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Index D-15414

D-15414 is a nonsteroidal weak estrogen of the 2-phenylindole group which was never marketed. [1]

16 relations: Antiestrogen, Breast cancer, Cell (biology), Clinical trial, Estradiol, Estrogen, Estrogen receptor, In vitro, Ligand (biochemistry), MCF-7, Metabolite, Methodology, Nonsteroidal, Selective estrogen receptor modulator, Zindoxifene, 2-Phenylindole.


Antiestrogens, also known as estrogen antagonists or estrogen blockers, are a class of drugs which prevent estrogens like estradiol from mediating their biological effects in the body.

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Breast cancer

Breast cancer is cancer that develops from breast tissue.

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Cell (biology)

The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.

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Clinical trial

Clinical trials are experiments or observations done in clinical research.

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Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone.

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Estrogen, or oestrogen, is the primary female sex hormone.

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Estrogen receptor

Estrogen receptors (ERs) are a group of proteins found inside cells.

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In vitro

In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.

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Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

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MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old Caucasian woman.

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A metabolite is the intermediate end product of metabolism.

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Methodology is the systematic, theoretical analysis of the methods applied to a field of study.

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Nonsteroidal is a term which is used to describe a compound that is not a steroid.

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Selective estrogen receptor modulator

Selective estrogen receptor modulators (SERMs) are a class of drugs that act on the estrogen receptor (ER).

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Zindoxifene (INN; former developmental code names D-16726, NSC-341952) is a nonsteroidal selective estrogen receptor modulator (SERM) that was under development in the 1980s and early 1990s for the treatment of breast cancer but was not marketed.

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2-Phenylindole is an organic compound.

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D 15414, D15414.


[1] https://en.wikipedia.org/wiki/D-15414

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