing country
A developing country (or a low and middle income country (LMIC), less developed country, less economically developed country (LEDC), underdeveloped country) is a country with a less developed industrial base and a low Human Development Index (HDI) relative to other countries.
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Dextromethorphan
Dextromethorphan (DXM or DM) is a drug of the morphinan class with sedative, dissociative, and stimulant properties (at higher doses).
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Diagnostic and Statistical Manual of Mental Disorders
The Diagnostic and Statistical Manual of Mental Disorders (DSM) is published by the American Psychiatric Association (APA) and offers a common language and standard criteria for the classification of mental disorders.
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Diarrhea
Diarrhea, also spelled diarrhoea, is the condition of having at least three loose or liquid bowel movements each day.
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Diphenhydramine
Diphenhydramine is an antihistamine mainly used to treat allergies.
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Dizziness
Dizziness is an impairment in spatial perception and stability.
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Donald Klein
Donald Franklin Klein (4 September 1928) is an American psychiatrist known for his work on anxiety disorders.
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Dopamine
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.
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Dopamine transporter
The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol.
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Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together.
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Drug metabolism
Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems.
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Dysthymia
Dysthymia, now known as persistent depressive disorder (PDD), is a mood disorder consisting of the same cognitive and physical problems as depression, with less severe but longer-lasting symptoms.
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Efficacy
Efficacy is the ability to get a job done satisfactorily.
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Eli Lilly and Company
Eli Lilly and Company is a global pharmaceutical company headquartered in Indianapolis, Indiana, with offices in 18 countries.
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Enzyme inhibitor
4QI9) An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.
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Epileptic seizure
An epileptic seizure is a brief episode of signs or symptoms due to abnormally excessive or synchronous neuronal activity in the brain.
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Escitalopram
Escitalopram, sold under the brand names Cipralex and Lexapro among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
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Federal Aviation Administration
The Federal Aviation Administration (FAA) of the United States is a national authority with powers to regulate all aspects of civil aviation.
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Florida
Florida (Spanish for "land of flowers") is the southernmost contiguous state in the United States.
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Fluvoxamine
Fluvoxamine, sold under the brand name Luvox among others, is a medication which is used primarily for the treatment of obsessive–compulsive disorder (OCD), and is also used to treat major depressive disorder and anxiety disorders such as panic disorder and post-traumatic stress disorder.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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GABAA receptor positive allosteric modulator
In pharmacology, GABAA receptor positive allosteric modulators are positive allosteric modulator (PAM) molecules that increase the activity of the GABAA receptor protein in the vertebrate central nervous system.
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Generic drug
A generic drug is a pharmaceutical drug that is equivalent to a brand-name product in dosage, strength, route of administration, quality, performance, and intended use, but does not carry the brand name.
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Genetic variability
Genetic variability is either the presence of, or the generation of, genetic differences.
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Health system
A health system, also sometimes referred to as health care system or as healthcare system, is the organization of people, institutions, and resources that deliver health care services to meet the health needs of target populations.
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Histamine H1 receptor
The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors.
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Human serum albumin
Human serum albumin is the serum albumin found in human blood.
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Imipramine
Imipramine, sold under the brand name Tofranil among others, is a tricyclic antidepressant (TCA) which is used mainly in the treatment of depression.
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In vitro
In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.
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In vivo
Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.
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Insomnia
Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.
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Ion channel
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore.
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Isozyme
Isozymes (also known as isoenzymes or more generally as multiple forms of enzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction.
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Lawton Chiles
Lawton Mainor Chiles Jr. (April 3, 1930 – December 12, 1998) was an American politician from the U.S. state of Florida.
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Libido
Libido, colloquially known as sex drive, is a person's overall sexual drive or desire for sexual activity.
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Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
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Liver
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
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Loperamide
Loperamide, sold under the brand name Imodium among others, is a medication used to decrease the frequency of diarrhea.
