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34 relations: Aciclovir, Adamantane, Cellular senescence, Coronary artery disease, De novo synthesis, Enzyme, Gene, Gout, Guanine, Guanosine monophosphate, HAT medium, HIF1A, Hybridoma technology, Hyperuricemia, Hypoxanthine, In silico, In vitro, Inosinic acid, Leishmania, Lesch–Nyhan syndrome, Monoclonal antibody, Multiple myeloma, Nucleotide, Nucleotide salvage, Pentamidine, Phosphoribosyl pyrophosphate, Plasma cell, Purine, Transcription factor, Transferase, Uric acid, Visceral leishmaniasis, Xanthine, Xanthosine monophosphate.
Aciclovir
Aciclovir (ACV), also known as acyclovir, is an antiviral medication.
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Adamantane
Adamantane is a colorless, crystalline chemical compound with a camphor-like odor.
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Cellular senescence
Cellular senescence is one phenomenon by which normal cells cease to divide.
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Coronary artery disease
Coronary artery disease (CAD), also known as ischemic heart disease (IHD), refers to a group of diseases which includes stable angina, unstable angina, myocardial infarction, and sudden cardiac death.
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De novo synthesis
De novo synthesis refers to the synthesis of complex molecules from simple molecules such as sugars or amino acids, as opposed to recycling after partial degradation.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Gout
Gout is a form of inflammatory arthritis characterized by recurrent attacks of a red, tender, hot, and swollen joint.
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Guanine
Guanine (or G, Gua) is one of the four main nucleobases found in the nucleic acids DNA and RNA, the others being adenine, cytosine, and thymine (uracil in RNA).
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Guanosine monophosphate
Guanosine monophosphate (GMP), also known as 5'-guanidylic acid or guanylic acid (conjugate base guanylate), is a nucleotide that is used as a monomer in RNA.
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HAT medium
HAT Medium (hypoxanthine-aminopterin-thymidine medium) is a selection medium for mammalian cell culture, which relies on the combination of aminopterin, a drug that acts as a powerful folate metabolism inhibitor by inhibiting dihydrofolate reductase, with hypoxanthine (a purine derivative) and thymidine (a deoxynucleoside) which are intermediates in DNA synthesis.
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HIF1A
Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene.
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Hybridoma technology
Hybridoma technology is a method for producing large numbers of identical antibodies (also called monoclonal antibodies).
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Hyperuricemia
Hyperuricemia is an abnormally high level of uric acid in the blood.
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Hypoxanthine
Hypoxanthine is a naturally occurring purine derivative.
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In silico
In silico (literally cod Latin for "in silicon", alluding to the mass use of silicon for semiconductor computer chips) is an expression used to mean "performed on computer or via computer simulation." The phrase was coined in 1989 as an allusion to the Latin phrases in vivo, in vitro, and in situ, which are commonly used in biology (see also systems biology) and refer to experiments done in living organisms, outside living organisms, and where they are found in nature, respectively.
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In vitro
In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.
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Inosinic acid
Inosinic acid or inosine monophosphate (IMP) is a nucleoside monophosphate.
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Leishmania
Leishmania is a genus of trypanosomes that are responsible for the disease leishmaniasis.
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Lesch–Nyhan syndrome
Lesch–Nyhan syndrome (LNS), also known as juvenile gout, is a rare inherited disorder caused by a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT), produced by mutations in the HPRT gene located on the X chromosome.
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Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell.
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Multiple myeloma
Multiple myeloma, also known as plasma cell myeloma, is a cancer of plasma cells, a type of white blood cell normally responsible for producing antibodies.
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Nucleotide
Nucleotides are organic molecules that serve as the monomer units for forming the nucleic acid polymers deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules within all life-forms on Earth.
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Nucleotide salvage
A salvage pathway is a pathway in which nucleotides (purine and pyrimidine) are synthesized from intermediates in the degradative pathway for nucleotides.
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Pentamidine
Pentamidine is an antimicrobial medication used to treat African trypanosomiasis, leishmaniasis, babesiosis, and to prevent and treat pneumocystis pneumonia (PCP) in people with poor immune function.
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Phosphoribosyl pyrophosphate
Phosphoribosyl pyrophosphate (PRPP) is a pentosephosphate.
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Plasma cell
Plasma cells, also called plasma B cells, plasmocytes, plasmacytes, or effector B cells, are white blood cells that secrete large volumes of antibodies.
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Purine
A purine is a heterocyclic aromatic organic compound that consists of a pyrimidine ring fused to an imidazole ring.
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Transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.
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Transferase
A transferase is any one of a class of enzymes that enact the transfer of specific functional groups (e.g. a methyl or glycosyl group) from one molecule (called the donor) to another (called the acceptor).
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Uric acid
Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C5H4N4O3.
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Visceral leishmaniasis
Visceral leishmaniasis (VL), also known as kala-azar, black fever, and Dumdum fever, is the most severe form of leishmaniasis and, without proper diagnosis and treatment, is associated with high fatality.
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Xanthine
Xanthine (or; archaically xanthic acid) (3,7-dihydropurine-2,6-dione), is a purine base found in most human body tissues and fluids and in other organisms.
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Xanthosine monophosphate
Xanthosine monophosphate is an intermediate in purine metabolism.
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Redirects here:
EC 2.4.2.8, GPRT, HGPRT, HPRT, HPRT1, HPRT1 (gene), Hgprt, High-performace guanine phophoriboost transferase, Hprt, Hypoxanthine guanine phosphoriberyltransform, Hypoxanthine guanine phosphoribory itransferase, Hypoxanthine guanine phosphoribosyl transferase, Hypoxanthine phosphoribosyltransferase, Hypoxanthine phosphoribosyltransferase 1, Hypoxanthine-guanine phosphoribosyl transferase, Hypoxanthine/guanine phosphoribosyl transferase, IMP:diphosphate phospho-D-ribosyltransferase.
References
[1] https://en.wikipedia.org/wiki/Hypoxanthine-guanine_phosphoribosyltransferase
