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147 relations: Acinus, Acne, Acute liver failure, Adenosine triphosphate, Alcohol (drug), Alcohol intolerance, Androgen, Androgen receptor, Apalutamide, Argentina, Asian people, Atrophy, Australia, Belgium, Bicalutamide, Binding selectivity, Biological half-life, Biosynthesis, Blood–brain barrier, Body hair, Bone, Bone fracture, Brazil, Breast development, Breast pain, Canada, Castration, Cell (biology), Cell growth, Central nervous system, Clinical trial, Color vision, Combination therapy, Constipation, Croatia, CYP17A1, CYP1A2, CYP2C19, CYP2C9, CYP3A4, Cyproterone acetate, Cytochrome P450, Czech Republic, Depression (mood), Dihydrotestosterone, Disulfiram, Drug intolerance, Efficacy, Egypt, Electron transport chain, ..., Elevated transaminases, Enzalutamide, Enzyme, Epithelium, Erectile dysfunction, Estradiol, Estrogen, Estrogen (medication), Ethinylestradiol, Europe, Facial hair, Fatigue, Feces, Feminization (biology), Finland, Flutamide, Follicle-stimulating hormone, France, Functional group, Glutathione, Gonadotropin-releasing hormone, Gonadotropin-releasing hormone analogue, Gynecomastia, Hepatitis, Hepatocyte, Hepatotoxicity, Histology, Hormone, Hot flash, Hydroxyflutamide, Hypothalamic–pituitary–gonadal axis, IC50, Insomnia, Interstitial cell, Interstitial lung disease, Japanese people, Latin America, Lebanon, Leuprorelin, Libido, Liver, Liver function tests, Luteinizing hormone, Maximum androgen blockade, Metabolism, Metabolite, Metribolone, Mexico, Mitochondrion, Muscle, NADH:ubiquinone oxidoreductase (H+-translocating), Nausea, Negative feedback, Netherlands, Nipple, Nitro compound, Nocturnal penile tumescence, Nonsteroidal antiandrogen, Norway, Oral administration, Pharmacovigilance, Poland, Portugal, Prolactin, Prostate, Prostate cancer, Pulmonary fibrosis, Pulmonary toxicity, Receptor antagonist, Respiratory failure, Roussel Uclaf, Seborrhoeic dermatitis, Seminiferous tubule, Serbia, Sex hormone-binding globulin, Sexual dysfunction, Shortness of breath, Side effect, Spironolactone, Steady state, Steroid, Stroma (tissue), Sweden, Switzerland, Testicle, Testosterone, Tolerability, Toxicity, Trademark distinctiveness, Trans woman, Transgender hormone therapy (male-to-female), United States, Urine, Vision disorder, Vomiting, Yugoslavia, 5α-Reductase. Expand index (97 more) »
Acinus
An acinus (plural, acini; adjective, acinar or acinous) refers to any cluster of cells that resembles a many-lobed "berry", such as a raspberry (acinus is Latin for "berry").
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Acne
Acne, also known as acne vulgaris, is a long-term skin disease that occurs when hair follicles are clogged with dead skin cells and oil from the skin.
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Acute liver failure
Acute liver failure is the appearance of severe complications rapidly after the first signs of liver disease (such as jaundice), and indicates that the liver has sustained severe damage (loss of function of 80–90% of liver cells).
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Adenosine triphosphate
Adenosine triphosphate (ATP) is a complex organic chemical that participates in many processes.
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Alcohol (drug)
Alcohol, also known by its chemical name ethanol, is a psychoactive substance or drug that is the active ingredient in alcoholic beverages such as beer, wine, and distilled spirits (hard liquor).
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Alcohol intolerance
Alcohol intolerance (or Acute alcohol sensitivity) is due to a genetic polymorphism of the enzyme alcohol dehydrogenase, the enzyme that metabolises ingested alcohol.
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Androgen
An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone which regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors.
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Androgen receptor
The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus.
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Apalutamide
Apalutamide, sold under the brand name Erleada, is a nonsteroidal antiandrogen (NSAA) medication which is used in the treatment of prostate cancer.
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Argentina
Argentina, officially the Argentine Republic (República Argentina), is a federal republic located mostly in the southern half of South America.
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Asian people
Asian people or Asiatic peopleUnited States National Library of Medicine.
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Atrophy
Atrophy is the partial or complete wasting away of a part of the body.
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Australia
Australia, officially the Commonwealth of Australia, is a sovereign country comprising the mainland of the Australian continent, the island of Tasmania and numerous smaller islands.
