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Thioredoxin

Index Thioredoxin

Thioredoxin is a class of small redox proteins known to be present in all organisms. [1]

57 relations: Amino acid, AMP-activated protein kinase, Antioxidants & Redox Signaling, AP-1 transcription factor, ASK1, Biological process, Biomolecular structure, Cardiac muscle cell, Cell nucleus, Cell signaling, Cellular compartment, Collagen, type I, alpha 1, Cysteine, Cytosol, Disulfide, DNA repair, Embryo, Free-radical theory of aging, Gene, Glucocorticoid receptor, Glutaredoxin, Glutathione, HDAC4, Let-7 microRNA precursor, Mammal, MicroRNA, Mir-92 microRNA precursor family, Mutation, NF-κB, NFE2L2, Nicotinamide adenine dinucleotide phosphate, NRF1, Organism, Oxidative stress, Peroxidase, Peroxiredoxin, Peroxisome, Plant, PPARGC1A, Protein, Protein–protein interaction, Reactive oxygen species, Redox, Ribonuclease, Ribonucleotide reductase, RuBisCO, SENP1, Sequence motif, Signal transduction, Thioredoxin fold, ..., Thioredoxin reductase, Transcription factor, Transgenesis, TXN2, TXNIP, Ventricular hypertrophy, Vicinal (chemistry). Expand index (7 more) »

Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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AMP-activated protein kinase

5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular energy homeostasis.

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Antioxidants & Redox Signaling

Antioxidants & Redox Signaling is a peer-reviewed scientific journal covering reduction–oxidation (redox) signaling and antioxidant research.

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AP-1 transcription factor

Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections.

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ASK1

Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5) is a member of MAP kinase kinase kinase family and as such a part of mitogen-activated protein kinase pathway.

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Biological process

Biological processes are the processes vital for a living organism to live.

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Biomolecular structure

Biomolecular structure is the intricate folded, three-dimensional shape that is formed by a molecule of protein, DNA, or RNA, and that is important to its function.

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Cardiac muscle cell

Cardiac muscle cells or cardiomyocytes (also known as myocardiocytes or cardiac myocytes) are the muscle cells (myocytes) that make up the cardiac muscle (heart muscle).

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Cell nucleus

In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.

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Cell signaling

Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions.

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Cellular compartment

Cellular compartments in cell biology comprise all of the closed parts within the cytosol of a eukaryotic cell, usually surrounded by a single or double lipid layer membrane.

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Collagen, type I, alpha 1

Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene.

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Cysteine

Cysteine (symbol Cys or C) is a semi-essential proteinogenic amino acid with the formula HO2CCH(NH2)CH2SH.

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Cytosol

The cytosol, also known as intracellular fluid (ICF) or cytoplasmic matrix, is the liquid found inside cells.

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Disulfide

In chemistry, a disulfide refers to a functional group with the structure R−S−S−R′.

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DNA repair

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.

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Embryo

An embryo is an early stage of development of a multicellular diploid eukaryotic organism.

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Free-radical theory of aging

The free radical theory of aging (FRTA) states that organisms age because cells accumulate free radical damage over time.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Glucocorticoid receptor

The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind.

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Glutaredoxin

Glutaredoxins are small redox enzymes of approximately one hundred amino-acid residues that use glutathione as a cofactor.

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Glutathione

Glutathione (GSH) is an important antioxidant in plants, animals, fungi, and some bacteria and archaea.

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HDAC4

Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene.

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Let-7 microRNA precursor

The Let-7 microRNA precursor was identified from a study of developmental timing in C. elegans, and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs.

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Mammal

Mammals are the vertebrates within the class Mammalia (from Latin mamma "breast"), a clade of endothermic amniotes distinguished from reptiles (including birds) by the possession of a neocortex (a region of the brain), hair, three middle ear bones, and mammary glands.

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MicroRNA

A microRNA (abbreviated miRNA) is a small non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression.

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Mir-92 microRNA precursor family

The miR-92 microRNAs are short single stranded non-protein coding RNA fragments initially discovered incorporated into an RNP complex with a proposed role of processing RNA molecules and further RNP assembly.

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Mutation

In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.

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NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival.

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NFE2L2

Nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2 or Nrf2, is a transcription factor that in humans is encoded by the NFE2L2 gene.

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Nicotinamide adenine dinucleotide phosphate

Nicotinamide adenine dinucleotide phosphate, abbreviated NADP or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.

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NRF1

Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.

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Organism

In biology, an organism (from Greek: ὀργανισμός, organismos) is any individual entity that exhibits the properties of life.

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Oxidative stress

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.

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Peroxidase

Peroxidases (EC number) are a large family of enzymes that typically catalyze a reaction of the form: For many of these enzymes the optimal substrate is hydrogen peroxide, but others are more active with organic hydroperoxides such as lipid peroxides.

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Peroxiredoxin

Peroxiredoxins (Prxs,; HGNC root symbol PRDX) are a ubiquitous family of antioxidant enzymes that also control cytokine-induced peroxide levels and thereby mediate signal transduction in mammalian cells.

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Peroxisome

A peroxisome is a type of organelle known as a microbody, found in virtually all eukaryotic cells.

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Plant

Plants are mainly multicellular, predominantly photosynthetic eukaryotes of the kingdom Plantae.

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PPARGC1A

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein–protein interaction

Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.

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Reactive oxygen species

Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen.

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Redox

Redox (short for reduction–oxidation reaction) (pronunciation: or) is a chemical reaction in which the oxidation states of atoms are changed.

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Ribonuclease

Ribonuclease (commonly abbreviated RNase) is a type of nuclease that catalyzes the degradation of RNA into smaller components.

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Ribonucleotide reductase

Ribonucleotide reductase (RNR), also known as ribonucleoside diphosphate reductase (rNDP), is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides.

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RuBisCO

Ribulose-1,5-bisphosphate carboxylase/oxygenase, commonly known by the abbreviations RuBisCO, RuBPCase, or RuBPco, is an enzyme involved in the first major step of carbon fixation, a process by which atmospheric carbon dioxide is converted by plants and other photosynthetic organisms to energy-rich molecules such as glucose.

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SENP1

Sentrin-specific protease 1 is an enzyme that in humans is encoded by the SENP1 gene.

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Sequence motif

In genetics, a sequence motif is a nucleotide or amino-acid sequence pattern that is widespread and has, or is conjectured to have, a biological significance.

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Signal transduction

Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.

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Thioredoxin fold

The thioredoxin fold is a protein fold common to enzymes that catalyze disulfide bond formation and isomerization.

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Thioredoxin reductase

Thioredoxin reductases (TR, TrxR) are the only known enzymes to reduce thioredoxin (Trx).

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Transcription factor

In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.

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Transgenesis

Transgenesis is the process of introducing an exogenous gene—called a transgene—into a living organism so that the organism will exhibit a new property and transmit that property to its offspring.

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TXN2

Thioredoxin, mitochondrial also known as thioredoxin-2 is a protein that in humans is encoded by the TXN2 gene on chromosome 22.

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TXNIP

Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene.

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Ventricular hypertrophy

Ventricular hypertrophy (VH) is thickening of the walls of a ventricle (lower chamber) of the heart.

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Vicinal (chemistry)

In chemistry the descriptor vicinal (from Latin vicinus.

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Redirects here:

TXN (gene), Thioredoxins.

References

[1] https://en.wikipedia.org/wiki/Thioredoxin

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