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47 relations: Adenosine triphosphate, Alzheimer's disease, Atherosclerosis, Autoimmune disease, Beta-Hydroxybutyric acid, Carcinogenesis, CARD domain, Caspase 1, Chromosome 1, Cold urticaria, Cryopyrin-associated periodic syndrome, Cytoplasm, Diabetes mellitus type 2, Familial Mediterranean fever, Gene, Gout, Hepatocellular carcinoma, Hsp90, Inflammasome, Innate immune system, Interleukin 1 beta, Keratoendotheliitis fugax hereditaria, Leucine-rich repeat, Macrophage, Major histocompatibility complex, Mechanosensitive channels, MEFV, Muckle–Wells syndrome, Multiple sclerosis, NACHT domain, Nature Medicine, Neonatal-onset multisystem inflammatory disease, Neuroinflammation, NOD-like receptor, Parkinson's disease, Pathogen-associated molecular pattern, Pathogenesis, Pattern recognition receptor, Periodic fever syndrome, Protein, Proteopathy, PYCARD, Pyrin domain, Reactive oxygen species, SUGT1, Transmissible spongiform encephalopathy, Uric acid.
Adenosine triphosphate
Adenosine triphosphate (ATP) is a complex organic chemical that participates in many processes.
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Alzheimer's disease
Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.
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Atherosclerosis
Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque.
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Autoimmune disease
An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.
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Beta-Hydroxybutyric acid
β-Hydroxybutyric acid, also known as 3-hydroxybutyric acid, is an organic compound and a beta hydroxy acid with the chemical formula CH3CH(OH)CH2CO2H; its conjugate base is β-hydroxybutyrate, also known as 3-hydroxybutyrate.
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Carcinogenesis
Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells.
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CARD domain
Caspase recruitment domains, or Caspase activation and recruitment domains (CARDs), are interaction motifs found in a wide array of proteins, typically those involved in processes relating to inflammation and apoptosis.
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Caspase 1
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides.
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Chromosome 1
Chromosome 1 is the designation for the largest human chromosome.
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Cold urticaria
Cold urticaria (essentially meaning "cold hives") is a disorder where hives (urticaria) or large red welts form on the skin after exposure to a cold stimulus.
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Cryopyrin-associated periodic syndrome
Cryopyrin-associated periodic syndrome (CAPS) is a group of rare, heterogeneous autoinflammatory disease characterized by interleukin 1β-mediated systemic inflammation and clinical symptoms involving skin, joints, central nervous system, and eyes.
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Cytoplasm
In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus.
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Diabetes mellitus type 2
Diabetes mellitus type 2 (also known as type 2 diabetes) is a long-term metabolic disorder that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
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Familial Mediterranean fever
Familial Mediterranean fever (FMF) is a hereditary inflammatory disorder.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Gout
Gout is a form of inflammatory arthritis characterized by recurrent attacks of a red, tender, hot, and swollen joint.
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Hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults, and is the most common cause of death in people with cirrhosis.
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Hsp90
Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation.
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Inflammasome
The inflammasome is a multiprotein oligomer responsible for the activation of inflammatory responses.
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Innate immune system
The innate immune system, also known as the non-specific immune system or in-born immunity system, is an important subsystem of the overall immune system that comprises the cells and mechanisms involved in the defense of the host from infection by other organisms.
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Interleukin 1 beta
Interleukin 1 beta (IL1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the IL1B gene.
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Keratoendotheliitis fugax hereditaria
Keratoendotheliitis fugax hereditaria is an autosomal dominantly inherited disease of the cornea, caused by a point mutation in cryopyrin (also known as NALP3) that in humans is encoded by the NLRP3 gene located on the long arm of chromosome 1.
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Leucine-rich repeat
A leucine-rich repeat (LRR) is a protein structural motif that forms an α/β horseshoe fold.
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Macrophage
Macrophages (big eaters, from Greek μακρός (makrós).
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Major histocompatibility complex
The major histocompatibility complex (MHC) is a set of cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates, which in turn determines histocompatibility.
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Mechanosensitive channels
Mechanosensitive channels, mechanosensitive ion channels or stretch-gated ion channels.
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MEFV
MEFV (Mediterranean fever) is a human gene that provides instructions for making a protein called pyrin (also known as marenostrin).
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Muckle–Wells syndrome
Muckle–Wells syndrome (MWS), also known as urticaria-deafness-amyloidosis syndrome (UDA), is a rare autosomal dominant disease which causes sensorineural deafness and recurrent hives, and can lead to amyloidosis.
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Multiple sclerosis
Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged.
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NACHT domain
The NACHT domain is an evolutionarily conserved protein domain.
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Nature Medicine
Nature Medicine is a monthly peer-reviewed medical journal publishing research articles, reviews, news and commentaries in the biomedical area, including both basic research and early-phase clinical research covering all aspects of medicine.
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Neonatal-onset multisystem inflammatory disease
Neonatal-onset multisystem inflammatory disease (abbreviated NOMID, also known as chronic infantile neurologic cutaneous and articular syndrome,James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders.. or CINCA) is a rare genetic periodic fever syndrome which causes uncontrolled inflammation in multiple parts of the body starting in the newborn period.
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Neuroinflammation
Neuroinflammation is inflammation of the nervous tissue.
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NOD-like receptor
The nucleotide-binding oligomerization domain-like receptors, in short NOD-like receptors (NLRs), are intracellular sensors of PAMPs that enter the cell via phagocytosis or pores and DAMPs that are associated with cell stress.
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Parkinson's disease
Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.
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Pathogen-associated molecular pattern
Pathogen-associated molecular patterns, or PAMPs, are molecules associated with groups of pathogens, that are recognized by cells of the innate immune system.
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Pathogenesis
The pathogenesis of a disease is the biological mechanism (or mechanisms) that leads to the diseased state.
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Pattern recognition receptor
Pattern recognition receptors (PRRs) play a crucial role in the proper function of the innate immune system.
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Periodic fever syndrome
Periodic fever syndromes (also known as autoinflammatory diseases or autoinflammatory syndromes) are a set of disorders characterized by recurrent episodes of systemic and organ-specific inflammation.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Proteopathy
In medicine, proteopathy (Proteo-; -pathy; proteopathies pl.; proteopathic adj.) refers to a class of diseases in which certain proteins become structurally abnormal, and thereby disrupt the function of cells, tissues and organs of the body.
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PYCARD
PYCARD, often referred to as ASC (Apoptosis-associated speck-like protein containing a CARD), is a protein that in humans is encoded by the PYCARD gene.
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Pyrin domain
A pyrin domain is a protein domain and a subclass of protein motif known as the death fold; it allows a pyrin domain containing protein to interact with other proteins that contain a pyrin domain.
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Reactive oxygen species
Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen.
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SUGT1
Suppressor of G2 allele of SKP1 homolog is a protein that in humans is encoded by the SUGT1 gene.
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Transmissible spongiform encephalopathy
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive, invariably fatal, conditions that affect the brain (encephalopathies) and nervous system of many animals, including humans.
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Uric acid
Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C5H4N4O3.
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CIAS1, Cryopyrin, NLRP3, NLRP3 (gene).
References
[1] https://en.wikipedia.org/wiki/NALP3
