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102 relations: Allosteric regulation, Alpha-1 adrenergic receptor, Alpha-2 adrenergic receptor, American Congress of Obstetricians and Gynecologists, Anorgasmia, Antidepressant, Ataxia, Beecham Group, Bipolar disorder, Class action, Clomipramine, Committee for Medicinal Products for Human Use, Competition and Markets Authority, Competition Appeal Tribunal, CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, Cytochrome P450, Delayed ejaculation, Diabetic neuropathy, Discovery (law), Dopamine receptor D2, Dopamine transporter, Dysthymia, Epileptic seizure, Erectile dysfunction, Escitalopram, European Medicines Agency, European Union, Feces, Fiona Godlee, First pass effect, Fluoxetine, Food and Drug Administration, Generalized anxiety disorder, Generic drug, GlaxoSmithKline, Half-life, Histamine H1 receptor, Hot flash, Hypomania, Imipramine, Insomnia, International Federation of Pharmaceutical Manufacturers & Associations, Kidney, Lethargy, Liebowitz social anxiety scale, ..., List of largest selling pharmaceutical products, Liver, Major depressive disorder, Mania, Menopause, Monoamine oxidase inhibitor, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M5, Neuroleptic malignant syndrome, Night sweats, Norepinephrine, Norepinephrine transporter, Obsessive–compulsive disorder, Panic disorder, Paresthesia, Pimozide, Posttraumatic stress disorder, Prefrontal cortex, Premature ejaculation, Premenstrual dysphoric disorder, Problem gambling, Retrospective cohort study, Selective serotonin reuptake inhibitor, Serotonin, Serotonin syndrome, Serotonin transporter, Sertraline, Social anxiety disorder, Social Phobia Inventory, Statin, Study 329, Substrate (chemistry), Systematic review, Tachycardia, Tension headache, The BMJ, The New York Review of Books, Thioridazine, Triptan, Tryptophan, United States Department of Justice, United States District Court for the District of Massachusetts, Venlafaxine, Vomiting, Warfarin, 5-HT1A receptor, 5-HT2A receptor, 5-HT2C receptor, 5-HT3 receptor. Expand index (52 more) »
Allosteric regulation
In biochemistry, allosteric regulation (or allosteric control) is the regulation of an enzyme by binding an effector molecule at a site other than the enzyme's active site.
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Alpha-1 adrenergic receptor
The alpha-1 (α1) adrenergic receptor is a G protein-coupled receptor (GPCR) associated with the Gq heterotrimeric G-protein.
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Alpha-2 adrenergic receptor
The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein.
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American Congress of Obstetricians and Gynecologists
The American College of Obstetricians and Gynecologists is a professional association of physicians specializing in obstetrics and gynecology in the United States.
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Anorgasmia
Anorgasmia, or Coughlan's syndrome, is a type of sexual dysfunction in which a person cannot achieve orgasm despite adequate stimulation.
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Antidepressant
Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.
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Ataxia
Ataxia is a neurological sign consisting of lack of voluntary coordination of muscle movements that includes gait abnormality.
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Beecham Group
The Beecham Group plc was a British pharmaceutical company.
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Bipolar disorder
Bipolar disorder, previously known as manic depression, is a mental disorder that causes periods of depression and periods of abnormally elevated mood.
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Class action
A class action, class suit, or representative action is a type of lawsuit where one of the parties is a group of people who are represented collectively by a member of that group.
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Clomipramine
Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA).
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Committee for Medicinal Products for Human Use
The Committee for Medicinal Products for Human Use (CHMP), formerly known as Committee for Proprietary Medicinal Products (CPMP), is the European Medicines Agency's committee responsible for elaborating the agency's opinions on all issues regarding medicinal products for human use.
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Competition and Markets Authority
The Competition and Markets Authority (CMA) is a non-ministerial government department in the United Kingdom, responsible for strengthening business competition and preventing and reducing anti-competitive activities.
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Competition Appeal Tribunal
The Competition Appeal Tribunal (CAT) of the United Kingdom was created by Section 12 and Schedule 2 to the Enterprise Act 2002 which came into force on 1 April 2003.
