Glomerular basement membrane

The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus. ^[1]

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Table of Contents

1. 25 relations: Agrin, Alport syndrome, Antibody, Basal lamina, Basement membrane, Bowman's capsule, Collagen, Edema, Endothelium, Glomerulosclerosis, Glomerulus (kidney), Goodpasture syndrome, Heparan sulfate, Hyperglycemia, Hyperlipidemia, Hypoalbuminemia, Insulin, Kidney, Laminin, Mesangial cell, Nephrin, Nephrotic syndrome, Podocyte, Proteinuria, Ultrafiltration (kidney).

2. Kidney anatomy

Agrin

Agrin is a large proteoglycan whose best-characterised role is in the development of the neuromuscular junction during embryogenesis.

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Alport syndrome

Alport syndrome is a genetic disorder affecting around 1 in 5,000-10,000 children, characterized by glomerulonephritis, end-stage kidney disease, and hearing loss.

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Antibody

An antibody (Ab) is the secreted form of a B cell receptor; the term immunoglobulin (Ig) can refer to either the membrane-bound form or the secreted form of the B cell receptor, but they are, broadly speaking, the same protein, and so the terms are often treated as synonymous.

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Basal lamina

The basal lamina is a layer of extracellular matrix secreted by the epithelial cells, on which the epithelium sits.

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Basement membrane

The basement membrane, also known as base membrane, is a thin, pliable sheet-like type of extracellular matrix that provides cell and tissue support and acts as a platform for complex signalling.

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Bowman's capsule

Bowman's capsule (or the Bowman capsule, capsula glomeruli, or glomerular capsule) is a cup-like sac at the beginning of the tubular component of a nephron in the mammalian kidney that performs the first step in the filtration of blood to form urine. Glomerular basement membrane and Bowman's capsule are kidney anatomy.

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Collagen

Collagen is the main structural protein in the extracellular matrix of a body's various connective tissues.

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Edema

Edema (AmE), also spelled oedema (BrE), and also known as fluid retention, dropsy, hydropsy and swelling, is the build-up of fluid in the body's tissue.

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Endothelium

The endothelium (endothelia) is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels.

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Glomerulosclerosis

Glomerulosclerosis is the hardening of the glomeruli in the kidney.

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Glomerulus (kidney)

The glomerulus (glomeruli) is a network of small blood vessels (capillaries) known as a tuft, located at the beginning of a nephron in the kidney. Glomerular basement membrane and glomerulus (kidney) are kidney anatomy.

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Goodpasture syndrome

Goodpasture syndrome (GPS), also known as anti–glomerular basement membrane disease, is a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys, leading to bleeding from the lungs, glomerulonephritis, and kidney failure.

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Heparan sulfate

Heparan sulfate (HS) is a linear polysaccharide found in all animal tissues.

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Hyperglycemia

Hyperglycemia or Hyperglycaemia is a condition in which an excessive amount of glucose circulates in the blood plasma.

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Hyperlipidemia

Hyperlipidemia is abnormally high levels of any or all lipids (e.g. fats, triglycerides, cholesterol, phospholipids) or lipoproteins in the blood.

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Hypoalbuminemia

Hypoalbuminemia (or hypoalbuminaemia) is a medical sign in which the level of albumin in the blood is low.

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Insulin

Insulin (from Latin insula, 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (INS) gene.

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Kidney

In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation.

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Laminin

Laminins are a family of glycoproteins of the extracellular matrix of all animals.

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Mesangial cell

Mesangial cells are specialised cells in the kidney that make up the mesangium of the glomerulus.

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Nephrin

Nephrin is a protein necessary for the proper functioning of the renal filtration barrier.

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Nephrotic syndrome

Nephrotic syndrome is a collection of symptoms due to kidney damage.

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Podocyte

Podocytes are cells in Bowman's capsule in the kidneys that wrap around capillaries of the glomerulus. Glomerular basement membrane and Podocyte are kidney anatomy.

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Proteinuria

Proteinuria is the presence of excess proteins in the urine.

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Ultrafiltration (kidney)

In renal physiology, ultrafiltration occurs at the barrier between the blood and the filtrate in the glomerular capsule (Bowman's capsule) in the kidneys.

See Glomerular basement membrane and Ultrafiltration (kidney)

See also

Kidney anatomy

• Afferent arterioles
• Arcuate arteries of the kidney
• Arcuate vein
• Ascending limb of loop of Henle
• Augmented renal clearance
• Bowman's capsule
• Brodel's bloodless line
• Collecting duct system
• Cortical lobule
• Crossed renal ectopia
• Descending limb of loop of Henle
• Distal convoluted tubule
• Ectopic kidney
• Efferent arteriole
• Glomerular basement membrane
• Glomerulus (kidney)
• Interlobar arteries
• Interlobar veins
• Interlobular arteries
• Interlobular veins
• Intraglomerular mesangial cell
• Juxtaglomerular apparatus
• Juxtaglomerular cell
• Loop of Henle
• Macula densa
• Medullary ray (anatomy)
• Nephron
• Peritubular capillaries
• Podocyte
• Precision cut kidney slices
• Proximal tubule
• Renal calyx
• Renal capsule
• Renal circulation
• Renal column
• Renal corpuscle
• Renal cortex
• Renal fascia
• Renal hilum
• Renal lobe
• Renal medulla
• Renal pelvis
• Renal sinus
• Stellate veins
• Thin segment of loop of Henle
• Vasa recta (kidney)

References

[1] https://en.wikipedia.org/wiki/Glomerular_basement_membrane

Also known as Glomerular basement membranes.

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