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20 relations: Acetoacetic acid, Acetoacetyl-CoA, Acetyl-CoA, Avadhesha Surolia, Bimal Kumar Bachhawat, Branched-chain amino acid, HMG-CoA reductase, Hydroxymethylglutaryl-CoA synthase, Isoleucine, Ketogenesis, Leucine, Metabolic intermediate, Metabolism, Mevalonate pathway, Mevalonic acid, Minor J. Coon, Steroidogenic enzyme, University of Illinois at Urbana–Champaign, Valine, 3-hydroxy-3-methylglutaryl-CoA lyase.
Acetoacetic acid
Acetoacetic acid (also diacetic acid) is the organic compound with the formula CH3COCH2COOH.
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Acetoacetyl-CoA
Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway, which is essential for cholesterol biosynthesis.
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Acetyl-CoA
Acetyl-CoA (acetyl coenzyme A) is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
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Avadhesha Surolia
Avadhesha Surolia (Born 3 December 1947, Kishangarh, Rajasthan) is a Glycobiologist at Indian Institute of Science (IISc), Bangalore.
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Bimal Kumar Bachhawat
Bimal Kumar Bachhawat (1925–1996) was an Indian neurochemist and glycobiologist, known for his discovery of HMG-CoA lyase, an intermediate in the mevalonate and ketogenesis pathway, and for the elucidation of the molecular cause of Metachromatic leukodystrophy, a hereditary disease of the brain His studies on sugar-bearing liposomes led to its use as a carrier for in situ delivery of drugs and hormones to diseased organs and he pioneered the therapy of systemic fungal infections using liposomal formulations.
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Branched-chain amino acid
A branched-chain amino acid (BCAA) is an amino acid having aliphatic side-chains with a branch (a central carbon atom bound to three or more carbon atoms).
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HMG-CoA reductase
HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, officially abbreviated HMGCR) is the rate-controlling enzyme (NADH-dependent,; NADPH-dependent) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids.
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Hydroxymethylglutaryl-CoA synthase
In molecular biology, Hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase is an enzyme which catalyzes the reaction in which Acetyl-CoA condenses with acetoacetyl-CoA to form 3-'''h'''ydroxy-3-'''m'''ethyl'''g'''lutaryl-CoA (HMG-CoA).
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Isoleucine
Isoleucine (symbol Ile or I) is an α-amino acid that is used in the biosynthesis of proteins.
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Ketogenesis
Ketogenesis is the biochemical process by which organisms produce a group of substances collectively known as ketone bodies by the breakdown of fatty acids and ketogenic amino acids.
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Leucine
Leucine (symbol Leu or L) is an essential amino acid that is used in the biosynthesis of proteins.
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Metabolic intermediate
Metabolic intermediates are molecules which are the precursors or metabolites of biologically significant molecules.
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Metabolism
Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.
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Mevalonate pathway
The mevalonate pathway, also known as the isoprenoid pathway or HMG-CoA reductase pathway is an essential metabolic pathway present in eukaryotes, archaea, and some bacteria.
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Mevalonic acid
Mevalonic acid (MVA) is a key organic compound in biochemistry; the name is a contraction of dihydroxymethylvalerolactone.
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Minor J. Coon
Minor Jesser (Jud) Coon (born July 29, 1921) is an American biochemist and Victor V Vaughan Distinguished University Professor Emeritus at the University of Michigan, Ann Arbor.
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Steroidogenic enzyme
Steroidogenic enzymes, or steroid-metabolizing enzymes, are enzymes that are involved in steroidogenesis and steroid metabolism.
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University of Illinois at Urbana–Champaign
The University of Illinois Urbana–Champaign (also known as U of I, Illinois, or colloquially as the University of Illinois or UIUC) is a public research university in the U.S. state of Illinois and the flagship institution of the University of Illinois System.
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Valine
Valine (symbol Val or V) is an α-amino acid that is used in the biosynthesis of proteins.
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3-hydroxy-3-methylglutaryl-CoA lyase
3-hydroxy-3-methylglutaryl-CoA lyase (or HMG-CoA lyase) is an enzyme that in human is encoded by the HMGCL gene located on chromosome 1.
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(S)-HMG-CoA, 3-Hydroxy-3-methylglutaryl-coenzyme A, 3-Hydroxy-3-methylglutarylcoenzyme A, 3-hydroxy-3-methyl-glutaryl CoA, 3-hydroxy-3-methyl-glutaryl-CoA, 3-hydroxy-3-methylglutaryl CoA, 3-hydroxy-3-methylglutaryl-CoA, 3-hydroxy-3-methylglutaryl-coenzyme A, 3-hydroxy-3-methylglutarylcoenzyme A, HMG CoA, Hydroxymethylglutaryl CoA, Hydroxymethylglutaryl-CoA, Hydroxymethylglutaryl-coenzyme A, Hydroxymethylglutarylcoenzyme A, Β-Hydroxy β-methylglutaryl-CoA, Β-hydroxy β-methylglutaryl-CoA.