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CYP1A2
Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.
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CYP2B6
Cytochrome P450 2B6 is an enzyme that in humans is encoded by the CYP2B6 gene.
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CYP2C19
Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme.
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CYP2C9
Cytochrome P450 2C9 (abbreviated CYP2C9) is an enzyme that in humans is encoded by the CYP2C9 gene.
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CYP2D6
Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene.
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CYP3A4
Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.
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Cytochrome P450
Cytochromes P450 (CYPs) are proteins of the superfamily containing heme as a cofactor and, therefore, are hemoproteins.
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Delayed ejaculation
Delayed ejaculation, also called retarded ejaculation or inhibited ejaculation, is a man's inability for or persistent difficulty in achieving orgasm, despite typical sexual desire and sexual stimulation.
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Diabetic neuropathy
Diabetic neuropathies are nerve damaging disorders associated with diabetes mellitus.
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Discovery (law)
Discovery, in the law of the United States and other countries, is a pre-trial procedure in a lawsuit in which each party, through the law of civil procedure, can obtain evidence from the other party or parties by means of discovery devices such as a request for answers to interrogatories, request for production of documents, request for admissions and depositions.
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Dopamine receptor D2
Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.
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Dopamine transporter
The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol.
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Dysthymia
Dysthymia, now known as persistent depressive disorder (PDD), is a mood disorder consisting of the same cognitive and physical problems as depression, with less severe but longer-lasting symptoms.
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Epileptic seizure
An epileptic seizure is a brief episode of signs or symptoms due to abnormally excessive or synchronous neuronal activity in the brain.
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Erectile dysfunction
Erectile dysfunction (ED), also known as impotence, is a type of sexual dysfunction characterized by the inability to develop or maintain an erection of the penis during sexual activity.
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Escitalopram
Escitalopram, sold under the brand names Cipralex and Lexapro among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
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European Medicines Agency
The European Medicines Agency (EMA) is a European Union agency for the evaluation of medicinal products.
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European Union
The European Union (EU) is a political and economic union of EUnum member states that are located primarily in Europe.
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Feces
Feces (or faeces) are the solid or semisolid remains of the food that could not be digested in the small intestine.
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Fiona Godlee
Fiona Godlee (born August 4, 1961) has been editor in chief of The BMJ since 2005; she is the first female editor appointed in the journal's history.
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First pass effect
The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation.
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Fluoxetine
Fluoxetine, also known by trade names Prozac and Sarafem, among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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Generalized anxiety disorder
Generalized anxiety disorder (GAD) is an anxiety disorder characterized by excessive, uncontrollable and often irrational worry, that is, apprehensive expectation about events or activities.
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Generic drug
A generic drug is a pharmaceutical drug that is equivalent to a brand-name product in dosage, strength, route of administration, quality, performance, and intended use, but does not carry the brand name.
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GlaxoSmithKline
GlaxoSmithKline plc (GSK) is a British pharmaceutical company headquartered in Brentford, London.
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Half-life
Half-life (symbol t1⁄2) is the time required for a quantity to reduce to half its initial value.
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Histamine H1 receptor
The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors.
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Hot flash
Hot flashes (American English) or hot flushes (British English) are a form of flushing due to reduced levels of estradiol.
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Hypomania
Hypomania (literally "under mania" or "less than mania") is a mood state characterized by persistent disinhibition and elevation (euphoria).
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Imipramine
Imipramine, sold under the brand name Tofranil among others, is a tricyclic antidepressant (TCA) which is used mainly in the treatment of depression.
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Insomnia
Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.
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International Federation of Pharmaceutical Manufacturers & Associations
The International Federation of Pharmaceutical Manufacturers & Associations (IFPMA) represents the research-based pharmaceutical companies and associations across the globe.
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Kidney
The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.
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Lethargy
Lethargy is a state of tiredness, weariness, fatigue, or lack of energy.
