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110 relations: Agranulocytosis, Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptor, Alpha-2A adrenergic receptor, Alpha-2B adrenergic receptor, Alpha-2C adrenergic receptor, Amnesia, Anemia, Aripiprazole, Arthralgia, Ataxia, Atypical antipsychotic, Bradycardia, Carbinoxamine, Cholestasis, Clozapine, Conjunctivitis, Creatinine, Czech Republic, Deep vein thrombosis, Diabetes mellitus, Diphenhydramine, Dopamine receptor, Dopamine receptor D1, Dopamine receptor D2, Dopamine receptor D3, Dopamine receptor D4, Dopamine receptor D5, Dopamine transporter, Dosulepin, Doxylamine, Drug, Edema, Eosinophilia, Extrapyramidal symptoms, Germany, Glaucoma, Hair loss, Haloperidol, Histamine H1 receptor, Histamine H2 receptor, Histamine H4 receptor, Hyperglycemia, Hyperlipidemia, Hyperprolactinaemia, Hypersalivation, Hyperthermia, Hypoesthesia, Hypoglycemia, Hypotension, ..., Hypothermia, Hypouricemia, Ileus, Indigestion, Indonesia, Japan, Leukopenia, Ligand (biochemistry), Metabolic syndrome, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M5, Muscle weakness, Myalgia, Mydriasis, Myoclonus, Neuroleptic malignant syndrome, Neutropenia, Norepinephrine reuptake inhibitor, Norepinephrine transporter, Nosebleed, Noxiptiline, Olanzapine, Orphenadrine, Orthostatic hypotension, Paliperidone, Palpitations, Pharmacodynamics, Portugal, QT interval, Quetiapine, Receptor antagonist, Risperidone, Schizophrenia, Serotonin transporter, Sexual dysfunction, Shortness of breath, Somnolence, Tachycardia, Tardive dyskinesia, Thrombocythemia, Thrombocytopenia, TLR4, Turkey, United Kingdom, Urinary retention, Xerostomia, 5-HT receptor, 5-HT1A receptor, 5-HT1B receptor, 5-HT1D receptor, 5-HT1E receptor, 5-HT2A receptor, 5-HT2C receptor, 5-HT3 receptor, 5-HT5A receptor, 5-HT6 receptor, 5-HT7 receptor. Expand index (60 more) »
Agranulocytosis
Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving a severe and dangerous leukopenia (lowered white blood cell count), most commonly of neutrophils causing a neutropenia in the circulating blood.
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Alpha-1A adrenergic receptor
The alpha-1A adrenergic receptor (α1A adrenoreceptor), also known as ADRA1A, formerly known also as the alpha-1C adrenergic receptor, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.
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Alpha-1B adrenergic receptor
The alpha-1B adrenergic receptor (α1B adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.
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Alpha-2A adrenergic receptor
The alpha-2A adrenergic receptor (α2A adrenoceptor), also known as ADRA2A, is an α2 adrenergic receptor, and also denotes the human gene encoding it.
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Alpha-2B adrenergic receptor
The alpha-2B adrenergic receptor (α2B adrenoceptor), is a G-protein coupled receptor.
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Alpha-2C adrenergic receptor
The alpha-2C adrenergic receptor (α2C adrenoceptor), also known as ADRA2C, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.
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Amnesia
Amnesia is a deficit in memory caused by brain damage, disease, or psychological trauma.
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Anemia
Anemia is a decrease in the total amount of red blood cells (RBCs) or hemoglobin in the blood, or a lowered ability of the blood to carry oxygen.
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Aripiprazole
Aripiprazole, sold under the brand name Abilify among others, is an atypical antipsychotic. It is recommended and primarily used in the treatment of schizophrenia and bipolar disorder. Other uses include as an add-on treatment in major depressive disorder, tic disorders, and irritability associated with autism. According to a Cochrane review, evidence for the oral form in schizophrenia is not sufficient to determine effects on general functioning. Additionally, because many people dropped out of the medication trials before they were completed, the overall strength of the conclusions is low. Side effects include neuroleptic malignant syndrome, a movement disorder known as tardive dyskinesia, and high blood sugar in those with diabetes. In the elderly there is an increased risk of death. It is thus not recommended for use in those with psychosis due to dementia. It is pregnancy category C in the United States and category C in Australia, meaning there is possible evidence of harm to the fetus. It is not recommended for women who are breastfeeding. It is unclear whether it is safe or effective in people less than 18 years old. It is a partial dopamine agonist. Aripiprazole was developed by Otsuka in Japan. In the United States, Otsuka America markets it jointly with Bristol-Myers Squibb. From April 2013 to March 2014, sales of Abilify amounted to almost $6.9 billion.