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Macmillan Publishers
Macmillan Publishers Ltd (occasionally known as the Macmillan Group) is an international publishing company owned by Holtzbrinck Publishing Group.
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Major depressive disorder
Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.
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Mania
Mania, also known as manic syndrome, is a state of abnormally elevated arousal, affect, and energy level, or "a state of heightened overall activation with enhanced affective expression together with lability of affect." Although mania is often conceived as a "mirror image" to depression, the heightened mood can be either euphoric or irritable; indeed, as the mania intensifies, irritability can be more pronounced and result in violence, or anxiety.
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MDMA
3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy (E), is a psychoactive drug used primarily as a recreational drug.
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Medicines and Healthcare products Regulatory Agency
The Medicines and Healthcare products Regulatory Agency (MHRA) is an executive agency of the Department of Health and Social Care in the United Kingdom which is responsible for ensuring that medicines and medical devices work and are acceptably safe.
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Membrane transport protein
A membrane transport protein (or simply transporter) is a membrane protein involved in the movement of ions, small molecules, or macromolecules, such as another protein, across a biological membrane.
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Merck Manual of Diagnosis and Therapy
The Merck Manual of Diagnosis and Therapy, referred to as The Merck Manual, is the world's best-selling medical textbook, and the oldest continuously published English language medical textbook.
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Meta-analysis
A meta-analysis is a statistical analysis that combines the results of multiple scientific studies.
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Metabolism
Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.
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Methamphetamine
Methamphetamine (contracted from) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity.
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Mole (unit)
The mole, symbol mol, is the SI unit of amount of substance.
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Monoamine oxidase inhibitor
Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B).
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Muscarinic acetylcholine receptor M1
The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the CHRM1 gene.
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Muscarinic acetylcholine receptor M2
The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor that in humans is encoded by the CHRM2 gene.
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Muscarinic acetylcholine receptor M3
The muscarinic acetylcholine receptor, also known as cholinergic/acetylcholine receptor M3, or the muscarinic 3, is a muscarinic acetylcholine receptor encoded by the human gene CHRM3.
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Muscarinic acetylcholine receptor M4
The muscarinic acetylcholine receptor M4, also known as the cholinergic receptor, muscarinic 4 (CHRM4), is a protein that, in humans, is encoded by the CHRM4 gene.
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Muscarinic acetylcholine receptor M5
The human muscarinic acetylcholine receptor M5, encoded by the gene, is a member of the G protein-coupled receptor superfamily of integral membrane proteins.
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National Institute for Health and Care Excellence
The National Institute for Health and Care Excellence (NICE) is an executive non-departmental public body of the Department of Health in the United Kingdom, which publishes guidelines in four areas.
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Nausea
Nausea or queasiness is an unpleasant sense of unease, discomfort, and revulsion towards food.
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Newcastle University
Newcastle University (officially, the University of Newcastle upon Tyne) is a public research university in Newcastle upon Tyne in the North-East of England.
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Nicotinic acetylcholine receptor
Nicotinic acetylcholine receptors, or nAChRs, are receptor proteins that respond to the neurotransmitter acetylcholine.
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Nonsteroidal anti-inflammatory drug
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a drug class that reduce pain, decrease fever, prevent blood clots and, in higher doses, decrease inflammation.
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Norepinephrine
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.
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Norepinephrine transporter
The norepinephrine transporter (NET), also known as solute carrier family 6 member 2 (SLC6A2), is a protein that in humans is encoded by the SLC6A2 gene.
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Obesity
Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health.
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Obsessive–compulsive disorder
Obsessive–compulsive disorder (OCD) is a mental disorder where people feel the need to check things repeatedly, perform certain routines repeatedly (called "rituals"), or have certain thoughts repeatedly (called "obsessions").
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Oral administration
| name.
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Oxford University Press
Oxford University Press (OUP) is the largest university press in the world, and the second oldest after Cambridge University Press.
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P-glycoprotein
P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells.
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Panic disorder
Panic disorder is an anxiety disorder characterized by reoccurring unexpected panic attacks.
