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F-15,599, also known as NLX-101, is a very potent and highly selective 5-HT1A receptor full agonist. [1]

18 relations: Agonist, Antidepressant, Autoreceptor, Befiradol, Binding selectivity, Chemical synapse, Eptapirone, Food and Drug Administration, Functional selectivity, Laboratoires Pierre Fabre, Neurolixis, Orphan drug, Prefrontal cortex, Raphe nuclei, Rare disease, Rett syndrome, University of Bristol, 5-HT1A receptor.


An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

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Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.

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An autoreceptor is a type of receptor located in the membranes of presynaptic nerve cells.

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Befiradol (F-13,640; NLX-112) is a very potent and highly selective 5-HT1A receptor full agonist.

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Binding selectivity

Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.

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Chemical synapse

Chemical synapses are specialized junctions through which neurons signal to each other and to non-neuronal cells such as those in muscles or glands.

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Eptapirone (F-11,440) is a very potent and highly selective 5-HT1A receptor full agonist of the azapirone family.

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Food and Drug Administration

The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.

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Functional selectivity

Functional selectivity (or “agonist trafficking”, “biased agonism”, "ligand bias", and “differential engagement”) is the ligand-dependent selectivity for certain signal transduction pathways in one and the same receptor.

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Laboratoires Pierre Fabre

Laboratoires Pierre Fabre is a French multinational pharmaceutical and cosmetics company.

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Neurolixis is a biopharmaceutical company focused on novel drugs for the treatment of human central nervous system diseases.

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Orphan drug

An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.

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Prefrontal cortex

In mammalian brain anatomy, the prefrontal cortex (PFC) is the cerebral cortex which covers the front part of the frontal lobe.

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Raphe nuclei

The raphe nuclei ("raffe", Greek: ῥαφή.

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Rare disease

A rare disease, also referred to as an orphan disease, is any disease that affects a small percentage of the population.

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Rett syndrome

Rett syndrome (RTT), originally termed cerebroatrophic hyperammonemia, is a rare genetic postnatal neurological disorder of the grey matter of the brain that almost exclusively affects females but has also been found in male patients.

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University of Bristol

The University of Bristol (abbreviated as Bris. in post-nominal letters, sometimes referred to as Bristol University) is a red brick research university located in Bristol, United Kingdom.

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5-HT1A receptor

The 5-HT1A receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

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Redirects here:

C19H22ClF2N4O, F 15,599, F 15599, F-15599, F15,599, F15599.


[1] https://en.wikipedia.org/wiki/F-15,599

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