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13 relations: Allosteric modulator, Anxiety, Biphenylindanone A, Clinical trial, Eglumegad, Janssen Pharmaceutica, LY-379,268, LY-404,039, LY-487,379, Major depressive disorder, Metabotropic glutamate receptor 2, Mixed anxiety–depressive disorder, Schizophrenia.
Allosteric modulator
In biochemistry and pharmacology, an allosteric modulator (allo- from the Greek meaning "other") is a substance which indirectly influences (modulates) the effects of a primary ligand that directly activates or deactivates the function of a target protein.
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Anxiety
Anxiety is an emotion characterized by an unpleasant state of inner turmoil, often accompanied by nervous behaviour such as pacing back and forth, somatic complaints, and rumination.
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Biphenylindanone A
Biphenylindanone A (BINA, LS-193,571) is a research agent which acts as a potent and selective positive allosteric modulator for the group II metabotropic glutamate receptor subtype mGluR2.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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Eglumegad
Eglumegad (LY354740) is a research drug developed by Eli Lilly and Company, which is being investigated for its potential in the treatment of anxiety and drug addiction.
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Janssen Pharmaceutica
Janssen Pharmaceutica is a pharmaceutical company headquartered in Beerse, Belgium.
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LY-379,268
LY-379,268 is a drug that is used in neuroscience research, which acts as a potent and selective agonist for the group II metabotropic glutamate receptors (mGluR2/3).
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LY-404,039
LY-404,039, also known as pomaglumetad, is an amino acid analog drug that acts as a highly selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3.
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LY-487,379
LY-487,379 is a drug used in scientific research that acts as a selective positive allosteric modulator for the metabotropic glutamate receptor group II subtype mGluR2.
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Major depressive disorder
Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.
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Metabotropic glutamate receptor 2
Metabotropic glutamate receptor 2 (mGluR2) is a protein that, in humans, is encoded by the GRM2 gene.
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Mixed anxiety–depressive disorder
Mixed anxiety–depressive disorder (MADD) is a diagnostic category defining patients who have both anxiety and depressive symptoms of limited and equal intensity accompanied by at least some autonomic features.
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Schizophrenia
Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand reality.
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ADX 71149, ADX71149, C19H15ClFNO2, JNJ 40411813, JNJ mGluR2 PAM, JNJ-40411813, JNJ-4041183, JNJ-mGluR2-PAM, JNJ40411813, JNJ4041183.