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Paresthesia
Paresthesia is an abnormal sensation such as tingling, tickling, pricking, numbness or burning of a person's skin with no apparent physical cause.
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Paroxetine
Paroxetine, also known by trade names including Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive-compulsive disorder, social anxiety disorder, panic disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder. It has also been used in the treatment of hot flashes and night sweats associated with menopause. It has a similar tolerability profile to other SSRIs. The common side effects include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping and delayed ejaculation. It may also be associated with a slightly increased risk of birth defects. The rate of withdrawal symptoms in young people may be higher with paroxetine and venlafaxine than other SSRIs and SNRIs. Several studies have associated paroxetine with suicidal thinking and behavior in children and adolescents. Marketing of the drug began in 1992 by the pharmaceutical company SmithKline Beecham, known since 2000 as GlaxoSmithKline. Generic formulations have been available since 2003 when the patent expired. The United States Department of Justice fined GlaxoSmithKline $3 billion in 2012, including a sum for withholding data on paroxetine, unlawfully promoting it for under-18s and preparing an article, following one of its clinical trials, study 329, that misleadingly reported the drug was effective in treating adolescent depression.
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Persistent fetal circulation
Persistent fetal circulation (also called persistent pulmonary hypertension of the newborn, PPHN) is a condition caused by a failure in the systemic circulation and pulmonary circulation to convert from the antenatal circulation pattern to the "normal" pattern.
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Phenelzine
Phenelzine (Nardil, Nardelzine) is a non-selective and irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class which is used as an antidepressant and anxiolytic.
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Physical dependence
Physical dependence is a physical condition caused by chronic use of a tolerance forming drug, in which abrupt or gradual drug withdrawal causes unpleasant physical symptoms.
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Pilot in command
The pilot in command (PIC) of an aircraft is the person aboard the aircraft who is ultimately responsible for its operation and safety during flight.
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Pimozide
Pimozide (sold under the brand name Orap) is an antipsychotic drug of the diphenylbutylpiperidine class.
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Placebo
A placebo is a substance or treatment of no intended therapeutic value.
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Plasma protein binding
Plasma protein binding refers to the degree to which medications attach to proteins within the blood.
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Posttraumatic stress disorder
Posttraumatic stress disorder (PTSD)Acceptable variants of this term exist; see the Terminology section in this article.
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Potency (pharmacology)
In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.
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Pregnancy
Pregnancy, also known as gestation, is the time during which one or more offspring develops inside a woman.
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Premature ejaculation
Premature ejaculation (PE) occurs when a man experiences orgasm and expels semen soon after sexual activity and with minimal penile stimulation.
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Premenstrual dysphoric disorder
Premenstrual dysphoric disorder (PMDD) is a severe and disabling form of premenstrual syndrome affecting 3–8% of menstruating women.
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Product line extension
A product line extension is the use of an established product brand name for a new item in the same product category.
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Prozac (disambiguation)
Prozac is a proprietary name for the antidepressant drug fluoxetine.
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Psychological dependence
Psychological dependence is a form of dependence that involves emotional–motivational withdrawal symptoms (e.g., a state of unease or dissatisfaction, a reduced capacity to experience pleasure, or anxiety) upon cessation of drug use or exposure to a stimulus.
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Psychotherapy
Psychotherapy is the use of psychological methods, particularly when based on regular personal interaction, to help a person change behavior and overcome problems in desired ways.
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Racemic mixture
In chemistry, a racemic mixture, or racemate, is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule.
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Rash
A rash is a change of the human skin which affects its color, appearance, or texture.
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Richard Wurtman
Richard ("Dick") Wurtman is a medical doctor who who spent his career doing basic and translational neuroscience research at Massachusetts Institute of Technology.
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Selective serotonin reuptake inhibitor
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders.
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Self-harm
Self-harm, also known as self-injury, is defined as the intentional, direct injuring of body tissue, done without suicidal intentions.