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Belgium
Belgium, officially the Kingdom of Belgium, is a country in Western Europe bordered by France, the Netherlands, Germany and Luxembourg.
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Bicalutamide
Bicalutamide, sold under the brand name Casodex among others, is an antiandrogen medication that is primarily used to treat prostate cancer.
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Binding selectivity
Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.
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Biological half-life
The biological half-life of a biological substance is the time it takes for half to be removed by biological processes when the rate of removal is roughly exponential.
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Biosynthesis
Biosynthesis (also called anabolism) is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms.
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Blood–brain barrier
The blood–brain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS).
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Body hair
Body hair, or androgenic hair, is the terminal hair that develops on the human body during and after puberty.
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Bone
A bone is a rigid organ that constitutes part of the vertebrate skeleton.
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Bone fracture
A bone fracture (sometimes abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a partial or complete break in the continuity of the bone.
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Brazil
Brazil (Brasil), officially the Federative Republic of Brazil (República Federativa do Brasil), is the largest country in both South America and Latin America.
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Breast development
Breast development, also known as mammogenesis, is a complex biological process in primates that takes place throughout a female's life.
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Breast pain
Breast pain is a medical symptom that is most often associated with a developing disease or condition of the breast.
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Canada
Canada is a country located in the northern part of North America.
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Castration
Castration (also known as gonadectomy) is any action, surgical, chemical, or otherwise, by which an individual loses use of the testicles.
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Cell (biology)
The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.
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Cell growth
The term cell growth is used in the contexts of biological cell development and cell division (reproduction).
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Central nervous system
The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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Color vision
Color vision is the ability of an organism or machine to distinguish objects based on the wavelengths (or frequencies) of the light they reflect, emit, or transmit.
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Combination therapy
Combination therapy or polytherapy is therapy that uses more than one medication or modality (versus monotherapy, which is any therapy taken alone).
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Constipation
Constipation refers to bowel movements that are infrequent or hard to pass.
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Croatia
Croatia (Hrvatska), officially the Republic of Croatia (Republika Hrvatska), is a country at the crossroads of Central and Southeast Europe, on the Adriatic Sea.
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CYP17A1
Cytochrome P450 17A1, also called steroid 17α-monooxygenase, 17α-hydroxylase, 17,20-lyase, or 17,20-desmolase, is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10.
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CYP1A2
Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.
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CYP2C19
Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme.
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CYP2C9
Cytochrome P450 2C9 (abbreviated CYP2C9) is an enzyme that in humans is encoded by the CYP2C9 gene.
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CYP3A4
Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.
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Cyproterone acetate
Cyproterone acetate (CPA), sold alone under the brand name Androcur or with ethinylestradiol (EE) under the brand names Diane or Diane-35 among others, is an antiandrogen and progestogen which is used in the treatment of androgen-dependent conditions like acne, excessive hair growth, early puberty, and prostate cancer, as a component of feminizing hormone therapy for transgender women, and in birth control pills.
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Cytochrome P450
Cytochromes P450 (CYPs) are proteins of the superfamily containing heme as a cofactor and, therefore, are hemoproteins.
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Czech Republic
The Czech Republic (Česká republika), also known by its short-form name Czechia (Česko), is a landlocked country in Central Europe bordered by Germany to the west, Austria to the south, Slovakia to the east and Poland to the northeast.
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Depression (mood)
Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, tendencies, feelings, and sense of well-being.
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Dihydrotestosterone
Dihydrotestosterone (DHT), or 5α-dihydrotestosterone (5α-DHT), also known as androstanolone or stanolone, is an endogenous androgen sex steroid and hormone.
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Disulfiram
Disulfiram (sold under the trade names Antabuse and Antabus) is a drug used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol).
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Drug intolerance
Drug intolerance or drug sensitivity refers to an inability to tolerate the adverse effects of a medication, generally at therapeutic or subtherapeutic doses.
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Efficacy
Efficacy is the ability to get a job done satisfactorily.
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Egypt
Egypt (مِصر, مَصر, Khēmi), officially the Arab Republic of Egypt, is a transcontinental country spanning the northeast corner of Africa and southwest corner of Asia by a land bridge formed by the Sinai Peninsula.
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Electron transport chain
An electron transport chain (ETC) is a series of complexes that transfer electrons from electron donors to electron acceptors via redox (both reduction and oxidation occurring simultaneously) reactions, and couples this electron transfer with the transfer of protons (H+ ions) across a membrane.
