Pavinetant

Pavinetant (developmental code names MLE-4901, AZD-4901, AZ-12472520, AZD-2624), is a small-molecule, orally active, selective neurokinin-3 (NK3) receptor antagonist which was under development by AstraZeneca and Millendo Therapeutics for the treatment of hot flashes and polycystic ovary syndrome (PCOS). ^[1]

9 relations: AstraZeneca, Binding selectivity, Hot flash, Oral administration, Polycystic ovary syndrome, Receptor antagonist, Schizophrenia, Small molecule, Tachykinin receptor 3.

AstraZeneca

AstraZeneca plc is an Anglo–Swedish multinational pharmaceutical and biopharmaceutical company.

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Binding selectivity

Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.

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Hot flash

Hot flashes (American English) or hot flushes (British English) are a form of flushing due to reduced levels of estradiol.

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Oral administration

| name.

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Polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a set of symptoms due to elevated androgens (male hormones) in females.

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Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.

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Schizophrenia

Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand reality.

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Small molecule

Within the fields of molecular biology and pharmacology, a small molecule is a low molecular weight (< 900 daltons) organic compound that may regulate a biological process, with a size on the order of 1 nm.

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Tachykinin receptor 3

Tachykinin receptor 3, also known as TACR3, is a protein which in humans is encoded by the TACR3 gene.

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Redirects here:

AZ 12472520, AZ-12472520, AZ12472520, AZD 2624, AZD 4901, AZD-2624, AZD-4901, AZD2624, AZD4901, MLE 4901, MLE-4901, MLE4901.

References

[1] https://en.wikipedia.org/wiki/Pavinetant

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