Table of Contents
34 relations: Adenylyl cyclase, Adverse effect, Agonist, Allodynia, Analgesic, Animal models of Parkinson's disease, Antagonist, Benzothiophene, Binding selectivity, Drug tolerance, Eptapirone, Extracellular signal-regulated kinases, F-15,599, Flesinoxan, Food and Drug Administration, G alpha subunit, G protein, Investigational New Drug, Laboratoires Pierre Fabre, Levodopa-induced dyskinesia, MPTP, Neurolixis, Opioid, Parkinson's disease, Parkinson's UK, Parkinsonism, Patient recruitment, Positron emission tomography, Potency (pharmacology), Receptor-mediated endocytosis, Structure–activity relationship, The Michael J. Fox Foundation, The Sunday Times, 5-HT1A receptor.
Adenylyl cyclase
Adenylate cyclase (EC 4.6.1.1, also commonly known as adenyl cyclase and adenylyl cyclase, abbreviated AC) is an enzyme with systematic name ATP diphosphate-lyase (cyclizing; 3′,5′-cyclic-AMP-forming).
See Befiradol and Adenylyl cyclase
Adverse effect
An adverse effect is an undesired harmful effect resulting from a medication or other intervention, such as surgery.
See Befiradol and Adverse effect
Agonist
An agonist is a chemical that activates a receptor to produce a biological response.
Allodynia
Allodynia is a condition in which pain is caused by a stimulus that does not normally elicit pain.
Analgesic
An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management. Befiradol and analgesic are analgesics.
Animal models of Parkinson's disease
Animal models of Parkinson's disease are essential in the research field and widely used to study Parkinson's disease.
See Befiradol and Animal models of Parkinson's disease
Antagonist
An antagonist is a character in a story who is presented as the main enemy and rival of the protagonist.
Benzothiophene
Benzothiophene is an aromatic organic compound with a molecular formula C8H6S and an odor similar to naphthalene (mothballs).
See Befiradol and Benzothiophene
Binding selectivity
In chemistry, binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.
See Befiradol and Binding selectivity
Drug tolerance
Drug tolerance or drug insensitivity is a pharmacological concept describing subjects' reduced reaction to a drug following its repeated use.
See Befiradol and Drug tolerance
Eptapirone
Eptapirone (F-11,440) is a very potent and highly selective 5-HT1A receptor full agonist of the azapirone family.
Extracellular signal-regulated kinases
In molecular biology, extracellular signal-regulated kinases (ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells.
See Befiradol and Extracellular signal-regulated kinases
F-15,599
F-15,599, also known as NLX-101, is a potent and selective 5-HT1A receptor full agonist. Befiradol and f-15,599 are Benzamides, Fluoroarenes and Piperidines.
Flesinoxan
Flesinoxan (DU-29,373) is a potent and selective 5-HT1A receptor partial/near-full agonist of the phenylpiperazine class. Befiradol and Flesinoxan are Benzamides and Fluoroarenes.
Food and Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services.
See Befiradol and Food and Drug Administration
G alpha subunit
G alpha subunits are one of the three types of subunit of guanine nucleotide binding proteins, which are membrane-associated, heterotrimeric G proteins.
See Befiradol and G alpha subunit
G protein
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.
Investigational New Drug
The United States Food and Drug Administration's Investigational New Drug (IND) program is the means by which a pharmaceutical company obtains permission to start human clinical trials and to ship an experimental drug across state lines (usually to clinical investigators) before a marketing application for the drug has been approved.
See Befiradol and Investigational New Drug
Laboratoires Pierre Fabre
Laboratoires Pierre Fabre is a French multinational pharmaceutical and cosmetics company.
See Befiradol and Laboratoires Pierre Fabre
Levodopa-induced dyskinesia
Levodopa-induced dyskinesia (LID) is a form of dyskinesia associated with levodopa (l-DOPA), used to treat Parkinson's disease.
See Befiradol and Levodopa-induced dyskinesia
MPTP
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is an organic compound.
Neurolixis
Neurolixis is a biopharmaceutical company focused on novel drugs for the treatment of human central nervous system diseases.
Opioid
Opioids are a class of drugs that derive from, or mimic, natural substances found in the opium poppy plant.
Parkinson's disease
Parkinson's disease (PD), or simply Parkinson's, is a long-term neurodegenerative disease of mainly the central nervous system that affects both the motor and non-motor systems of the body.
See Befiradol and Parkinson's disease
Parkinson's UK
Parkinson's UK is a Parkinson's research and support charity in the United Kingdom.
See Befiradol and Parkinson's UK
Parkinsonism
Parkinsonism is a clinical syndrome characterized by tremor, bradykinesia (slowed movements), rigidity, and postural instability.
See Befiradol and Parkinsonism
Patient recruitment
Patient recruitment is the process of finding and enrolling suitable participants for clinical trials.
See Befiradol and Patient recruitment
Positron emission tomography
Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption.
See Befiradol and Positron emission tomography
Potency (pharmacology)
In pharmacology, potency or biological potency is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity.
See Befiradol and Potency (pharmacology)
Receptor-mediated endocytosis
Receptor-mediated endocytosis (RME), also called clathrin-mediated endocytosis, is a process by which cells absorb metabolites, hormones, proteins – and in some cases viruses – by the inward budding of the plasma membrane (invagination).
See Befiradol and Receptor-mediated endocytosis
Structure–activity relationship
The structure–activity relationship (SAR) is the relationship between the chemical structure of a molecule and its biological activity.
See Befiradol and Structure–activity relationship
The Michael J. Fox Foundation
The Michael J. Fox Foundation for Parkinson's Research is a US non-profit organization founded in 2000 by Canadian-American actor Michael J. Fox to find a cure for Parkinson's disease.
See Befiradol and The Michael J. Fox Foundation
The Sunday Times
The Sunday Times is a British Sunday newspaper whose circulation makes it the largest in Britain's quality press market category.
See Befiradol and The Sunday Times
5-HT1A receptor
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin, also known as 5-HT, a neurotransmitter.
See Befiradol and 5-HT1A receptor
References
Also known as C20H22ClF2N3O, F 13640, F-13,640, F-13640, F13640.