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Liebowitz social anxiety scale
The Liebowitz Social Anxiety Scale (LSAS) is a short questionnaire developed in 1987 by Michael Liebowitz, a psychiatrist and researcher at Columbia University and the New York State Psychiatric Institute.
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List of largest selling pharmaceutical products
Drugs with sales above $5 billion in 2015 included.
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Liver
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
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Major depressive disorder
Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.
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Mania
Mania, also known as manic syndrome, is a state of abnormally elevated arousal, affect, and energy level, or "a state of heightened overall activation with enhanced affective expression together with lability of affect." Although mania is often conceived as a "mirror image" to depression, the heightened mood can be either euphoric or irritable; indeed, as the mania intensifies, irritability can be more pronounced and result in violence, or anxiety.
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Menopause
Menopause, also known as the climacteric, is the time in most women's lives when menstrual periods stop permanently, and they are no longer able to bear children.
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Monoamine oxidase inhibitor
Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B).
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Muscarinic acetylcholine receptor M1
The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the CHRM1 gene.
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Muscarinic acetylcholine receptor M2
The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor that in humans is encoded by the CHRM2 gene.
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Muscarinic acetylcholine receptor M3
The muscarinic acetylcholine receptor, also known as cholinergic/acetylcholine receptor M3, or the muscarinic 3, is a muscarinic acetylcholine receptor encoded by the human gene CHRM3.
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Muscarinic acetylcholine receptor M4
The muscarinic acetylcholine receptor M4, also known as the cholinergic receptor, muscarinic 4 (CHRM4), is a protein that, in humans, is encoded by the CHRM4 gene.
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Muscarinic acetylcholine receptor M5
The human muscarinic acetylcholine receptor M5, encoded by the gene, is a member of the G protein-coupled receptor superfamily of integral membrane proteins.
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Neuroleptic malignant syndrome
Neuroleptic malignant syndrome (NMS) is a life-threatening reaction that occasionally occurs in response to neuroleptic or antipsychotic medication.
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Night sweats
Night sweats, also known as nocturnal hyperhidrosis, is the occurrence of excessive sweating during sleep.
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Norepinephrine
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.
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Norepinephrine transporter
The norepinephrine transporter (NET), also known as solute carrier family 6 member 2 (SLC6A2), is a protein that in humans is encoded by the SLC6A2 gene.
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Obsessive–compulsive disorder
Obsessive–compulsive disorder (OCD) is a mental disorder where people feel the need to check things repeatedly, perform certain routines repeatedly (called "rituals"), or have certain thoughts repeatedly (called "obsessions").
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Panic disorder
Panic disorder is an anxiety disorder characterized by reoccurring unexpected panic attacks.
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Paresthesia
Paresthesia is an abnormal sensation such as tingling, tickling, pricking, numbness or burning of a person's skin with no apparent physical cause.
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Pimozide
Pimozide (sold under the brand name Orap) is an antipsychotic drug of the diphenylbutylpiperidine class.
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Posttraumatic stress disorder
Posttraumatic stress disorder (PTSD)Acceptable variants of this term exist; see the Terminology section in this article.
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Prefrontal cortex
In mammalian brain anatomy, the prefrontal cortex (PFC) is the cerebral cortex which covers the front part of the frontal lobe.
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Premature ejaculation
Premature ejaculation (PE) occurs when a man experiences orgasm and expels semen soon after sexual activity and with minimal penile stimulation.
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Premenstrual dysphoric disorder
Premenstrual dysphoric disorder (PMDD) is a severe and disabling form of premenstrual syndrome affecting 3–8% of menstruating women.
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Problem gambling
Problem gambling (or ludomania, but usually referred to as "gambling addiction" or "compulsive gambling") is an urge to gamble continuously despite harmful negative consequences or a desire to stop.
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Retrospective cohort study
A retrospective cohort study, also called a historic cohort study, is a longitudinal cohort study used in medical and psychological research.
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Selective serotonin reuptake inhibitor
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders.
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Serotonin
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
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Serotonin syndrome
Serotonin syndrome (SS) is a group of symptoms that may occur following use of certain serotonergic medications or drugs.
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Serotonin transporter
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.
