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51 relations: Abelson murine leukemia virus, ABL (gene), Acute lymphoblastic leukemia, Acute myeloid leukemia, Alternative splicing, Axitinib, BCR (gene), Brian Druker, Carcinogenesis, Cell cycle, Cell division, Cell signaling, Chemotherapy, Chromosomal translocation, Chromosome 22, Chromosome 9, Chronic myelogenous leukemia, Cord blood, Dasatinib, David Hungerford, DNA repair, Enzyme, Fluorescence in situ hybridization, Fusion gene, G banding, Gastrointestinal stromal tumor, Gene expression, Genome instability, Imatinib, Interleukin-3 receptor, International System for Human Cytogenetic Nomenclature, Janet Rowley, John Kuriyan, Leukemia, Murine leukemia virus, Nilotinib, Novartis, Oregon Health & Science University, Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Peter Nowell, Protein, Protein kinase inhibitor, Receptor tyrosine kinase, Renal cell carcinoma, Science (journal), Sensitivity and specificity, Sunitinib, Tyrosine kinase, Unified atomic mass unit, ..., University of Chicago. Expand index (1 more) »
Abelson murine leukemia virus
The Abelson murine leukemia virus (Ab-MLV or A-MuLV) is a retrovirus (Class VI) used to induce transformation of murine lymphoid cells.
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ABL (gene)
Abelson murine leukemia viral oncogene homolog 1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL) located on chromosome 9.
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Acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes.
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Acute myeloid leukemia
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells.
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Alternative splicing
Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins.
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Axitinib
Axitinib (AG013736; trade name Inlyta) is a small molecule tyrosine kinase inhibitor developed by Pfizer.
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BCR (gene)
The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is encoded by the BCR gene.
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Brian Druker
Brian J. Druker (born April 30, 1955) is a physician-scientist at Oregon Health & Science University, in Portland, Oregon.
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Carcinogenesis
Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells.
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Cell cycle
The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication of its DNA (DNA replication) to produce two daughter cells.
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Cell division
Cell division is the process by which a parent cell divides into two or more daughter cells.
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Cell signaling
Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions.
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Chemotherapy
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen.
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Chromosomal translocation
In genetics, a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes.
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Chromosome 22
Chromosome 22 is one of the 23 pairs of chromosomes in human cells.
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Chromosome 9
Chromosome 9 is one of the 23 pairs of chromosomes in humans.
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Chronic myelogenous leukemia
Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells.
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Cord blood
Umbilical cord blood is blood that remains in the placenta and in the attached umbilical cord after childbirth.
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Dasatinib
Dasatinib, sold under the brand name Sprycel, is a chemotherapy medication used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL).
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David Hungerford
David A. Hungerford (1927–1993) was an American cancer researcher and co-discoverer of the Philadelphia chromosome.
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DNA repair
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Fluorescence in situ hybridization
Fluorescent in situ hybridization (FISH) is a molecular cytogenetic technique that uses fluorescent probes that bind to only those parts of the chromosome with a high degree of sequence complementarity.
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Fusion gene
A fusion gene is a hybrid gene formed from two previously separate genes.
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G banding
G-banding, G banding, or Giemsa banding is a technique used in cytogenetics to produce a visible karyotype by staining condensed chromosomes.
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Gastrointestinal stromal tumor
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract.
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Gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product.
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Genome instability
Genome instability (also genetic instability or genomic instability) refers to a high frequency of mutations within the genome of a cellular lineage.
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Imatinib
Imatinib, sold under the brand names Gleevec among others, is a medication used to treat cancer.
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Interleukin-3 receptor
The interleukin-3 receptor (also known as CD123 antigen) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system.
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International System for Human Cytogenetic Nomenclature
The International System for Human Cytogenetic Nomenclature (ISCN) is an international standard for human chromosome nomenclature, which includes band names, symbols and abbreviated terms used in the description of human chromosome and chromosome abnormalities.
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Janet Rowley
Janet Davison Rowley (April 5, 1925 – December 17, 2013) was an American human geneticist and the first scientist to identify a chromosomal translocation as the cause of leukemia and other cancers.
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John Kuriyan
John Kuriyan is Chancellor's Professor at the University of California, Berkeley in the departments of Molecular and Cell Biology (MCB) and Chemistry.
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Leukemia
Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells.
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Murine leukemia virus
The murine leukemia viruses (MLVs or MuLVs) are retroviruses named for their ability to cause cancer in murine (mouse) hosts.
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Nilotinib
Nilotinib (AMN107, trade name Tasigna), in the form of the hydrochloride monohydrate salt, is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia.
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Novartis
Novartis International AG is a Swiss multinational pharmaceutical company based in Basel, Switzerland.
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Oregon Health & Science University
Oregon Health & Science University (OHSU) is a public university in Oregon with a main campus, including two hospitals, in Portland.
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Pediatrics
Pediatrics (also spelled paediatrics or pædiatrics) is the branch of medicine that involves the medical care of infants, children, and adolescents.
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Perelman School of Medicine at the University of Pennsylvania
The Perelman School of Medicine, commonly known as Penn Med, is the medical school of the University of Pennsylvania.
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Peter Nowell
Peter Carey Nowell (February 8, 1928 – December 26, 2016) was a cancer researcher and co-discoverer of the Philadelphia Chromosome.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Protein kinase inhibitor
A protein kinase inhibitor is a type of enzyme inhibitor that blocks the action of one or more protein kinases.
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Receptor tyrosine kinase
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones.
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Renal cell carcinoma
Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine.
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Science (journal)
Science, also widely referred to as Science Magazine, is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals.
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Sensitivity and specificity
Sensitivity and specificity are statistical measures of the performance of a binary classification test, also known in statistics as a classification function.
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Sunitinib
Sunitinib (marketed as Sutent by Pfizer, and previously known as SU11248) is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006.
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Tyrosine kinase
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell.
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Unified atomic mass unit
The unified atomic mass unit or dalton (symbol: u, or Da) is a standard unit of mass that quantifies mass on an atomic or molecular scale (atomic mass).
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University of Chicago
The University of Chicago (UChicago, U of C, or Chicago) is a private, non-profit research university in Chicago, Illinois.
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BCR-ABL, BCR-Abl, BCR/ABL, BCRABL, Bcl-Abr, Bcr-Abl, Bcr-abl, Bcr-abl fusion protein, Bcr:abl, Fusion proteins, bcr-abl, Ph chromosome, Philadelphia 1, Philadelphia Chromosome, Philadelphia gene, Philadelphia translocation, Philidelphia chromosome, Philidelphia gene, T(9;22).
References
[1] https://en.wikipedia.org/wiki/Philadelphia_chromosome
