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51 relations: Activation, Antibody, Apoptosis, Biochemical cascade, C-terminus, Cancer, Cell growth, Cellular differentiation, Conformational change, Crenolanib, Cytoplasm, Embryogenesis, Enzyme, Extracellular, Guanosine diphosphate, Guanosine triphosphate, Imatinib, Immune system, Inflammation, Intrinsically disordered proteins, Kinase, Mitogen-activated protein kinase kinase, Monomer, Morphogenesis, PDGFA, PDGFB, PDGFRA, PDGFRB, Phenylalanine, Phosphoinositide 3-kinase, Phosphorylation, Phosphotyrosine-binding domain, Platelet-derived growth factor, Protein dimer, Protein isoform, Protein kinase B, Protein tyrosine phosphatase, PTPN11, Ras subfamily, Reactive oxygen species, Receptor (biochemistry), Receptor tyrosine kinase, Serine, SH3 domain, SHC1, Signal transduction, STAT3, Substrate (chemistry), Transphosphorylation, Tyrosine, ..., Tyrosine kinase. Expand index (1 more) »
Activation
Activation in (bio-)chemical sciences generally refers to the process whereby something is prepared or excited for a subsequent reaction.
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Antibody
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.
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Apoptosis
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
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Biochemical cascade
A biochemical cascade, also known as a signaling cascade or signaling pathway, is a series of chemical reactions which are initiated by a stimulus (first messenger) acting on a receptor that is transduced to the cell interior through second messengers (which amplify the initial signal) and ultimately to effector molecules, resulting in a cell response to the initial stimulus.
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C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
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Cell growth
The term cell growth is used in the contexts of biological cell development and cell division (reproduction).
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Cellular differentiation
In developmental biology, cellular differentiation is the process where a cell changes from one cell type to another.
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Conformational change
In biochemistry, a conformational change is a change in the shape of a macromolecule, often induced by environmental factors.
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Crenolanib
Crenolanib besylate (CP-868,596-26 or AR-868,596-26, 4-piperidinamine, 1--, monobenzenesulfonate) is an investigational inhibitor being developed by AROG Pharmaceuticals, LLC.
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Cytoplasm
In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus.
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Embryogenesis
Embryogenesis is the process by which the embryo forms and develops.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Extracellular
In cell biology, molecular biology and related fields, the word extracellular (or sometimes extracellular space) means "outside the cell".
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Guanosine diphosphate
Guanosine diphosphate, abbreviated GDP, is a nucleoside diphosphate.
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Guanosine triphosphate
Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate.
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Imatinib
Imatinib, sold under the brand names Gleevec among others, is a medication used to treat cancer.
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Immune system
The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease.
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Inflammation
Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.
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Intrinsically disordered proteins
An intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure.
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Kinase
In biochemistry, a kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.
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Mitogen-activated protein kinase kinase
Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a kinase enzyme which phosphorylates mitogen-activated protein kinase (MAPK).
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Monomer
A monomer (mono-, "one" + -mer, "part") is a molecule that "can undergo polymerization thereby contributing constitutional units to the essential structure of a macromolecule".
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Morphogenesis
Morphogenesis (from the Greek morphê shape and genesis creation, literally, "beginning of the shape") is the biological process that causes an organism to develop its shape.
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PDGFA
Platelet-derived growth factor subunit A is a protein that in humans is encoded by the PDGFA gene.
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PDGFB
Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene.
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PDGFRA
PDGFRA, i.e. platelet-derived growth factor receptor A, also termed PDGFRα, i.e. platelet-derived growth factor receptor α, is a receptor located on the surface of a wide range of cell types.
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PDGFRB
Beta-type platelet-derived growth factor receptor is a protein that in humans is encoded by the PDGFRB gene.
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Phenylalanine
Phenylalanine (symbol Phe or F) is an α-amino acid with the formula.
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Phosphoinositide 3-kinase
Phosphatidylinositol-4,5-bisphosphate 3-kinase (also called phosphatidylinositide 3-kinases, phosphatidylinositol-3-kinases, PI 3-kinases, PI(3)Ks, PI-3Ks or by the HUGO official stem symbol for the gene family, PI3K(s)) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.
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Phosphorylation
In chemistry, phosphorylation of a molecule is the attachment of a phosphoryl group.
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Phosphotyrosine-binding domain
In molecular biology, Phosphotyrosine-binding domains are protein domains which bind to phosphotyrosine.
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Platelet-derived growth factor
Platelet-derived growth factor (PDGF) is one of numerous growth factors that regulate cell growth and division.
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Protein dimer
In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.
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Protein isoform
A protein isoform, or "protein variant" is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.
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Protein kinase B
Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.
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Protein tyrosine phosphatase
Protein tyrosine phosphatases are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins.
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PTPN11
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), SHP-2, or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene.
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Ras subfamily
Ras is a family of related proteins which is expressed in all animal cell lineages and organs.
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Reactive oxygen species
Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen.
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Receptor (biochemistry)
In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.
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Receptor tyrosine kinase
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones.
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Serine
Serine (symbol Ser or S) is an ɑ-amino acid that is used in the biosynthesis of proteins.
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SH3 domain
The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues.
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SHC1
SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene.
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Signal transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.
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STAT3
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 gene.
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Substrate (chemistry)
In chemistry, a substrate is typically the chemical species being observed in a chemical reaction, which reacts with a reagent to generate a product.
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Transphosphorylation
Transphosphorylation is a chemical reaction in which a phosphate group or a phosphono group is transferred between a substrate and a receptor.
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Tyrosine
Tyrosine (symbol Tyr or Y) or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins.
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Tyrosine kinase
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell.
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Redirects here:
PDGF receptor, PDGF-R, PDGFR, Pdgfr, Platelet derived growth factor receptor, Receptors, platelet-derived growth factor.
References
[1] https://en.wikipedia.org/wiki/Platelet-derived_growth_factor_receptor