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Sertraline
Sertraline, sold under the trade names Zoloft among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
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Social anxiety disorder
Social anxiety disorder (SAD), also known as social phobia, is an anxiety disorder characterized by a significant amount of fear in one or more social situations, causing considerable distress and impaired ability to function in at least some parts of daily life.
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Social Phobia Inventory
Social Phobia Inventory (SPIN) is a questionnaire developed by the department of Psychiatry and Behavioral Sciences of Duke University for screening and measuring severity of social anxiety disorder.
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Statin
Statins, also known as HMG-CoA reductase inhibitors, are a class of lipid-lowering medications.
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Study 329
Study 329 was a clinical trial conducted in North America from 1994 to 1998 to study the efficacy of paroxetine, an SSRI anti-depressant, in treating 12- to 18-year-olds diagnosed with major depressive disorder.
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Substrate (chemistry)
In chemistry, a substrate is typically the chemical species being observed in a chemical reaction, which reacts with a reagent to generate a product.
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Systematic review
Systematic reviews are a type of literature review that uses systematic methods to collect secondary data, critically appraise research studies, and synthesize studies.
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Tachycardia
Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate.
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Tension headache
Tension headache, also known as tension-type headache, is the most common type of primary headache.
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The BMJ
The BMJ is a weekly peer-reviewed medical journal.
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The New York Review of Books
The New York Review of Books (or NYREV or NYRB) is a semi-monthly magazine with articles on literature, culture, economics, science and current affairs.
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Thioridazine
Thioridazine (Mellaril or Melleril) is a piperidine typical antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis.
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Triptan
Triptans are a family of tryptamine-based drugs used as abortive medication in the treatment of migraines and cluster headaches.
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Tryptophan
Tryptophan (symbol Trp or W) is an α-amino acid that is used in the biosynthesis of proteins.
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United States Department of Justice
The United States Department of Justice (DOJ), also known as the Justice Department, is a federal executive department of the U.S. government, responsible for the enforcement of the law and administration of justice in the United States, equivalent to the justice or interior ministries of other countries. The department was formed in 1870 during the Ulysses S. Grant administration. The Department of Justice administers several federal law enforcement agencies including the Federal Bureau of Investigation (FBI), and the Drug Enforcement Administration (DEA). The department is responsible for investigating instances of financial fraud, representing the United States government in legal matters (such as in cases before the Supreme Court), and running the federal prison system. The department is also responsible for reviewing the conduct of local law enforcement as directed by the Violent Crime Control and Law Enforcement Act of 1994. The department is headed by the United States Attorney General, who is nominated by the President and confirmed by the Senate and is a member of the Cabinet. The current Attorney General is Jeff Sessions.
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United States District Court for the District of Massachusetts
The United States District Court for the District of Massachusetts (in case citations, D. Mass.) is the federal district court whose territorial jurisdiction is the Commonwealth of Massachusetts, United States.
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Venlafaxine
Venlafaxine, sold under the brand name Effexor among others, is an antidepressant of the selective serotonin-norepinephrine reuptake inhibitor (SNRI) class.
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Vomiting
Vomiting, also known as emesis, puking, barfing, throwing up, among other terms, is the involuntary, forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose.
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Warfarin
Warfarin, sold under the brand name Coumadin among others, is a medication that is used as an anticoagulant (blood thinner).
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5-HT1A receptor
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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5-HT2A receptor
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).
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5-HT2C receptor
The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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5-HT3 receptor
The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin) receptors which are G protein-coupled receptors.
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ATC code N06AB05, ATCvet code QN06AB05, Aropax, Aroxat, Brisdelle, C19H20FNO3, Deroxat, Divarius, Loxamine, Optipar, Oxetine, Paronex, Paroxatine, Paroxetin, Paroxetine Hydrochloride, Paroxetine hydrochloride, Paroxetine mesylate, Paroxitine, Paxil, Paxil CR, Paxil cr, Pexeva, Posivyl, Seretran, Seroxat, Seroxat CR.
References
[1] https://en.wikipedia.org/wiki/Paroxetine
