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Glucose-6-phosphate dehydrogenase

Index Glucose-6-phosphate dehydrogenase

Glucose-6-phosphate dehydrogenase (G6PD or G6PDH) is a cytosolic enzyme that catalyzes the chemical reaction This enzyme participates in the pentose phosphate pathway (see image), a metabolic pathway that supplies reducing energy to cells (such as erythrocytes) by maintaining the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH). [1]

45 relations: Acetylation, Acute myeloid leukemia, Arginine, Bacteria, Catalysis, Chemical reaction, Cofactor (biochemistry), Cytosol, Dehydroepiandrosterone, Enzyme, Enzyme assay, Glucose 6-phosphate, Glucose-6-phosphate dehydrogenase deficiency, Glutamic acid, Glutathione, Glycolysis, Hemolytic anemia, HIF1A, Histidine, Human, Human genetic resistance to malaria, Hydrogen bond, Lysine, Metabolic pathway, Missense mutation, Mycobacterium tuberculosis, Nicotinamide adenine dinucleotide, Nicotinamide adenine dinucleotide phosphate, Pentose phosphate pathway, Peroxisome, PH, Proline, Protein dimer, Protein isoform, Rate-determining step, Red blood cell, Redox, Rossmann fold, Sirtuin 2, Stacking (chemistry), Transcription factor, Tuberculosis, Vicia faba, 4-Hydroxynonenal, 6-Phosphogluconolactone.

Acetylation

Acetylation (or in IUPAC nomenclature ethanoylation) describes a reaction that introduces an acetyl functional group into a chemical compound.

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Acute myeloid leukemia

Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells.

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Arginine

Arginine (symbol Arg or R) is an α-amino acid that is used in the biosynthesis of proteins.

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Bacteria

Bacteria (common noun bacteria, singular bacterium) is a type of biological cell.

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Catalysis

Catalysis is the increase in the rate of a chemical reaction due to the participation of an additional substance called a catalysthttp://goldbook.iupac.org/C00876.html, which is not consumed in the catalyzed reaction and can continue to act repeatedly.

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Chemical reaction

A chemical reaction is a process that leads to the transformation of one set of chemical substances to another.

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Cofactor (biochemistry)

A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's activity.

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Cytosol

The cytosol, also known as intracellular fluid (ICF) or cytoplasmic matrix, is the liquid found inside cells.

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Dehydroepiandrosterone

Dehydroepiandrosterone (DHEA), also known as androstenolone, is an endogenous steroid hormone.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Enzyme assay

Enzyme assays are laboratory methods for measuring enzymatic activity.

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Glucose 6-phosphate

Glucose 6-phosphate (sometimes called the Robison ester) is a glucose sugar phosphorylated at the hydroxy group on carbon 6.

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Glucose-6-phosphate dehydrogenase deficiency

Glucose-6-phosphate dehydrogenase deficiency (G6PDD) is an inborn error of metabolism that predisposes to red blood cell breakdown.

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Glutamic acid

Glutamic acid (symbol Glu or E) is an α-amino acid with formula.

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Glutathione

Glutathione (GSH) is an important antioxidant in plants, animals, fungi, and some bacteria and archaea.

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Glycolysis

Glycolysis (from glycose, an older term for glucose + -lysis degradation) is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+.

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Hemolytic anemia

Hemolytic anemia or haemolytic anaemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs), either in the blood vessels (intravascular hemolysis) or elsewhere in the human body (extravascular, but usually in the spleen).

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HIF1A

Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene.

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Histidine

Histidine (symbol His or H) is an α-amino acid that is used in the biosynthesis of proteins.

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Human

Humans (taxonomically Homo sapiens) are the only extant members of the subtribe Hominina.

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Human genetic resistance to malaria

Human genetic resistance to malaria refers to inherited changes in the DNA of humans which increase resistance to malaria and result in increased survival of individuals with those genetic changes.

