Ribonucleotide reductase inhibitor

Ribonucleotide reductase inhibitors are a family of anti-cancer drugs that interfere with the growth of tumor cells by blocking the formation of deoxyribonucleotides (building blocks of DNA). ^[1]

14 relations: Chemotherapy, Cladribine, Deoxyribonucleotide, DNA, Fludarabine, Gallium maltolate, Gallium nitrate, Gemcitabine, Hydroxycarbamide, Motexafin gadolinium, Neoplasm, Ribonucleotide reductase, Tezacitabine, 3-Aminopyridine-2-carboxaldehyde thiosemicarbazone.

Chemotherapy

Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen.

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Cladribine

Cladribine, sold under the brand name Leustatin among others, is a medication used to treat hairy cell leukemia (HCL, leukemic reticuloendotheliosis) and B-cell chronic lymphocytic leukemia.

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Deoxyribonucleotide

A deoxyribonucleotide is the monomer, or single unit, of DNA, or deoxyribonucleic acid.

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DNA

Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.

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Fludarabine

Fludarabine, sold under the brand name Fludara among others, is a chemotherapy medication used in the treatment of leukemia and lymphoma.

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Gallium maltolate

Gallium maltolate is a coordination complex consisting of a trivalent gallium cation coordinated to three maltolate ligands.

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Gallium nitrate

Gallium nitrate (brand name Ganite) is the gallium salt of nitric acid with the chemical formula Ga(NO3)3.

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Gemcitabine

Gemcitabine, sold under the brand name Gemzar, among others, is a chemotherapy medication used to treat a number of types of cancer.

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Hydroxycarbamide

Hydroxycarbamide, also known as hydroxyurea, is a medication used in sickle-cell disease, chronic myelogenous leukemia, cervical cancer, and polycythemia vera.

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Motexafin gadolinium

Motexafin gadolinium (proposed tradename Xcytrin) is an inhibitor of thioredoxin reductase and ribonucleotide reductase.

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Neoplasm

Neoplasia is a type of abnormal and excessive growth of tissue.

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Ribonucleotide reductase

Ribonucleotide reductase (RNR), also known as ribonucleoside diphosphate reductase (rNDP), is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides.

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Tezacitabine

Tezacitabine is a ribonucleotide reductase inhibitor.

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3-Aminopyridine-2-carboxaldehyde thiosemicarbazone

3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, also called Triapine) is a substance that is being studied in the treatment of cancer.

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References

[1] https://en.wikipedia.org/wiki/Ribonucleotide_reductase_inhibitor

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