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9 relations: Catharanthus roseus, Methylation, Tabersonine, Tabersonine 16-hydroxylase, Tabersonine 16-O-methyltransferase, Vinblastine, Vincristine, Vindoline, 16-Methoxytabersonine.
Catharanthus roseus
Catharanthus roseus, commonly known as the Madagascar periwinkle, rose periwinkle, or rosy periwinkle, is a species of flowering plant in the dogbane family Apocynaceae.
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Methylation
In the chemical sciences, methylation denotes the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group.
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Tabersonine
Tabersonine is a terpene indole alkaloid found in the medicinal plant Catharanthus roseus.
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Tabersonine 16-hydroxylase
In enzymology, a tabersonine 16-hydroxylase is an enzyme that catalyzes the chemical reaction The 4 substrates of this enzyme are tabersonine, NADPH, H+, and O2, whereas its 3 products are 16-hydroxytabersonine, NADP+, and H2O.
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Tabersonine 16-O-methyltransferase
In enzymology, a tabersonine 16-O-methyltransferase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are S-adenosyl methionine and 16-hydroxytabersonine, whereas its two products are S-adenosylhomocysteine and 16-methoxytabersonine.
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Vinblastine
Vinblastine is a chemotherapy medication, typically used with other medications, to treat a number of types of cancer.
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Vincristine
Vincristine, also known as leurocristine and marketed under the brandname Oncovin among others, is a chemotherapy medication used to treat a number of types of cancer. This includes acute lymphocytic leukemia, acute myeloid leukemia, Hodgkin's disease, neuroblastoma, and small cell lung cancer among others. It is given intravenously. Most people experience some side effects from vincristine treatment. Commonly it causes a change in sensation, hair loss, constipation, difficulty walking, and headaches. Serious side effects may include neuropathic pain, lung damage, or low blood white cells. It will likely cause harm to the baby if given during pregnancy. It works by stopping cells from dividing properly. Vincristine was first isolated in 1961. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is between 1.80 and 42.60 USD per dose. It is a vinca alkaloid that can be obtained from the Madagascar periwinkle Catharanthus roseus.
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Vindoline
Vindoline is a chemical precursor to vinblastine.
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16-Methoxytabersonine
16-Methoxytabersonine is a terpene indole alkaloid produced by the medicinal plant Catharanthus roseus.
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16-hydroxytabersonine, Hydroxytabersonine.
