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HMG-CoA

Index HMG-CoA

β-Hydroxy β-methylglutaryl-CoA (HMG-CoA), also known as 3-hydroxy-3-methylglutaryl-CoA, is an intermediate in the mevalonate and ketogenesis pathways. [1]

20 relations: Acetoacetic acid, Acetoacetyl-CoA, Acetyl-CoA, Avadhesha Surolia, Bimal Kumar Bachhawat, Branched-chain amino acid, HMG-CoA reductase, Hydroxymethylglutaryl-CoA synthase, Isoleucine, Ketogenesis, Leucine, Metabolic intermediate, Metabolism, Mevalonate pathway, Mevalonic acid, Minor J. Coon, Steroidogenic enzyme, University of Illinois at Urbana–Champaign, Valine, 3-hydroxy-3-methylglutaryl-CoA lyase.

Acetoacetic acid

Acetoacetic acid (also diacetic acid) is the organic compound with the formula CH3COCH2COOH.

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Acetoacetyl-CoA

Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway, which is essential for cholesterol biosynthesis.

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Acetyl-CoA

Acetyl-CoA (acetyl coenzyme A) is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.

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Avadhesha Surolia

Avadhesha Surolia (Born 3 December 1947, Kishangarh, Rajasthan) is a Glycobiologist at Indian Institute of Science (IISc), Bangalore.

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Bimal Kumar Bachhawat

Bimal Kumar Bachhawat (1925–1996) was an Indian neurochemist and glycobiologist, known for his discovery of HMG-CoA lyase, an intermediate in the mevalonate and ketogenesis pathway, and for the elucidation of the molecular cause of Metachromatic leukodystrophy, a hereditary disease of the brain His studies on sugar-bearing liposomes led to its use as a carrier for in situ delivery of drugs and hormones to diseased organs and he pioneered the therapy of systemic fungal infections using liposomal formulations.

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Branched-chain amino acid

A branched-chain amino acid (BCAA) is an amino acid having aliphatic side-chains with a branch (a central carbon atom bound to three or more carbon atoms).

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HMG-CoA reductase

HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, officially abbreviated HMGCR) is the rate-controlling enzyme (NADH-dependent,; NADPH-dependent) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids.

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Hydroxymethylglutaryl-CoA synthase

In molecular biology, Hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase is an enzyme which catalyzes the reaction in which Acetyl-CoA condenses with acetoacetyl-CoA to form 3-'''h'''ydroxy-3-'''m'''ethyl'''g'''lutaryl-CoA (HMG-CoA).

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Isoleucine

Isoleucine (symbol Ile or I) is an α-amino acid that is used in the biosynthesis of proteins.

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Ketogenesis

Ketogenesis is the biochemical process by which organisms produce a group of substances collectively known as ketone bodies by the breakdown of fatty acids and ketogenic amino acids.

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Leucine

Leucine (symbol Leu or L) is an essential amino acid that is used in the biosynthesis of proteins.

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Metabolic intermediate

Metabolic intermediates are molecules which are the precursors or metabolites of biologically significant molecules.

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Metabolism

Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.

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Mevalonate pathway

The mevalonate pathway, also known as the isoprenoid pathway or HMG-CoA reductase pathway is an essential metabolic pathway present in eukaryotes, archaea, and some bacteria.

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Mevalonic acid

Mevalonic acid (MVA) is a key organic compound in biochemistry; the name is a contraction of dihydroxymethylvalerolactone.

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Minor J. Coon

Minor Jesser (Jud) Coon (born July 29, 1921) is an American biochemist and Victor V Vaughan Distinguished University Professor Emeritus at the University of Michigan, Ann Arbor.

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Steroidogenic enzyme

Steroidogenic enzymes, or steroid-metabolizing enzymes, are enzymes that are involved in steroidogenesis and steroid metabolism.

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University of Illinois at Urbana–Champaign

The University of Illinois Urbana–Champaign (also known as U of I, Illinois, or colloquially as the University of Illinois or UIUC) is a public research university in the U.S. state of Illinois and the flagship institution of the University of Illinois System.

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Valine

Valine (symbol Val or V) is an α-amino acid that is used in the biosynthesis of proteins.

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3-hydroxy-3-methylglutaryl-CoA lyase

3-hydroxy-3-methylglutaryl-CoA lyase (or HMG-CoA lyase) is an enzyme that in human is encoded by the HMGCL gene located on chromosome 1.

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Redirects here:

(S)-HMG-CoA, 3-Hydroxy-3-methylglutaryl-coenzyme A, 3-Hydroxy-3-methylglutarylcoenzyme A, 3-hydroxy-3-methyl-glutaryl CoA, 3-hydroxy-3-methyl-glutaryl-CoA, 3-hydroxy-3-methylglutaryl CoA, 3-hydroxy-3-methylglutaryl-CoA, 3-hydroxy-3-methylglutaryl-coenzyme A, 3-hydroxy-3-methylglutarylcoenzyme A, HMG CoA, Hydroxymethylglutaryl CoA, Hydroxymethylglutaryl-CoA, Hydroxymethylglutaryl-coenzyme A, Hydroxymethylglutarylcoenzyme A, Β-Hydroxy β-methylglutaryl-CoA, Β-hydroxy β-methylglutaryl-CoA.

References

[1] https://en.wikipedia.org/wiki/HMG-CoA

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