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18 relations: Agonist, Antidepressant, Autoreceptor, Befiradol, Binding selectivity, Chemical synapse, Eptapirone, Food and Drug Administration, Functional selectivity, Laboratoires Pierre Fabre, Neurolixis, Orphan drug, Prefrontal cortex, Raphe nuclei, Rare disease, Rett syndrome, University of Bristol, 5-HT1A receptor.
Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Antidepressant
Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.
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Autoreceptor
An autoreceptor is a type of receptor located in the membranes of presynaptic nerve cells.
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Befiradol
Befiradol (F-13,640; NLX-112) is a very potent and highly selective 5-HT1A receptor full agonist.
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Binding selectivity
Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.
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Chemical synapse
Chemical synapses are biological junctions through which neurons' signals can be exchanged to each other and to non-neuronal cells such as those in muscles or glands.
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Eptapirone
Eptapirone (F-11,440) is a very potent and highly selective 5-HT1A receptor full agonist of the azapirone family.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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Functional selectivity
Functional selectivity (or “agonist trafficking”, “biased agonism”, “biased signalling”, "ligand bias" and “differential engagement”) is the ligand-dependent selectivity for certain signal transduction pathways relative to a reference ligand (often the endogenous hormone or peptide) at the same receptor.
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Laboratoires Pierre Fabre
Laboratoires Pierre Fabre is a French multinational pharmaceutical and cosmetics company.
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Neurolixis
Neurolixis is a biopharmaceutical company focused on novel drugs for the treatment of human central nervous system diseases.
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Orphan drug
An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.
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Prefrontal cortex
In mammalian brain anatomy, the prefrontal cortex (PFC) is the cerebral cortex which covers the front part of the frontal lobe.
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Raphe nuclei
The raphe nuclei (ῥαφή "seam"Liddell, H.G. & Scott, R. (1940). A Greek-English Lexicon. revised and augmented throughout by Sir Henry Stuart Jones. with the assistance of. Roderick McKenzie. Oxford: Clarendon Press.) are a moderate-size cluster of nuclei found in the brain stem.
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Rare disease
A rare disease is any disease that affects a small percentage of the population.
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Rett syndrome
Rett syndrome (RTT) is a genetic brain disorder which typically becomes apparent after 6 to 18 months of age in females.
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University of Bristol
The University of Bristol (simply referred to as Bristol University and abbreviated as Bris. in post-nominal letters, or UoB) is a red brick research university located in Bristol, United Kingdom.
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5-HT1A receptor
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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