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Elevated transaminases
In medicine, the presence of elevated transaminases, commonly the transaminases alanine transaminase (ALT) and aspartate transaminase (AST), may be an indicator of liver damage.
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Enzalutamide
Enzalutamide, sold under the brand name Xtandi, is a nonsteroidal antiandrogen (NSAA) medication which is used in the treatment of prostate cancer.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Epithelium
Epithelium is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue.
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Erectile dysfunction
Erectile dysfunction (ED), also known as impotence, is a type of sexual dysfunction characterized by the inability to develop or maintain an erection of the penis during sexual activity.
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Estradiol
Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone.
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Estrogen
Estrogen, or oestrogen, is the primary female sex hormone.
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Estrogen (medication)
An estrogen is a type of medication which is used most commonly in hormonal birth control and menopausal hormone therapy.
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Ethinylestradiol
Ethinylestradiol (EE) is an estrogen medication which is used widely in birth control pills in combination with progestins.
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Europe
Europe is a continent located entirely in the Northern Hemisphere and mostly in the Eastern Hemisphere.
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Facial hair
Facial hair is hair grown on the face, usually on the chin, cheeks, and upper lip region.
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Fatigue
Fatigue is a subjective feeling of tiredness that has a gradual onset.
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Feces
Feces (or faeces) are the solid or semisolid remains of the food that could not be digested in the small intestine.
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Feminization (biology)
In biology and medicine, feminization is the development in an organism of physical characteristics that are usually unique to the female of the species.
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Finland
Finland (Suomi; Finland), officially the Republic of Finland is a country in Northern Europe bordering the Baltic Sea, Gulf of Bothnia, and Gulf of Finland, between Norway to the north, Sweden to the northwest, and Russia to the east.
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Flutamide
Flutamide, sold under the brand name Eulexin among others, is a nonsteroidal antiandrogen (NSAA) which is used primarily to treat prostate cancer.
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Follicle-stimulating hormone
Follicle-stimulating hormone (FSH) is a gonadotropin, a glycoprotein polypeptide hormone.
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France
France, officially the French Republic (République française), is a sovereign state whose territory consists of metropolitan France in Western Europe, as well as several overseas regions and territories.
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Functional group
In organic chemistry, functional groups are specific substituents or moieties within molecules that are responsible for the characteristic chemical reactions of those molecules.
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Glutathione
Glutathione (GSH) is an important antioxidant in plants, animals, fungi, and some bacteria and archaea.
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Gonadotropin-releasing hormone
Gonadotropin-releasing hormone (GnRH) also known as gonadoliberin, and by various other names in its endogenous form and as gonadorelin in its pharmaceutical form, is a releasing hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.
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Gonadotropin-releasing hormone analogue
A gonadotropin-releasing hormone analogue (GnRH analogue or analog), also known as a luteinizing hormone releasing hormone agonist (LHRH agonist) or LHRH analogue is a synthetic peptide drug modeled after the human hypothalamic gonadotropin-releasing hormone (GnRH).
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Gynecomastia
Gynecomastia is an endocrine system disorder in which a noncancerous increase in the size of male breast tissue occurs.
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Hepatitis
Hepatitis is inflammation of the liver tissue.
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Hepatocyte
A hepatocyte is a cell of the main parenchymal tissue of the liver.
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Hepatotoxicity
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.
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Histology
Histology, also microanatomy, is the study of the anatomy of cells and tissues of plants and animals using microscopy.
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Hormone
A hormone (from the Greek participle “ὁρμῶ”, "to set in motion, urge on") is any member of a class of signaling molecules produced by glands in multicellular organisms that are transported by the circulatory system to target distant organs to regulate physiology and behaviour.
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Hot flash
Hot flashes (American English) or hot flushes (British English) are a form of flushing due to reduced levels of estradiol.
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Hydroxyflutamide
Hydroxyflutamide (HF, OHF) (developmental code name SCH-16423), or 2-hydroxyflutamide, is a nonsteroidal antiandrogen (NSAA) and the major active metabolite of flutamide, which is considered to be a a prodrug of hydroxyflutamide as the active form.
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Hypothalamic–pituitary–gonadal axis
The hypothalamic–pituitary–gonadal axis (HPG axis) refers to the hypothalamus, pituitary gland, and gonadal glands as if these individual endocrine glands were a single entity.
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IC50
The half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function.
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Insomnia
Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.
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Interstitial cell
Interstitial cell refers to any cell that lies between other cells.