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Arthralgia
Arthralgia (from Greek arthro-, joint + -algos, pain) literally means joint pain; it is a symptom of injury, infection, illnesses (in particular arthritis) or an allergic reaction to medication.
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Ataxia
Ataxia is a neurological sign consisting of lack of voluntary coordination of muscle movements that includes gait abnormality.
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Atypical antipsychotic
The atypical antipsychotics (AAP; also known as second generation antipsychotics (SGAs)) are a group of antipsychotic drugs (antipsychotic drugs in general are also known as major tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) used to treat psychiatric conditions.
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Bradycardia
Bradycardia is a condition wherein an individual has a very slow heart rate, typically defined as a resting heart rate of under 60 beats per minute (BPM) in adults.
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Carbinoxamine
Carbinoxamine (Clistin, Palgic, Rondec, Rhinopront) is a antihistamine and anticholinergic agent.
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Cholestasis
Cholestasis is a condition where bile cannot flow from the liver to the duodenum.
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Clozapine
Clozapine, sold under the brand name Clozaril among others, is an atypical antipsychotic medication.
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Conjunctivitis
Conjunctivitis, also known as pink eye, is inflammation of the outermost layer of the white part of the eye and the inner surface of the eyelid.
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Creatinine
Creatinine (or; from flesh) is a breakdown product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body (depending on muscle mass).
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Czech Republic
The Czech Republic (Česká republika), also known by its short-form name Czechia (Česko), is a landlocked country in Central Europe bordered by Germany to the west, Austria to the south, Slovakia to the east and Poland to the northeast.
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Deep vein thrombosis
Deep vein thrombosis (DVT), is the formation of a blood clot in a deep vein, most commonly the legs.
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Diabetes mellitus
Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period.
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Diphenhydramine
Diphenhydramine is an antihistamine mainly used to treat allergies.
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Dopamine receptor
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS).
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Dopamine receptor D1
Dopamine receptor D1, also known as DRD1, is a protein that in humans is encoded by the DRD1 gene.
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Dopamine receptor D2
Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.
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Dopamine receptor D3
Dopamine receptor D3 is a protein that in humans is encoded by the DRD3 gene.
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Dopamine receptor D4
The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the gene on chromosome 11 at 11p15.5.
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Dopamine receptor D5
Dopamine receptor D5, also known as D1BR, is a protein that in humans is encoded by the DRD5 gene.
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Dopamine transporter
The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol.
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Dosulepin
Dosulepin, also known as dothiepin and sold under the brand name Prothiaden among others, is a tricyclic antidepressant (TCA) which is used in the treatment of depression.
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Doxylamine
Doxylamine is a first-generation antihistamine.
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Drug
A drug is any substance (other than food that provides nutritional support) that, when inhaled, injected, smoked, consumed, absorbed via a patch on the skin, or dissolved under the tongue causes a temporary physiological (and often psychological) change in the body.
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Edema
Edema, also spelled oedema or œdema, is an abnormal accumulation of fluid in the interstitium, located beneath the skin and in the cavities of the body, which can cause severe pain.
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Eosinophilia
Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds.
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Extrapyramidal symptoms
Extrapyramidal symptoms (EPS), also known as extrapyramidal side effects (EPSE), are drug-induced movement disorders that include acute and tardive symptoms.
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Germany
Germany (Deutschland), officially the Federal Republic of Germany (Bundesrepublik Deutschland), is a sovereign state in central-western Europe.
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Glaucoma
Glaucoma is a group of eye diseases which result in damage to the optic nerve and vision loss.
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Hair loss
Hair loss, also known as alopecia or baldness, refers to a loss of hair from part of the head or body.
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Haloperidol
Haloperidol, marketed under the trade name Haldol among others, is a typical antipsychotic medication.
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Histamine H1 receptor
The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors.
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Histamine H2 receptor
H2 receptors are positively coupled to adenylate cyclase via Gs.
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Histamine H4 receptor
The histamine H4 receptor is, like the other three histamine receptors, a member of the G protein-coupled receptor superfamily.
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Hyperglycemia
Hyperglycemia, or high blood sugar (also spelled hyperglycaemia or hyperglycæmia) is a condition in which an excessive amount of glucose circulates in the blood plasma.