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Hydrogen bond

A hydrogen bond is a partially electrostatic attraction between a hydrogen (H) which is bound to a more electronegative atom such as nitrogen (N), oxygen (O), or fluorine (F), and another adjacent atom bearing a lone pair of electrons.

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Lysine

Lysine (symbol Lys or K) is an α-amino acid that is used in the biosynthesis of proteins.

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Metabolic pathway

In biochemistry, a metabolic pathway is a linked series of chemical reactions occurring within a cell.

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Missense mutation

In genetics, a missense mutation is a point mutation in which a single nucleotide change results in a codon that codes for a different amino acid.

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Mycobacterium tuberculosis

Mycobacterium tuberculosis is a species of pathogenic bacteria in the family Mycobacteriaceae and the causative agent of tuberculosis.

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Nicotinamide adenine dinucleotide

Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells.

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Nicotinamide adenine dinucleotide phosphate

Nicotinamide adenine dinucleotide phosphate, abbreviated NADP or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.

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Pentose phosphate pathway

The pentose phosphate pathway (also called the phosphogluconate pathway and the hexose monophosphate shunt) is a metabolic pathway parallel to glycolysis.

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Peroxisome

A peroxisome is a type of organelle known as a microbody, found in virtually all eukaryotic cells.

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PH

In chemistry, pH is a logarithmic scale used to specify the acidity or basicity of an aqueous solution.

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Proline

Proline (symbol Pro or P) is a proteinogenic amino acid that is used in the biosynthesis of proteins.

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Protein dimer

In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.

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Protein isoform

A protein isoform, or "protein variant" is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.

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Rate-determining step

In chemical kinetics, the overall rate of a reaction is often approximately determined by the slowest step, known as the rate-determining step (RDS) or rate-limiting step.

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Red blood cell

Red blood cells-- also known as RBCs, red cells, red blood corpuscles, haematids, erythroid cells or erythrocytes (from Greek erythros for "red" and kytos for "hollow vessel", with -cyte translated as "cell" in modern usage), are the most common type of blood cell and the vertebrate's principal means of delivering oxygen (O2) to the body tissues—via blood flow through the circulatory system.

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Redox

Redox (short for reduction–oxidation reaction) (pronunciation: or) is a chemical reaction in which the oxidation states of atoms are changed.

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Rossmann fold

The Rossmann fold is a structural motif found in proteins that bind nucleotides, such as enzyme cofactors FAD, NAD+, and NADP+.

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Sirtuin 2

NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene.

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Stacking (chemistry)

In chemistry, pi stacking (also called π–π stacking) refers to attractive, noncovalent interactions between aromatic rings, since they contain pi bonds.

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Transcription factor

In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.

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Tuberculosis

Tuberculosis (TB) is an infectious disease usually caused by the bacterium Mycobacterium tuberculosis (MTB).

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Vicia faba

Vicia faba, also known as the broad bean, fava bean, faba bean, field bean, bell bean, or tic bean, is a species of flowering plant in the pea and bean family Fabaceae.

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4-Hydroxynonenal

4-Hydroxynonenal, or 4-hydroxy-2-nonenal or 4-HNE or HNE, (9162), is an α,β-unsaturated hydroxyalkenal that is produced by lipid peroxidation in cells.

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6-Phosphogluconolactone

6-Phosphogluconolactone is an intermediate in the pentose phosphate pathway.

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Redirects here:

D-glucose-6-phosphate:NADP+ 1-oxidoreductase, EC 1.1.1.49, G6P dehydrogenase, G6PD, G6PD (gene), G6PD1, G6PDH, G6pd1, G^PD, Glucose 6-p dehydrogenase, Glucose 6-phosphate dehydrogenase, Glucose-6-Phosphate Dehydrogenase, Glucose-6-phosphate-dehydrogenase.

References

[1] https://en.wikipedia.org/wiki/Glucose-6-phosphate_dehydrogenase

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