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Oblimersen

Index Oblimersen

Oblimersen (INN, trade name Genasense; also known as Augmerosen and bcl-2 antisense oligodeoxynucleotide G3139) is an antisense oligodeoxyribonucleotide being studied as a possible treatment for several types of cancer, including chronic lymphocytic leukemia, B-cell lymphoma, and breast cancer. [1]

19 relations: Antisense therapy, B-cell lymphoma, Bcl-2, Breast cancer, Cancer, Cell (biology), Chronic lymphocytic leukemia, European Journal of Pharmaceutics and Biopharmaceutics, Food and Drug Administration, Genetic code, Genta (company), In vitro, International nonproprietary name, Lymphoma, Messenger RNA, Oblimersen, Oligonucleotide, Protein, Sense (molecular biology).

Antisense therapy

Antisense therapy is a form of treatment for genetic disorders or infections.

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B-cell lymphoma

The B-cell lymphomas are types of lymphoma affecting B cells.

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Bcl-2

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inducing (pro-apoptotic) or inhibiting (anti-apoptotic) apoptosis.

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Breast cancer

Breast cancer is cancer that develops from breast tissue.

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Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Cell (biology)

The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.

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Chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell).

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European Journal of Pharmaceutics and Biopharmaceutics

The European Journal of Pharmaceutics and Biopharmaceutics is a peer-reviewed medical journal and the official journal of the International Association for Pharmaceutical Technology.

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Food and Drug Administration

The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.

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Genetic code

The genetic code is the set of rules used by living cells to translate information encoded within genetic material (DNA or mRNA sequences) into proteins.

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Genta (company)

Genta Inc. was a biopharmaceutical company based in Berkeley Heights, New Jersey, United States, which developed products for the treatment of patients with cancer.

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In vitro

In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.

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International nonproprietary name

The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.

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Lymphoma

Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell).

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Messenger RNA

Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.

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Oblimersen

Oblimersen (INN, trade name Genasense; also known as Augmerosen and bcl-2 antisense oligodeoxynucleotide G3139) is an antisense oligodeoxyribonucleotide being studied as a possible treatment for several types of cancer, including chronic lymphocytic leukemia, B-cell lymphoma, and breast cancer.

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Oligonucleotide

Oligonucleotides are short DNA or RNA molecules, oligomers, that have a wide range of applications in genetic testing, research, and forensics.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Sense (molecular biology)

In molecular biology and genetics, the sense of nucleic acid molecules (often DNA or RNA) is the nature of their roles and their complementary molecules' nucleic acid units' roles in specifying amino acids.

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Redirects here:

ATC code L01XX36, ATCvet code QL01XX36, Augmerosen, Bcl-2 antisense oligodeoxynucleotide G3139, Genasense.

References

[1] https://en.wikipedia.org/wiki/Oblimersen

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