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Hyperlipidemia
Hyperlipidemia is abnormally elevated levels of any or all lipids or lipoproteins in the blood.
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Hyperprolactinaemia
Hyperprolactinemia or hyperprolactinaemia is the presence of abnormally high levels of prolactin in the blood.
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Hypersalivation
Hypersalivation (also called ptyalism or sialorrhea) is excessive production of saliva.
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Hyperthermia
Hyperthermia is elevated body temperature due to failed thermoregulation that occurs when a body produces or absorbs more heat than it dissipates.
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Hypoesthesia
Hypoesthesia (also spelled as hypesthesia) is a common side effect of various medical conditions which manifests as a reduced sense of touch or sensation, or a partial loss of sensitivity to sensory stimuli.
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Hypoglycemia
Hypoglycemia, also known as low blood sugar, is when blood sugar decreases to below normal levels.
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Hypotension
Hypotension is low blood pressure, especially in the arteries of the systemic circulation.
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Hypothermia
Hypothermia is reduced body temperature that happens when a body dissipates more heat than it absorbs.
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Hypouricemia
Hypouricemia is a level of uric acid in blood serum that is below normal.
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Ileus
Ileus is a disruption of the normal propulsive ability of the gastrointestinal tract.
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Indigestion
Indigestion, also known as dyspepsia, is a condition of impaired digestion.
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Indonesia
Indonesia (or; Indonesian), officially the Republic of Indonesia (Republik Indonesia), is a transcontinental unitary sovereign state located mainly in Southeast Asia, with some territories in Oceania.
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Japan
Japan (日本; Nippon or Nihon; formally 日本国 or Nihon-koku, lit. "State of Japan") is a sovereign island country in East Asia.
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Leukopenia
Leukopenia is a decrease in the number of white blood cells (leukocytes) found in the blood, which places individuals at increased risk of infection.
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Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
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Metabolic syndrome
Metabolic syndrome, sometimes known by other names, is a clustering of at least three of the five following medical conditions: abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides and low high-density lipoprotein (HDL) levels.
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Muscarinic acetylcholine receptor M1
The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the CHRM1 gene.
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Muscarinic acetylcholine receptor M2
The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor that in humans is encoded by the CHRM2 gene.
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Muscarinic acetylcholine receptor M3
The muscarinic acetylcholine receptor, also known as cholinergic/acetylcholine receptor M3, or the muscarinic 3, is a muscarinic acetylcholine receptor encoded by the human gene CHRM3.
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Muscarinic acetylcholine receptor M4
The muscarinic acetylcholine receptor M4, also known as the cholinergic receptor, muscarinic 4 (CHRM4), is a protein that, in humans, is encoded by the CHRM4 gene.
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Muscarinic acetylcholine receptor M5
The human muscarinic acetylcholine receptor M5, encoded by the gene, is a member of the G protein-coupled receptor superfamily of integral membrane proteins.
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Muscle weakness
Muscle weakness or myasthenia (my- from Greek μυο meaning "muscle" + -asthenia ἀσθένεια meaning "weakness") is a lack of muscle strength.
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Myalgia
Myalgia, or muscle pain, is a symptom of many diseases and disorders.
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Mydriasis
Mydriasis is the dilation of the pupil, usually having a non-physiological cause, or sometimes a physiological pupillary response.
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Myoclonus
Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles.
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Neuroleptic malignant syndrome
Neuroleptic malignant syndrome (NMS) is a life-threatening reaction that occasionally occurs in response to neuroleptic or antipsychotic medication.
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Neutropenia
Neutropenia or neutropaenia is an abnormally low concentration of neutrophils (a type of white blood cell) in the blood.
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Norepinephrine reuptake inhibitor
A norepinephrine reuptake inhibitor (NRI, NERI) or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline) by blocking the action of the norepinephrine transporter (NET).
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Norepinephrine transporter
The norepinephrine transporter (NET), also known as solute carrier family 6 member 2 (SLC6A2), is a protein that in humans is encoded by the SLC6A2 gene.
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Nosebleed
A nosebleed, also known as epistaxis, is the common occurrence of bleeding from the nose.
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Noxiptiline
Noxiptiline (brand names Agedal, Elronon, Nogedal), also known as noxiptyline and dibenzoxine, is a tricyclic antidepressant (TCA) that was introduced in Europe in the 1970s for the treatment of depression. It has imipramine-like effects, acting as a serotonin and norepinephrine reuptake inhibitor, among other properties. Of the TCAs, noxiptiline has been described as one of the most effective, rivaling amitriptyline in clinical efficacy.
