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14 relations: Autoimmune disease, Ciliary neurotrophic factor, Cluster of differentiation, Gene, Glycoprotein 130, Interleukin 6, Melanocyte, Microphthalmia-associated transcription factor, Multiple myeloma, Prostate cancer, Protein–protein interaction, Sarilumab, Tocilizumab, Type I cytokine receptor.
Autoimmune disease
An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.
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Ciliary neurotrophic factor
Ciliary neurotrophic factor is a protein that in humans is encoded by the CNTF gene.
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Cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Glycoprotein 130
Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors.
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Interleukin 6
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine.
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Melanocyte
Melanocytes are melanin-producing neural crest-derived cells located in the bottom layer (the stratum basale) of the skin's epidermis, the middle layer of the eye (the uvea), the inner ear, vaginal epithelium, meninges, bones, and heart.
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Microphthalmia-associated transcription factor
Microphthalmia-associated transcription factor also known as class E basic helix-loop-helix protein 32 or bHLHe32 is a protein that in humans is encoded by the MITF gene.
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Multiple myeloma
Multiple myeloma, also known as plasma cell myeloma, is a cancer of plasma cells, a type of white blood cell normally responsible for producing antibodies.
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Prostate cancer
Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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Sarilumab
Sarilumab (trade name Kevzara) is a human monoclonal antibody against the interleukin-6 receptor.
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Tocilizumab
Tocilizumab, also known as atlizumab, is an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis, a severe form of arthritis in children.
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Type I cytokine receptor
Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands.
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CD126, IL-6 receptor, IL6R, IL6R (gene), IL6RA, Interleukin 6 receptor.
