16 relations: Antiestrogen, Breast cancer, Cell (biology), Clinical trial, Estradiol, Estrogen, Estrogen receptor, In vitro, Ligand (biochemistry), MCF-7, Metabolite, Methodology, Nonsteroidal, Selective estrogen receptor modulator, Zindoxifene, 2-Phenylindole.
Antiestrogens, also known as estrogen antagonists or estrogen blockers, are a class of drugs which prevent estrogens like estradiol from mediating their biological effects in the body.
Breast cancer is cancer that develops from breast tissue.
The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.
Clinical trials are experiments or observations done in clinical research.
Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone.
Estrogen, or oestrogen, is the primary female sex hormone.
Estrogen receptors (ERs) are a group of proteins found inside cells.
In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old Caucasian woman.
A metabolite is the intermediate end product of metabolism.
Methodology is the systematic, theoretical analysis of the methods applied to a field of study.
Nonsteroidal is a term which is used to describe a compound that is not a steroid.
Selective estrogen receptor modulators (SERMs) are a class of drugs that act on the estrogen receptor (ER).
Zindoxifene (INN; former developmental code names D-16726, NSC-341952) is a nonsteroidal selective estrogen receptor modulator (SERM) that was under development in the 1980s and early 1990s for the treatment of breast cancer but was not marketed.
2-Phenylindole is an organic compound.