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MHC class I polypeptide-related sequence A

Index MHC class I polypeptide-related sequence A

MHC class I polypeptide-related sequence A (MICA) is a cell surface glycoprotein encoded by the MICA gene located within MHC locus. [1]

8 relations: Beta-2 microglobulin, Gene, Glycoprotein, Induced-self antigen, Major histocompatibility complex, MHC class I, MHC class I polypeptide-related sequence B, NKG2D.

Beta-2 microglobulin

β2 microglobulin also known as B2M is a component of MHC class I molecules, MHC class I molecules have α1, α2, and α3 proteins which are present on all nucleated cells (excludes red blood cells).

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Glycoprotein

Glycoproteins are proteins that contain oligosaccharide chains (glycans) covalently attached to amino acid side-chains.

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Induced-self antigen

Induced-self antigen is a marker of abnormal self, which can be recognized upon infected (in particular, virus-infected) and transformed cells.

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Major histocompatibility complex

The major histocompatibility complex (MHC) is a set of cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates, which in turn determines histocompatibility.

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MHC class I

MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other being MHC class II) and are found on the cell surface of all nucleated cells in the bodies of jawed vertebrates.

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MHC class I polypeptide-related sequence B

MHC class I polypeptide-related sequence B (MICB) is a protein that is encoded by the MICB gene located within MHC locus.

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NKG2D

NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors.

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Redirects here:

MIC-A, MICA (gene), PERB11.1, Perb11.1.

References

[1] https://en.wikipedia.org/wiki/MHC_class_I_polypeptide-related_sequence_A

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