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44 relations: Accelerated approval (FDA), Adenoid cystic carcinoma, Adjuvant therapy, AMP-activated protein kinase, Angiogenesis, Apocrine gland carcinoma, Atezolizumab, BRCA1, BRCA2, Breast cancer, Cancer Epidemiology, Biomarkers & Prevention, Capecitabine, Case-control study, Caveolin, Combination therapy, Cytokeratin, Ductal carcinoma, Epidermal growth factor receptor, Estrogen receptor, Gene expression, Germline mutation, Glembatumumab vedotin, GPNMB, HER2/neu, Hormone therapy, Inflammatory breast cancer, Iniparib, Medullary carcinoma, Metastasis, Metformin, Neoadjuvant therapy, NK012, Nottingham Prognostic Index, PARP inhibitor, Positron emission tomography, Progesterone receptor, Protein-bound paclitaxel, Sacituzumab govitecan, Secretory component, Squamous cell carcinoma, Survivin, Taxane, Triple Negative Breast Cancer Foundation, Vantictumab.
Accelerated approval (FDA)
The United States Food and Drug Administration (FDA) initiated the FDA Accelerated Approval Program in 1992 to allow faster approval of drugs for serious conditions that fill an unmet medical need.
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Adenoid cystic carcinoma
Adenoid cystic carcinoma (sometimes referred to as adenocyst, malignant cylindroma, adenocystic, adenoidcystic, ACC or AdCC.) is a rare type of cancer that can exist in many different body sites.
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Adjuvant therapy
Adjuvant therapy, also known as adjunct therapy, add-on therapy, and adjuvant care, is therapy that is given in addition to the primary or initial therapy to maximize its effectiveness.
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AMP-activated protein kinase
5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular energy homeostasis.
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Angiogenesis
Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels.
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Apocrine gland carcinoma
Apocrine gland carcinoma is a cutaneous condition characterized by skin lesions which form in the axilla or anogenital regions.
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Atezolizumab
Atezolizumab (trade name Tecentriq) is a fully humanized, engineered monoclonal antibody of IgG1 isotype against the protein programmed cell death-ligand 1 (PD-L1).
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BRCA1
BRCA1 and BRCA1 are a human gene and its protein product, respectively.
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BRCA2
BRCA2 and BRCA2 are a human gene and its protein product, respectively.
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Breast cancer
Breast cancer is cancer that develops from breast tissue.
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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention is a peer-reviewed medical journal devoted to research in the field of cancer epidemiology.
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Capecitabine
Capecitabine, sold under the brand name Xeloda among others, is a chemotherapy medication used to treat breast cancer, gastric cancer and colorectal cancer.
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Case-control study
A case-control study is a type of observational study in which two existing groups differing in outcome are identified and compared on the basis of some supposed causal attribute.
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Caveolin
In molecular biology Caveolins are a family of integral membrane proteins that are the principal components of caveolae membranes and involved in receptor-independent endocytosis.
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Combination therapy
Combination therapy or polytherapy is therapy that uses more than one medication or modality (versus monotherapy, which is any therapy taken alone).
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Cytokeratin
Cytokeratins are keratin proteins found in the intracytoplasmic cytoskeleton of epithelial tissue.
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Ductal carcinoma
Ductal carcinoma is a type of tumor that primarily presents in the ducts of a gland.
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Epidermal growth factor receptor
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.
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Estrogen receptor
Estrogen receptors (ERs) are a group of proteins found inside cells.
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Gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product.
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Germline mutation
A germline mutation, or germinal mutation, is any detectable variation within germ cells (cells that, when fully developed, become sperm and ovum).
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Glembatumumab vedotin
Glembatumumab vedotin (also known as CDX-011 and CR011-vcMMAE) is an antibody-drug conjugate (ADC) that targets cancer cells expressing transmembrane glycoprotein NMB (GPNMB).
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GPNMB
Transmembrane glycoprotein NMB is a protein that in humans is encoded by the GPNMB gene.
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HER2/neu
Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene.
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Hormone therapy
Hormone therapy or hormonal therapy is the use of hormones in medical treatment.
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Inflammatory breast cancer
Inflammatory breast cancer is one of the most aggressive types of breast cancer that can occur in women of any age (and, extremely rarely, in men).
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Iniparib
Iniparib (INN, previously known as BSI 201) was a drug candidate for cancer treatment.
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Medullary carcinoma
Medullary carcinoma may refer to one of several different tumors of epithelial origin.
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Metastasis
Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; it is typically spoken of as such spread by a cancerous tumor.
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Metformin
Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight.
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Neoadjuvant therapy
Neoadjuvant therapy is the administration of therapeutic agents before a main treatment.
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NK012
NK012 is a 'nanodevice' formulation of SN-38 (an irinotecan metabolite).
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Nottingham Prognostic Index
The Nottingham prognostic index (NPI) is used to determine prognosis following surgery for breast cancer.
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PARP inhibitor
PARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP).
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Positron emission tomography
Positron-emission tomography (PET) is a nuclear medicine functional imaging technique that is used to observe metabolic processes in the body as an aid to the diagnosis of disease.
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Progesterone receptor
The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells.
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Protein-bound paclitaxel
Protein-bound paclitaxel, also known as nanoparticle albumin–bound paclitaxel or nab-paclitaxel, is an injectable formulation of paclitaxel used to treat breast cancer, lung cancer and pancreatic cancer, among others.
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Sacituzumab govitecan
Sacituzumab govitecan (IMMU-132 or hRS7-SN-38) is an investigational antibody-drug conjugate.
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Secretory component
The secretory component is a component of immunoglobulin A (IgA).
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Squamous cell carcinoma
Squamous cell carcinomas, also known as epidermoid carcinoma are a number of different types of cancer that result from squamous cells.
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Survivin
Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene.
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Taxane
Taxanes are a class of diterpenes.
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Triple Negative Breast Cancer Foundation
The Triple Negative Breast Cancer Foundation ("TNBC Foundation" or "TNBCF") is a nonprofit organization dedicated to raising awareness of triple-negative breast cancer.
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Vantictumab
Vantictumab is a human IgG2 monoclonal antibody designed for the treatment of cancer.
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Redirects here:
Triple Negative Breast Cancer, Triple negative breast cancer, Triple negative metastatic breast cancer.
References
[1] https://en.wikipedia.org/wiki/Triple-negative_breast_cancer
