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73 relations: Active site, Akt/PKB signaling pathway, Androgen receptor, Autism, Auxilin, Bannayan–Riley–Ruvalcaba syndrome, Base pair, Biological target, Breast, C2 domain, Cancer, Casein kinase 2, alpha 1, Cell cycle, Cell membrane, Cowden syndrome, CSNK2A2, Cysteine, Deletion (genetics), Dephosphorylation, Dishevelled, Endometrial cancer, Enzyme, Gene, Glioblastoma, Hamartoma, Homology (biology), Inositol, Intrinsically disordered proteins, IRS1, Learning disability, Leucine, Lhermitte–Duclos disease, List of breast cancer cell lines, LNCaP, MAGI3, Major vault protein, Mammal, MDA-MB-468, Methionine, MIRN21, Multiple hamartoma syndrome, Mutation, NCI-60, NEDD4, Oncomir, P53, PC3, Phosphatase, Phosphatidylinositol, Phosphatidylinositol (3,4,5)-trisphosphate, ..., Phosphatidylinositol 4,5-bisphosphate, Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, Phosphodiester bond, Phosphorylation, PI3K/AKT/mTOR pathway, Prostate cancer, Protein, Protein kinase B, Protein tyrosine phosphatase, Protein–protein interaction, Proteus-like syndrome, PTK2, Sarcopoterium, Sirolimus, Structural biology, Substrate (chemistry), Temsirolimus, Tensin, Thyroid, TNS1, Tumor suppressor, Uterus, X-ray crystallography. Expand index (23 more) »
Active site
In biology, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction.
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Akt/PKB signaling pathway
The Akt Pathway, or PI3K-Akt Pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals.
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Androgen receptor
The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus.
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Autism
Autism is a developmental disorder characterized by troubles with social interaction and communication and by restricted and repetitive behavior.
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Auxilin
Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.
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Bannayan–Riley–Ruvalcaba syndrome
Bannayan–Riley–Ruvalcaba syndrome (BRRS) is a rare overgrowth syndrome and hamartomatous disorder with occurrence of multiple subcutaneous lipomas, macrocephaly and hemangiomas.
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Base pair
A base pair (bp) is a unit consisting of two nucleobases bound to each other by hydrogen bonds.
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Biological target
A biological target is anything within a living organism to which some other entity (like an endogenous ligand or a drug) is directed and/or binds, resulting in a change in its behavior or function.
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Breast
The breast is one of two prominences located on the upper ventral region of the torso of primates.
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C2 domain
A C2 domain is a protein structural domain involved in targeting proteins to cell membranes.
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
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Casein kinase 2, alpha 1
Casein kinase II subunit alpha is an enzyme that in humans is encoded by the CSNK2A1 gene.
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Cell cycle
The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication of its DNA (DNA replication) to produce two daughter cells.
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Cell membrane
The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates the interior of all cells from the outside environment (the extracellular space).
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Cowden syndrome
Cowden syndrome (also known as Cowden's disease and multiple hamartoma syndrome) is an autosomal dominant inherited condition characterized by benign overgrowths called hamartomas as well as an increased lifetime risk of breast, thyroid, uterine, and other cancers.
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CSNK2A2
Casein kinase II subunit alpha' is an enzyme that in humans is encoded by the CSNK2A2 gene.
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Cysteine
Cysteine (symbol Cys or C) is a semi-essential proteinogenic amino acid with the formula HO2CCH(NH2)CH2SH.
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Deletion (genetics)
In genetics, a deletion (also called gene deletion, deficiency, or deletion mutation) (sign: Δ) is a mutation (a genetic aberration) in which a part of a chromosome or a sequence of DNA is lost during DNA replication.
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Dephosphorylation
Dephosphorylation is the removal of a phosphate (PO43−) group from an organic compound by hydrolysis.
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Dishevelled
Dishevelled (Dsh) is a family of proteins involved in canonical and non-canonical Wnt signalling pathways.
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Endometrial cancer
Endometrial cancer is a cancer that arises from the endometrium (the lining of the uterus or womb).
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Enzyme
Enzymes are macromolecular biological catalysts.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Glioblastoma
Glioblastoma, also known as glioblastoma multiforme (GBM), is the most aggressive cancer that begins within the brain.
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Hamartoma
A hamartoma is a mostly benign, focal malformation that resembles a neoplasm in the tissue of its origin.
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Homology (biology)
In biology, homology is the existence of shared ancestry between a pair of structures, or genes, in different taxa.
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Inositol
Myo-inositol, or simply inositol, is a carbocyclic sugar that is abundant in brain and other mammalian tissues, mediates cell signal transduction in response to a variety of hormones, neurotransmitters and growth factors and participates in osmoregulation It is a sugar alcohol with half the sweetness of sucrose (table sugar).
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Intrinsically disordered proteins
An intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure.
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IRS1
Insulin receptor substrate 1 (IRS-1) is a signaling adapter protein that in humans is encoded by the IRS-1 gene.
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Learning disability
Learning disability is a classification that includes several areas of functioning in which a person has difficulty learning in a typical manner, usually caused by an unknown factor or factors.
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Leucine
Leucine (symbol Leu or L) is an essential amino acid that is used in the biosynthesis of proteins.
