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Glomerular basement membrane

Index Glomerular basement membrane

The glomerular basement membrane (GBM) of the kidney is the basal lamina layer of the glomerulus. [1]

25 relations: Agrin, Alport syndrome, Antibody, Basal lamina, Basement membrane, Bowman's capsule, Collagen, Edema, Endothelium, Glomerulosclerosis, Glomerulus (kidney), Goodpasture syndrome, Heparan sulfate, Hyperglycemia, Hyperlipidemia, Hypoalbuminemia, Insulin, Kidney, Laminin, Mesangial cell, Nephrin, Nephrotic syndrome, Podocyte, Proteinuria, Ultrafiltration (renal).

Agrin

Agrin is a large proteoglycan whose best-characterised role is in the development of the neuromuscular junction during embryogenesis.

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Alport syndrome

Alport syndrome is a genetic disorder affecting around 1 in 50,000 children, characterized by glomerulonephritis, end-stage kidney disease, and hearing loss.

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Antibody

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.

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Basal lamina

The basal lamina is a layer of extracellular matrix secreted by the epithelial cells, on which the epithelium sits.

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Basement membrane

The basement membrane is a thin, fibrous, extracellular matrix of tissue that separates the lining of an internal or external body surface from underlying connective tissue in metazoans.

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Bowman's capsule

Bowman's capsule (or the Bowman capsule, capsula glomeruli, or glomerular capsule) is a cup-like sack at the beginning of the tubular component of a nephron in the mammalian kidney that performs the first step in the filtration of blood to form urine.

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Collagen

Collagen is the main structural protein in the extracellular space in the various connective tissues in animal bodies.

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Edema

Edema, also spelled oedema or œdema, is an abnormal accumulation of fluid in the interstitium, located beneath the skin and in the cavities of the body, which can cause severe pain.

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Endothelium

Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.

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Glomerulosclerosis

Glomerulosclerosis, also known as glomerular sclerosis, is hardening of the glomeruli in the kidney.

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Glomerulus (kidney)

The glomerulus, plural glomeruli, is a network of capillaries known as a tuft, located at the beginning of a nephron in the kidney.

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Goodpasture syndrome

Goodpasture syndrome (GPS) is a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys, leading to bleeding from the lungs and kidney failure.

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Heparan sulfate

Heparan sulfate (HS) is a linear polysaccharide found in all animal tissues.

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Hyperglycemia

Hyperglycemia, or high blood sugar (also spelled hyperglycaemia or hyperglycæmia) is a condition in which an excessive amount of glucose circulates in the blood plasma.

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Hyperlipidemia

Hyperlipidemia is abnormally elevated levels of any or all lipids or lipoproteins in the blood.

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Hypoalbuminemia

Hypoalbuminemia (or hypoalbuminaemia) is a medical sign in which the level of albumin in the blood is abnormally low.

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Insulin

Insulin (from Latin insula, island) is a peptide hormone produced by beta cells of the pancreatic islets; it is considered to be the main anabolic hormone of the body.

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Kidney

The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.

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Laminin

Laminins are high-molecular weight (~400 to ~900 kDa) proteins of the extracellular matrix.

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Mesangial cell

Mesangial cells are specialised cells in the kidney that make up the mesangium of the glomerulus.

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Nephrin

Nephrin is a protein necessary for the proper functioning of the renal filtration barrier.

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Nephrotic syndrome

Nephrotic syndrome is a collection of symptoms due to kidney damage.

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Podocyte

Podocytes are cells in the Bowman's capsule in the kidneys that wrap around capillaries of the glomerulus.

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Proteinuria

Proteinuria is the presence of excess proteins in the urine.

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Ultrafiltration (renal)

In renal physiology, ultrafiltration occurs at the barrier between the blood and the filtrate in the glomerular capsule (Bowman's capsule) in the kidneys.

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Glomerular basement membranes.

References

[1] https://en.wikipedia.org/wiki/Glomerular_basement_membrane

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