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Olanzapine
Olanzapine (originally branded Zyprexa) is an antipsychotic medication used to treat schizophrenia and bipolar disorder.
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Orphenadrine
Orphenadrine (sold under many brand names worldwide Page accessed Feb 5, 2016) is an anticholinergic drug of the ethanolamine antihistamine class; it is closely related to diphenhydramine.
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Orthostatic hypotension
Orthostatic hypotension, also known as postural hypotension, occurs when a person's blood pressure falls when suddenly standing up from a lying or sitting position.
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Paliperidone
Paliperidone, sold under the trade name Invega among others, is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class of medications.
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Palpitations
Palpitations are the perceived abnormality of the heartbeat characterized by awareness of cardiac muscle contractions in the chest: hard, fast and/or irregular beats.
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Pharmacodynamics
Pharmacodynamics is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).
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Portugal
Portugal, officially the Portuguese Republic (República Portuguesa),In recognized minority languages of Portugal: Portugal is the oldest state in the Iberian Peninsula and one of the oldest in Europe, its territory having been continuously settled, invaded and fought over since prehistoric times.
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QT interval
In cardiology, the QT interval is a measure of the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle.
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Quetiapine
Quetiapine, marketed as Seroquel among other names, is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.
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Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
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Risperidone
Risperidone, sold under the trade name Risperdal among others, is an antipsychotic medication.
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Schizophrenia
Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand reality.
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Serotonin transporter
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.
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Sexual dysfunction
Sexual dysfunction (or sexual malfunction or sexual disorder) is difficulty experienced by an individual or a couple during any stage of a normal sexual activity, including physical pleasure, desire, preference, arousal or orgasm.
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Shortness of breath
Shortness of breath, also known as dyspnea, is the feeling that one cannot breathe well enough.
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Somnolence
Somnolence (alternatively "sleepiness" or "drowsiness") is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia).
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Tachycardia
Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate.
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Tardive dyskinesia
Tardive dyskinesia (TD) is a disorder that results in involuntary, repetitive body movements.
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Thrombocythemia
Thrombocythemia (also thrombocytosis) is the presence of high platelet (thrombocyte) counts in the blood, and can be either primary (also termed essential thrombocythemia, and caused by a myeloproliferative disease) or secondary (also termed reactive).
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Thrombocytopenia
Thrombocytopenia is a condition characterized by abnormally low levels of thrombocytes, also known as platelets, in the blood.
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TLR4
Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene.
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Turkey
Turkey (Türkiye), officially the Republic of Turkey (Türkiye Cumhuriyeti), is a transcontinental country in Eurasia, mainly in Anatolia in Western Asia, with a smaller portion on the Balkan peninsula in Southeast Europe.
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United Kingdom
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain,Usage is mixed with some organisations, including the and preferring to use Britain as shorthand for Great Britain is a sovereign country in western Europe.
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Urinary retention
Urinary retention is an inability to completely empty the bladder.
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Xerostomia
Xerostomia, also known as dry mouth and dry mouth syndrome, is dryness in the mouth, which may be associated with a change in the composition of saliva, or reduced salivary flow, or have no identifiable cause.
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5-HT receptor
5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.
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5-HT1A receptor
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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5-HT1B receptor
5-hydroxytryptamine receptor 1B also known as the 5-HT1B receptor is a protein that in humans is encoded by the HTR1B gene.
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5-HT1D receptor
5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it.
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5-HT1E receptor
5-hydroxytryptamine (serotonin) 1E receptor (5-HT1E) is a highly expressed human G-protein coupled receptor that belongs to the 5-HT1 receptor family (Gi-coupled serotonin receptor).
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5-HT2A receptor
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).
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5-HT2C receptor
The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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5-HT3 receptor
The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin) receptors which are G protein-coupled receptors.
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5-HT5A receptor
5-Hydroxytryptamine (serotonin) receptor 5A, also known as HTR5A, is a protein that in humans is encoded by the HTR5A gene.
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5-HT6 receptor
The 5HT6 receptor is a subtype of 5HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5HT).
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5-HT7 receptor
The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) The 5-HT7 receptor is coupled to Gs (stimulates the production of the intracellular signaling molecule cAMP) and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in various blood vessels.
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ATC code N05AX11, ATCvet code QN05AX11, C18H18ClNOS.
References
[1] https://en.wikipedia.org/wiki/Zotepine
