Table of Contents
38 relations: Alpha helix, Amiodarone, Antitarget, Arginine, Arrhythmia, C-terminus, Cardiac action potential, Cardiac conduction system, Cardiac muscle, Cell membrane, Channelopathy, City of Hope National Medical Center, Crystallography, Diethyl ether, Drosophila, Duarte, California, Food and Drug Administration, Good laboratory practice, Heterologous, KcsA potassium channel, Long QT syndrome, Lysine, N-terminus, PAS domain, Potassium channel, Protein isoform, Protein subunit, Protein–protein interaction, Schizophrenia Research Forum, Short QT syndrome, Thioridazine, Torsades de pointes, University of Wisconsin–Madison, Ventricular tachycardia, Voltage-gated potassium channel, West Hollywood, California, Whisky a Go Go, YWHAE.
- PAS-domain-containing proteins
Alpha helix
An alpha helix (or α-helix) is a sequence of amino acids in a protein that are twisted into a coil (a helix).
Amiodarone
Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of cardiac dysrhythmias.
Antitarget
In pharmacology, an antitarget (or off-target) is a receptor, enzyme, or other biological target that, when affected by a drug, causes undesirable side-effects.
Arginine
Arginine is the amino acid with the formula (H2N)(HN)CN(H)(CH2)3CH(NH2)CO2H.
Arrhythmia
Arrhythmias, also known as cardiac arrhythmias, are irregularities in the heartbeat, including when it is too fast or too slow.
C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, carboxy tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
Cardiac action potential
Unlike the action potential in skeletal muscle cells, the cardiac action potential is not initiated by nervous activity.
See HERG and Cardiac action potential
Cardiac conduction system
The cardiac conduction system (CCS, also called the electrical conduction system of the heart) transmits the signals generated by the sinoatrial node – the heart's pacemaker, to cause the heart muscle to contract, and pump blood through the body's circulatory system.
See HERG and Cardiac conduction system
Cardiac muscle
Cardiac muscle (also called heart muscle or myocardium) is one of three types of vertebrate muscle tissues, with the other two being skeletal muscle and smooth muscle.
Cell membrane
The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of a cell from the outside environment (the extracellular space).
Channelopathy
Channelopathies are a group of diseases caused by the dysfunction of ion channel subunits or their interacting proteins.
City of Hope National Medical Center
City of Hope is a private, non-profit clinical research center, hospital and graduate school located in Duarte, California, United States.
See HERG and City of Hope National Medical Center
Crystallography
Crystallography is the branch of science devoted to the study of molecular and crystalline structure and properties.
Diethyl ether
Diethyl ether, or simply ether, is an organic compound with the chemical formula, sometimes abbreviated as.
Drosophila
Drosophila is a genus of fly, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species to linger around overripe or rotting fruit.
Duarte, California
Duarte is a city in Los Angeles County, California, United States.
See HERG and Duarte, California
Food and Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services.
See HERG and Food and Drug Administration
Good laboratory practice
The establish rules and criteria for a quality system that oversees the organizational processes and conditions in which non-clinical health and environmental safety studies are planned, conducted, monitored, recorded, reported, and archived.
See HERG and Good laboratory practice
Heterologous
The term heterologous has several meanings in biology.
KcsA potassium channel
KcsA (K channel of streptomyces A) is a prokaryotic potassium channel from the soil bacterium ''Streptomyces lividans'' that has been studied extensively in ion channel research. HERG and KcsA potassium channel are ion channels.
See HERG and KcsA potassium channel
Long QT syndrome
Long QT syndrome (LQTS) is a condition affecting repolarization (relaxing) of the heart after a heartbeat, giving rise to an abnormally lengthy QT interval.
Lysine
Lysine (symbol Lys or K) is an α-amino acid that is a precursor to many proteins.
See HERG and Lysine
N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide, referring to the free amine group (-NH2) located at the end of a polypeptide.
PAS domain
A Per-Arnt-Sim (PAS) domain is a protein domain found in all kingdoms of life.
Potassium channel
Potassium channels are the most widely distributed type of ion channel found in virtually all organisms. HERG and Potassium channel are ion channels.
See HERG and Potassium channel
Protein isoform
A protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.
Protein subunit
In structural biology, a protein subunit is a polypeptide chain or single protein molecule that assembles (or "coassembles") with others to form a protein complex.
Protein–protein interaction
Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forces, hydrogen bonding and the hydrophobic effect.
See HERG and Protein–protein interaction
Schizophrenia Research Forum
Schizophrenia Research Forum is a web knowledge environment dedicated to news, information resources, and discussion about research on schizophrenia.
See HERG and Schizophrenia Research Forum
Short QT syndrome
Short QT syndrome (SQT) is a very rare genetic disease of the electrical system of the heart, and is associated with an increased risk of abnormal heart rhythms and sudden cardiac death.
See HERG and Short QT syndrome
Thioridazine
Thioridazine (Mellaril or Melleril) is a first generation antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis.
Torsades de pointes
Torsades de pointes, torsade de pointes or torsades des pointes (TdP; also called torsades) (translated as "twisting of peaks") is a specific type of abnormal heart rhythm that can lead to sudden cardiac death.
See HERG and Torsades de pointes
University of Wisconsin–Madison
The University of Wisconsin–Madison (University of Wisconsin, Wisconsin, UW, UW–Madison, or simply Madison) is a public land-grant research university in Madison, Wisconsin, United States.
See HERG and University of Wisconsin–Madison
Ventricular tachycardia
Ventricular tachycardia (V-tach or VT) is a cardiovascular disorder in which fast heart rate occurs in the ventricles of the heart.
See HERG and Ventricular tachycardia
Voltage-gated potassium channel
Voltage-gated potassium channels (VGKCs) are transmembrane channels specific for potassium and sensitive to voltage changes in the cell's membrane potential.
See HERG and Voltage-gated potassium channel
West Hollywood, California
West Hollywood is a city in Los Angeles County, California, United States.
See HERG and West Hollywood, California
Whisky a Go Go
The Whisky a Go Go (informally nicknamed The Whisky) is a historic nightclub in West Hollywood, California, United States.
YWHAE
14-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene.
See HERG and YWHAE
See also
PAS-domain-containing proteins
- ARNT2
- ARNTL2
- Aryl hydrocarbon receptor
- Aryl hydrocarbon receptor nuclear translocator
- Basic helix-loop-helix ARNT-like protein 1
- CLOCK
- EPAS1
- HERG
- HIF1A
- HIF3A
- KCNH1
- KCNH3
- KCNH4
- NPAS1
- NPAS2
- NPAS3
- Nuclear receptor coactivator 1
- Nuclear receptor coactivator 2
- Nuclear receptor coactivator 3
- PASD1
- PASK
- PDE8A
- PDE8B
- PER2
- PER3
- Period (gene)
- Period circadian protein homolog 1
- SIM1
- SIM2
References
Also known as ERG1, HERG1, Human Ether-à-go-go-Related Gene, IKR, KCNH2, KCNH2 (gene), Kv11.1, SQT1.