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Seproxetine
Seproxetine, also known as (S)-norfluoxetine, is a selective serotonin reuptake inhibitor (SSRI).
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Serotonin
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
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Serotonin syndrome
Serotonin syndrome (SS) is a group of symptoms that may occur following use of certain serotonergic medications or drugs.
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Serotonin transporter
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.
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Serotonin–norepinephrine reuptake inhibitor
Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant drugs that treat major depressive disorder (MDD) and can also treat anxiety disorders, obsessive-compulsive disorder (OCD), attention-deficit hyperactivity disorder (ADHD), chronic neuropathic pain, fibromyalgia syndrome (FMS), and menopausal symptoms.
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Sertraline
Sertraline, sold under the trade names Zoloft among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
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Sigma-1 receptor
The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor.
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Somnolence
Somnolence (alternatively "sleepiness" or "drowsiness") is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia).
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Sphingomyelin
Sphingomyelin (SPH, ˌsfɪŋɡoˈmaɪəlɪn) is a type of sphingolipid found in animal cell membranes, especially in the membranous myelin sheath that surrounds some nerve cell axons.
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Statistical significance
In statistical hypothesis testing, a result has statistical significance when it is very unlikely to have occurred given the null hypothesis.
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Suicide
Suicide is the act of intentionally causing one's own death.
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Systematic review
Systematic reviews are a type of literature review that uses systematic methods to collect secondary data, critically appraise research studies, and synthesize studies.
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The New York Times
The New York Times (sometimes abbreviated as The NYT or The Times) is an American newspaper based in New York City with worldwide influence and readership.
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The Village Voice
The Village Voice is an American news and culture paper, known for being the country's first alternative newsweekly.
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The Wall Street Journal
The Wall Street Journal is a U.S. business-focused, English-language international daily newspaper based in New York City.
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The Washington Post
The Washington Post is a major American daily newspaper founded on December 6, 1877.
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Thioridazine
Thioridazine (Mellaril or Melleril) is a piperidine typical antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis.
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Tranylcypromine
Tranylcypromine (contracted from trans-2-phenylcyclopropylamine; original trade name Parnate)Drugs.com.
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Trichotillomania
Trichotillomania (TTM), also known as hair pulling disorder, is an impulse control disorder characterised by a long term urge that results in the pulling out of one's hair.
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Tricyclic antidepressant
Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants.
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Triptan
Triptans are a family of tryptamine-based drugs used as abortive medication in the treatment of migraines and cluster headaches.
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United States Department of Transportation
The United States Department of Transportation (USDOT or DOT) is a federal Cabinet department of the U.S. government concerned with transportation.
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United States National Library of Medicine
The United States National Library of Medicine (NLM), operated by the United States federal government, is the world's largest medical library.
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WHO Model List of Essential Medicines
The WHO Model List of Essential Medicines (EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system.
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5-HT2A receptor
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).
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5-HT2B receptor
5-Hydroxytryptamine receptor 2B (5-HT2B) also known as serotonin receptor 2B is a protein that in humans is encoded by the HTR2B gene.
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5-HT2C receptor
The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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5-HT3 receptor
The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin) receptors which are G protein-coupled receptors.
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Redirects here:
110140, ATC code N06AB03, ATCvet code QN06AB03, Adofen, Animex-On, C17H18F3NO, Deprex, Floxetine, Fluctin, Fluctine, Fludac, Fluohexal, Fluoxeren, Fluoxetin, Fluoxetine Hydrochloride, Fluoxetine hydrochloride, Fluoxifar, Fluxetine hydrochloride, Fontex, Foxetin, Ladose, Lilly 110140, Prodep, Prohexal, Prozac, Prozac Weekly, Prozac weekly, Prozak, Rapiflux, Reconcile (drug), Reneuron, Sarafem, Selfemra, Seromex, Seronil.
References
[1] https://en.wikipedia.org/wiki/Fluoxetine