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Interstitial lung disease
Interstitial lung disease (ILD), or diffuse parenchymal lung disease (DPLD), is a group of lung diseases affecting the interstitium (the tissue and space around the air sacs of the lungs).
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Japanese people
are a nation and an ethnic group that is native to Japan and makes up 98.5% of the total population of that country.
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Latin America
Latin America is a group of countries and dependencies in the Western Hemisphere where Spanish, French and Portuguese are spoken; it is broader than the terms Ibero-America or Hispanic America.
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Lebanon
Lebanon (لبنان; Lebanese pronunciation:; Liban), officially known as the Lebanese RepublicRepublic of Lebanon is the most common phrase used by Lebanese government agencies.
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Leuprorelin
Leuprorelin, also known as leuprolide, is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, and early puberty.
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Libido
Libido, colloquially known as sex drive, is a person's overall sexual drive or desire for sexual activity.
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Liver
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
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Liver function tests
Liver function tests (LFTs or LFs) are groups of blood tests that give information about the state of a patient's liver.
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Luteinizing hormone
Luteinizing hormone (LH, also known as lutropin and sometimes lutrophin) is a hormone produced by gonadotropic cells in the anterior pituitary gland.
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Maximum androgen blockade
Maximum or maximal androgen blockade (MAB) or complete or combined androgen blockade (CAB) is a medical treatment involving the combination of both androgen receptor (AR) antagonism and inhibition or suppression of androgen production to attain maximal effectiveness in androgen deprivation therapy (ADT).
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Metabolism
Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.
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Metabolite
A metabolite is the intermediate end product of metabolism.
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Metribolone
Metribolone (developmental code name R1881), also known as methyltrienolone, is a synthetic and orally active anabolic–androgenic steroid (AAS) and a 17α-alkylated nandrolone (19-nortestosterone) derivative which was never marketed for medical use but has been widely used in scientific research as a hot ligand in androgen receptor (AR) ligand binding assays (LBAs) and as a photoaffinity label for the AR.
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Mexico
Mexico (México; Mēxihco), officially called the United Mexican States (Estados Unidos Mexicanos) is a federal republic in the southern portion of North America.
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Mitochondrion
The mitochondrion (plural mitochondria) is a double-membrane-bound organelle found in most eukaryotic organisms.
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Muscle
Muscle is a soft tissue found in most animals.
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NADH:ubiquinone oxidoreductase (H+-translocating)
NADH:ubiquinone oxidoreductase (also referred to as Type I NADH dehydrogenase and mitochondrial Complex I especially in humans) is an enzyme of the respiratory chains of myriad organisms from bacteria to humans.
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Nausea
Nausea or queasiness is an unpleasant sense of unease, discomfort, and revulsion towards food.
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Negative feedback
Negative feedback (or balancing feedback) occurs when some function of the output of a system, process, or mechanism is fed back in a manner that tends to reduce the fluctuations in the output, whether caused by changes in the input or by other disturbances.
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Netherlands
The Netherlands (Nederland), often referred to as Holland, is a country located mostly in Western Europe with a population of seventeen million.
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Nipple
The nipple is a raised region of tissue on the surface of the breast from which milk leaves the breast through the lactiferous ducts.
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Nitro compound
Nitro compounds are organic compounds that contain one or more nitro functional groups (−2).
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Nocturnal penile tumescence
Nocturnal penile tumescence (abbreviated as NPT) is a spontaneous erection of the penis during sleep or when waking up.
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Nonsteroidal antiandrogen
A nonsteroidal antiandrogen (NSAA) is an antiandrogen with a nonsteroidal chemical structure.
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Norway
Norway (Norwegian: (Bokmål) or (Nynorsk); Norga), officially the Kingdom of Norway, is a unitary sovereign state whose territory comprises the western portion of the Scandinavian Peninsula plus the remote island of Jan Mayen and the archipelago of Svalbard.
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Oral administration
| name.
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Pharmacovigilance
Pharmacovigilance (PV or PhV), also known as drug safety, is the pharmacological science relating to the collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products.
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Poland
Poland (Polska), officially the Republic of Poland (Rzeczpospolita Polska), is a country located in Central Europe.
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Portugal
Portugal, officially the Portuguese Republic (República Portuguesa),In recognized minority languages of Portugal: Portugal is the oldest state in the Iberian Peninsula and one of the oldest in Europe, its territory having been continuously settled, invaded and fought over since prehistoric times.
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Prolactin
Prolactin (PRL), also known as luteotropic hormone or luteotropin, is a protein that is best known for its role in enabling mammals, usually females, to produce milk.