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Lhermitte–Duclos disease
Lhermitte–Duclos disease (LDD), also called dysplastic gangliocytoma of the cerebellum, is a rare, slowly growing tumor of the cerebellum, a gangliocytoma sometimes considered to be a hamartoma, characterized by diffuse hypertrophy of the granular layer of the cerebellum.
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List of breast cancer cell lines
Scientists study the behaviour of isolated cells grown in the laboratory for insights into how cells function in the body in health and disease.
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LNCaP
LNCaP cells are a cell line of human cells commonly used in the field of oncology.
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MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 is an enzyme that in humans is encoded by the MAGI3 gene.
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Major vault protein
Major vault protein is a protein that in humans is encoded by the MVP gene.
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Mammal
Mammals are the vertebrates within the class Mammalia (from Latin mamma "breast"), a clade of endothermic amniotes distinguished from reptiles (including birds) by the possession of a neocortex (a region of the brain), hair, three middle ear bones, and mammary glands.
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MDA-MB-468
MDA-MB-468 is a cell line that was isolated from a 51-year-old female human in 1977, and is commonly used in breast cancer research.
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Methionine
Methionine (symbol Met or M) is an essential amino acid in humans.
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MIRN21
microRNA 21 also known as hsa-mir-21 or miRNA21 is a mammalian microRNA that is encoded by the MIR21 gene.
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Multiple hamartoma syndrome
Multiple hamartoma syndrome is a syndrome characterized by more than one hamartoma.
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Mutation
In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.
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NCI-60
The NCI-60 cancer cell line panel is a group of 60 human cancer cell lines used by the National Cancer Institute (NCI) for the screening of compounds to detect potential anticancer activity.
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NEDD4
E3 ubiquitin-protein ligase NEDD4 also known as neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4) is an enzyme that in humans is encoded by the NEDD4 gene.
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Oncomir
An oncomir (also oncomiR) is a microRNA (miRNA) that is associated with cancer.
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P53
Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).
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PC3
PC3 (PC-3) is a human prostate cancer cell line used in prostate cancer research and drug development.
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Phosphatase
A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol.
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Phosphatidylinositol
Phosphatidylinositol consists of a family of lipids as illustrated on the right, a class of the phosphatidylglycerides.
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Phosphatidylinositol (3,4,5)-trisphosphate
Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3), abbreviated PIP3, is the product of the class I phosphoinositide 3-kinases (PI 3-kinases) phosphorylation of phosphatidylinositol (4,5)-bisphosphate (PIP2).
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Phosphatidylinositol 4,5-bisphosphate
Phosphatidylinositol 4,5-bisphosphate or PtdIns(4,5)P2, also known simply as PIP2 or PI(4,5)P2, is a minor phospholipid component of cell membranes.
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Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
In enzymology, a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are phosphatidylinositol 3,4,5-trisphosphate and H2O, whereas its two products are phosphatidylinositol 4,5-bisphosphate and phosphate.
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Phosphodiester bond
A phosphodiester bond occurs when exactly two of the hydroxyl groups in phosphoric acid react with hydroxyl groups on other molecules to form two ester bonds.
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Phosphorylation
In chemistry, phosphorylation of a molecule is the attachment of a phosphoryl group.
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PI3K/AKT/mTOR pathway
The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle.
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Prostate cancer
Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Protein kinase B
Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.
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Protein tyrosine phosphatase
Protein tyrosine phosphatases are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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Proteus-like syndrome
Proteus-like syndrome (PLS) is a condition similar to Proteus syndrome, but with an uncertain cause.
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PTK2
PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene.
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Sarcopoterium
Sarcopoterium is a genus of flowering plants in the rose family.
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Sirolimus
Sirolimus, also known as rapamycin, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection and to treat a rare lung disease called lymphangioleiomyomatosis.
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Structural biology
Structural biology is a branch of molecular biology, biochemistry, and biophysics concerned with the molecular structure of biological macromolecules (especially proteins, made up of amino acids, and RNA or DNA, made up of nucleic acids), how they acquire the structures they have, and how alterations in their structures affect their function.
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Substrate (chemistry)
In chemistry, a substrate is typically the chemical species being observed in a chemical reaction, which reacts with a reagent to generate a product.
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Temsirolimus
Temsirolimus (codenamed CCI-779) is an intravenous drug for the treatment of renal cell carcinoma (RCC), developed by Wyeth Pharmaceuticals and approved by the U.S. Food and Drug Administration (FDA) in late May 2007, and was also approved by the European Medicines Agency (EMEA) on November 2007.
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Tensin
Tensin was first identified as a 220 kDa multi-domain protein localized to the specialized regions of plasma membrane called integrin-mediated focal adhesions (which are formed around a transmembrane core of an αβ integrin heterodimer).
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Thyroid
The thyroid gland, or simply the thyroid, is an endocrine gland in the neck, consisting of two lobes connected by an isthmus.
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TNS1
Tensin-1 is a protein that in humans is encoded by the TNS1 gene.
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Tumor suppressor
A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer.
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Uterus
The uterus (from Latin "uterus", plural uteri) or womb is a major female hormone-responsive secondary sex organ of the reproductive system in humans and most other mammals.
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X-ray crystallography
X-ray crystallography is a technique used for determining the atomic and molecular structure of a crystal, in which the crystalline atoms cause a beam of incident X-rays to diffract into many specific directions.
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Redirects here:
PTEN gene, Phosphatase and tensin homolog.
References
[1] https://en.wikipedia.org/wiki/PTEN_(gene)