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Prostate
The prostate (from Ancient Greek προστάτης, prostates, literally "one who stands before", "protector", "guardian") is a compound tubuloalveolar exocrine gland of the male reproductive system in most mammals.
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Prostate cancer
Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system.
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Pulmonary fibrosis
Pulmonary fibrosis (literally "scarring of the lungs") is a respiratory disease in which scars are formed in the lung tissues, leading to serious breathing problems.
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Pulmonary toxicity
Pulmonary toxicity is the medical name for side effects on the lungs.
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Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
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Respiratory failure
Respiratory failure results from inadequate gas exchange by the respiratory system, meaning that the arterial oxygen, carbon dioxide or both cannot be kept at normal levels.
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Roussel Uclaf
Roussel Uclaf S.A. was a French pharmaceutical company and one of several predecessor companies of today's Sanofi.
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Seborrhoeic dermatitis
Seborrhoeic dermatitis, also known as seborrhoea, is a long-term skin disorder.
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Seminiferous tubule
Seminiferous tubules are located within the testes, and are the specific location of meiosis, and the subsequent creation of male gametes, namely spermatozoa.
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Serbia
Serbia (Србија / Srbija),Pannonian Rusyn: Сербия; Szerbia; Albanian and Romanian: Serbia; Slovak and Czech: Srbsko,; Сърбия.
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Sex hormone-binding globulin
Sex hormone-binding globulin (SHBG) or sex steroid-binding globulin (SSBG) is a glycoprotein that binds to the two sex hormones: androgen and estrogen.
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Sexual dysfunction
Sexual dysfunction (or sexual malfunction or sexual disorder) is difficulty experienced by an individual or a couple during any stage of a normal sexual activity, including physical pleasure, desire, preference, arousal or orgasm.
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Shortness of breath
Shortness of breath, also known as dyspnea, is the feeling that one cannot breathe well enough.
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Side effect
In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.
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Spironolactone
Spironolactone, sold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease.
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Steady state
In systems theory, a system or a process is in a steady state if the variables (called state variables) which define the behavior of the system or the process are unchanging in time.
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Steroid
A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration.
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Stroma (tissue)
Stroma is the part of a tissue or organ with a structural or connective role.
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Sweden
Sweden (Sverige), officially the Kingdom of Sweden (Swedish), is a Scandinavian country in Northern Europe.
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Switzerland
Switzerland, officially the Swiss Confederation, is a sovereign state in Europe.
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Testicle
The testicle or testis is the male reproductive gland in all animals, including humans.
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Testosterone
Testosterone is the primary male sex hormone and an anabolic steroid.
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Tolerability
Tolerability refers to the degree to which overt adverse effects of a drug can be tolerated by a patient.
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Toxicity
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism.
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Trademark distinctiveness
Trademark distinctiveness is an important concept in the law governing trademarks and service marks.
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Trans woman
A trans woman (sometimes trans-woman or transwoman) is a woman who was assigned male at birth.
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Transgender hormone therapy (male-to-female)
Transgender hormone therapy of the male-to-female (MTF) type, also known as feminizing hormone therapy, is a form of hormone replacement therapy (HRT) and sex reassignment therapy which is used to change the secondary sexual characteristics of transgender people from masculine (or androgynous) to feminine.
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United States
The United States of America (USA), commonly known as the United States (U.S.) or America, is a federal republic composed of 50 states, a federal district, five major self-governing territories, and various possessions.
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Urine
Urine is a liquid by-product of metabolism in humans and in many animals.
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Vision disorder
A vision disorder is an impairment of the sense of vision.
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Vomiting
Vomiting, also known as emesis, puking, barfing, throwing up, among other terms, is the involuntary, forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose.
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Yugoslavia
Yugoslavia (Jugoslavija/Југославија; Jugoslavija; Југославија; Pannonian Rusyn: Югославия, transcr. Juhoslavija)Jugosllavia; Jugoszlávia; Juhoslávia; Iugoslavia; Jugoslávie; Iugoslavia; Yugoslavya; Югославия, transcr. Jugoslavija.
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5α-Reductase
5α-reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism.
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Redirects here:
ATC code L02BB02, ATCvet code QL02BB02, Anandron, Nilandron, Nilandrone, Nilutamida, Nilutamidum, RU 23,908, RU 23908, RU-23,908, RU-23908, RU23,908, RU23908.
References
[1] https://en.wikipedia.org/wiki/Nilutamide
